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Simone Fulda
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Journal Articles

Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth

Tim Hensel, Chiara Giorgi, Oxana Schmidt, Hsi-Yu Yen, Katja Steiger, Simone Fulda, Felix K. Niggli, Wilko Weigert, Shudong Wang, Beat W. Schäfer, Stefan Burdach, Günther H.S. Richter
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): PR13.
https://doi.org/10.1158/1538-7445.PEDCA17-PR13
Published: 01 October 2018
View articletitled, Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth
Journal Articles

NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3K α

Nadezda Dolgikh, Manuela Hugle, Meike Vogler, Simone Fulda
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2000–2013.
https://doi.org/10.1158/0008-5472.CAN-17-1737
Published: 12 April 2018
View articletitled, NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3K α
Open the PDF for NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3K α in another window
Includes: Supplementary data
Journal Articles

Abstract 5119: Smac mimetic inhibits tumorigenicity and growth of glioblastoma by promoting differentiation of glioblastoma cancer stem-like cells

Aurelie Tchoghandjian, Claudia Jennewein, Ines Eckhardt, Stefan Momma, Dominique Figarella-Branger, Simone Fulda
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5119.
https://doi.org/10.1158/1538-7445.AM2014-5119
Published: 01 October 2014
View articletitled, Abstract 5119: Smac mimetic inhibits tumorigenicity and growth of glioblastoma by promoting differentiation of glioblastoma cancer stem-like cells
Journal Articles

Abstract 837: Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.

Aurelie Tchoghandjian, Claudia Jennewein, Ines Eckhardt, Krishna Rajalingam, Simone Fulda
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 837.
https://doi.org/10.1158/1538-7445.AM2013-837
Published: 15 April 2013
View articletitled, Abstract 837: Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.
Journal Articles

Abstract SY24-03: Targeting IAP proteins in cancer: From molecular mechanism to therapeutic application.

Simone Fulda
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): SY24-03.
https://doi.org/10.1158/1538-7445.AM2013-SY24-03
Published: 15 April 2013
View articletitled, Abstract SY24-03: Targeting IAP proteins in cancer: From molecular mechanism to therapeutic application.
Journal Articles

Abstract 2278: Smac mimetic primes FADD- or caspase-8-deficient leukemia cells for TNFα-induced necroptosis and overcomes apoptosis resistance

Barbara Schenk, Bram Laukens, Claudia Jennewein, Nele Vanlangenakker, Silvia Cristofanon, Domagoj Vucic, Irmela Jeremias, Mathieu Bertrand, Peter Vandenabeele, Simone Fulda
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2278.
https://doi.org/10.1158/1538-7445.AM2012-2278
Published: 15 April 2012
View articletitled, Abstract 2278: Smac mimetic primes FADD- or caspase-8-deficient leukemia cells for TNFα-induced necroptosis and overcomes apoptosis resistance
Journal Articles

Abstract 4692: IAP inhibitors prime childhood leukemia cells to chemotherapy-induced apoptosis in a strictly RIP1-dependent manner and exert anti-leukemic activity in a NOD/SCID mouse model in vivo

Sandra Löder, Melanie Fakler, Nele Vanlangenakker, Mathieu Bertrand, Peter Vandenabeele, Irmela Jeremias, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4692.
https://doi.org/10.1158/1538-7445.AM2011-4692
Published: 15 April 2011
View articletitled, Abstract 4692: IAP inhibitors prime childhood leukemia cells to chemotherapy-induced apoptosis in a strictly RIP1-dependent manner and exert anti-leukemic activity in a NOD/SCID mouse model in vivo
Journal Articles

Abstract 5343: Aberrant activation of hedgehog signaling confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma

Arne Zibat, Edoardo Missiaglia, Albert Rosenberger, Kathy Pritchard-Jones, Janet Shipley, Heidi Hahn, Simone Fulda
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5343.
https://doi.org/10.1158/1538-7445.AM2011-5343
Published: 15 April 2011
View articletitled, Abstract 5343: Aberrant activation of hedgehog signaling confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma
Journal Articles

Abstract 4341: Bortezomib primes neuroblastoma cells for TRAIL- triggered apoptosis by linking the death receptor to the mitochondrial pathway

Ivonne Naumann, Roland Kappler, Dietrich von Schweinitz, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4341.
https://doi.org/10.1158/1538-7445.AM2011-4341
Published: 15 April 2011
View articletitled, Abstract 4341: Bortezomib primes neuroblastoma cells for TRAIL- triggered apoptosis by linking the death receptor to the mitochondrial pathway
Journal Articles

Abstract 5250: PI3K inhibitors prime neuroblastoma cells for chemotherapy-induced apoptosis apoptosis in vitro and in vivo by shifting the balance towards pro-apoptotic Bcl-2 proteins and increased mitochondrial perturbations

Ariane Bender, Daniela Opel, Lori Friedman, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5250.
https://doi.org/10.1158/1538-7445.AM10-5250
Published: 15 April 2010
View articletitled, Abstract 5250: PI3K inhibitors prime neuroblastoma cells for chemotherapy-induced apoptosis apoptosis in vitro and in vivo by shifting the balance towards pro-apoptotic Bcl-2 proteins and increased mitochondrial perturbations
Journal Articles

Abstract 3480: XIAP inhibitors prime glioblastoma cells for γ-irradiation-induced apoptosis and circumvent radioresistance of glioblastoma stem cells

Sri Harikrishna Vellanki, Andreas Grabrucker, Stefan Liebau, Adriana Eramo, Veit Braun, Tobias Böckers, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3480.
https://doi.org/10.1158/1538-7445.AM10-3480
Published: 15 April 2010
View articletitled, Abstract 3480: XIAP inhibitors prime glioblastoma cells for γ-irradiation-induced apoptosis and circumvent radioresistance of glioblastoma stem cells
Journal Articles

Abstract 4508: Targeting XIAP as a novel paradigm to induce apoptosis in chronic lymphocytic leukemia

Sandra Löder, Thorsten Zenz, Andrea Schnaiter, Daniel Mertens, Dirk Winkler, Hartmut Döhner, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4508.
https://doi.org/10.1158/1538-7445.AM10-4508
Published: 15 April 2010
View articletitled, Abstract 4508: Targeting XIAP as a novel paradigm to induce apoptosis in chronic lymphocytic leukemia
Journal Articles

Abstract 2911: Small molecule XIAP inhibitors sensitize acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, overcome Bcl-2-mediated resistance and reduce leukemic burden in vivo in NOD/SCID mice

Melanie Fakler, Sandra Löder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2911.
https://doi.org/10.1158/1538-7445.AM10-2911
Published: 15 April 2010
View articletitled, Abstract 2911: Small molecule XIAP inhibitors sensitize acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, overcome Bcl-2-mediated resistance and reduce leukemic burden in vivo in NOD/SCID mice
Journal Articles

A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia

Sandra Loeder, Thorsten Zenz, Andrea Schnaiter, Daniel Mertens, Dirk Winkler, Hartmut Döhner, Klaus-Michael Debatin, Stephan Stilgenbauer, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8977–8986.
https://doi.org/10.1158/0008-5472.CAN-09-2604
Published: 30 November 2009
View articletitled, A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia
Open the PDF for A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract #402: Identification of aberrant histone deacetylation as a novel mechanism of epigenetic silencing of caspase-8: from mechanisms to therapeutic applications

Sabine Haecker, Tilmann Schweitzer, Stefan Rutkowski, Juergen Krauss, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 402.
Published: 01 May 2009
View articletitled, Abstract #402: Identification of aberrant histone deacetylation as a novel mechanism of epigenetic silencing of caspase-8: from mechanisms to therapeutic applications
Journal Articles

Abstract #2782: XIAP inhibitors sensitize glioblastoma stem cells for \#947;-irradiation-induced apoptosis and overcome radioresistance of glioblastoma

Sri Harikrishna Vellanki, Veit Braun, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2782.
Published: 01 May 2009
View articletitled, Abstract #2782: XIAP inhibitors sensitize glioblastoma stem cells for \#947;-irradiation-induced apoptosis and overcome radioresistance of glioblastoma
Journal Articles

Abstract #2039: Targeting XIAP overcomes Bcl-2-imposed resistance of pancreatic carcinoma towards TRAIL in vitro and in vivo

Dominic Stadel, Meike Vogler, Tobias Haas, Henning Walczak, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2039.
Published: 01 May 2009
View articletitled, Abstract #2039: Targeting XIAP overcomes Bcl-2-imposed resistance of pancreatic carcinoma towards TRAIL in vitro and in vivo
Journal Articles

Abstract #2781: XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis, overcome Bcl-2-mediated resistance and exert anti-leukemic activity in a NOD/SCID mouse model of childhood acute leukemia

Melanie Fakler, Sandra Loeder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2781.
Published: 01 May 2009
View articletitled, Abstract #2781: XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis, overcome Bcl-2-mediated resistance and exert anti-leukemic activity in a NOD/SCID mouse model of childhood acute leukemia
Journal Articles

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

Meike Vogler, Henning Walczak, Dominic Stadel, Tobias L. Haas, Felicitas Genze, Marjana Jovanovic, Umesh Bhanot, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend, Thomas Simmet, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2425–2434.
https://doi.org/10.1158/0008-5472.CAN-08-2436
Published: 17 March 2009
View articletitled, Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma
Open the PDF for Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma in another window
Includes: Supplementary data
Journal Articles

Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

Meike Vogler, Henning Walczak, Dominic Stadel, Tobias L. Haas, Felicitas Genze, Marjana Jovanovic, Jürgen E. Gschwend, Thomas Simmet, Klaus-Michael Debatin, Simone Fulda
Journal: Cancer Research
Cancer Res (2008) 68 (19): 7956–7965.
https://doi.org/10.1158/0008-5472.CAN-08-1296
Published: 30 September 2008
View articletitled, Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo
Open the PDF for Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo in another window
Includes: Supplementary data