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Journal Articles

M⁶A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

Pooja Yadav, Panneerdoss Subbarayalu, Daisy Medina, Saif Nirzhor, Santosh Timilsina, Subapriya Rajamanickam, Vijay K. Eedunuri, Yogesh Gupta, Siyuan Zheng, Nourhan Abdelfattah, Yufei Huang, Ratna Vadlamudi, Robert Hromas, Paul Meltzer, Peter Houghton, Yidong Chen, Manjeet K. Rao

Cancer Res (2022) 82 (10): 1872–1889.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2106

Published: 16 May 2022

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Includes: Supplementary data

Journal Articles

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton, Myron S. Ignatius

Cancer Res (2021) 81 (21): 5451–5463.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-4191

Published: 01 November 2021

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Includes: Supplementary data

Journal Articles

Abstract 2026: KDM1A inhibition augment ER stress inducers efficacy to reduce glioblastoma stemness

Yi He, Prabhakar Pitta Venkata, Salvador Alejo, Yihong Chen, Bridgitte Palacios, Gabrielle Gray, Uday P. Pratap, Suryavathi Viswanadhapalli, Siyuan Zheng, Rajeshwar R. Tekmal, Andrew J. Brenner, Gangadhara R. Sareddy

Cancer Res (2021) 81 (13_Supplement): 2026.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2026

Published: 01 July 2021

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Journal Articles

Abstract 6220: KDM1A inhibition sensitizes glioblastoma cells to temozolomide therapy through DNA damage and apoptosis pathway modulation

Bridgitte E. Palacios, Prabhakar Pitta Venkata, Yihong Chen, Salvador Alejo, Yi He, Suryavathi Viswanadhapalli, Uday Pratap, Junhao Liu, Xiaonan Li, Takayoshi Suzuki, Siyuan Zheng, Andrew Brenner, Ratna Vadlamudi, Gangadhara Sareddy

Cancer Res (2020) 80 (16_Supplement): 6220.

DOI: https://doi.org/10.1158/1538-7445.AM2020-6220

Published: 15 August 2020

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Journal Articles

Abstract 187: PCaT: An integrated platform for the analysis of pediatric cancer genomic data

Juechen Yang, Qilin Li, Xiaojing Wang, Peter Houghton, Siyuan Zheng

Cancer Res (2020) 80 (16_Supplement): 187.

DOI: https://doi.org/10.1158/1538-7445.AM2020-187

Published: 15 August 2020

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Journal Articles

Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma

Xiaolong Li, Emmanuel Martinez-Ledesma, Chen Zhang, Feng Gao, Siyuan Zheng, Jie Ding, Shaofang Wu, Nghi Nguyen, Stephan C. Clifford, Patrick Y. Wen, Keith L. Ligon, W.K. Alfred Yung, Dimpy Koul

Cancer Res (2019) 79 (19): 5088–5101.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-0325

Published: 01 October 2019

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Includes: Supplementary data

Journal Articles

Abstract 1781: EGFR amplification-A candidate predictive biomarker of PARP inhibitor Talazoparib sensitivity in gliomas

Shaofang Wu, Feng Gao, Xiaolong Li, Jie Ding, Siyuan Zheng, Emmanuel Martinez-Ledesma, Ningping Feng, Erik Sulman, Roel Verhaak, John de Groot, Dimpy Koul, W.K.Alfred Yung

Cancer Res (2017) 77 (13_Supplement): 1781.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1781

Published: 01 July 2017

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Journal Articles

Abstract 3468: Comprehensive analysis of telomere length and telomere maintenance mechanisms across 31 human cancer types

Floris P. Barthel, Siyuan Zheng, Roel G. Verhaak

Cancer Res (2017) 77 (13_Supplement): 3468.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3468

Published: 01 July 2017

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Journal Articles

Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Liem M. Phan, Enrique Fuentes-Mattei, Weixin Wu, Guermarie Velazquez-Torres, Kanishka Sircar, Christopher G. Wood, Tao Hai, Camilo Jimenez, Gilbert J. Cote, Levent Ozsari, Marie-Claude Hofmann, Siyuan Zheng, Roeland Verhaak, Lance Pagliaro, Maria Angelica Cortez, Mong-Hong Lee, Sai-Ching J. Yeung, Mouhammed Amir Habra

Cancer Res (2015) 75 (19): 4131–4142.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-3707

Published: 30 September 2015

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Includes: Supplementary data

Journal Articles

Abstract 4795: A novel gene fusion in glioblastoma and a radiation response methylation signature identified by genomic characterization of glioma sphere-forming cells

Qianghu Wang, Ravesanker Ezhilarasan, Lindsey D. Goodman, Joy Gumin, Siyuan Zheng, Kosuke Yoshihara, Peng Sun, Jie Yang, Tim Heffernan, Giulio Draetta, Kenneth D. Aldape, Frederick F. Lang, Roel G.W. Verhaak, Erik P. Sulman

Cancer Res (2015) 75 (15_Supplement): 4795.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4795

Published: 01 August 2015

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Journal Articles

Abstract 2976: Comprehensive Pan-Genomic characterization of adrenocortical carcinoma

Cancer Res (2015) 75 (15_Supplement): 2976.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2976

Published: 01 August 2015

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Journal Articles

Abstract 31: WEE1 kinase inhibition enhances PI3K inhibitor response in p53 deficient gliomas

Shaofang Wu, Siyuan Zheng, Shuzhen Wang, W.K.Alfred Yung, Dimpy Koul

Cancer Res (2015) 75 (15_Supplement): 31.

DOI: https://doi.org/10.1158/1538-7445.AM2015-31

Published: 01 August 2015

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Journal Articles

Abstract 3762: The landscape of therapeutic targetable fusions

Kosuke Yoshihara, Qianghu Wang, Wandaliz Torres-Garcia, Siyuan Zheng, Rahulsimham Vegesna, Hoon Kim, Roel GW Verhaak

Cancer Res (2015) 75 (15_Supplement): 3762.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3762

Published: 01 August 2015

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Journal Articles

Abstract 1720: MSK1 mediates PI3K inhibition resistance by induction of β-catenin phosphorylation in glioblastoma

Shaofang Wu, Jun Fu, Siyuan Zheng, Roel G. Verhaak, W. K Yung, Dimpy Koul

Cancer Res (2014) 74 (19_Supplement): 1720.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1720

Published: 01 October 2014

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Journal Articles

Abstract 4170: Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma

Jun Fu, Dimpy Koul, Shaofang Wu, Siyuan Zheng, Roel G. Verhaak, W.K Yung

Cancer Res (2014) 74 (19_Supplement): 4170.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4170

Published: 01 October 2014

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Journal Articles

Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma

Cancer Res (2014) 74 (19_Supplement): 984.

DOI: https://doi.org/10.1158/1538-7445.AM2014-984

Published: 01 October 2014

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Journal Articles

Abstract 4909: Olig2 phosphorylation by CDK2 implicated in glioma proliferation.

Jun Fu, Dimpy Koul, Siyuan Zheng, Vivek Singh, Jun Yao, Yanhua Zheng, Zhimin Lu, Erik P. Sulman, Frederick F. Lang, Alfred W.K Yung

Cancer Res (2013) 73 (8_Supplement): 4909.

DOI: https://doi.org/10.1158/1538-7445.AM2013-4909

Published: 15 April 2013

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Journal Articles

Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression

David R. Simpson, Min Yu, Siyuan Zheng, Zhongming Zhao, Senthil K. Muthuswamy, William P. Tansey

Cancer Res (2011) 71 (11): 3822–3830.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-3782

Published: 31 May 2011

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Includes: Supplementary data

Journal Articles

Abstract 170: Combined mRNA and miRNA profiles in lung cancer cell lines as a tool to screen the targets contributes to cisplatin resistance

Yunguang Sun, Siyuan Zheng, Zhongming Zhao, Bo Lu

Cancer Res (2011) 71 (8_Supplement): 170.

DOI: https://doi.org/10.1158/1538-7445.AM2011-170

Published: 15 April 2011

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Journal Articles

Abstract 4914: A novel integrative network study identifies key genes and pathways in the progression of Hepatitis C virus induced hepatocellular carcinoma

Zhongming Zhao, Siyuan Zheng

Cancer Res (2011) 71 (8_Supplement): 4914.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4914

Published: 15 April 2011

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NARROW

M⁶A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation

Abstract 2026: KDM1A inhibition augment ER stress inducers efficacy to reduce glioblastoma stemness

Abstract 6220: KDM1A inhibition sensitizes glioblastoma cells to temozolomide therapy through DNA damage and apoptosis pathway modulation

Abstract 187: PCaT: An integrated platform for the analysis of pediatric cancer genomic data

Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma

Abstract 1781: EGFR amplification-A candidate predictive biomarker of PARP inhibitor Talazoparib sensitivity in gliomas

Abstract 3468: Comprehensive analysis of telomere length and telomere maintenance mechanisms across 31 human cancer types

Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Abstract 4795: A novel gene fusion in glioblastoma and a radiation response methylation signature identified by genomic characterization of glioma sphere-forming cells

Abstract 2976: Comprehensive Pan-Genomic characterization of adrenocortical carcinoma

Abstract 31: WEE1 kinase inhibition enhances PI3K inhibitor response in p53 deficient gliomas

Abstract 3762: The landscape of therapeutic targetable fusions

Abstract 1720: MSK1 mediates PI3K inhibition resistance by induction of β-catenin phosphorylation in glioblastoma

Abstract 4170: Oncogenic activation of LMO2 by EGFR signaling regulates STAT3 phosphorylation and transcriptional activity in human glioma

Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma

Abstract 4909: Olig2 phosphorylation by CDK2 implicated in glioma proliferation.

Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression

Abstract 170: Combined mRNA and miRNA profiles in lung cancer cell lines as a tool to screen the targets contributes to cisplatin resistance

Abstract 4914: A novel integrative network study identifies key genes and pathways in the progression of Hepatitis C virus induced hepatocellular carcinoma

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