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Journal Articles

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Zheqi Li, Yang Wu, Megan E. Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M. Levine, Nolan M. Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K. Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A. Montanez, Prithu Sundd, Callen T. Wallace, Simon C. Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C. Tseng, Nikhil Wagle, Jason S. Carroll, Paul Jank, Carsten Denkert, Maria M. Karsten, Jens-Uwe Blohmer, Ben H. Park, Peter C. Lucas, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1321–1339.
https://doi.org/10.1158/0008-5472.CAN-21-2576
Published: 01 April 2022
View articletitled, Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration

Manjulata Singh, Xiao-Jun Tian, Vera S. Donnenberg, Alan M. Watson, JingYu Zhang, Laura P. Stabile, Simon C. Watkins, Jianhua Xing, Shilpa Sant
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2962–2977.
https://doi.org/10.1158/0008-5472.CAN-18-3151
Published: 03 June 2019
View articletitled, Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration
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Includes: Multimedia, Supplementary data
Journal Articles

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

Kristen M. Livesey, Rui Kang, Philip Vernon, William Buchser, Patricia Loughran, Simon C. Watkins, Lin Zhang, James J. Manfredi, Herbert J. Zeh, III, Luyuan Li, Michael T. Lotze, Daolin Tang
Journal: Cancer Research
Cancer Res (2012) 72 (8): 1996–2005.
https://doi.org/10.1158/0008-5472.CAN-11-2291
Published: 16 April 2012
View articletitled, p53/HMGB1 Complexes Regulate Autophagy and Apoptosis
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Includes: Supplementary data
Journal Articles

Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4

Xinhui Wang, Akihiro Katayama, Yangyang Wang, Ling Yu, Elvira Favoino, Koichi Sakakura, Alessandra Favole, Takahiro Tsuchikawa, Susan Silver, Simon C. Watkins, Toshiro Kageshita, Soldano Ferrone
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7410–7422.
https://doi.org/10.1158/0008-5472.CAN-10-1134
Published: 15 December 2011
View articletitled, Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4
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Includes: Supplementary data
Journal Articles

Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10

Mitsugu Fujita, Xinmei Zhu, Ryo Ueda, Kotaro Sasaki, Gary Kohanbash, Edward R. Kastenhuber, Heather A. McDonald, Gregory A. Gibson, Simon C. Watkins, Ravikumar Muthuswamy, Pawel Kalinski, Hideho Okada
Journal: Cancer Research
Cancer Res (2009) 69 (4): 1587–1595.
https://doi.org/10.1158/0008-5472.CAN-08-2915
Published: 12 February 2009
View articletitled, Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10
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Includes: Supplementary data
Journal Articles

CD8+ T-Cell Responses against Hemoglobin-β Prevent Solid Tumor Growth

Hideo Komita, Xi Zhao, Jennifer L. Taylor, Louis J. Sparvero, Andrew A. Amoscato, Sean Alber, Simon C. Watkins, Angela D. Pardee, Amy K. Wesa, Walter J. Storkus
Journal: Cancer Research
Cancer Res (2008) 68 (19): 8076–8084.
https://doi.org/10.1158/0008-5472.CAN-08-0387
Published: 30 September 2008
View articletitled, CD8+ T-Cell Responses against Hemoglobin-β Prevent Solid Tumor Growth
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Includes: Supplementary data
Journal Articles

Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8+ T-Cell Cross-priming but Is Ineffective as a Therapy

Aklile Berhanu, Jian Huang, Sean M. Alber, Simon C. Watkins, Walter J. Storkus
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4895–4903.
https://doi.org/10.1158/0008-5472.CAN-05-2384
Published: 01 May 2006
View articletitled, Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8+ T-Cell Cross-priming but Is Ineffective as a Therapy
Open the PDF for Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8+ T-Cell Cross-priming but Is Ineffective as a Therapy in another window
Journal Articles

Tumor Cell Loaded Type-1 Polarized Dendritic Cells Induce Th1-Mediated Tumor Immunity

David A. Hokey, Adriana T. Larregina, Geza Erdos, Simon C. Watkins, Louis D. Falo, Jr.
Journal: Cancer Research
Cancer Res (2005) 65 (21): 10059–10067.
https://doi.org/10.1158/0008-5472.CAN-05-1692
Published: 01 November 2005
View articletitled, Tumor Cell Loaded Type-1 Polarized Dendritic Cells Induce Th1-Mediated Tumor Immunity
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Journal Articles

Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin

Eva Pizzoferrato, Ye Liu, Andrea Gambotto, Michaele J. Armstrong, Michael T. Stang, William E. Gooding, Sean M. Alber, Stuart H. Shand, Simon C. Watkins, Walter J. Storkus, John H. Yim
Journal: Cancer Research
Cancer Res (2004) 64 (22): 8381–8388.
https://doi.org/10.1158/0008-5472.CAN-04-2223
Published: 17 November 2004
View articletitled, Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin
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Journal Articles

Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53

Tracy Cook, Zifa Wang, Sean Alber, Kaihong Liu, Simon C. Watkins, Yoram Vodovotz, Timothy R. Billiar, David Blumberg
Journal: Cancer Research
Cancer Res (2004) 64 (21): 8015–8021.
https://doi.org/10.1158/0008-5472.CAN-04-2212
Published: 01 November 2004
View articletitled, Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53
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Journal Articles

Delivery of Interferon-α Transfected Dendritic Cells into Central Nervous System Tumors Enhances the Antitumor Efficacy of Peripheral Peptide-Based Vaccines

Hideho Okada, Takahiko Tsugawa, Hidemitsu Sato, Naruo Kuwashima, Andrea Gambotto, Kaori Okada, Jill E. Dusak, Wendy K. Fellows-Mayle, Glenn D. Papworth, Simon C. Watkins, William H. Chambers, Douglas M. Potter, Walter J. Storkus, Ian F. Pollack
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5830–5838.
https://doi.org/10.1158/0008-5472.CAN-04-0130
Published: 16 August 2004
View articletitled, Delivery of Interferon-α Transfected Dendritic Cells into Central Nervous System Tumors Enhances the Antitumor Efficacy of Peripheral Peptide-Based Vaccines
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Journal Articles

Autocrine secretion of angiogenic factors and CCR7 expression by dendritic cells determine their migration.

Christine F. Odoux, Andreas Albers, Simon C. Watkins, Michael K. Wong, Theresa L. Whiteside
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 544.
Published: 01 April 2004
View articletitled, Autocrine secretion of angiogenic factors and CCR7 expression by dendritic cells determine their migration.
Journal Articles

Intratumoral Delivery of Dendritic Cells Engineered to Secrete Both Interleukin (IL)-12 and IL-18 Effectively Treats Local and Distant Disease in Association with Broadly Reactive Tc1-type Immunity

Tomohide Tatsumi, Jian Huang, William E. Gooding, Andrea Gambotto, Paul D. Robbins, Nikola L. Vujanovic, Sean M. Alber, Simon C. Watkins, Hideho Okada, Walter J. Storkus
Journal: Cancer Research
Cancer Res (2003) 63 (19): 6378–6386.
Published: 14 October 2003
View articletitled, Intratumoral Delivery of Dendritic Cells Engineered to Secrete Both Interleukin (IL)-12 and IL-18 Effectively Treats Local and Distant Disease in Association with Broadly Reactive Tc1-type Immunity
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Journal Articles

Tumor-induced Apoptosis of T Cells: Amplification by a Mitochondrial Cascade

Brian R. Gastman, Xiao-Ming Yin, Daniel E. Johnson, Eva Wieckowski, Gui-Qiang Wang, Simon C. Watkins, Hannah Rabinowich
Journal: Cancer Research
Cancer Res (2000) 60 (24): 6811–6817.
Published: 01 December 2000
View articletitled, Tumor-induced Apoptosis of T Cells: Amplification by a Mitochondrial Cascade
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Journal Articles

CC Chemokine Receptor-7 on Dendritic Cells Is Induced after Interaction with Apoptotic Tumor Cells: Critical Role in Migration from the Tumor Site to Draining Lymph Nodes

Motohiro Hirao, Nobuyuki Onai, Kazumasa Hiroishi, Simon C. Watkins, Kouji Matsushima, Paul D. Robbins, Michael T. Lotze, Hideaki Tahara
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2209–2217.
Published: 01 April 2000
View articletitled, CC Chemokine Receptor-7 on Dendritic Cells Is Induced after Interaction with Apoptotic Tumor Cells: Critical Role in Migration from the Tumor Site to Draining Lymph Nodes
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Journal Articles

Human Dendritic Cells Genetically Engineered to Express High Levels of the Human Epithelial Tumor Antigen Mucin (MUC-1)

Robert A. Henderson, Maya T. Nimgaonkar, Simon C. Watkins, Paul D. Robbins, Edward D. Ball, Olivera J. Finn
Journal: Cancer Research
Cancer Res (1996) 56 (16): 3763–3770.
Published: 01 August 1996
View articletitled, Human Dendritic Cells Genetically Engineered to Express High Levels of the Human Epithelial Tumor Antigen Mucin (MUC-1)
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Journal Articles

Metallothionein Localization and Cisplatin Resistance in Human Hormone-independent Prostatic Tumor Cell Lines

Yukihiro Kondo, Shiu-Ming Kuo, Simon C. Watkins, John S. Lazo
Journal: Cancer Research
Cancer Res (1995) 55 (3): 474–477.
Published: 01 February 1995
View articletitled, Metallothionein Localization and Cisplatin Resistance in Human Hormone-independent Prostatic Tumor Cell Lines
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Journal Articles

Fibroblasts Genetically Engineered to Secrete Interleukin 12 Can Suppress Tumor Growth and Induce Antitumor Immunity to a Murine Melanoma in Vivo

Hideaki Tahara, Herbert J. Zeh, III, Walter J. Storkus, Itzhak Pappo, Simon C. Watkins, Ueli Gubler, Stanley F. Wolf, Paul D. Robbins, Michael T. Lotze
Journal: Cancer Research
Cancer Res (1994) 54 (1): 182–189.
Published: 01 January 1994
View articletitled, Fibroblasts Genetically Engineered to Secrete Interleukin 12 Can Suppress Tumor Growth and Induce Antitumor Immunity to a Murine Melanoma in Vivo
Open the PDF for Fibroblasts Genetically Engineered to Secrete Interleukin 12 Can Suppress Tumor Growth and Induce Antitumor Immunity to a Murine Melanoma in Vivo in another window
Journal Articles

Isolation and Identification of Fresh Tumor-derived Endothelial Cells from a Murine RIF-1 Fibrosarcoma

Ruth A. Modzelewski, Paul Davies, Simon C. Watkins, Robert Auerbach, Ming-Jei Chang, Candace S. Johnson
Journal: Cancer Research
Cancer Res (1994) 54 (2): 336–339.
Published: 01 January 1994
View articletitled, Isolation and Identification of Fresh Tumor-derived Endothelial Cells from a Murine RIF-1 Fibrosarcoma
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