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Sofia D. Merajver
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Journal Articles

Abstract B013: Precision medicine platform to guide the treatment of NSCLC

Nathan M Merrill, Aaron M Udager, Angel Qin, Kiran Lagisetty, Liwei Bao, Xu Cheng, Hamadi Madhi, Ananya Banerjee, Marziyeh Salehi Jahromi, Laura Goo, Varun Kathawate, Bryce Vandenburg, Mary Horn, Derek Nancarrow, Tusharika Rastogi, Albert Liu, Ning Gu, Zhaoping Qin, Habib Serhan, Marisa Aikins, Vishal Navani, John Jefferies, Muhammad Sajawal Ali, Michael Monument, Johannes Kratz, Amber Smith, Andrew Chang, Gregory Kalemkerian, Stacy Fry, Peter Ulintz, Sunitha Nagrath, Peggy Hsu, Matthew B Soellner, Sofia D Merajver
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): B013.
https://doi.org/10.1158/1538-7445.GENFUNC25-B013
Published: 11 March 2025
View articletitled, Abstract B013: Precision medicine platform to guide the treatment of NSCLC
Journal Articles

Abstract 7091: Significance of the tryptophan catabolism pathway in triple-negative breast cancer shows potential targets in certain subsets relating to the serine pathway

Jin Heon Jeon, Abhinav Achreja, Mark Slayton, Olamide Animasahun, Minal Nenwani, Miya Paserba, Zackariah Farah, Sofia D. Merajver, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7091.
https://doi.org/10.1158/1538-7445.AM2024-7091
Published: 22 March 2024
View articletitled, Abstract 7091: Significance of the tryptophan catabolism pathway in triple-negative breast cancer shows potential targets in certain subsets relating to the serine pathway
Journal Articles

Abstract 431: Malic enzyme 2 inhibition reveals metabolic vulnerability in serine-dependent triple-negative breast cancer

Mark D. Slayton, Zackariah A. Farah, Jin Heon Jeon, Abhinav Achreja, Ben Krinkel, Brisilda Nilaj, Yi-Hsien Eu, Justin Sung, Alyssa Rosenfeld, Alisa Lui, Mason Collard, Liwei Bao, Xu Cheng, Celina Kleer, Kerry Loomes, Deepak Nagrath, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 431.
https://doi.org/10.1158/1538-7445.AM2024-431
Published: 22 March 2024
View articletitled, Abstract 431: Malic enzyme 2 inhibition reveals metabolic vulnerability in serine-dependent triple-negative breast cancer
Journal Articles

Abstract 4548: Discovering novel ALK-lung carcinoma therapeutic strategies by identifying combinations with Alectinib from ALK-positive lung carcinoma cell lines

Hamadi Madhi, Habib Serhan, Nathalie M. Vandecan, Zhaoping Qin, Albert Liu, Aaron Udager, Sofia D. Merajver, Matthew B. Soellner, Nathan Merrill
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4548.
https://doi.org/10.1158/1538-7445.AM2024-4548
Published: 22 March 2024
View articletitled, Abstract 4548: Discovering novel ALK-lung carcinoma therapeutic strategies by identifying combinations with Alectinib from ALK-positive lung carcinoma cell lines
Journal Articles

Abstract 351: Quaratusugene ozeplasmid mediated TUSC2 upregulation in EML4-ALK bearing non-small cell lung carcinoma can induce cellular apoptosis

Ananya Banerjee, Neeke Busette, Mark S. Berger, Matthew B. Soellner, Angel Qin, Sofia D. Merajver, Nathan M. Merrill
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 351.
https://doi.org/10.1158/1538-7445.AM2024-351
Published: 22 March 2024
View articletitled, Abstract 351: Quaratusugene ozeplasmid mediated TUSC2 upregulation in EML4-ALK bearing non-small cell lung carcinoma can induce cellular apoptosis
Journal Articles

Abstract 7504: Longitudinal multi-omics characterization of circulating tumor cells from ALK positive NSCLC patients

Yuru Chen, Shamileh Fouladdel, Harrison Ball, Zhaoping Qin, Albert Liu, Xu Cheng, Liwei Bao, Habib Serhan, Bryce Vandenburg, Varun Kathawate, Larua Goo, Peter Ulintz, Nathan Merrill, Aaron Udager, Angel Qin, Sofia D. Merajver, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7504.
https://doi.org/10.1158/1538-7445.AM2024-7504
Published: 22 March 2024
View articletitled, Abstract 7504: Longitudinal multi-omics characterization of circulating tumor cells from ALK positive NSCLC patients
Journal Articles

Abstract 223: Precision medicine-based platform to guide the treatment of EML4-ALK fusion lung cancers and other NSCLC

Nathan M. Merrill, Aaron Udager, Angel Qin, Kiran Lagisetty, Liwei Bao, Xu Cheng, Hamadi Madhi, Ananya Banerjee, Marziyeh Salehi Jahromi, Laura Goo, Varun Kathawate, Bryce Vandenburg, Marisa Aikins, Mark Slayton, Peter Ulintz, Zhaoping Qin, Chia-jen Liu, Habib Serhan, John Jefferies, Muhammad Sajawal Ali, Vishal Navani, Michael Monument, Johannes Kratz, Amber Smith, Andrew Chang, Gregory Kalemkerian, Sunitha Nagrath, Peggy Hsu, Matthew B. Soellner, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 223.
https://doi.org/10.1158/1538-7445.AM2024-223
Published: 22 March 2024
View articletitled, Abstract 223: Precision medicine-based platform to guide the treatment of EML4-ALK fusion lung cancers and other NSCLC
Journal Articles

Abstract 2026: Comprehensive metabolic flux analysis on triple-negative breast cancer shows potential collaterally lethal targets related to the serine pathway

Jin Heon Jeon, Abhinav Achreja, Mark Slayton, Olamide Animasahun, Miya Paserba, Jyotirmoy Roy, Deepak Nagrath, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2026.
https://doi.org/10.1158/1538-7445.AM2023-2026
Published: 04 April 2023
View articletitled, Abstract 2026: Comprehensive metabolic flux analysis on triple-negative breast cancer shows potential collaterally lethal targets related to the serine pathway
Journal Articles

Abstract 1322: Comparison of brain extracellular matrices in a blood brain barrier organ on a chip model

Ehsanul Hoque Apu, Huing li, Victor Zhao, Habib Serhan, Aki Morikawa, Pedro R. Lowenstein, Maria G. Castro, Sofia D. Merajver, Christopher Ryan Oliver
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1322.
https://doi.org/10.1158/1538-7445.AM2023-1322
Published: 04 April 2023
View articletitled, Abstract 1322: Comparison of brain extracellular matrices in a blood brain barrier organ on a chip model
Journal Articles

Abstract 6037: Identification of collateral lethal targets in cancers using integrated machine learning and flux analysis platform for personalized metabolic therapy

Abhinav Achreja, Jin Heon Jeon, Mark Slayton, Tao Yu, Olamide Animasahun, Minal Nenwani, Fulei Wuchu, Anjali Mittal, Xiongbin Lu, Sofia D. Merajver, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6037.
https://doi.org/10.1158/1538-7445.AM2023-6037
Published: 04 April 2023
View articletitled, Abstract 6037: Identification of collateral lethal targets in cancers using integrated machine learning and flux analysis platform for personalized metabolic therapy
Journal Articles

Abstract 3921: Malic enzyme 2 identified as metabolic target in triple-negative breast cancers with increased serine biosynthesis

Mark D. Slayton, Jin Heon Jeon, Abhinav Achreja, Zackariah A. Farah, Brisilda Nilaj, Yi-Hsien Eu, Alisa Lui, Mason Collard, Liwei Bao, Celina Kleer, Deepak Nagrath, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3921.
https://doi.org/10.1158/1538-7445.AM2023-3921
Published: 04 April 2023
View articletitled, Abstract 3921: Malic enzyme 2 identified as metabolic target in triple-negative breast cancers with increased serine biosynthesis
Journal Articles

Abstract 5592: Expansion and characterization on ALK positive NSCLC circulating tumor cells isolated using a size based inertial microfluidic Labyrinth device

Yuru Chen, Shamileh Fouladdel, Harrison Ball, Xu Cheng, Liwei Bao, Habib Serhan, Albert Liu, Bryce Vandenburg, Laura Goo, Nathan Merrill, Aaron Udager, Angel Qin, Sofia D. Merajver, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5592.
https://doi.org/10.1158/1538-7445.AM2023-5592
Published: 04 April 2023
View articletitled, Abstract 5592: Expansion and characterization on ALK positive NSCLC circulating tumor cells isolated using a size based inertial microfluidic Labyrinth device
Journal Articles

Abstract 4012: EGFR inhibition in combination with PI3K/AKT/mTOR and/or Bcl-2 inhibition is a promising novel therapeutic approach for inverted sinonasal papillomas and associated sinonasal carcinomas

Athena M. Apfel, Zhaoping Qin, Albert Liu, Matthew B. Soellner, Sofia D. Merajver, Aaron M. Udager, Nathan M. Merrill
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4012.
https://doi.org/10.1158/1538-7445.AM2022-4012
Published: 15 June 2022
View articletitled, Abstract 4012: EGFR inhibition in combination with PI3K/AKT/mTOR and/or Bcl-2 inhibition is a promising novel therapeutic approach for inverted sinonasal papillomas and associated sinonasal carcinomas
Journal Articles

Abstract 1194: MEK inhibition in combination with PI3K/AKT/MTOR is a promising therapeutic in basal bladder cancer

Athena M. Apfel, Nathan M. Merrill, Nathalie M. Vandecan, Liwei Bao, Xu Cheng, Lluis A. Lopez-Barcons, Kathleen C. Day, Phillip L. Palmbos, Mark L. Day, Aaron M. Udager, Matthew B. Soellner, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1194.
https://doi.org/10.1158/1538-7445.AM2021-1194
Published: 01 July 2021
View articletitled, Abstract 1194: MEK inhibition in combination with PI3K/AKT/MTOR is a promising therapeutic in basal bladder cancer
Journal Articles

Abstract 2996: Creating PDXs from continental African breast tumors: addressing racial inequity through science

Evelyn M. Jiagge, Tahra K. Suhan, Jessica M. Bensenhaver, Michele Dziubinski, Joseph K. Oppong, Francis Aitpillah, Awuah Baffour, John D. Carpten, Lisa A. Newman, Sofia D. Merajver, Max S. Wicha
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2996.
https://doi.org/10.1158/1538-7445.AM2021-2996
Published: 01 July 2021
View articletitled, Abstract 2996: Creating PDXs from continental African breast tumors: addressing racial inequity through science
Journal Articles

Abstract 1187: Optimizing gemcitabine in metastatic TNBC by rational PI3K/AKT combination

Nathan M. Merrill, Nathalie M. Vandecan, Athena M. Apfel, Peter J. Ulintz, Liwei Bao, Xu Cheng, Aki Morikawa, Sofia D. Merajver, Matthew B. Soellner
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1187.
https://doi.org/10.1158/1538-7445.AM2021-1187
Published: 01 July 2021
View articletitled, Abstract 1187: Optimizing gemcitabine in metastatic TNBC by rational PI3K/AKT combination
Journal Articles

Abstract PS7-06: Incidence and survival of inflammatory breast cancer between 1973 - 2015 in the surveillance, epidemiology and end results (SEER) database

Hannah Abraham, Yaoxuan Xia, Bhramar Mukherjee, Sofia D Merajver
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS7-06.
https://doi.org/10.1158/1538-7445.SABCS20-PS7-06
Published: 15 February 2021
View articletitled, Abstract PS7-06: Incidence and survival of inflammatory breast cancer between 1973 - 2015 in the surveillance, epidemiology and end results (SEER) database
Journal Articles

Abstract 2616: RhoC decreases tight junction stabilization in breast cancer cells, revealing a potential therapeutic target

Hannah Abraham, Laura Goo, Andrew Little, Joel Yates, Zhifen Wu, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2616.
https://doi.org/10.1158/1538-7445.AM2020-2616
Published: 15 August 2020
View articletitled, Abstract 2616: RhoC decreases tight junction stabilization in breast cancer cells, revealing a potential therapeutic target
Journal Articles

Abstract 4363: Effects of the small GTPase RhoC on inflammatory breast cancer metabolism

Laura E. Goo, Joel A. Yates, Andrew C. Little, Daniel Kremer, Ilya Kovalenko, Christopher R. Oliver, Trisha Westerhof, Zhifen Wu, Nathalie Vandecan, Liwei Bao, Peter J. Ulintz, Costas A. Lyssiotis, Sofia D. Merajver
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4363.
https://doi.org/10.1158/1538-7445.AM2019-4363
Published: 01 July 2019
View articletitled, Abstract 4363: Effects of the small GTPase RhoC on inflammatory breast cancer metabolism
Journal Articles

Abstract 3989: Identification of biomarkers for UM-164 in triple-negative breast cancer

Nathan M. Merrill, Nathalie M. Vandecan, John P. Lloyd, Eric J. Lachacz, Peter J. Ulintz, Sofia D. Merajver, Matthew B. Soellner
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3989.
https://doi.org/10.1158/1538-7445.AM2019-3989
Published: 01 July 2019
View articletitled, Abstract 3989: Identification of biomarkers for UM-164 in triple-negative breast cancer