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Journal Articles

Abstract CT503: A phase I/Ib study of the safety and preliminary efficacy of NZV930 alone and in combination with spartalizumab and/or taminadenant in patients (pts) with advanced malignancies

Siqing Fu, Udai Banerji, Philippe L. Bedard, Aitana Calvo Ferrándiz, Alberto Chiappori, Jayesh Desai, Rahima Jamal, Desamparados Roda Perez, Noboru Yamamoto, Erica Vieira, Gabrielle Wong, Kulandayan K. Subramanian, Shunguang Wang, Britta Mueller, Javier A. Otero, Si-Lin Koo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT503.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT503
Published: 15 June 2022
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Journal Articles

Abstract CT148: A phase 1b dose-escalation study of ZN-c3, a WEE1 inhibitor, in combination with chemotherapy (CT) in subjects with platinum-resistant or refractory ovarian, peritoneal, or fallopian tube cancer

Anes Pasic, Gary Richardson, Zivko Vranjes, Tarek Meniawy, Jennifer Rodriquez, Lukas Makris, Soamnauth Misir, Philippe Pultar, Dimitris Voliotis, Siqing Fu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT148.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT148
Published: 15 June 2022
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Journal Articles

Abstract 5237: B-Raf V600E harboring non-melanoma cancers treated with Vemurafenib monotherapy and in combination with Everolimus/Sorafenib/Crizotinib/Paclitaxel+ Carboplatin: A pooled analysis of five phase 1/2 studies

Blessie Elizabeth Nelson, Jason Roszik, Filip Janku, David Hong, Shumei Kato, Aung Naing, Sarina Piha-Paul, Siqing Fu, Apostolia Tsimberidou, Maria Cabanillas, Naifa Busaidy, Milind Javle, Lauren Byers, John Heymach, Funda Meric-Bernstam, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5237.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5237
Published: 15 June 2022
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Journal Articles

Abstract 974: Phase II trial of the Wee1 inhibitor adavosertib in advanced refractory solid tumors with CCNE1 amplification

Siqing Fu, Shuyang Yao, Yuan Yuan, Rebecca A. Previs, Anthony D. Elias, Richard Carvajal, Thomas J. George, Ying Yuan, Yuko Yamamura, Shannon Westin, Yan Xing, Ecaterina E. Ileana Dumbrava, Daniel D. Karp, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Jordi Rodon, Naoko Takebe, Charles Kunos, Karen Lu, Khanda Keyomarsi, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 974.
DOI: https://doi.org/10.1158/1538-7445.AM2021-974
Published: 01 July 2021
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Journal Articles

Abstract CT163: Temsirolimus in combinaton with metformin in patients with advanced or refractory endometrial cancers

Aung Naing, Daniel Karp, Sarina A. Piha-Paul, Shubham Pant, Vivek Subbiah, Diane C. Bodurka, Siqing Fu, Amir A. Jazaeri, Shumei Kato, Kathleen Schmeler, Alpa Nick, Yali Yang, Fechukwu O. Akhmedzhanov, Senait Fessahaye, Jing Gong, Bettzy Stephen, Amber M. Johnson, Pamela T. Soliman, Anil K. Sood, Funda Meric-Bernstam, Karen H. Lu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT163.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT163
Published: 15 August 2020
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Journal Articles

Abstract P1-19-18: Everolimus, letrozole and trastuzumab in hormone receptor-positive, HER2-positive/amplified or mutant metastatic cancer: Evaluating synergy and overcoming resistance

Alexej Ballhausen, Jennifer J Wheler, Daniel D Karp, Sarina A Piha-Paul, Siqing Fu, Shubham Pant, Apostolia M Tsimberidou, David S Hong, Vivek Subbiah, Veronica R Holley, Helen J Huang, Abeena M Brewster, Kimberly H Koenig, Nuhad K Ibrahim, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-19-18.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P1-19-18
Published: 15 February 2020
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Journal Articles

Abstract CT012: Open-label, multicenter, Phase Ib study to assess safety, tolerability and efficacy of adavosertib monotherapy in patients with advanced solid tumors: Expansion cohorts

Todd M. Bauer, Kathleen Moore, Janet S. Rader, Fiona Simpkins, Alain Mita, J Thaddeus Beck, Lowell Hart, Quincy Chu, Amit Oza, Anna V. Tinker, Karen So, Esteban Rodrigo Imedio, Sanjeev Kumar, Ganesh M. Mugundu, Suzanne Jenkins, Juliann Chmielecki, Suzanne Jones, David R. Spigel, Siqing Fu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT012.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT012
Published: 01 July 2019
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Journal Articles

Abstract CT025: Phase Ib study of adavosertib in combination with olaparib in patients with refractory solid tumors: Dose escalation

Erika Hamilton, Gerald S. Falchook, Judy S. Wang, Siqing Fu, Amit Oza, So Karen, Esteban Rodrigo Imedio, Sanjeev Kumar, Lone Ottesen, Ganesh M. Mugundu, Juliann Chmielecki, Suzanne Jones, David R. Spigel, Bob T. Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT025.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT025
Published: 01 July 2019
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Journal Articles

Abstract CT024: Results of a phase I dose escalation study of ARQ 751 in adult subjects with advanced solid tumors with AKT1, 2, 3 genetic alterations, activating PI3K mutations, PTEN-null, or other known actionable PTEN mutations

Shubham Pant, Vivek Subbiah, Jordi Rodon, Filip Janku, David Hong, Daniel Karp, Sarina Piha-Paul, Apostolia M. Tsimberidou, Aung Naing, Siqing Fu, Ron E. Savage, Feng Chai, Yi Yu, Brian Schwartz, Funda Meric-Bernstam, Tim Yap
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT024.
DOI: https://doi.org/10.1158/1538-7445.AM2018-CT024
Published: 01 July 2018
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Journal Articles

Abstract 642: Detection of circulating antibodies against KRAS in patients with advanced cancers

Ed Kheder, Helen J. Huang, Alice Wu, David S. Hong, Sarina A. Piha-Paul, Daniel D. Karp, Siqing Fu, Vivek Subbiah, Apostolia M. Tsimberidou, Aung Naing, Adi Diab, Milind Javle, Scott Kopetz, Anil K. Sood, Jonathan M. Kurie, Funda Meric-Bernstam, Martin Gleeson, Filip Janku
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 642.
DOI: https://doi.org/10.1158/1538-7445.AM2017-642
Published: 01 July 2017
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Journal Articles

Abstract 3291: Development of a novel prognostic scoring system for patient selection in immune checkpoint inhibitor phase 1 clinical trials

Shiraj Sen, Kenneth Hess, David Hong, Aung Naing, Sarina Piha-Paul, Filip Janku, Siqing Fu, Holly Liu, Yunfang Jiang, Rahil Khanji, Daniel Karp, Apostolia Tsimberidou, Nizar Tannir, Funda Meric-Bernstam, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3291.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3291
Published: 01 July 2017
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Journal Articles

Abstract B90: PFK-158 is a first-in-human inhibitor of PFKFB3 that selectively suppresses glucose metabolism of cancer cells and inhibits the immunosuppressive Th17 cells and MDSCs in advanced cancer patients

Sucheta Telang, Kavitha Yaddanapudi, Jaspreet Grewal, Rebecca Redman, Siqing Fu, Paula Pohlmann, Devalingam Mahalingam, Michael Kurman, Gilles Tapolsky, Jason Chesney
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B90.
DOI: https://doi.org/10.1158/1538-7445.PANCA16-B90
Published: 14 December 2016
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Journal Articles

Abstract B83: Targeting TRPV6 oncochannel for the treatment of pancreatic cancer: A Phase I trial experience

Siqing Fu, Stephen Welch, Toney T. Ilenchuk, Dominique Dugourd, Tyler Lutes, Chris Rice, Jack M. Stewart
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B83.
DOI: https://doi.org/10.1158/1538-7445.PANCA16-B83
Published: 14 December 2016
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Journal Articles

Abstract 493: Quantity of KRAS mutations in cell-free DNA is associated with survival of patients with advanced cancers

Kiran Madwani, Helen J. Huang, Dawne N. Shelton, Siqing Fu, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Aung Naing, David S. Hong, Daniel D. Karp, Debra L. Andrews, Goran Cabrilo, E. Scott Kopetz, Rajyalakshmi Luthra, Bryan K. Kee, Cathy Eng, Van K. Morris, George A. Karlin-Neumann, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 493.
DOI: https://doi.org/10.1158/1538-7445.AM2016-493
Published: 15 July 2016
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Journal Articles

Abstract CT142: A phase I open-label, dose escalation study of a novel peptide (SOR-C13) antagonistic to the TRPV6 ion channel in patients with advanced solid tumor cancers

Siqing Fu, Hal H. Hirte, Stephen Welch, Toney T. Ilenchuk, Dominique Dugourd, Tyler Lutes, Christopher Rice, Jack M. Stewart
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT142.
DOI: https://doi.org/10.1158/1538-7445.AM2016-CT142
Published: 15 July 2016
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Journal Articles

Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study

Jennifer J. Wheler, Filip Janku, Aung Naing, Yali Li, Bettzy Stephen, Ralph Zinner, Vivek Subbiah, Siqing Fu, Daniel Karp, Gerald S. Falchook, Apostolia M. Tsimberidou, Sarina Piha-Paul, Roosevelt Anderson, Danxia Ke, Vincent Miller, Roman Yelensky, J. Jack Lee, David S. Hong, Razelle Kurzrock
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (13): 3690–3701.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-3043
Published: 30 June 2016
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Includes: Supplementary data
Journal Articles

Abstract 246: Phase 1 study: Ipilimumab (anti CTLA-4) in combination with Lenalidomide in patients with advanced cancers

Divya Sakamuri, Sonia L. Betancourt Cuellar, Isabella C. Glitza, Siqing Fu, Jennifer J. Wheler, Gerald S. Falchook, Apostolia M. Tsimberidou, David S. Hong, Vivek Subbiah, Michelle A. Fanale, Maria E. Cabanillas, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 246.
DOI: https://doi.org/10.1158/1538-7445.AM2015-246
Published: 01 August 2015
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Journal Articles

Abstract 2413: Rapid, automated BRAF mutation testing of cell-free DNA from plasma of patients with advanced cancers using the novel Idylla platform

Filip Janku, Helen J. Huang, Bart Claes, Gerald S. Falchook, Siqing Fu, Apostolia M. Tsimberidou, David S. Hong, Aung Naing, Jennifer J. Wheler, Sarina A. Piha-Paul, Daniel D. Karp, Vivek Subbiah, Ralph G. Zinner, Nishma Ramzanali, Rajyalakshmi Luthra, Sapna P. Patel, E. Scott Kopetz, Erwin Sablon, Geert Maertens, Razelle Kurzrock, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2413.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2413
Published: 01 August 2015
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Journal Articles

Abstract 2407: Multiplex KRAS G12/G13 mutation testing of 16ng of unamplified cell-free DNA from plasma of patients with advanced cancers using Droplet Digital PCR

Helen J. Huang, Dawne N. Shelton, Siqing Fu, Sarina A. Piha-Paul, Apostolia M. Tsimberidou, Ralph G. Zinner, Jennifer J. Wheler, Aung Naing, David S. Hong, Gerald S. Falckook, Scott Kopetz, Rajyalakshmi Luthra, Bryan K. Kee, George A. Karlin-Neumann, Funda Meric-Bernstam, Filip Janku
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2407.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2407
Published: 01 August 2015
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Journal Articles

Abstract P2-05-03: Anastrozole and everolimus in hormone receptor-positive metastatic breast cancer: Safety profile, activity and associations of molecular alterations in the PI3K/AKT/mTOR pathway

Jennifer J Wheler, Filip Janku, Stacy L Moulder, Aung Naing, Sarina A Piha-Paul, Gerald S Falchook, Ralph G Zinner, Apostolia M Tsimberidou, Siqing Fu, David S Hong, Johnique T Atkins, Roman Yelensky, Vince Miller, Philip J Stephens, Vincente Valero, Funda Meric-Bernstam, Razelle Kurzrock
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P2-05-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS14-P2-05-03
Published: 01 May 2015
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