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Shukuan Li
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Journal Articles

Abstract 3258: THOR-707, a novel not-alpha IL-2, elicits durable pharmacodynamic responses in non-human primates and efficacy as single agent and in combination with anti PD-1 in multiple syngeneic mouse models

Ingrid B. Joseph, Lina Ma, Jerod L. Ptacin, Carolina E. Caffaro, Hans R. Aerni, Kristine M. San Jose, Michael J. Pena, Robert W. Herman, Yelena Pavlova, David B. Chen, Ken Bragstad, Shukuan Li, Jasmine Nguyen, Laura K. Shawver, Lilia K. Koriazova, Marcos E. Milla
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3258.
https://doi.org/10.1158/1538-7445.AM2019-3258
Published: 01 July 2019
View article titled, Abstract 3258: THOR-707, a novel not-alpha IL-2, elicits durable pharmacodynamic responses in non-human primates and efficacy as single agent and in combination with anti PD-1 in multiple syngeneic mouse models
Journal Articles

Abstract 2686: Methioninase S-phase block of cancer cells imaged in real time by cell-cycle-specific fluorescence reporters

Shuya Yano, Shukuan Li, Qinghong Han, Yuying Tan, Toshiyoshi Fujiwara, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2686.
https://doi.org/10.1158/1538-7445.AM2012-2686
Published: 15 April 2012
View article titled, Abstract 2686: Methioninase S-phase block of cancer cells imaged in real time by cell-cycle-specific fluorescence reporters
Journal Articles

Abstract 2679: Color-coded selective chemotherapy of methioninase-synchronized S-phase cancer cells expressing cell-cycle-specific fluorescent reporters: A general approach to the treatment of cancer

Shuya Yano, Shukuan Li, Qinghong Han, Yuying Tan, Toshiyoshi Fujiwara, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2679.
https://doi.org/10.1158/1538-7445.AM2012-2679
Published: 15 April 2012
View article titled, Abstract 2679: Color-coded selective chemotherapy of methioninase-synchronized S-phase cancer cells expressing cell-cycle-specific fluorescent reporters: A general approach to the treatment of cancer
Journal Articles

Human cancer growth in the nude mice model is associated with impaired metabolism of the methionine cycle

Farida Al-Awadi, Meng Yang, Yuying Tan, Qinghong Han, Shukuan Li, Robert Hoffman
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2739.
Published: 01 May 2008
View article titled, Human cancer growth in the nude mice model is associated with impaired metabolism of the methionine cycle
Journal Articles

Quantitation of PEGylated methioninase protein in blood

Shukuan Li, Zhijian Yang, Huaiyu Ma, Ming Zhao, Xiao-ming Li, Yuying Tan, Shigeo Yagi, Robert Hoffman
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5569.
Published: 01 May 2007
View article titled, Quantitation of PEGylated methioninase protein in blood
Journal Articles

Targeted Therapy with a Salmonella Typhimurium Leucine-Arginine Auxotroph Cures Orthotopic Human Breast Tumors in Nude Mice

Ming Zhao, Meng Yang, Huaiyu Ma, Xiaoming Li, Xiuying Tan, Shukuan Li, Zhijian Yang, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (15): 7647–7652.
https://doi.org/10.1158/0008-5472.CAN-06-0716
Published: 02 August 2006
View article titled, Targeted Therapy with a <em>Salmonella Typhimurium</em> Leucine-Arginine Auxotroph Cures Orthotopic Human Breast Tumors in Nude Mice
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Journal Articles

An effective method to remove endotoxin from PEGylated recombinant methioninase

Shukuan Li, Xinghua Sun, Zhijian Yang, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 513.
Published: 15 April 2006
View article titled, An effective method to remove endotoxin from PEGylated recombinant methioninase
Journal Articles

The effect of PEGylation on the enzyme kinetics of recombinant methioninase

Shukuan Li, Zhijian Yang, Xinghua Sun, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 513.
Published: 15 April 2006
View article titled, The effect of PEGylation on the enzyme kinetics of recombinant methioninase
Journal Articles

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuki Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 329.
Published: 01 May 2005
View article titled, PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
Journal Articles

Tumor-targeting bacterial therapy with amino-acid auxotrophs of GFP-expressing Salmonella typhimurium

Ming Zhao, Meng Yang, Xiao-Ming Li, Ping Jiang, Eugene Baranov, Shukuan Li, Mingxu Xu, Sheldon Penman, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1189.
Published: 01 May 2005
View article titled, Tumor-targeting bacterial therapy with amino-acid auxotrophs of GFP-expressing <em>Salmonella typhimurium</em>
Journal Articles

Sensitive assay of tumor S-adenosyl-methionine and S-adenosyl-homocysteine

Shukuan Li, Zhijian Yang, Xinghua Sun, Xiao-Ming Li, Mingxu Xu, Huaiyu Ma, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 556.
Published: 01 May 2005
View article titled, Sensitive assay of tumor S-adenosyl-methionine and S-adenosyl-homocysteine
Journal Articles

PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuji Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6673–6678.
https://doi.org/10.1158/0008-5472.CAN-04-1822
Published: 16 September 2004
View article titled, PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates
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Journal Articles

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5775–5778.
https://doi.org/10.1158/0008-5472.CAN-04-1406
Published: 16 August 2004
View article titled, Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate
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Journal Articles

Addition of primary amines to proteins increases the extent of polyethylene glycol (PEG) conjugation

Shukuan Li, Zhijian Yang, Xinghua Sun, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 234.
Published: 01 April 2004
View article titled, Addition of primary amines to proteins increases the extent of polyethylene glycol (PEG) conjugation
Journal Articles

In vivo stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akinori Suginaka, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 234.
Published: 01 April 2004
View article titled, <em>In vivo</em> stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate
Journal Articles

In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akio Takimoto, Kenji Mitsushima, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8377–8383.
Published: 16 December 2003
View article titled, <em>In Vivo</em> Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation
Open the PDF for <em>In Vivo</em> Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation in another window