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Sireesha Yalavarthi
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Journal Articles

Abstract 5305: M9657, a tumor-targeted anti-CD137 agonist, induced significant antitumor immunity in combination with anti-PD-1 antibody

Chunxiao Xu, Sireesha Yalavarthi, Hong Zhang, Uma Mahesh Gundra, Clotilde Bourin, Laura Helming
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5305.
https://doi.org/10.1158/1538-7445.AM2024-5305
Published: 22 March 2024
View articletitled, Abstract 5305: M9657, a tumor-targeted anti-CD137 agonist, induced significant antitumor immunity in combination with anti-PD-1 antibody
Journal Articles

Abstract 4126: Anti-tumor immunity of M9657, a conditional CD137 immune agonist, is correlated with mesothelin expression on tumor cells

Chunxiao Xu, Xueyuan Zhou, Sireesha Yalavarthi, Rene Schweickhardt, Andree Blaukat, Laura Helming
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4126.
https://doi.org/10.1158/1538-7445.AM2023-4126
Published: 04 April 2023
View articletitled, Abstract 4126: Anti-tumor immunity of M9657, a conditional CD137 immune agonist, is correlated with mesothelin expression on tumor cells
Journal Articles

Abstract 593: Anti-tumor immunity and efficacy of combination treatment of M6223 and bintrafusp alfa versus the combination of M6223 and anti-PD-L1 in preclinical tumor models

Chunxiao Xu, Sireesha Yalavarthi, Clotilde Bourin, Christie Kelton, Joern-Peter Halle, Jacques Moisan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 593.
https://doi.org/10.1158/1538-7445.AM2022-593
Published: 15 June 2022
View articletitled, Abstract 593: Anti-tumor immunity and efficacy of combination treatment of M6223 and bintrafusp alfa versus the combination of M6223 and anti-PD-L1 in preclinical tumor models
Journal Articles

Abstract 2737: Spontaneous genomic alterations identified in a chimeric model of colorectal cancer guide effective combinatorial therapy.

Yinghui Zhou, William M. Rideout, Angela Bressel, Sireesha Yalavarthi, Tong Zi, Anthony Monti, Steve Bottega, Bin Feng, M. Isabel Chiu, Marcus Bosenberg, Joerg Heyer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2737.
https://doi.org/10.1158/1538-7445.AM2013-2737
Published: 15 April 2013
View articletitled, Abstract 2737: Spontaneous genomic alterations identified in a chimeric model of colorectal cancer guide effective combinatorial therapy.
Journal Articles

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

James W. Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy Kohl, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8949–8957.
https://doi.org/10.1158/0008-5472.CAN-09-1544
Published: 30 November 2009
View articletitled, De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model
Open the PDF for De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model in another window
Includes: Supplementary data
Journal Articles

Abstract #4922: Population based in vivo genetic models of tumor metastasis

Carol Meeske, Joseph Growney, Arnold Sengooba, Sireesha Yalavarthi, Lingxin Kong, Ruojie Wang, Richard Nicoletti, Bin Feng, Murray Robinson, M Chiu, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4922.
Published: 01 May 2009
View articletitled, Abstract #4922: Population based in vivo genetic models of tumor metastasis
Journal Articles

Abstract #1348: Fibroblast growth factor receptor-2 cancer models for biomarker discovery and therapeutic response prediction

Omar Kabbarah, Lorena Lerner, Zakir Siddiquee, Guangmu Li, Jianhua Zhao, John Yang, Jodi Zarycki, Zhigang Weng, Sriram Kollipara, Karuppiah Kannan, Sireesha Yalavarthi, Steven Clark, Jeno Gyuris, Murray Robinson, M Chiu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1348.
Published: 01 May 2009
View articletitled, Abstract #1348: Fibroblast growth factor receptor-2 cancer models for biomarker discovery and therapeutic response prediction
Journal Articles

Variation in response to VEGFR inhibitor AV-951 across a population of genetically engineered breast tumors reveals distinct phenotypic classes of resistance

Jie Lin, karrupiah Kannan, Joerg Heyer, Hongmei Yang, nan Liu, Gaoyuan Meng, Yinghui Zhou, William Rideout, Angela Bressel, Tong Zi, Sireesha Yalavarthi, Ruojie Wang, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2499.
Published: 01 May 2008
View articletitled, Variation in response to VEGFR inhibitor AV-951 across a population of genetically engineered breast tumors reveals distinct phenotypic classes of resistance
Journal Articles

Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer

Karuppiah Kannan, Sireesha Yalavarthi, Jie Lin, Richard Nicoletti, Ruojie Wang, William Rideout, Yinghui Zhou, Joerg Heyer, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1734.
Published: 01 May 2008
View articletitled, Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer
Journal Articles

Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Ruojie Wang, Lu Li, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3615.
Published: 01 May 2008
View articletitled, Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
Journal Articles

Directed complementation of inducible tumor models: an approach to generate broad panels of tumors with defined genetic contexts

Lorena Lerner, Jie Lin, Omar Kabbarah, John Yang, Nan Liu, Fanglei You, Jianhua Zhou, Jodi Zarycki, Ti Cai, Karuppiah Kannan, Sireesha Yalavarthi, Isabel Chiu, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3070.
Published: 01 May 2007
View articletitled, Directed complementation of inducible tumor models: an approach to generate broad panels of tumors with defined genetic contexts
Journal Articles

Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis

Isabel Chiu, Lorena Lerner, Ti Cai, Jodi Zarycki, Omar Kabbarah, John Yang, Wei Hu, Sireesha Yalavarthi, Karuppiah Kannan, David Bailey, Kathryn Sun, Dmitri Bichko, Fanglei You, Jianhua Zhao, Sylvie Vincent, Steve Bottega, Ronan O'Hagan, Alisa Bell, Heidi Okamura, Yinghui Zhou, William Rideout, Min Wu, Joerg Heyer, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5686.
Published: 01 May 2007
View articletitled, Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis
Journal Articles

Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Nan Liu, Ruojie Wang, Angela Bressel, Tong Zi, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2230.
Published: 01 May 2007
View articletitled, Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model