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Shugaku Takeda
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Journal Articles

Abstract LB021: TJ102: A promising bispecific dual-payload ADC targeting CDH6 and folate receptor alpha (FRα) for the treatment of ovarian and kidney cancers

Free
Yangxin Zhang, Shugaku Takeda, Li Qi, Mao Huang, Lianjun Zhang, Wenchao Liu, Yanli Mao, Zhaoyuan Chen, Siyi Hu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB021.
https://doi.org/10.1158/1538-7445.AM2025-LB021
Published: 25 April 2025
View article titled, Abstract LB021: TJ102: A promising bispecific dual-payload ADC targeting CDH6 and folate receptor alpha (FRα) for the treatment of ovarian and kidney cancers
Journal Articles

Abstract 2955: Preclinical development of TJ101, a potent bispecific ADC targeting EGFR and B7-H3 for the treatment of solid cancers

Free
Li Qi, Shugaku Takeda, Yangxin Zhang, Mao Huang, Dongdong Zhou, Yanli Mao, Zhaoyuan Chen, Siyi Hu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2955.
https://doi.org/10.1158/1538-7445.AM2025-2955
Published: 21 April 2025
View article titled, Abstract 2955: Preclinical development of TJ101, a potent bispecific ADC targeting EGFR and B7-H3 for the treatment of solid cancers
Journal Articles

Abstract 6341: Targeting myeloid epithelial tyrosine kinase (MERTK) receptor in acute myeloid leukemia using a novel antibody-drug conjugate, RGX-019-MMAE

Free
Anudishi Tyagi, Maryam Siddiqui, Isabel Kurth, Shugaku Takeda, Amanda Eckstrom, Jenny Borgman, Abhishek Maiti, Venkata Lokesh Battula
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6341.
https://doi.org/10.1158/1538-7445.AM2024-6341
Published: 22 March 2024
View article titled, Abstract 6341: Targeting myeloid epithelial tyrosine kinase (MERTK) receptor in acute myeloid leukemia using a novel antibody-drug conjugate, RGX-019-MMAE
Journal Articles

Abstract 447: Anti-tumor efficacy of ompenaclid, a creatine transporter inhibitor, in KRAS mutant tumors, including NSCLC

Free
PuiChi Lo, Victor Sanz Chavez, Shugaku Takeda, Masoud Tavazoie, Isabel Kurth
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 447.
https://doi.org/10.1158/1538-7445.AM2024-447
Published: 22 March 2024
View article titled, Abstract 447: Anti-tumor efficacy of ompenaclid, a creatine transporter inhibitor, in KRAS mutant tumors, including NSCLC
Journal Articles

Abstract LB-277: Characterization of the anti-cancer and immunologic activity of RGX-019, a novel pre-clinical stage humanized monoclonal antibody targeting the MERTK receptor

Free
Shugaku Takeda, Celia Andreu-Agullo, Subhasree Sridhar, Nils Halberg, Ivo C. Lorenz, Sohail Tavazoie, Isabel Kurth, Masoud Tavazoie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-277.
https://doi.org/10.1158/1538-7445.AM2019-LB-277
Published: 01 July 2019
View article titled, Abstract LB-277: Characterization of the anti-cancer and immunologic activity of RGX-019, a novel pre-clinical stage humanized monoclonal antibody targeting the MERTK receptor
Journal Articles

Abstract 5863: RGX-202, a first-in-class small-molecule inhibitor of the creatine transporter SLC6a8, is a robust suppressor of cancer growth and metastatic progression

Free
Isabel Kurth, Celia Andreu, Shugaku Takeda, Helen Tian, Foster Gonsalves, Katya Leites, Subhasree Sridhar, Jia Min Loo, Rob Busby, Sohail Tavazoie, Masoud Tavazoie
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5863.
https://doi.org/10.1158/1538-7445.AM2018-5863
Published: 01 July 2018
View article titled, Abstract 5863: RGX-202, a first-in-class small-molecule inhibitor of the creatine transporter SLC6a8, is a robust suppressor of cancer growth and metastatic progression
Journal Articles

Abstract 3515: Pathway convergent evolution underscores treatment response to MTOR inhibitors in kidney cancers.

Free
Martin H. Voss, A Ari Hakimi, Can G. Pham, A Rose Brannon, Ying-Bei Chen, Luis F. Cunha, Oguz Akin, Han Liu, Shugaku Takeda, Sasinya N. Scott, Nicholas D. Socci, Agnes Viale, Nikolaus Schultz, Chris Sander, Victor E. Reuter, Paul Russo, Emily H. Cheng, Robert J. Motzer, Michael F. Berger, James J. Hsieh
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3515.
https://doi.org/10.1158/1538-7445.AM2013-3515
Published: 15 April 2013
View article titled, Abstract 3515: Pathway convergent evolution underscores treatment response to MTOR inhibitors in kidney cancers.
Journal Articles

Targeting Taspase1 for Cancer Therapy—Response

Free
David Y. Chen, Shugaku Takeda, Toshinao Oyama, James J. Hsieh
Journal: Cancer Research
Cancer Res (2012) 72 (11): 2913.
https://doi.org/10.1158/0008-5472.CAN-12-1074
Published: 31 May 2012
View article titled, Targeting Taspase1 for Cancer Therapy—Response
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Journal Articles

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

Free
David Y. Chen, Yishan Lee, Brian A. Van Tine, Adam C. Searleman, Todd D. Westergard, Han Liu, Ho-Chou Tu, Shugaku Takeda, Yiyu Dong, David R. Piwnica-Worms, Kyoung J. Oh, Stanley J. Korsmeyer, Ann Hermone, Richard Gussio, Robert H. Shoemaker, Emily H.-Y. Cheng, James J.-D. Hsieh
Journal: Cancer Research
Cancer Res (2012) 72 (3): 736–746.
https://doi.org/10.1158/0008-5472.CAN-11-2584
Published: 31 January 2012
View article titled, A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
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Includes: Supplementary data
Journal Articles

Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

Free
David Y. Chen, Han Liu, Shugaku Takeda, Ho-Chou Tu, Satoru Sasagawa, Brian A. Van Tine, Dongsi Lu, Emily H-Y. Cheng, James J-D. Hsieh
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5358–5367.
https://doi.org/10.1158/0008-5472.CAN-10-0027
Published: 30 June 2010
View article titled, Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
Open the PDF for Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis in another window
Includes: Supplementary data