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Journal Articles

Abstract 4572: 3D-EXpress ex vivo platform using a biorepository of characterized fresh patient tumoroids allows development of rational combinations with drugs targeting DNA damage response and immune checkpoint blockade

Jared Ehrhart, Seth Currlin, Sharon Camacho, Samantha Hoffman, Angie Rivera, Soner Altiok
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4572.
https://doi.org/10.1158/1538-7445.AM2023-4572
Published: 04 April 2023
View article titled, Abstract 4572: 3D-EXpress ex vivo platform using a biorepository of characterized fresh patient tumoroids allows development of rational combinations with drugs targeting DNA damage response and immune checkpoint blockade
Journal Articles

Abstract 4571: A novel ex vivo platform, 3D-EXpress, to rapidly assess the efficacy of KRAS targeting drugs alone and in combination with nivolumab using a biorepository of fresh patient tumoroids with intact tumor microenvironment

Jared Ehrhart, Brittney Ruedlinger, Angie Rivera, Romanus Ezeoke, Sharon Camacho, Seth Currlin, Soner Altiok
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4571.
https://doi.org/10.1158/1538-7445.AM2023-4571
Published: 04 April 2023
View article titled, Abstract 4571: A novel <em>ex vivo</em> platform, 3D-EXpress, to rapidly assess the efficacy of KRAS targeting drugs alone and in combination with nivolumab using a biorepository of fresh patient tumoroids with intact tumor microenvironment
Journal Articles

Abstract 4557: 3D-EXpress platform utilizing tumoroids from patients with MSS and MSI-H tumors allows rapid assessment of anti-tumor activity of immune checkpoint inhibitors and development of clinically relevant biomarkers of treatment response

Brittney Ruedlinger, Seth Currlin, Sharon Camacho, Alliyah Humphrey, Jared Ehrhart, Soner Altiok
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4557.
https://doi.org/10.1158/1538-7445.AM2023-4557
Published: 04 April 2023
View article titled, Abstract 4557: 3D-EXpress platform utilizing tumoroids from patients with MSS and MSI-H tumors allows rapid assessment of anti-tumor activity of immune checkpoint inhibitors and development of clinically relevant biomarkers of treatment response
Journal Articles

Abstract 4552: 3D-EXplore platform of fresh patient tumoroids with intact TME allows assessment of the efficacy of drugs targeting the tumor stroma on ex vivo tumor immunotherapy

Seth Currlin, Brittney Ruedlinger, Sharon Camacho, Angie Rivera, Jasmin D'Andrea, Jared Ehrhart, Soner Altiok
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4552.
https://doi.org/10.1158/1538-7445.AM2023-4552
Published: 04 April 2023
View article titled, Abstract 4552: 3D-EXplore platform of fresh patient tumoroids with intact TME allows assessment of the efficacy of drugs targeting the tumor stroma on <em>ex vivo</em> tumor immunotherapy
Journal Articles

Abstract 288: An ex-vivo 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess transcriptional and compositional changes of the immune landscape in intact tumor microenvironment using single-cell proteogenomics

Jonathan P. Waterman-Smith, Jared Ehrhart, Brittany Bunch, Krithika Kodumudi, Matt Weitzman, Olivia MacIntosh, Kelly Sussman, Soner Altiok
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 288.
https://doi.org/10.1158/1538-7445.AM2022-288
Published: 15 June 2022
View article titled, Abstract 288: An <em>ex-vivo</em> 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess transcriptional and compositional changes of the immune landscape in intact tumor microenvironment using single-cell proteogenomics
Journal Articles

Abstract 246: Application of the 3d fresh patient tumoroid platform 3d-explore to assess the immunomodulatory and phagocytic activity of the receptor tyrosine kinase inhibitor, Sunitinib

Brittany Bunch, Krithika N. Kodumudi, Jared Ehrhart, Matt Weitzman, Olivia MacIntosh, Kelly Sussman, Soner Altiok
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 246.
https://doi.org/10.1158/1538-7445.AM2022-246
Published: 15 June 2022
View article titled, Abstract 246: Application of the 3d fresh patient tumoroid platform 3d-explore to assess the immunomodulatory and phagocytic activity of the receptor tyrosine kinase inhibitor, Sunitinib
Journal Articles

Abstract 239: Assessment of immunotherapeutic efficacy of entinostat by using the 3d-explore ex vivo platform utilizing tumoroids of fresh patient tumor samples with intact tumor microenvironment

Krithika Nandakumar Kodumudi, Brittany Bunch, Jared Ehrhart, Matt Weitzman, Olivia MacIntosh, Kelly Sussman, Soner Altiok
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 239.
https://doi.org/10.1158/1538-7445.AM2022-239
Published: 15 June 2022
View article titled, Abstract 239: Assessment of immunotherapeutic efficacy of entinostat by using the 3d-explore <em>ex vivo</em> platform utilizing tumoroids of fresh patient tumor samples with intact tumor microenvironment
Journal Articles

Abstract 2649: An ex vivo 3D tumoroid model of fresh patient tissue (3D-EX) to assess the efficacy of anti-angiogenic compounds in renal cell carcinoma

Jared Ehrhart, Mibel M. Pabón, Stephen Iwanowycz, Zhisong Tong, Tina Pastoor, Soner Altiok
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2649.
https://doi.org/10.1158/1538-7445.AM2021-2649
Published: 01 July 2021
View article titled, Abstract 2649: An ex vivo 3D tumoroid model of fresh patient tissue (3D-EX) to assess the efficacy of anti-angiogenic compounds in renal cell carcinoma
Journal Articles

Abstract 1501: Employing 3D-ACT platform to assess the ability of stromal-targeting agents to improve penetration and efficacy of cell therapy

Zhisong Tong, Stephen Iwanowycz, Jared Ehrhart, Mibel M. Pabón, Tina Pastoor, Soner Altiok
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1501.
https://doi.org/10.1158/1538-7445.AM2021-1501
Published: 01 July 2021
View article titled, Abstract 1501: Employing 3D-ACT platform to assess the ability of stromal-targeting agents to improve penetration and efficacy of cell therapy
Journal Articles

Abstract 1566: Monitoring the impact of IL15 in combination with Sting agonists and nivolumab on activation and proliferation of tumor resident immune cells in 3D-EX platform of intact patient tumoroids

Mibel M. Pabón, Jared Ehrhart, Stephen Iwanowycz, Zhisong Tong, Tina Pastoor, Soner Altiok
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1566.
https://doi.org/10.1158/1538-7445.AM2021-1566
Published: 01 July 2021
View article titled, Abstract 1566: Monitoring the impact of IL15 in combination with Sting agonists and nivolumab on activation and proliferation of tumor resident immune cells in 3D-EX platform of intact patient tumoroids
Journal Articles

Abstract 935: Optimization of checkpoint inhibitor-TKI combinations in renal cell carcinoma using an ex vivo 3D tumor organoid model of fresh patient tissue with intact TME

Jared C. Ehrhart, Mibel M. Pabón, Vijayendra Agrawal, Tina Pastoor, Jenny M. Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 935.
https://doi.org/10.1158/1538-7445.AM2020-935
Published: 15 August 2020
View article titled, Abstract 935: Optimization of checkpoint inhibitor-TKI combinations in renal cell carcinoma using an <em>ex vivo</em> 3D tumor organoid model of fresh patient tissue with intact TME
Journal Articles

Abstract 6652: Employing ex vivo 3D-Screen technology for the development of rational combinations of immuno-oncology drugs in tumor organoids of fresh patient tissue

Vijayendra Agrawal, Mibel M. Pabón, Jared C. Ehrhart, Tina Pastoor, Jenny M. Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6652.
https://doi.org/10.1158/1538-7445.AM2020-6652
Published: 15 August 2020
View article titled, Abstract 6652: Employing <em>ex vivo</em> 3D-Screen technology for the development of rational combinations of immuno-oncology drugs in tumor organoids of fresh patient tissue
Journal Articles

Abstract 2546: Impact of CDK4/6 inhibition on tumor immune microenvironment and immunomodulatory effects PD-L1 blockade in a physiologically relevant 3D-tumoroid model of fresh patient tumor tissue ex vivo

Melba Marie Page, Melanie Mediavilla Varela, Vijayendra Agrawal, Jenny Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2546.
https://doi.org/10.1158/1538-7445.AM2019-2546
Published: 01 July 2019
View article titled, Abstract 2546: Impact of CDK4/6 inhibition on tumor immune microenvironment and immunomodulatory effects PD-L1 blockade in a physiologically relevant 3D-tumoroid model of fresh patient tumor tissue <em>ex vivo</em>
Journal Articles

Abstract 34: A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples

Melanie Mediavilla-Varela, Vijayendra Agrawal, Melba Marie Page, Jenny Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 34.
https://doi.org/10.1158/1538-7445.AM2019-34
Published: 01 July 2019
View article titled, Abstract 34: A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples
Journal Articles

Abstract 42: The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation

Vijayendra Agrawal, Melanie Mediavilla-Varela, Melba Marie Page, Jenny Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 42.
https://doi.org/10.1158/1538-7445.AM2019-42
Published: 01 July 2019
View article titled, Abstract 42: The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation
Journal Articles

Abstract LB-347: Integrated Comprehensive Analysis of Immune Cell Subsets and Assessment of Checkpoint Inhibitor Response in Head and Neck Squamous Cell Carcinoma, Urothelial Carcinoma and Renal Cell Carcinoma 3D Ex Vivo

Melba Marie Page, Melanie Mediavilla Varela, Jenny Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-347.
https://doi.org/10.1158/1538-7445.AM2018-LB-347
Published: 01 July 2018
View article titled, Abstract LB-347: Integrated Comprehensive Analysis of Immune Cell Subsets and Assessment of Checkpoint Inhibitor Response in Head and Neck Squamous Cell Carcinoma, Urothelial Carcinoma and Renal Cell Carcinoma 3D <em>Ex Vivo</em>
Journal Articles

Abstract 1020: Characterization of the immune landscape and analysis of tumor response after anti-PD-1 blockade in a 3D ex vivo system of non-small lung cancer

Melanie Mediavilla-Varela, Melba Marie Page, Jenny Kreahling, Soner Altiok
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1020.
https://doi.org/10.1158/1538-7445.AM2018-1020
Published: 01 July 2018
View article titled, Abstract 1020: Characterization of the immune landscape and analysis of tumor response after anti-PD-1 blockade in a 3D <em>ex vivo</em> system of non-small lung cancer
Journal Articles

Abstract 274: Bavituximab modulates tumor microenvironment and activates CD8+ tumor infiltrating lymphocytes in a patient-derived 3D ex vivo system of lung cancer

Soner Altiok, Melanie Mediavilla-Valera, Jenny Kreahling, David Noyes, Tiffany N. Razabdouski, Nikoletta L. Kallinteris, Joseph Shan, Scott Antonia
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 274.
https://doi.org/10.1158/1538-7445.AM2015-274
Published: 01 August 2015
View article titled, Abstract 274: Bavituximab modulates tumor microenvironment and activates CD8+ tumor infiltrating lymphocytes in a patient-derived 3D <em>ex vivo</em> system of lung cancer
Journal Articles

Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy

Rupal Ramakrishnan, Chun Huang, Hyun-Il Cho, Mark Lloyd, Joseph Johnson, Xiubao Ren, Soner Altiok, Daniel Sullivan, Jeffrey Weber, Esteban Celis, Dmitry I. Gabrilovich
Journal: Cancer Research
Cancer Res (2012) 72 (21): 5483–5493.
https://doi.org/10.1158/0008-5472.CAN-12-2236
Published: 31 October 2012
View article titled, Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy
Open the PDF for Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors

Yun Bai, Jiannong Li, Bin Fang, Arthur Edwards, Guolin Zhang, Marilyn Bui, Steven Eschrich, Soner Altiok, John Koomen, Eric B. Haura
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2501–2511.
https://doi.org/10.1158/0008-5472.CAN-11-3015
Published: 14 May 2012
View article titled, Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Open the PDF for Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors in another window
Includes: Supplementary data