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Snorri S. Thorgeirsson
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Journal Articles

Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma

Atsushi Takai, Hien Dang, Naoki Oishi, Subreen Khatib, Sean P. Martin, Dana A. Dominguez, Ji Luo, Rachel Bagni, Xiaolin Wu, Katie Powell, Qing-Hai Ye, Hu-Liang Jia, Lun-Xiu Qin, Jinqiu Chen, Gary A. Mitchell, Xiaoling Luo, Snorri S. Thorgeirsson, Xin Wei Wang
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2379–2391.
https://doi.org/10.1158/0008-5472.CAN-18-3015
Published: 01 May 2019
View article titled, Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM<sup>+</sup> Hepatocellular Carcinoma
Open the PDF for Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM<sup>+</sup> Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1902: Enrichment of putative cancer stem cells during anti-angiogenic therapies promotes relapse formation in hepatocellular carcinoma

Darko Castven, Carolin Czauderna, Diana Becker, Marcus A. Wörns, Snorri S. Thorgeirsson, Peter Grimminger, Hauke Lang, Peter R. Galle, Jens U. Marquardt
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1902.
https://doi.org/10.1158/1538-7445.AM2017-1902
Published: 01 July 2017
View article titled, Abstract 1902: Enrichment of putative cancer stem cells during anti-angiogenic therapies promotes relapse formation in hepatocellular carcinoma
Journal Articles

Abstract 4390: The Thailand initiative in genomics and expression research in liver cancer: Race related common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma identified by integrated genomics

Anuradha Budhu, Jittiporn Chaisaingmongkol, Hien Dang, Siritida Rabibhadana, Benjarath Pupacdi, So Mee Kwon, Marshonna Forgues, Yotsawat Pomyen, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu U. Auewarakul, Thaniya Sricharunrat, Kannika Phornphutkul, Suleeporn Sangrajrang, Maggie Cam, Ping He, Stephen M. Hewitt, Xiaolin Wu, Snorri S. Thorgeirsson, Joshua J. Waterfall, Yuelin J. Zhu, Jennifer Walling, Holly S. Stevenson, Daniel Edelman, Paul S. Meltzer, Christopher A. Loffredo, Robert H. Wiltrout, Curtis C. Harris, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin W. Wang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4390.
https://doi.org/10.1158/1538-7445.AM2017-4390
Published: 01 July 2017
View article titled, Abstract 4390: The Thailand initiative in genomics and expression research in liver cancer: Race related common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma identified by integrated genomics
Journal Articles

Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma

Gang Chen, Ikuo Nakamura, Renumathy Dhanasekaran, Eriko Iguchi, Ezequiel J. Tolosa, Paola A. Romecin, Renzo E. Vera, Luciana L. Almada, Alexander G. Miamen, Roongruedee Chaiteerakij, Mengtao Zhou, Michael K. Asiedu, Catherine D. Moser, Shaoshan Han, Chunling Hu, Bubu A. Banini, Abdul M. Oseini, Yichun Chen, Yong Fang, Dongye Yang, Hassan M. Shaleh, Shaoqing Wang, Dehai Wu, Tao Song, Ju-Seog Lee, Snorri S. Thorgeirsson, Eric Chevet, Vijay H. Shah, Martin E. Fernandez-Zapico, Lewis R. Roberts
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (3): 632–645.
https://doi.org/10.1158/0008-5472.CAN-15-2556
Published: 31 January 2017
View article titled, Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma
Open the PDF for Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB-173: The Thailand initiative in genomics and expression research for liver cancer (TIGER-LC): Defining novel subtypes of hepatocellular carcinoma and cholangiocarcinoma

Jittiporn Chaisaingmongkol, Anuradha Budhu, Hien Dang, Siritida Rabibhadana, Benjarath Pupacdi, Marshonna Forgues, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu U. Auewarakul, Thaniya Sricharunrat, Kannika Phornphutkul, Suleeporn Sangrajrang, Maggie Cam, Ping He, Stephen M. Hewitt, Xiaolin Wu, Snorri S. Thorgeirsson, Paul S. Meltzer, Christopher A. Loffredo, Robert H. Wiltrout, Curtis C. Harris, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin W. Wang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-173.
https://doi.org/10.1158/1538-7445.AM2015-LB-173
Published: 01 August 2015
View article titled, Abstract LB-173: The Thailand initiative in genomics and expression research for liver cancer (TIGER-LC): Defining novel subtypes of hepatocellular carcinoma and cholangiocarcinoma
Journal Articles

MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism

Hirofumi Akita, Jens U. Marquardt, Marian E. Durkin, Mitsuteru Kitade, Daekwan Seo, Elizabeth A. Conner, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2014) 74 (20): 5903–5913.
https://doi.org/10.1158/0008-5472.CAN-14-0527
Published: 14 October 2014
View article titled, MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism
Open the PDF for MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism in another window
Includes: Supplementary data
Journal Articles

Abstract 339: Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer (CRC) cells, enhances the efficacy of BH3 mimetics and inhibits clonogenicity

Abid R. Mattoo, Jingyu Zhang, Luis A. Espinoza, Snorri S. Thorgeirsson, J. M. Jessup
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 339.
https://doi.org/10.1158/1538-7445.AM2014-339
Published: 01 October 2014
View article titled, Abstract 339: Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer (CRC) cells, enhances the efficacy of BH3 mimetics and inhibits clonogenicity
Journal Articles

Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2

Yun-Han Lee, Daekwan Seo, Kyung-Ju Choi, Jesper B. Andersen, Min-Ah Won, Mitsuteru Kitade, Luis E. Gómez-Quiroz, Adam D. Judge, Jens U. Marquardt, Chiara Raggi, Elizabeth A. Conner, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4752–4761.
https://doi.org/10.1158/0008-5472.CAN-13-3531
Published: 01 September 2014
View article titled, Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
Open the PDF for Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2 in another window
Includes: Supplementary data
Journal Articles

Abstract 5661: Nanoparticle based combinatorial siRNA therapy against human hepatocellular carcinoma (HCC) .

Thomas Decaens, Valentina M. Factor, Iva Kulic, Jesper B. Andersen, Daekwan Seo, Yun-Han Lee, Adam D. Judge, Elizabeth A. Conner, Ian MacLachlan, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5661.
https://doi.org/10.1158/1538-7445.AM2013-5661
Published: 15 April 2013
View article titled, Abstract 5661: Nanoparticle based combinatorial siRNA therapy against human hepatocellular carcinoma (HCC) .
Journal Articles

Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.

Jean-Pierre Gillet, Jesper B. Andersen, James P. Madigan, Sudhir Varma, Chung-Pu Wu, Anna M. Calcagno, Suresh V. Ambudkar, Snorri S. Thorgeirsson, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2013-954
Published: 15 April 2013
View article titled, Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.
Journal Articles

Abstract 2653: Direct oncogenic reprogramming of adult mouse hepatocytes into cancer stem cells.

Agnes Holczbauer, Valentina M. Factor, Jesper B. Andersen, David E. Kleiner, Jens U. Marquardt, Chiara Raggi, Mitsuteru Kitade, Daekwan Seo, Akita Hirofumi, Marian E. Durkin, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2653.
https://doi.org/10.1158/1538-7445.AM2013-2653
Published: 15 April 2013
View article titled, Abstract 2653: Direct oncogenic reprogramming of adult mouse hepatocytes into cancer stem cells.
Journal Articles

Abstract 272: Identification of MicroRNAs unique to cancer stem cells by small RNA deep sequencing.

Junfang Ji, Marshonna Forgues, Taro Yamashita, Eliane Wauthier, Lola M. Reid, Xinyu Wen, Young Song, Jun Wei, Javed Khan, Snorri S. Thorgeirsson, Xin W. Wang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 272.
https://doi.org/10.1158/1538-7445.AM2013-272
Published: 15 April 2013
View article titled, Abstract 272: Identification of MicroRNAs unique to cancer stem cells by small RNA deep sequencing.
Journal Articles

Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma

Cédric Coulouarn, Anne Corlu, Denise Glaise, Isabelle Guénon, Snorri S. Thorgeirsson, Bruno Clément
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2533–2542.
https://doi.org/10.1158/0008-5472.CAN-11-3317
Published: 14 May 2012
View article titled, Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma
Open the PDF for Hepatocyte–Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas

Pu Wang, Qiong-Zhu Dong, Chong Zhang, Pei-Fen Kuan, Yufeng Liu, William R. Jeck, Jesper B. Andersen, James Todd Auman, Janelle M. Hoskins, Jin Woo Kim, Kristian Cibulskis, Gad Getz, Heike V. Hunt, Snorri S. Thorgeirsson, Lewis R. Roberts, Dan Ye, Kun-Liang Guan, Yue Xiong, Lun-Xiu Qin, Derek Y. Chiang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1058.
https://doi.org/10.1158/1538-7445.AM2012-1058
Published: 15 April 2012
View article titled, Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas
Journal Articles

Abstract 5646: Allele-specific shRNA to Nanog family members inhibits 3-D growth of colorectal carcinoma through the intrinsic apoptotic pathway

Jingyu Zhang, Snorri S. Thorgeirsson, J. Milburn Jessup
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5646.
https://doi.org/10.1158/1538-7445.AM2012-5646
Published: 15 April 2012
View article titled, Abstract 5646: Allele-specific shRNA to Nanog family members inhibits 3-D growth of colorectal carcinoma through the intrinsic apoptotic pathway
Journal Articles

Abstract 4927: Translational genomics analyses of cholangiocarcinoma identify patients who may respond to tyrosine kinase inhibitors

Jesper Boeje Andersen, Matthew Gillen, Elisabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4927.
https://doi.org/10.1158/1538-7445.AM2012-4927
Published: 15 April 2012
View article titled, Abstract 4927: Translational genomics analyses of cholangiocarcinoma identify patients who may respond to tyrosine kinase inhibitors
Journal Articles

Abstract 4261: Epigenetic reprogramming affects malignant properties of human liver cancer cells

Chiara Raggi, Jens U. Marquardt, Daekwan Seo, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4261.
https://doi.org/10.1158/1538-7445.AM2012-4261
Published: 15 April 2012
View article titled, Abstract 4261: Epigenetic reprogramming affects malignant properties of human liver cancer cells
Journal Articles

Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growth in vitro and in vivo

Yun-Han Lee, Jesper B. Andersen, Adam D. Judge, Daekwan Seo, Chiara Raggi, Marquardt U. Jens, Elizabeth A. Conner, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1644.
https://doi.org/10.1158/1538-7445.AM2011-1644
Published: 15 April 2011
View article titled, Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growth <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract 5206: Nanog family members are essential for spherogenicity and metastasis in colorectal carcinoma

Jingyu Zhang, Snorri S. Thorgeirsson, J. Milburn Jessup
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5206.
https://doi.org/10.1158/1538-7445.AM2011-5206
Published: 15 April 2011
View article titled, Abstract 5206: Nanog family members are essential for spherogenicity and metastasis in colorectal carcinoma
Journal Articles

Abstract 478: Human solid organ cancers contain stem-like label-retaining cancer cells that undergo asymmetric cell division and have superior tumor initiating capacity

Hongwu Xin, Danielle M. Hari, John E. Mullinax, Chenwi M. Ambe, Satyajit Ray, Tomotake Koizumi, Gordon W. Wiegand, Tyler Miller, Andrew J. Andersen, Susan H. Garfield, Snorri S. Thorgeirsson, Itzhak Avital
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 478.
https://doi.org/10.1158/1538-7445.AM2011-478
Published: 15 April 2011
View article titled, Abstract 478: Human solid organ cancers contain stem-like label-retaining cancer cells that undergo asymmetric cell division and have superior tumor initiating capacity