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Sonya Zabludoff
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Journal Articles

Abstract CT040: First-in-human dose-expansion study of NBF-006, a novel investigational siRNA targeting GSTP, in patients with KRAS-mutated non-small cell lung cancer

Lyudmila Bazhenova, Hirva Mamdani, Alberto Chiappori, Alexander Spira, Wade Iams, Anthony Tolcher, Minal Barve, Afshin Gabayan, Andrae Vandross, Cima Cina, Yael Cohen-Arazi, Zachary Albaugh, Annie Huynh, Joachim Gullbo, Sonya Zabludoff
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT040.
https://doi.org/10.1158/1538-7445.AM2024-CT040
Published: 05 April 2024
View articletitled, Abstract CT040: First-in-human dose-expansion study of NBF-006, a novel investigational siRNA targeting GSTP, in patients with KRAS-mutated non-small cell lung cancer
Journal Articles

Abstract 7165: Clinical population pharmacokinetic (popPK) analysis of NBF-006, a novel siRNA inhibitor of glutathione-S-transferase P (GSTP) encapsulated in a lipid nano particle (LNP), for treatment of advanced non-small cell lung cancer (NSCLC)

Michael P. Hall, Zhihong O'Brien, Xi Chen, Angelean Hendrix, Stacy Brenes-Coto, Sonya Zabludoff
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7165.
https://doi.org/10.1158/1538-7445.AM2024-7165
Published: 22 March 2024
View articletitled, Abstract 7165: Clinical population pharmacokinetic (popPK) analysis of NBF-006, a novel siRNA inhibitor of glutathione-S-transferase P (GSTP) encapsulated in a lipid nano particle (LNP), for treatment of advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer

Cima Cina, Jens Harborth, Zhihong O'Brien, Nish Beltran-Raygoza, Jung-kang Jin, Jessica Xu, Sang Jun Lee, Kwok Tsang, Jiping Yao, Roger Adami, Sonya Zabludoff, Wenbin Ying
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5918.
https://doi.org/10.1158/1538-7445.AM2018-5918
Published: 01 July 2018
View articletitled, Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer
Journal Articles

Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer

Zhihong O'Brien*, Li Wang*, Bharat Majeti*, Jeanpierre Clamme, Robiel Baclig, James Chu, Steven Fong, Jens Harborth, Jose Ibarra, Haiqing Yin, Jing Yu, Clayton Zhang, Roger Adami, Sonya Zabludoff, Wenbin Ying
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5917.
https://doi.org/10.1158/1538-7445.AM2018-5917
Published: 01 July 2018
View articletitled, Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer
Journal Articles

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

Jing Zhang, Jingjing Jiao, Silvia Cermelli, Kyle Muir, Kwang Hwa Jung, Ruhai Zou, Asif Rashid, Mihai Gagea, Sonya Zabludoff, Raghu Kalluri, Laura Beretta
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1859–1867.
https://doi.org/10.1158/0008-5472.CAN-14-1254
Published: 30 April 2015
View articletitled, miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Open the PDF for miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 5234: Serum microRNAs reflect microRNA expression in tumor tissues as well as systemic response to disease in HRAS-driven mouse models of HCC

Adam Pavlicek, Vladyslava Ratushna, Shirley Phillips, Cynthia Heinlein, Jian Li, Vivek Kaimal, Sonya Zabludoff, Nelson Chau
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5234.
https://doi.org/10.1158/1538-7445.AM2014-5234
Published: 01 October 2014
View articletitled, Abstract 5234: Serum microRNAs reflect microRNA expression in tumor tissues as well as systemic response to disease in HRAS-driven mouse models of HCC
Journal Articles

Abstract 4787: Targeting miR-21 in hepatocellular carcinoma

Sonya Zabludoff, Timothy Wagenaar, Francisco Adrian, Charles Allerson, Heike Arlt, Raffaele Baffa, Bal Bhat, Hui Cao, Scott Davis, Carlos Garcia-Echeverria, Kathrin Heermeier, Shih-Min Huang, Lan Jiang, Eric Marcusson, Christiane Metz-Weidmann, Adam Pavlicek, Jack Pollard, Jennifer Rocnik, Sabine Scheidler, Chaomei Shi, Fangxian Sun, Tatiana Tolstykh, Qunyan Yu, Gang Zheng, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4787.
https://doi.org/10.1158/1538-7445.AM2014-4787
Published: 01 October 2014
View articletitled, Abstract 4787: Targeting miR-21 in hepatocellular carcinoma
Journal Articles

Abstract 1459: miR-221: A potential therapeutic target for hepatocellular carcinoma

Edmund C. Lee, Jessica Xu, Thomas Vincent, Jie Chen, Michael Nelson, Xinqiang Huang, Eric Marcusson, John Androsavich, Scott Davis, Adam Pavlicek, Neil Gibson, Sonya Zabludoff
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1459.
https://doi.org/10.1158/1538-7445.AM2014-1459
Published: 01 October 2014
View articletitled, Abstract 1459: miR-221: A potential therapeutic target for hepatocellular carcinoma
Journal Articles

Abstract 1461: A miR-221 multigene pharmacodynamic signature for assessing miR-221 inhibition

Adam Pavlicek, Thomas Vincent, Oivin Guicherit, Nelson Chau, Sonya Zabludoff, Neil Gibson, Edmund C. Lee
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1461.
https://doi.org/10.1158/1538-7445.AM2014-1461
Published: 01 October 2014
View articletitled, Abstract 1461: A miR-221 multigene pharmacodynamic signature for assessing miR-221 inhibition
Journal Articles

Abstract LB-390: Antitumor efficacy of crizotinib (PF-02341066), a potent and selective ALK and c-Met RTK inhibitor, in EML4-ALK driven NSCLC tumors in vitro and in vivo

Helen Y. Zou, Qiuhua Li, Joseph Lee, Lars Engstrom, Melissa West Lu, Alex Young, Sergei Timofeevski, Dac M. Dinh, Shinji Yamazaki, Justine Lam, Zheng Feng, Jeffrey Nickel, Patrick B. Lappin, Tim Nichols, Anthony Wong, Brittany Snider, Hovhannes Gukasyan, Steve Bender, Sonya Zabludoff, Tod Smeal, James R. Christensen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-390.
https://doi.org/10.1158/1538-7445.AM2011-LB-390
Published: 15 April 2011
View articletitled, Abstract LB-390: Antitumor efficacy of crizotinib (PF-02341066), a potent and selective ALK and c-Met RTK inhibitor, in EML4-ALK driven NSCLC tumors in vitro and in vivo
Journal Articles

Abstract 491: The roles of homologous recombination repair and cell cycle checkpoints in radiosensitization by the Chk1/2 inhibitor, AZD7762

Meredith Ann Morgan, Leslie Parsels, Lili Zhao, Joshua Parsels, Mary Davis, Sankari Arumugarajah, Christine Canman, Sonya Zabludoff, Jonathan Maybaum, Theodore Lawrence
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 491.
https://doi.org/10.1158/1538-7445.AM10-491
Published: 15 April 2010
View articletitled, Abstract 491: The roles of homologous recombination repair and cell cycle checkpoints in radiosensitization by the Chk1/2 inhibitor, AZD7762
Journal Articles

Abstract #2291: Targeting Chk1 to enhance gemcitabine-radiation therapy efficacy in pancreatic cancer

Meredith Morgan, Leslie Parsels, Joshua Parsels, Mary Davis, Linda Hylander-Gans, Sonya Zabludoff, Diane Simeone, Jonathan Maybaum, Theodore Lawrence
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2291.
Published: 01 May 2009
View articletitled, Abstract #2291: Targeting Chk1 to enhance gemcitabine-radiation therapy efficacy in pancreatic cancer
Journal Articles

Abstract #2487: Olaparib (AZD2281; PARP inhibitor) and AZD7762 (CHK inhibitor) act synergistically to enhance cell death and reduce tumor growth in preclinical models

Sonya Zabludoff, Zhu Cao, Linda Hylander-Gans, Patricia McCoon, Deborah Morosini, Mark O'Connor, Lourdes Pablo, Adam Sheehy
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2487.
Published: 01 May 2009
View articletitled, Abstract #2487: Olaparib (AZD2281; PARP inhibitor) and AZD7762 (CHK inhibitor) act synergistically to enhance cell death and reduce tumor growth in preclinical models
Journal Articles

A novel in vivo pharmacodynamic model for cell cycle targeted cancer therapeutics

Dongfang Liu, Shannon Ready, Sonya Zabludoff, Lucienne Ronco, Kevin Webster, Christophe Queva
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 968–969.
Published: 01 May 2005
View articletitled, A novel in vivo pharmacodynamic model for cell cycle targeted cancer therapeutics