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Silvia Pomella
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Journal Articles

Abstract 668: A MYOD-SKP2 axis boosts oncogenic properties of fusion negative rhabdomyosarcoma and is counteracted by neddylation inhibition in vitro and in vivo

Silvia Pomella, Matteo Cassandri, Doris Phelps, Clara Perrone, Michele Pezzella, Marco Wachtel, Benjamin Sunkel, Antonella Cardinale, Zoe Walters, Cristina Cossetti, Sonia Rodriguez, Nadia Carlesso, Janet Shipley, Lucio Miele, Beat Schafer, Enrico Velardi, Peter Houghton, Berkley Gryder, Benjamin Stanton, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Rossella Rota
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 668.
DOI: https://doi.org/10.1158/1538-7445.AM2022-668
Published: 15 June 2022
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Journal Articles

Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Yong Yean Kim, Girma Woldemichael, Berkley Gryder, Silvia Pomella, Ranuka Sinniah, Josh Kowalczyk, Young Song, Mehal Churiwal, Joseph Barchi, John Schneekloth, Xinyu Wen, Hsein-Chao Chou, Barry Okeefe, John Shern, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 703.
DOI: https://doi.org/10.1158/1538-7445.AM2022-703
Published: 15 June 2022
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Journal Articles

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton, Myron S. Ignatius
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5451–5463.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-4191
Published: 01 November 2021
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Includes: Supplementary data
Journal Articles

Abstract 47: Identification of first-in-class KDM3B inhibitors that suppress PAX3-FOXO1 oncogene activity in fusion positive rhabdomyosarcoma

Yong Yean Kim, Robert G. Hawley, Berkley Gryder, Silvia Pomella, Joshua Kowalczyk, Joseph Barchi, Young Song, Javed Khan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 47.
DOI: https://doi.org/10.1158/1538-7445.AM2021-47
Published: 01 July 2021
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Journal Articles

Abstract 4175: Identification of novel inhibitors of the PAX3-FOXO1 fusion oncogene in rhabdomyosarcoma

Yong Yean Kim, Robert Hawley, Berkley Gryder, Silvia Pomella, Josh Kowalczyk, Ranu Sinniah, Young Song, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4175.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4175
Published: 15 August 2020
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Journal Articles

Abstract B35: Liaison between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in fusion-negative rhabdomyosarcoma

Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Marielle Yohe, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota, Myron S. Ignatius
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B35.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B35
Published: 15 July 2020
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Journal Articles

Abstract A08: Development of FGFR4-specific chimeric antibody receptor (CAR) T cell and bispecific T cell engager (BiTE) for rhabdomyosarcoma (RMS) immunotherapy

Adam Cheuk, Nityashree Shivaprasad, Dina Schneider, Marielle Yohe, Meijie Tan, Peter Azorsa, Ronald Sams, Silvia Pomella, Berkley Gryder, Rossella Rota, Ben Stanton, Jun Wei, Young Song, Xinyu Wen, Sivasish Sindiri, Jeetendra Kumar, Robert Hawley, Joon-Yong Chung, Doncho Zhelev, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A08.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A08
Published: 15 July 2020
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Journal Articles

Abstract 4139: SNAI2 inhibition promotes myogenic differentiation and prevents tumorigenic features of embryonal rhabdomyosarcoma

Silvia Pomella, Elena Carcarino, Cristina Cossetti, Franco Locatelli, Rossella Rota
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4139.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4139
Published: 01 July 2018
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Journal Articles

Abstract 2065: Targeting the crosstalk between MET and Notch signaling in Rhabdomyosarcoma

Rossella Rota, Cristina Cossetti, Silvia Pomella, Alberto Gualtieri, Elena Carcarino, Carola Ponzetto, Riccardo Taulli, Lucio Miele, Franco Locatelli
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2065.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2065
Published: 01 July 2017
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Journal Articles

Abstract 1922: miR-301 expression is deregulated in rhabdomyosarcoma

Rossella Rota, Alberto Gualtieri, Cristina Cossetti, Silvia Pomella, Laura Adesso, Franco Locatelli
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1922.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1922
Published: 15 July 2016
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Journal Articles

Abstract 1772: Inhibition of DNA repair by the small molecule Chk1/Chk2 inhibitor PF-0477736 (Pfizer) in B-acute lymphoblastic leukemia (ALL)

Ilaria Iacobucci, Federica Cattina, Silvia Pomella, Elisa Brighenti, Cristina Papayannidis, Enrico Derenzini, Annalisa Lonetti, Anna Ferrari, Maria Vittoria Verga Falzacappa, Viviana Guadagnuolo, Michela Aluigi, Emanuela Ottaviani, Maria Chiara Abbenante, Simona Soverini, Domenico Russo, Pier Giuseppe Pelicci, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1772.
DOI: https://doi.org/10.1158/1538-7445.AM2012-1772
Published: 15 April 2012
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