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Journal Articles

Abstract IA008: Targeting homologous recombination deficiency (HRD) using optimized ionizing radiation and drug combinations

Simon N. Powell, Niamh McDermott, Robert Delsite
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): IA008.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-IA008
Published: 09 January 2024
View article titled, Abstract IA008: Targeting homologous recombination deficiency (HRD) using optimized ionizing radiation and drug combinations
Journal Articles

Abstract 6056: Activation of Sting in response to partial-tumor radiation exposure

Mickael Mathieu, Prerna R. Nepali, Sadna Budhu, Simon N. Powell, John Humm, Joseph Deasy, Adriana Haimovitz-Friedman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6056.
https://doi.org/10.1158/1538-7445.AM2022-6056
Published: 15 June 2022
View article titled, Abstract 6056: Activation of Sting in response to partial-tumor radiation exposure
Journal Articles

Abstract 5688: RNA-mediated DNA repair: A novel repair pathway in homologous recombination-deficient cancers

Manisha Jalan, Juber Patel, Kyrie S Olsen, Sana Ahmed-Seghir, Daniel S Higginson, Jorge S Reis-Filho, Nadeem Riaz, Simon N Powell
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5688.
https://doi.org/10.1158/1538-7445.AM2022-5688
Published: 15 June 2022
View article titled, Abstract 5688: RNA-mediated DNA repair: A novel repair pathway in homologous recombination-deficient cancers
Journal Articles

Abstract P2-06-04: Pathognomonic long molecule footprints of backup repair pathways in homologous recombination deficient cancers

Jeremy Setton, Kevin Hadi, Huasong Tian, Arnaud Da Cruz Paula, Joel Rosiene, Zi-Ning Choo, Julie Behr, Xiaotong Yao, Olivier Elemento, Britta Weigelt, Nadeem Riaz, Jorge S Reis-Filho, Marcin Imielinski, Simon N Powell
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-06-04.
https://doi.org/10.1158/1538-7445.SABCS21-P2-06-04
Published: 15 February 2022
View article titled, Abstract P2-06-04: Pathognomonic long molecule footprints of backup repair pathways in homologous recombination deficient cancers
Journal Articles

Abstract 1663: Activation of STING in response to partial-tumor radiation exposure

Mickael Mathieu, Prerna R. Nepali, Sadna Budhu, Simon N. Powell, John L. Humm, Joseph O. Deasy, Adriana Haimovitz-Friedman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1663.
https://doi.org/10.1158/1538-7445.AM2021-1663
Published: 01 July 2021
View article titled, Abstract 1663: Activation of STING in response to partial-tumor radiation exposure
Journal Articles

Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability

Xinzhu Deng, Jason Tchieu, Daniel S. Higginson, Kuo-Shun Hsu, Regina Feldman, Lorenz Studer, Shai Shaham, Simon N. Powell, Zvi Fuks, Richard Kolesnick
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3706–3716.
https://doi.org/10.1158/0008-5472.CAN-20-3309
Published: 01 July 2021
View article titled, Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability
Open the PDF for Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability in another window
Includes: Supplementary data
Journal Articles

Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer

Jeremy S. Setton, Simon N. Powell
Journal: Cancer Research
Cancer Res (2020) 80 (11): 2085–2086.
https://doi.org/10.1158/0008-5472.CAN-20-0966
Published: 02 June 2020
View article titled, Moving beyond PARP Inhibition in ATM-Deficient Prostate Cancer
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Journal Articles

Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response

Samuel F. Bakhoum, Bryon Ngo, Ashley L. Bakhoum, Julie-Ann Cavallo, Charles J. Murphy, Peter Ly, Pragya Shah, Roshan K. Sriram, Thomas B.k. Watkins, Neil K. Taunk, Mercedes Duran, Chantal Pauli, Christine Shaw, Kalyani Chadalavada, Vinagolu K. Rajasekhar, Giulio Genovese, Subramanian Venkatesan, Nicolai J. Birkbak, Nicholas McGranahan, Mark Lundquist, Quincy LaPlant, John H. Healey, Olivier Elemento, Christine H. Chung, Nancy Y. Lee, Marcin Imielinski, Gouri Nanjangud, Dana Pe'er, Don W. Cleveland, Simon N. Powell, Jan Lammerding, Charles Swanton, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): NG03.
https://doi.org/10.1158/1538-7445.AM2018-NG03
Published: 01 July 2018
View article titled, Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response
Journal Articles

Abstract 4122: Tumor-specific PI3K inhibition via nanoparticle targeted delivery in head and neck squamous cell carcinoma

Aviram Mizrachi, Yosi Shamay, Janki Shah, Samuel I. Brook, Joanne Soong, Vinagolu K. Rajasekhar, John L. Humm, Simon N. Powell, José Baselga, Daniel A. Heller, Adriana Haimovitz-Friedman, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4122.
https://doi.org/10.1158/1538-7445.AM2017-4122
Published: 01 July 2017
View article titled, Abstract 4122: Tumor-specific PI3K inhibition via nanoparticle targeted delivery in head and neck squamous cell carcinoma
Journal Articles

Abstract 831: TGFβ controls the DNA damage response via miR-182 regulation of BRCA1 and ATM

Qi Liu, Haydeliz Martinez-Ruiz, John Murnane, Simon N. Powell, Mary Helen Barcellos-Hoff
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 831.
https://doi.org/10.1158/1538-7445.AM2017-831
Published: 01 July 2017
View article titled, Abstract 831: TGFβ controls the DNA damage response via miR-182 regulation of BRCA1 and ATM
Journal Articles

Abstract 3756: PARP inhibitor sensitivity in small cell lung cancer cell lines and patient-derived xenografts correlates with SLFN11 expression but not with structural homologous recombination deficiency

Benjamin H. Lok, Ying Feng, G. Karen Yu, Eric E. Gardner, Nadeem Riaz, Yuanbin (Kevin) Ru, Elisa de Stanchina, Simon N. Powell, Jerry Shen, John T. Poirier, Charles M. Rudin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3756.
https://doi.org/10.1158/1538-7445.AM2016-3756
Published: 15 July 2016
View article titled, Abstract 3756: PARP inhibitor sensitivity in small cell lung cancer cell lines and patient-derived xenografts correlates with SLFN11 expression but not with structural homologous recombination deficiency
Journal Articles

Abstract LB-215: Epigenetic loss-of-function BRCA1 mediates tumor cure by single dose radiotherapy

Cecile G. CAMPAGNE, Tin H. Thin, John D. Fuller, Ellen Ackerstaff, Jason A. Koutcher, Adriana Haimovitz-Friedman, Simon N. Powell, Richard N. Kolesnick, Zvi Fuks
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-215.
https://doi.org/10.1158/1538-7445.AM2015-LB-215
Published: 01 August 2015
View article titled, Abstract LB-215: Epigenetic loss-of-function BRCA1 mediates tumor cure by single dose radiotherapy
Journal Articles

Abstract SY28-02: Connections in the BRCA1-BRCA2 pathway of homologous recombination: Implications for breast cancer development and treatment

Simon N. Powell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): SY28-02.
https://doi.org/10.1158/1538-7445.AM10-SY28-02
Published: 15 April 2010
View article titled, Abstract SY28-02: Connections in the BRCA1-BRCA2 pathway of homologous recombination: Implications for breast cancer development and treatment
Journal Articles

Negative Regulation of AKT Activation by BRCA1

Tao Xiang, Amiko Ohashi, Yuping Huang, Tej K. Pandita, Thomas Ludwig, Simon N. Powell, Qin Yang
Journal: Cancer Research
Cancer Res (2008) 68 (24): 10040–10044.
https://doi.org/10.1158/0008-5472.CAN-08-3009
Published: 15 December 2008
View article titled, Negative Regulation of AKT Activation by BRCA1
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Includes: Supplementary data
Journal Articles

Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells

James W. Evans, Sophia B. Chernikova, Lisa A. Kachnic, Judit P. Banath, Olivier Sordet, Yvette M. Delahoussaye, Alejandro Treszezamsky, Brian H. Chon, Zhihui Feng, Yongchuan Gu, William R. Wilson, Yves Pommier, Peggy L. Olive, Simon N. Powell, J. Martin Brown
Journal: Cancer Research
Cancer Res (2008) 68 (1): 257–265.
https://doi.org/10.1158/0008-5472.CAN-06-4497
Published: 02 January 2008
View article titled, Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells
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Journal Articles

BRCA1- and BRCA2-Deficient Cells Are Sensitive to Etoposide-Induced DNA Double-Strand Breaks via Topoisomerase II

Alejandro D. Treszezamsky, Lisa A. Kachnic, Zhihui Feng, Junran Zhang, Chake Tokadjian, Simon N. Powell
Journal: Cancer Research
Cancer Res (2007) 67 (15): 7078–7081.
https://doi.org/10.1158/0008-5472.CAN-07-0601
Published: 01 August 2007
View article titled, BRCA1- and BRCA2-Deficient Cells Are Sensitive to Etoposide-Induced DNA Double-Strand Breaks via Topoisomerase II
Open the PDF for BRCA1- and BRCA2-Deficient Cells Are Sensitive to Etoposide-Induced DNA Double-Strand Breaks via Topoisomerase II in another window
Journal Articles

BRCA1 nuclear export, a novel avenue to sensitize p53-deficient cancer cells to ionizing radition and cisplatin

Fen Xia, Hong Wang, Zhihui Feng, Bapsi Chakravarthy, Simon N. Powell, Bruce Haffty, Dennis E. Hallahan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 544.
Published: 15 April 2006
View article titled, BRCA1 nuclear export, a novel avenue to sensitize p53-deficient cancer cells to ionizing radition and cisplatin
Journal Articles

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Jing Zhuang, Junran Zhang, Henning Willers, Hong Wang, Jay H. Chung, Dik C. van Gent, Dennis E. Hallahan, Simon N. Powell, Fen Xia
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1401–1408.
https://doi.org/10.1158/0008-5472.CAN-05-3278
Published: 01 February 2006
View article titled, Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining
Open the PDF for Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining in another window
Journal Articles

Fhit and CHK1 Have Opposing Effects on Homologous Recombination Repair

Baocheng Hu, Hongyan Wang, Xiang Wang, Hua-Rui Lu, Cuifen Huang, Simon N. Powell, Kay Huebner, Ya Wang
Journal: Cancer Research
Cancer Res (2005) 65 (19): 8613–8616.
https://doi.org/10.1158/0008-5472.CAN-05-1966
Published: 03 October 2005
View article titled, Fhit and CHK1 Have Opposing Effects on Homologous Recombination Repair
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Journal Articles

Role of MDC1 in homologous recombination

Junran Zhang, Zhefu Ma, Alejandro Treszezamsky, Simon N. Powell
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 380–381.
Published: 01 May 2005
View article titled, Role of MDC1 in homologous recombination