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Journal Articles

Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer

Carolina Gemma, Chun-Fui Lai, Anup K. Singh, Antonino Belfiore, Neil Portman, Heloisa Z. Milioli, Manikandan Periyasamy, Sara Raafat, Alyssa J. Nicholls, Claire M. Davies, Naina R. Patel, Georgia M. Simmons, Hailing Fan, Van T.M. Nguyen, Luca Magnani, Emad Rakha, Lesley-Ann Martin, Elgene Lim, R. Charles Coombes, Giancarlo Pruneri, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4283–4297.
https://doi.org/10.1158/0008-5472.CAN-24-0013
Published: 16 December 2024
View article titled, Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer
Open the PDF for Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO2-24-04: Exploring the role and therapeutic potential of Ubiquitin Specific Peptidase 11 (USP11) in estrogen receptor positive breast cancer

Rachel Moore, Anna Blümel, Elspeth Ward, Elizabeth Sainsbury, Emer Conroy, Fergal O’Brien, Caroline Curtin, Simak Ali, Helen McCarthy, William Gallagher, Darran O'Connor
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-24-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-24-04
Published: 02 May 2024
View article titled, Abstract PO2-24-04: Exploring the role and therapeutic potential of Ubiquitin Specific Peptidase 11 (USP11) in estrogen receptor positive breast cancer
Journal Articles

Abstract 1557: Defining modulators of response to samuraciclib, a CDK7 inhibitor for breast cancer

Kaste Jurgaityte, Georgina Sava, Chun Fui Lai, Hailing Fan, Van Nguyen, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1557.
https://doi.org/10.1158/1538-7445.AM2023-1557
Published: 04 April 2023
View article titled, Abstract 1557: Defining modulators of response to samuraciclib, a CDK7 inhibitor for breast cancer
Journal Articles

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Zheqi Li, Yang Wu, Megan E. Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M. Levine, Nolan M. Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K. Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A. Montanez, Prithu Sundd, Callen T. Wallace, Simon C. Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C. Tseng, Nikhil Wagle, Jason S. Carroll, Paul Jank, Carsten Denkert, Maria M. Karsten, Jens-Uwe Blohmer, Ben H. Park, Peter C. Lucas, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1321–1339.
https://doi.org/10.1158/0008-5472.CAN-21-2576
Published: 01 April 2022
View article titled, Hotspot <em>ESR1</em> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
Open the PDF for Hotspot <em>ESR1</em> Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract GS3-10: Study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in combination with fulvestrant in patients with advanced hormone receptor positive HER2 negative breast cancer (HR+BC)

Charles Coombes, Sasha J Howell, Matthew G Krebs, Simon Lord, Laura M Kenny, Ash Bahl, Glen Clack, Edward Ainscow, Paul A Dickinson, Raluca Fostea, Janine Mansi, Carlo Palmieri, Gianflippo Bertelli, Rinath Jeselsohn, Zahi Mitri, William J Gradishar, Sagar Sardesai, Joyce O'Shaughnessy, Patrick Ward, Pavani Chalasani, Manfred Lehnert, Simak Ali, Stuart McIntosh
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS3-10.
https://doi.org/10.1158/1538-7445.SABCS21-GS3-10
Published: 15 February 2022
View article titled, Abstract GS3-10: Study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in combination with fulvestrant in patients with advanced hormone receptor positive HER2 negative breast cancer (HR+BC)
Journal Articles

Abstract P1-18-10: A clinical study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in patients with advanced triple negative breast cancer (TNBC)

Sacha J Howell, Laura M Kenny, Simon Lord, Matthew G Krebs, Tobias Arkenau, Richard Baird, Iain R MacPherson, Ash Bahl, Glen Clack, Edward Ainscow, Anthony GM Barrett, Paul A Dickinson, Matthew J Fuchter, Manfred Lehnert, Simak Ali, Stuart McIntosh, Charles Coombes
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-18-10.
https://doi.org/10.1158/1538-7445.SABCS21-P1-18-10
Published: 15 February 2022
View article titled, Abstract P1-18-10: A clinical study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in patients with advanced triple negative breast cancer (TNBC)
Journal Articles

Abstract PD1-08: Esr1 mutant breast cancers show elevated basal cytokeratins and immune activation

Zheqi Li, Yang Wu, Olivia Mcginn, Amir Bahreini, Nolan M. Priedigkeit, Kai Ding, Sayali Onkar, Carol A. Sartorius, Lori Miller, Margaret Rosenzweig, Nikhil Wagle, Jennifer K. Richer, William J. Muller, Laki Buluwela, Simak Ali, Dario A.A. Vignali, Yusi Fang, Li Zhu, George C. Tseng, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-08.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-08
Published: 15 February 2022
View article titled, Abstract PD1-08: <em>Esr1</em> mutant breast cancers show elevated basal cytokeratins and immune activation
Journal Articles

Abstract 2848: Neomorphic cell-cell adhesion reprogramming facilitates metastasis of ESR1 mutant breast cancer

Yang Wu, Zheqi Li, Amir Bahreini, Jian Chen, Ye Qin, Kevin M. Levine, Nilgun Tasdemir, Nolan M. Priedigkeit, Li Zhu, George C. Tseng, Yu Jiang, Benjamin Troness, Laki Buluwela, Simak Ali, Spencer Arnesen, Jason Gertz, Ben Ho Park, Jennifer M. Atkinson, Dorraya El-Ashry, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2848.
https://doi.org/10.1158/1538-7445.AM2021-2848
Published: 01 July 2021
View article titled, Abstract 2848: Neomorphic cell-cell adhesion reprogramming facilitates metastasis of <em>ESR1</em> mutant breast cancer
Journal Articles

Abstract GS1-05: Hotspot ESR1 mutations rewire cell-cell adhesome to facilitate breast cancer metastasis

Zheqi Li, Yang Wu, Amir Bahreini, Jian Chen, Ye Qin, Kevin M. Levine, Nilgun Tasdemir, Nolan Priedigkeit, Li Zhu, George C. Tseng, Yu Jiang, Benjamin Troness, Laki Buluwela, Simak Ali, Spencer Arnesen, Jason Gertz, Ben H. Park, Qiang Zhang, Lorenzo Gerratana, Andrew Davis, Jennifer M. Atkinson, Dorraya El-Ashry, Massimo Cristofanilli, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS1-05.
https://doi.org/10.1158/1538-7445.SABCS20-GS1-05
Published: 15 February 2021
View article titled, Abstract GS1-05: Hotspot <em>ESR1</em> mutations rewire cell-cell adhesome to facilitate breast cancer metastasis
Journal Articles

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

Koen D. Flach, Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C. Siefert, Theresa E. Hickey, Mark Opdam, Hetal Patel, Sander Canisius, David M. Wilson, III, Maria Donaldson Collier, Stefan Prekovic, Marja Nieuwland, Roelof J.C. Kluin, Alexey V. Zakharov, Jelle Wesseling, Lodewyk F.A. Wessels, Sabine C. Linn, Wayne D. Tilley, Anton Simeonov, Simak Ali, Wilbert Zwart
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1914–1926.
https://doi.org/10.1158/0008-5472.CAN-19-2207
Published: 15 May 2020
View article titled, Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract P6-04-18: The regulatory role of activating transcription factor-2 (ATF2) in modulating tamoxifen resistance in estrogen-receptor positive breast cancer

Athina Giannoudis, Mohammed I Malki, Hisham Mohammed, Bharath Rudraraju, Suraj Menon, Simak Ali, Jason S Carroll, Carlo Palmieri
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-04-18.
https://doi.org/10.1158/1538-7445.SABCS19-P6-04-18
Published: 15 February 2020
View article titled, Abstract P6-04-18: The regulatory role of activating transcription factor-2 (ATF2) in modulating tamoxifen resistance in estrogen-receptor positive breast cancer
Journal Articles

Abstract LB-224: Circulating tumor DNA for early detection and intervention in breast cancer: ctDNA profiles discriminate between healthy women in a true cancer screening setting and disease-free women on follow up

Jacqui A. Shaw, Karen Page, Daniel Fernandez-Garcia, Allison Hills, Anna R. Boydell, Lindsay Primrose, Bradley Toghill, Robert K. Hastings, Kelly Gleeson, Brenda M. Rosales, Kate Goddard, David S. Guttery, Simak Ali, Raoul C. Coombes
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-224.
https://doi.org/10.1158/1538-7445.AM2018-LB-224
Published: 01 July 2018
View article titled, Abstract LB-224: Circulating tumor DNA for early detection and intervention in breast cancer: ctDNA profiles discriminate between healthy women in a true cancer screening setting and disease-free women on follow up
Journal Articles

Abstract 4834: CT7001: An orally bioavailable CDK7 inhibitor is a potential therapy for breast, small-cell lung and haematological cancers

Edward K. Ainscow, Andrew Leishman, Elaine Sullivan, Bo Li, William Gallagher, Adam Peall, Kristopher Clark, Stuart Thomson, Simak Ali, Raoul C. Coombes, Ash Bahl
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4834.
https://doi.org/10.1158/1538-7445.AM2018-4834
Published: 01 July 2018
View article titled, Abstract 4834: CT7001: An orally bioavailable CDK7 inhibitor is a potential therapy for breast, small-cell lung and haematological cancers
Journal Articles

Abstract LB-339: Mutation analysis of cell-free DNA captures heterogeneity of individual circulating tumor cells in metastatic breast cancer

David S. Guttery, Jacqueline A. Shaw, Allison Hills, Daniel Fernandez-Garcia, Karen Page, Brenda Rosales, Kate Goddard, Robert Hastings, Jinli Luo, Olivia Ogle, Laura Woodley, Simak Ali, Justin Stebbing, Charles Coombes
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-339.
https://doi.org/10.1158/1538-7445.AM2016-LB-339
Published: 15 July 2016
View article titled, Abstract LB-339: Mutation analysis of cell-free DNA captures heterogeneity of individual circulating tumor cells in metastatic breast cancer
Journal Articles

Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.

Hetal Patel, Silvia Ottaviani, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B Kroll, Sean Delaney, Zahida Zahoor, Matthew J. Fuchter, Anthony G.M Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 694.
https://doi.org/10.1158/1538-7445.AM2013-694
Published: 15 April 2013
View article titled, Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.
Journal Articles

Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.

Silvia Ottaviani, Sean Delaney, Hetal Patel, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B. Kroll, Matthew J. Fuchter, Anthony G.M. Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 700.
https://doi.org/10.1158/1538-7445.AM2013-700
Published: 15 April 2013
View article titled, Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.
Journal Articles

Abstract 4762: Anti-Nicastrin antibodies for the treatment of endocrine resistant breast cancer .

Monica Faronato, Ylenia Lombardo, Aleksandra Filipovic, Simak Ali, R.Charles Coombes
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4762.
https://doi.org/10.1158/1538-7445.AM2013-4762
Published: 15 April 2013
View article titled, Abstract 4762: Anti-Nicastrin antibodies for the treatment of endocrine resistant breast cancer .
Journal Articles

Abstract 4205: Identification of glycine N-methyltransferase-regulated genes in prostate cancer cells

Silvia Ottaviani, Ciara O'Hanlon Brown, Jonathan Waxman, Simak Ali, Laki Buluwela
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4205.
https://doi.org/10.1158/1538-7445.AM2012-4205
Published: 15 April 2012
View article titled, Abstract 4205: Identification of glycine N-methyltransferase-regulated genes in prostate cancer cells
Journal Articles

Abstract LB-178: Characterization of estrogen responses in breast cancer cell lines highlights ERα as an LRH-1 regulated gene

Paul T.R Thiruchelvam, Hui Hua, Chun Fui Lai, Andy Photiou, Fiona Kyle, Charles Coombes, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-178.
https://doi.org/10.1158/1538-7445.AM10-LB-178
Published: 15 April 2010
View article titled, Abstract LB-178: Characterization of estrogen responses in breast cancer cell lines highlights ERα as an LRH-1 regulated gene
Journal Articles

The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Simak Ali, Dean A. Heathcote, Sebastian H.B. Kroll, Ashutosh S. Jogalekar, Bodo Scheiper, Hetal Patel, Jan Brackow, Alekasandra Siwicka, Matthew J. Fuchter, Manikandan Periyasamy, Robert S. Tolhurst, Seshu K. Kanneganti, James P. Snyder, Dennis C. Liotta, Eric O. Aboagye, Anthony G.M. Barrett, R. Charles Coombes
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6208–6215.
https://doi.org/10.1158/0008-5472.CAN-09-0301
Published: 29 July 2009
View article titled, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Open the PDF for The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity in another window
Includes: Supplementary data