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Abstract CT061: A Phase Ib trial of lenvatinib (LEN) plus pembrolizumab (PEMBRO) in unresectable hepatocellular carcinoma (uHCC): Updated results

Masafumi Ikeda, Max W. Sung, Masatoshi Kudo, Masahiro Kobayashi, Ari D. Baron, Richard S. Finn, Shuichi Kaneko, Andrew X. Zhu, Tomoki Kubota, Silvija Kralijevic, Hiroki Ikezawa, Abby B. Siegel, Hiromitsu Kumada, Takuji Okusaka

Cancer Res (2019) 79 (13_Supplement): CT061.

DOI: https://doi.org/10.1158/1538-7445.AM2019-CT061

Published: 01 July 2019

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Journal Articles

Abstract 1904: Polyprenoic acid, the first-discovered hepatocyte nuclear factor 4 alpha agonist, inhibits multistep liver carcinogenesis

Taro Yamashita, Hikari Okada, Masao Honda, Shuichi Kaneko

Cancer Res (2018) 78 (13_Supplement): 1904.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1904

Published: 01 July 2018

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Journal Articles

Abstract 5245: Peretinoin prevents the accumulation of somatic gene mutations and reverts neoplastic lesions to normal liver-like in platelet-derived growth factor-c transgenic mice

Taro Yamashita, Hikari Okada, Masao Honda, Shuichi Kaneko

Cancer Res (2017) 77 (13_Supplement): 5245.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5245

Published: 01 July 2017

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Journal Articles

Abstract 4688: Novel prognostic subtype of hepatocellular carcinoma reflecting stem/maturational status of the tumor defined by Gd-EOB-DTPA-enhanced MRI and serum AFP

Taro Yamashita, Masao Honda, Shuichi Kaneko

Cancer Res (2014) 74 (19_Supplement): 4688.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4688

Published: 01 October 2014

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Journal Articles

Abstract 262: The evolution of diverse cancer stem cells in human liver cancer.

Taro Yamashita, Masao Honda, Kouki Nio, Yasumasa Hara, Takehiro Hayashi, Naoki Oishi, Hajime Sunakozaka, Hajime Takatori, Shuichi Kaneko

Cancer Res (2013) 73 (8_Supplement): 262.

DOI: https://doi.org/10.1158/1538-7445.AM2013-262

Published: 15 April 2013

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Journal Articles

Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development

Hikari Okada, Masao Honda, Jean S. Campbell, Yoshio Sakai, Taro Yamashita, Yuuki Takebuchi, Kazuhiro Hada, Takayoshi Shirasaki, Riuta Takabatake, Mikiko Nakamura, Hajime Sunagozaka, Takuji Tanaka, Nelson Fausto, Shuichi Kaneko

Cancer Res (2012) 72 (17): 4459–4471.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-0028

Published: 30 August 2012

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Includes: Supplementary data

Journal Articles

Abstract 5336: Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma

Taro Yamashita, Masao Honda, Kazunori Kawaguchi, Hajime Takatori, Hajime Sunakozaka, Xin W. Wang, Shuichi Kaneko

Cancer Res (2012) 72 (8_Supplement): 5336.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5336

Published: 15 April 2012

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Journal Articles

Abstract 3915: α-Fetoprotein-producing hepatoma cells have increased Jagged1 gene copy numbers and their growth can be suppressed by gamma secretase inhibitor

Kazunori Kawaguchi, Masao Honda, Taro Yamashita, Hajime Takatori, Teruyuki Ueda, Masataka Kanno, Shuichi Kaneko

Cancer Res (2011) 71 (8_Supplement): 3915.

DOI: https://doi.org/10.1158/1538-7445.AM2011-3915

Published: 15 April 2011

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Journal Articles

Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α

Noriho Iida, Yasunari Nakamoto, Tomohisa Baba, Hidetoshi Nakagawa, Eishiro Mizukoshi, Makoto Naito, Naofumi Mukaida, Shuichi Kaneko

Cancer Res (2010) 70 (16): 6556–6565.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-0096

Published: 14 August 2010

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Journal Articles

Oncostatin M Renders Epithelial Cell Adhesion Molecule–Positive Liver Cancer Stem Cells Sensitive to 5-Fluorouracil by Inducing Hepatocytic Differentiation

Taro Yamashita, Masao Honda, Kouki Nio, Yasunari Nakamoto, Tatsuya Yamashita, Hiroyuki Takamura, Takashi Tani, Yoh Zen, Shuichi Kaneko

Cancer Res (2010) 70 (11): 4687–4697.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-4210

Published: 01 June 2010

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Includes: Supplementary data

Journal Articles

Abstract 4281: Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation

Taro Yamashita, Masao Honda, Kouki Nio, Shuichi Kaneko

Cancer Res (2010) 70 (8_Supplement): 4281.

DOI: https://doi.org/10.1158/1538-7445.AM10-4281

Published: 15 April 2010

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Journal Articles

Abstract 5009: Analyses of human specimens and knockout mouse model reveal a tumor suppressor function of EphA2 in liver

Hong Guo, Hui Miao, Xin Chen, Hiroshi Iida, Shuichi Kaneko, Bingcheng Wang

Cancer Res (2010) 70 (8_Supplement): 5009.

DOI: https://doi.org/10.1158/1538-7445.AM10-5009

Published: 15 April 2010

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Journal Articles

Abstract #1948: Bolstering hepatic cancer stem cells by wnt/\#946;-catenin signaling

Taro Yamashita, Junfang Ji, Anuradha Budhu, Marshonna Forgues, Huliang Jia, Qinghai Ye, Lun-Xiu Qin, Elaine Wauthier, Lola Reid, Hiroshi Minato, Masao Honda, Shuichi Kaneko, Wen Yang, Hongyang Wang, Zhao-You Tang, Xin Wang

Cancer Res (2009) 69 (9_Supplement): 1948.

Published: 01 May 2009

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Journal Articles

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

Yoshio Sakai, Masao Honda, Haruo Fujinaga, Isamu Tatsumi, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko

Cancer Res (2008) 68 (24): 10267–10279.

DOI: https://doi.org/10.1158/0008-5472.CAN-08-0911

Published: 15 December 2008

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Includes: Supplementary data

Journal Articles

Different Procarcinogenic Potentials of Lymphocyte Subsets in a Transgenic Mouse Model of Chronic Hepatitis B

Yasunari Nakamoto, Takashi Suda, Takashi Momoi, Shuichi Kaneko

Cancer Res (2004) 64 (9): 3326–3333.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-3817

Published: 03 May 2004

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Journal Articles

Adenovirus-mediated Gene Therapy of Hepatocellular Carcinoma Using Cancer-specific Gene Expression

Shuichi Kaneko, Paul Hallenbeck, Toshi Kotani, Hidekazu Nakabayashi, Gary McGarrity, Taiki Tamaoki, W. French Anderson, Yawen L. Chiang

Cancer Res (1995) 55 (22): 5283–5287.

Published: 01 November 1995

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Journal Articles

Stable Integration of Woodchuck Hepatitis Virus DNA in Transplanted Tumors and Established Tissue Culture Cells Derived from a Woodchuck Primary Hepatocellular Carcinoma

Shuichi Kaneko, Tohru Oshima, Kazuya Kodama, Syou Aoyama, Hiroshi Yoshikawa, Masashi Unoura, Kenichi Fukuoka, Fumiaki Matsushita, Hideo Morimoto, Kenichi Kobayashi, Nobu Hattori, Seishi Murakami

Cancer Res (1986) 46 (7): 3608–3613.

Published: 01 July 1986

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NARROW

Abstract CT061: A Phase Ib trial of lenvatinib (LEN) plus pembrolizumab (PEMBRO) in unresectable hepatocellular carcinoma (uHCC): Updated results

Abstract 1904: Polyprenoic acid, the first-discovered hepatocyte nuclear factor 4 alpha agonist, inhibits multistep liver carcinogenesis

Abstract 5245: Peretinoin prevents the accumulation of somatic gene mutations and reverts neoplastic lesions to normal liver-like in platelet-derived growth factor-c transgenic mice

Abstract 4688: Novel prognostic subtype of hepatocellular carcinoma reflecting stem/maturational status of the tumor defined by Gd-EOB-DTPA-enhanced MRI and serum AFP

Abstract 262: The evolution of diverse cancer stem cells in human liver cancer.

Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development

Abstract 5336: Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma

Abstract 3915: α-Fetoprotein-producing hepatoma cells have increased Jagged1 gene copy numbers and their growth can be suppressed by gamma secretase inhibitor

Antitumor Effect after Radiofrequency Ablation of Murine Hepatoma Is Augmented by an Active Variant of CC Chemokine Ligand 3/Macrophage Inflammatory Protein-1α

Oncostatin M Renders Epithelial Cell Adhesion Molecule–Positive Liver Cancer Stem Cells Sensitive to 5-Fluorouracil by Inducing Hepatocytic Differentiation

Abstract 4281: Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation

Abstract 5009: Analyses of human specimens and knockout mouse model reveal a tumor suppressor function of EphA2 in liver

Abstract #1948: Bolstering hepatic cancer stem cells by wnt/\#946;-catenin signaling

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

Different Procarcinogenic Potentials of Lymphocyte Subsets in a Transgenic Mouse Model of Chronic Hepatitis B

Adenovirus-mediated Gene Therapy of Hepatocellular Carcinoma Using Cancer-specific Gene Expression

Stable Integration of Woodchuck Hepatitis Virus DNA in Transplanted Tumors and Established Tissue Culture Cells Derived from a Woodchuck Primary Hepatocellular Carcinoma

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