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Sid P. Kerkar
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Journal Articles

Abstract 4016: mRNA encoding a CAR specific stimulating protein (CSSP) mediates tumor metabolism regulated (TMR) CAR signaling for CAR-T expansion beyond the tumor microenvironment

Frederic Vigant, Anirban Kundu, Michael Betts, Sid P. Kerkar, Gregory I. Frost
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4016.
https://doi.org/10.1158/1538-7445.AM2024-4016
Published: 22 March 2024
View article titled, Abstract 4016: mRNA encoding a CAR specific stimulating protein (CSSP) mediates tumor metabolism regulated (TMR) CAR signaling for CAR-T expansion beyond the tumor microenvironment
Journal Articles

Abstract 2918: In vivo delivery of CD3-directed CD19-CAR lentivectors leads to the generation of CAR T and NK-like (CAR-TaNK) cells capable of complete ablation of B cells in the blood, bone marrow, and tissue of NSG-SGM3 CD34+ humanized mice

Frederic Vigant, Ani Kundu, Ramya Yarlagadda, Cody Gowan, Michael Betts, Jonathan Kato, Renata Soares, Alan Ponce, Lintao Liu, Junyi Zhang, Ewa Jaruga-Killeen, Michelle Andraza, Suraj Kachgal, Gregory Schreiber, Wei Zhang, Gregory Wade, Gregory I. Frost, Sid P. Kerkar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2918.
https://doi.org/10.1158/1538-7445.AM2023-2918
Published: 04 April 2023
View article titled, Abstract 2918: <em>In vivo</em> delivery of CD3-directed CD19-CAR lentivectors leads to the generation of CAR T and NK-like (CAR-TaNK) cells capable of complete ablation of B cells in the blood, bone marrow, and tissue of NSG-SGM3 CD34+ humanized mice
Journal Articles

Abstract 560: Generation of tertiary lymphoid structures and CD3+ CD8+ CD56+ NKG2D+ CAR TaNK cells following subcutaneous injection of CD3-directed lentiviral-loaded PBMCs

Ani Kundu, Dongming Zhang, Frederic Vigant, Junyi Zhang, Greg Schreiber, Ewa Jaruga-Killeen, Alissa Kerner, Michelle Andraza, Wei Zhang, John Henkelman, Renata Soares, Gregory I. Frost, Sid P. Kerkar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 560.
https://doi.org/10.1158/1538-7445.AM2022-560
Published: 15 June 2022
View article titled, Abstract 560: Generation of tertiary lymphoid structures and CD3+ CD8+ CD56+ NKG2D+ CAR TaNK cells following subcutaneous injection of CD3-directed lentiviral-loaded PBMCs
Journal Articles

Abstract 3294: In vivo delivery of a novel CD3-targeted lentiviral vector generates CD19 CAR-T cells in two different humanized mouse models and results in complete B cell depletion

Frederic Vigant, Ani Kundu, Dongming Zhang, Wei Zhang, Ewa Jaruga-Killeen, Michelle Andraza, Gregory Schreiber, Alissa Kerner, Junyi Zhang, John Henkelman, Renata Soares, Ramya Yarlagadda, Gregory I. Frost, Sid P. Kerkar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3294.
https://doi.org/10.1158/1538-7445.AM2022-3294
Published: 15 June 2022
View article titled, Abstract 3294: In vivo delivery of a novel CD3-targeted lentiviral vector generates CD19 CAR-T cells in two different humanized mouse models and results in complete B cell depletion
Journal Articles

Abstract 1511: Subcutaneous injection of total nucleated cells rapidly isolated following four-hour peripheral whole blood exposure to CD3-directed CAR-T lentiviruses with a synthetic driver results in robust CAR-T proliferation and anti-tumor immunity

Dongming Zhang, Frederic Vigant, Qun He, Anirban Kundu, Wei Zhang, Hongliang Zong, Ewa Jaruga-Killeen, Gregory Schreiber, Michelle Andraza, Alissa R. Kerner, Gregory I. Frost, Sid P. Kerkar
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1511.
https://doi.org/10.1158/1538-7445.AM2021-1511
Published: 01 July 2021
View article titled, Abstract 1511: Subcutaneous injection of total nucleated cells rapidly isolated following four-hour peripheral whole blood exposure to CD3-directed CAR-T lentiviruses with a synthetic driver results in robust CAR-T proliferation and anti-tumor immunity
Journal Articles

Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

Joseph G. Crompton, Madhusudhanan Sukumar, Rahul Roychoudhuri, David Clever, Alena Gros, Robert L. Eil, Eric Tran, Ken-ichi Hanada, Zhiya Yu, Douglas C. Palmer, Sid P. Kerkar, Ryan D. Michalek, Trevor Upham, Anthony Leonardi, Nicolas Acquavella, Ena Wang, Francesco M. Marincola, Luca Gattinoni, Pawel Muranski, Mark S. Sundrud, Christopher A. Klebanoff, Steven A. Rosenberg, Douglas T. Fearon, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2015) 75 (2): 296–305.
https://doi.org/10.1158/0008-5472.CAN-14-2277
Published: 14 January 2015
View article titled, Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
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Includes: Supplementary data
Journal Articles

Cellular Constituents of Immune Escape within the Tumor Microenvironment

Sid P. Kerkar, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3125–3130.
https://doi.org/10.1158/0008-5472.CAN-11-4094
Published: 01 July 2012
View article titled, Cellular Constituents of Immune Escape within the Tumor Microenvironment
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Journal Articles

Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Sid P. Kerkar, Pawel Muranski, Andrew Kaiser, Andrea Boni, Luis Sanchez-Perez, Zhiya Yu, Douglas C. Palmer, Robert N. Reger, Zachary A. Borman, Ling Zhang, Richard A. Morgan, Luca Gattinoni, Steven A. Rosenberg, Giorgio Trinchieri, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2010) 70 (17): 6725–6734.
https://doi.org/10.1158/0008-5472.CAN-10-0735
Published: 31 August 2010
View article titled, Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
Open the PDF for Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts in another window
Includes: Supplementary data