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Silvia Deaglio
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Journal Articles

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Lin Wang, Luz M. Londono, Jessica Cowell, Ozge Saatci, Mertkaya Aras, Pelin G. Ersan, Sara Serra, Hong Pei, Renee Clift, Qiping Zhao, Kim B. Phan, Lei Huang, Michael J. LaBarre, Xiaoming Li, H. Michael Shepard, Silvia Deaglio, Joel Linden, Christopher D. Thanos, Ozgur Sahin, Caglar Cekic
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3319–3332.
https://doi.org/10.1158/0008-5472.CAN-21-0340
Published: 15 June 2021
View article titled, Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors
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Includes: Supplementary data
Journal Articles

Abstract 1845: BRAF-mediated NAMPT overexpression induces a melanoma cell dedifferentiation program leading to metabolic reprogramming and intrinsic resistant to BRAF inhibitors

Valentina Audrito, Antonella Managò, Federica Gaudino, Ilaria Manfredonia, Vincenzo Gianluca Messana, Nicoletta Vitale, Lorenzo Brandimarte, Enrico Moiso, Roberto Piva, Nadia Raffaelli, Mario Mandalà, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1845.
https://doi.org/10.1158/1538-7445.AM2019-1845
Published: 01 July 2019
View article titled, Abstract 1845: BRAF-mediated NAMPT overexpression induces a melanoma cell dedifferentiation program leading to metabolic reprogramming and intrinsic resistant to BRAF inhibitors
Journal Articles

Novel Richter Syndrome Xenograft Models to Study Genetic Architecture, Biology, and Therapy Responses

Tiziana Vaisitti, Esteban Braggio, John N. Allan, Francesca Arruga, Sara Serra, Alberto Zamò, Wayne Tam, Amy Chadburn, Richard R. Furman, Silvia Deaglio
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (13): 3413–3420.
https://doi.org/10.1158/0008-5472.CAN-17-4004
Published: 01 July 2018
View article titled, Novel Richter Syndrome Xenograft Models to Study Genetic Architecture, Biology, and Therapy Responses
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Includes: Supplementary data
Journal Articles

Abstract LB-269: IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies

Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Elisabetta Mereu, Nicoletta Vitale, Cecilia Bandini, Elisa Pellegrino, Paola Omedè, Katia Todoerti, Valentina Audrito, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo, Roberto Piva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-269.
https://doi.org/10.1158/1538-7445.AM2018-LB-269
Published: 01 July 2018
View article titled, Abstract LB-269: IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
Journal Articles

Abstract 5583: Pegylated adenosine deaminase 2 (PEG-ADA2) abrogates the cytoprotective effects of adenosine against chronic lymphocytic leukemia cells

Sara Serra, Cinzia Bologna, Luz Londono, Lin Wang, Michael Shepard, Sanna Rosengren, Christopher Thanos, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5583.
https://doi.org/10.1158/1538-7445.AM2017-5583
Published: 01 July 2017
View article titled, Abstract 5583: Pegylated adenosine deaminase 2 (PEG-ADA2) abrogates the cytoprotective effects of adenosine against chronic lymphocytic leukemia cells
Journal Articles

miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer

Francesca Orso, Lorena Quirico, Federico Virga, Elisa Penna, Daniela Dettori, Daniela Cimino, Roberto Coppo, Elena Grassi, Angela Rita Elia, Davide Brusa, Silvia Deaglio, Maria Felice Brizzi, Michael B. Stadler, Paolo Provero, Michele Caselle, Daniela Taverna
Journal: Cancer Research
Cancer Res (2016) 76 (17): 5151–5162.
https://doi.org/10.1158/0008-5472.CAN-15-1322
Published: 31 August 2016
View article titled, miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 241: Up-regulation of PD-L1 in melanoma determines resistance to BRAF and MEK inhibitors, induces a more aggressive phenotype and is partially mediated through post-transcriptional mechanisms involving miR-17-5p

Davide Brusa, Aureliano Stingi, Valentina Audrito, Francesca Orso, Sara Serra, Roberta Buonincontri, Francesco Neri, Gianna Baroni, Barbara Merelli, Romina Nassini, Daniela Massi, Salvatore Oliviero, Daniela Taverna, Mario Mandalà, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 241.
https://doi.org/10.1158/1538-7445.AM2016-241
Published: 15 July 2016
View article titled, Abstract 241: Up-regulation of PD-L1 in melanoma determines resistance to BRAF and MEK inhibitors, induces a more aggressive phenotype and is partially mediated through post-transcriptional mechanisms involving miR-17-5p
Journal Articles

Abstract 3192: Cooperation between adenosinergic and hypoxic signals in shaping chronic lymphocytic leukemia microenvironment

Sara Serra, Davide Brusa, Roberta Buonincontri, Valentina Audrito, Tiziana Vaisitti, Simon Robson, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3192.
https://doi.org/10.1158/1538-7445.AM2015-3192
Published: 01 August 2015
View article titled, Abstract 3192: Cooperation between adenosinergic and hypoxic signals in shaping chronic lymphocytic leukemia microenvironment
Journal Articles

Abstract 5604: PD-L1 expression identifies a subpopulation of melanoma cells characterized by enhanced invasiveness and aggressiveness

Davide Brusa, Daniela Massi, Barbara Merelli, Michela Ciano, Valentina Audrito, Sara Serra, Gianna Baroni, Romina Nassini, Daiana Minocci, Laura Cattaneo, Alessandra Carobbio, Silvia Deaglio, Mario Mandala
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5604.
https://doi.org/10.1158/1538-7445.AM2014-5604
Published: 01 October 2014
View article titled, Abstract 5604: PD-L1 expression identifies a subpopulation of melanoma cells characterized by enhanced invasiveness and aggressiveness
Journal Articles

Abstract 2302: The extracellular form of NAMPT contributes to creating a proinflammatory environment in chronic lymphocytic leukemia.

Valentina Audrito, Sara Serra, Tiziana Vaisitti, Nadia Raffaelli, Luca Laurenti, Giovanni D'Arena, Davide Rossi, Gianluca Gaidano, Menico Rizzi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2302.
https://doi.org/10.1158/1538-7445.AM2013-2302
Published: 15 April 2013
View article titled, Abstract 2302: The extracellular form of NAMPT contributes to creating a proinflammatory environment in chronic lymphocytic leukemia.
Journal Articles

Abstract 1348: CD38 regulates homing and engraftment in a mouse model of CLL

Tiziana Vaisitti, Valentina Audrito, Sara Serra, Chris Pepper, Davide Rossi, Giovanni D'Arena, Luca Laurenti, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1348.
https://doi.org/10.1158/1538-7445.AM2012-1348
Published: 15 April 2012
View article titled, Abstract 1348: CD38 regulates homing and engraftment in a mouse model of CLL
Journal Articles

Abstract 5170: Metabolism and cancer: The CD38-NAMPT connection in chronic lymphocytic leukemia

Valentina Audrito, Tiziana Vaisitti, Sara Serra, Davide Rossi, Giovanni D'Arena, Luca Laurenti, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5170.
https://doi.org/10.1158/1538-7445.AM2012-5170
Published: 15 April 2012
View article titled, Abstract 5170: Metabolism and cancer: The CD38-NAMPT connection in chronic lymphocytic leukemia
Journal Articles

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

Valentina Audrito, Tiziana Vaisitti, Davide Rossi, Daniela Gottardi, Giovanni D'Arena, Luca Laurenti, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4473–4483.
https://doi.org/10.1158/0008-5472.CAN-10-4452
Published: 30 June 2011
View article titled, Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
Open the PDF for Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network in another window
Includes: Supplementary data
Journal Articles

Abstract 389: CD38 is part of a network of molecules regulating chemotaxis and homing of CLL cells

Tiziana Vaisitti, Cinzia Bologna, Sara Serra, Davide Rossi, Giovanni D'arena, Luca Laurenti, Daniela Gottardi, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 389.
https://doi.org/10.1158/1538-7445.AM2011-389
Published: 15 April 2011
View article titled, Abstract 389: CD38 is part of a network of molecules regulating chemotaxis and homing of CLL cells
Journal Articles

Abstract 2630: Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells

Valentina Audrito, Tiziana Vaisitti, Davide Rossi, Daniela Gottardi, Giovanni D'Arena, Luca Laurenti, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2630.
https://doi.org/10.1158/1538-7445.AM2011-2630
Published: 15 April 2011
View article titled, Abstract 2630: Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells
Journal Articles

Abstract 1542: CD38 is physically associated with CD49d and enhances CD49d-mediated adhesion of B-Cell chronic lymphocytic leukemia cells

Dania Benedetti, Antonella Zucchetto, Tiziana Vaisitti, Giovanni Del Poeta, Amy VanMeter, Virginia Espina, Fabio Malavasi, Silvia Deaglio, Valter Gattei
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1542.
https://doi.org/10.1158/1538-7445.AM2011-1542
Published: 15 April 2011
View article titled, Abstract 1542: CD38 is physically associated with CD49d and enhances CD49d-mediated adhesion of B-Cell chronic lymphocytic leukemia cells
Journal Articles

CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival

Antonella Zucchetto, Dania Benedetti, Claudio Tripodo, Riccardo Bomben, Michele Dal Bo, Daniela Marconi, Fleur Bossi, Debora Lorenzon, Massimo Degan, Francesca Maria Rossi, Davide Rossi, Pietro Bulian, Vito Franco, Giovanni Del Poeta, Silvia Deaglio, Gianluca Gaidano, Francesco Tedesco, Fabio Malavasi, Valter Gattei
Journal: Cancer Research
Cancer Res (2009) 69 (9): 4001–4009.
https://doi.org/10.1158/0008-5472.CAN-08-4173
Published: 30 April 2009
View article titled, CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival
Open the PDF for CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival in another window
Includes: Supplementary data
Journal Articles

Oxytocin Is a Growth Factor for Kaposi’s Sarcoma Cells: Evidence of Endocrine-Immunological Cross-Talk

Paola Cassoni, Anna Sapino, Silvia Deaglio, Benedetta Bussolati, Marco Volante, Luca Munaron, Adriana Albini, Antonietta Torrisi, Gianni Bussolati
Journal: Cancer Research
Cancer Res (2002) 62 (8): 2406–2413.
Published: 01 April 2002
View article titled, Oxytocin Is a Growth Factor for Kaposi’s Sarcoma Cells: <subtitle>Evidence of Endocrine-Immunological Cross-Talk</subtitle>
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