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Siddhartha Kar
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Journal Articles

Abstract 5227: Cross-trait genome-wide association meta-analyses of clonal hematopoiesis and solid tumor risk

Free
Victoria Gray, George Richenberg, Pedro Quirós, Matthew Freedman, Paul Pharoah, Simon Gayther, Michelle Jones, George Vassiliou, Kate Lawrenson, Siddhartha Kar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5227.
https://doi.org/10.1158/1538-7445.AM2023-5227
Published: 04 April 2023
View articletitled, Abstract 5227: Cross-trait genome-wide association meta-analyses of clonal hematopoiesis and solid tumor risk
Journal Articles

Abstract 6504: Germline genetically predicted body mass index is associated with endometrial cancer somatic transcriptomic, immune, and mutational signatures in The Cancer Genome Atlas

Free
George Richenberg, Victoria Gray, Carina Owen, Tom Gaunt, Caroline Relton, Emma Vincent, Siddhartha Kar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6504.
https://doi.org/10.1158/1538-7445.AM2023-6504
Published: 04 April 2023
View articletitled, Abstract 6504: Germline genetically predicted body mass index is associated with endometrial cancer somatic transcriptomic, immune, and mutational signatures in The Cancer Genome Atlas
Journal Articles

Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response

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Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp H. Richter, Marsha D. Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson J. Ryan, Joanna L. Selfe, Janet Shipley, Siddhartha Kar, Paul D. Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel V. Ebner, Meghana Pagadala, Sarah P. Blagden, Timothy S. Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth L. Bond
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1667–1680.
https://doi.org/10.1158/0008-5472.CAN-20-0177
Published: 01 April 2021
View articletitled, Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response
Open the PDF for Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response in another window
Includes: Supplementary data
Journal Articles

Abstract 1194: Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions

Free
Sara Lindström, Siddhartha Kar, Lu Wang, Constance Turman, James MacDonald, Theo Bammler, BCAC, OCAC, PRACTICAL, Jeroen Huyghe, Stephanie Schmit, Tracy A. O'Mara, Deborah J. Thompson, Puya Gharahkhani, Stuart MacGregor, Paul Brennan, Richard S. Houlston, Beatrice S. Melin, Christopher I. Amos, James McKay, Mark M. Iles, Matthew H. Law, Alison Klein, Laufey Amundadottir, Bogdan Pasaniuc, Paul Pharoah, Rayjean J. Hung, Peter Kraft
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1194.
https://doi.org/10.1158/1538-7445.AM2020-1194
Published: 15 August 2020
View articletitled, Abstract 1194: Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions
Journal Articles

Abstract 30: Cross-cancer cross-tissue transcriptome-wide association study (TWAS) of 11 cancers identifies 56 novel genes

Free
Helian Feng, Arunabha Majumdar, Bogdan Pasaniuc, Hongjie Chen, Sara Lindström, BCAC, OCAC, PRACTICAL, Jeroen Huyghe, Stephanie L. Schmit, Tracy A. O'Mara, Deborah J. Thompson, Stuart MacGregor, Paul Brennan, James McKay, Richard S. Houlston, Beatrice S. Melin, Christopher Amos, Anne E. Cus, Mark M. Iles, Siddhartha Kar, Paul Pharoah, Rayjean J. Hung, Peter Kraft
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 30.
https://doi.org/10.1158/1538-7445.AM2020-30
Published: 15 August 2020
View articletitled, Abstract 30: Cross-cancer cross-tissue transcriptome-wide association study (TWAS) of 11 cancers identifies 56 novel genes
Journal Articles

Abstract 1299: Common germline risk loci and the tumor anticancer immune response in breast cancer

Free
Siddhartha Kar, Jonathan Tyrer, Paul Pharoah, Breast Cancer Association Consortium (BCAC)
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1299.
https://doi.org/10.1158/1538-7445.AM2017-1299
Published: 01 July 2017
View articletitled, Abstract 1299: Common germline risk loci and the tumor anticancer immune response in breast cancer
Journal Articles

Abstract 1308: Transcriptome-wide association study among 66,450 women to identify candidate susceptible genes for ovarian cancer risk

Free
Yingchang Lu, Joellen M. Schildkraut, Thomas A. Sellers, Lang Wu, Xingyi Guo, Bingshan Li, Y. Ann Chen, Jennifer B. Doherty, Simon Gayther, Ellen L. Goode, Hae Kyung Im, Siddhartha Kar, Kate Lawrenson, Ani W. Manichaikul, Jennifer B. Permuth, Brett M. Reid, Jamie K. Teer, Paul Pharoah, Wei Zheng, Jirong Long
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1308.
https://doi.org/10.1158/1538-7445.AM2017-1308
Published: 01 July 2017
View articletitled, Abstract 1308: Transcriptome-wide association study among 66,450 women to identify candidate susceptible genes for ovarian cancer risk
Journal Articles

Abstract 2783: Common functional mechanisms underlying pleiotropy at the 19p13.1 breast and ovarian cancer cusceptibility locus

Free
Kate Lawrenson, Siddhartha Kar, Karoline Kuckenbaeker, Stacey Edwards, Qiyuan Li, Jonathan Tyrer, Jonathan Beesley, Kyriaki Michailidou, Susan Ramus, Alison Dunning, Fergus Couch, Alvaro Monteiro, Jacques Simard, Matthew Freedman, Douglas Easton, Georgia Chenevix-Trench, Paul Pharoah, Antonis Antoniou, Simon Gayther, OCAC, BCAC and CIMBA
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2783.
https://doi.org/10.1158/1538-7445.AM2015-2783
Published: 01 August 2015
View articletitled, Abstract 2783: Common functional mechanisms underlying pleiotropy at the 19p13.1 breast and ovarian cancer cusceptibility locus
Journal Articles

Abstract 2779: A genome-wide analysis of more than 160,000 individuals identifies four novel pleiotropic risk loci shared between breast and ovarian cancer

Free
Siddhartha Kar, Kyriaki Michailidou, Jonathan Tyrer, Deborah Thompson, Diether Lambrechts, Ovarian Cancer Association Consortium (OCAC) and Breast Cancer Association Consortium (BCAC)
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2779.
https://doi.org/10.1158/1538-7445.AM2015-2779
Published: 01 August 2015
View articletitled, Abstract 2779: A genome-wide analysis of more than 160,000 individuals identifies four novel pleiotropic risk loci shared between breast and ovarian cancer
Journal Articles

Abstract 3288: Integration of GWAS, gene expression and protein interaction data identifies a HOX-centric gene network associated with serous ovarian cancer risk

Free
Siddhartha Kar, Jonathan Tyrer, Thomas Sellers, Simon Gayther, Paul Pharoah, Ovarian Cancer Association Consortium
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3288.
https://doi.org/10.1158/1538-7445.AM2014-3288
Published: 01 October 2014
View articletitled, Abstract 3288: Integration of GWAS, gene expression and protein interaction data identifies a HOX-centric gene network associated with serous ovarian cancer risk
Journal Articles

2-Methoxyestradiol inhibits hepatoma, but not hepatocyte, cell growth by inhibiting Cdc25, inducing cell cycle arrest and apoptosis

Free
Siddhartha Kar, Meifang Wang, Brian Carr
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4894.
Published: 01 May 2008
View articletitled, 2-Methoxyestradiol inhibits hepatoma, but not hepatocyte, cell growth by inhibiting Cdc25, inducing cell cycle arrest and apoptosis
Journal Articles

HKH40A (RTA 502) inhibits growth of hepatocellular carcinoma cells both in vitro and in vivo by arresting cells in G2/M phase of the cell cycle via Cdc25C phosphorylation and inducing apoptosis

Free
Siddhartha Kar, Ziqiu Wang, Meifang Wang, Christopher Michejda, Brian Carr
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5621.
Published: 01 May 2007
View articletitled, HKH40A (RTA 502) inhibits growth of hepatocellular carcinoma cells both in vitro and in vivo by arresting cells in G2/M phase of the cell cycle via Cdc25C phosphorylation and inducing apoptosis
Journal Articles

α-thrombin inhibits EGF-mediated DNA synthesis of rat hepatocytes, but not hepatoma cell growth.

Free
Siddhartha Kar, Meifang Wang, Brian Carr
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4680.
Published: 01 May 2007
View articletitled, α-thrombin inhibits EGF-mediated DNA synthesis of rat hepatocytes, but not hepatoma cell growth.
Journal Articles

H32, a new non-quinone vitamin K sulfone analog, inhibits tumor cell growth by MAPK activation

Free
Siddhartha Kar, Meifang Wang, Seung Wook Ham, Brian I. Carr
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 892.
Published: 15 April 2006
View articletitled, H32, a new non-quinone vitamin K sulfone analog, inhibits tumor cell growth by MAPK activation
Journal Articles

Growth regulatory role of prothrombin and its under-carboxylated form des-gamma-carboxy-prothrombin (DCP) in hepatocytes and hepatomas

Free
Brian I. Carr, Siddhartha Kar, Meifang Wang, Ziqiu Wang
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 393.
Published: 15 April 2006
View articletitled, Growth regulatory role of prothrombin and its under-carboxylated form des-gamma-carboxy-prothrombin (DCP) in hepatocytes and hepatomas
Journal Articles

Fluorinated Cpd 5, an arylating K-vitamin derivative, inhibits human tumor cell growth by activation of MAPK

Free
Siddhartha Kar, Meifang Wang, Seung Wook Ham, Brian I. Carr
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 156.
Published: 01 May 2005
View articletitled, Fluorinated Cpd 5, an arylating K-vitamin derivative, inhibits human tumor cell growth by activation of MAPK
Journal Articles

Phenyl maleiimide deivatives, a new class of phosphatase inhibitors that are active against hepatoma cells in vitro

Free
Siddhartha Kar, Meifang Wang, Wei Yao, Christopher J. Michejda, Brian I. Carr
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 893–894.
Published: 01 April 2004
View articletitled, Phenyl maleiimide deivatives, a new class of phosphatase inhibitors that are active against hepatoma cells in vitro
Journal Articles

Thioalkyl derivatives of vitamin K are potent inhibitors of growth and Cdc25 phosphatases in human hepatoma cells

Free
Vincent Peyregne, Seung-Wook Ham, Siddhartha Kar, Meifang Wang, Brian I. Carr
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 895.
Published: 01 April 2004
View articletitled, Thioalkyl derivatives of vitamin K are potent inhibitors of growth and Cdc25 phosphatases in human hepatoma cells
Journal Articles

Involvement of Cdc25A Phosphatase in Hep3B Hepatoma Cell Growth Inhibition Induced by Novel K Vitamin Analogs

Free
Ziqiu Wang, Eileen C. Southwick, Meifang Wang, Siddhartha Kar, Kathryn S. Rosi, Craig S. Wilcox, John S. Lazo, Brian I. Carr
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7211–7216.
Published: 01 October 2001
View articletitled, Involvement of Cdc25A Phosphatase in Hep3B Hepatoma Cell Growth Inhibition Induced by Novel K Vitamin Analogs
Open the PDF for Involvement of Cdc25A Phosphatase in Hep3B Hepatoma Cell Growth Inhibition Induced by Novel K Vitamin Analogs in another window