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Journal Articles

Abstract 4854: Alleviation of low pH induced immunosuppression through antagonism of the pH sensor GPR65 in highly glycolytic NSCLC tumors

Prajna Behera, Samantha Buongervino, Kayla Guidry, Kyle Krois, Yanah Hossain, Victor Du, Tamara Ouspenskaia, Hongyu (Annie) Liang, Shu-Yun Zhang, Laura Johnston, Abby Lin, Tolu Aweda, Ramona Plant, Paul Bojczuk, Marica Speranza, Chris Hopson, Charles McHugh, Stacey Kendrew, Bradley Spencer-Dene, Susanne Moore, Deon Hildebrand, Jonathan Lea, Kerena Norris, Antonia Lewis, Jacob Brett, Paru Rao, Carol Harris, Joseph Pero, Laura Ator, Jing Fang, David washburn, Lisa Sloan, Catherine Alder, Richard Lonsdale, Nick Barton, Sue Griffin, Paul Redford, James Smothers
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4854.
https://doi.org/10.1158/1538-7445.AM2025-4854
Published: 21 April 2025
View articletitled, Abstract 4854: Alleviation of low pH induced immunosuppression through antagonism of the pH sensor GPR65 in highly glycolytic NSCLC tumors
Journal Articles

Abstract 2220: Non-clinical tumor models reveal broad combination potential of ICOS agonist antibodies

Jeremy D. Waight, Meixia Bi, David Kilian, Christopher Hopson, Shu-Yun Zhang, Sara Brett, Sapna Yadavilli, Tianqian Zhang, Hong Shi, Kenneth W. Hance, Marc Ballas, Axel Hoos
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2220.
https://doi.org/10.1158/1538-7445.AM2020-2220
Published: 15 August 2020
View articletitled, Abstract 2220: Non-clinical tumor models reveal broad combination potential of ICOS agonist antibodies
Journal Articles

Abstract 1637: ICOS agonism induces potent immune activation and anti-tumor response in non-clinical models

Sapna Yadavilli, Tianqian Zhang, Ashleigh Hahn, Laura M. Seestaller-Wehr, Hong Shi, Yao-Bin Liu, M.Phillip DeYoung, David J. Kilian, Meixia Bi, Michael P. Adam, Shu-Yun Zhang, Sabyasachi Bhattacharya, Yuliya Katlinskaya, Christina Blackwell, Christopher B. Hopson, Niranjan Yanamandra, Roopa Srinivasan, Patrick A. Mayes, Axel Hoos
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1637.
https://doi.org/10.1158/1538-7445.AM2017-1637
Published: 01 July 2017
View articletitled, Abstract 1637: ICOS agonism induces potent immune activation and anti-tumor response in non-clinical models
Journal Articles

Abstract 5031: Effects of BRAF and MEK inhibitors, dabrafenib and trametinib, on the immune system and in combination with immunomodulatory antibodies targeting PD1, PD-L1 and CTLA-4

Li Liu, Patrick Mayes, Stephen Eastman, Hong Shi, Sapna Yadavilli, Xiaoyu Pan, Jingsong Yang, Laura Seestaller-Wehr, Shu-Yun Zhang, Chris Hopson, Lyuben Tsvetkov, Junping Jing, James Smothers, Drew M. Pardoll, Axel Hoos
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5031.
https://doi.org/10.1158/1538-7445.AM2014-5031
Published: 01 October 2014
View articletitled, Abstract 5031: Effects of BRAF and MEK inhibitors, dabrafenib and trametinib, on the immune system and in combination with immunomodulatory antibodies targeting PD1, PD-L1 and CTLA-4
Journal Articles

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

Charity Atkins, Qi Liu, Elisabeth Minthorn, Shu-Yun Zhang, David J. Figueroa, Katherine Moss, Thomas B. Stanley, Brent Sanders, Aaron Goetz, Nathan Gaul, Anthony E. Choudhry, Hasan Alsaid, Beat M. Jucker, Jeffrey M. Axten, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2013) 73 (6): 1993–2002.
https://doi.org/10.1158/0008-5472.CAN-12-3109
Published: 14 March 2013
View articletitled, Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
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Includes: Supplementary data
Journal Articles

Role of glycogenolysis and reduced glucose uptake in AKT inhibitor-induced hyperglycemia

Ming-Chih Crouthamel, Jason Kahana, Susan Korenchuk, Shu-Yun Zhang, Derek Eberwein, Kathleen Brown, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4335.
Published: 01 May 2008
View articletitled, Role of glycogenolysis and reduced glucose uptake in AKT inhibitor-induced hyperglycemia
Journal Articles

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Nelson Rhodes, Dirk A. Heerding, Derek R. Duckett, Derek J. Eberwein, Victoria B. Knick, Timothy J. Lansing, Randy T. McConnell, Tona M. Gilmer, Shu-Yun Zhang, Kimberly Robell, Jason A. Kahana, Robert S. Geske, Elena V. Kleymenova, Anthony E. Choudhry, Zhihong Lai, Jack D. Leber, Elisabeth A. Minthorn, Susan L. Strum, Edgar R. Wood, Pearl S. Huang, Robert A. Copeland, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2366–2374.
https://doi.org/10.1158/0008-5472.CAN-07-5783
Published: 01 April 2008
View articletitled, Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Open the PDF for Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Alastair J. King, Denis R. Patrick, Roberta S. Batorsky, Maureen L. Ho, Hieu T. Do, Shu Yun Zhang, Rakesh Kumar, David W. Rusnak, Andrew K. Takle, David M. Wilson, Erin Hugger, Lifu Wang, Florian Karreth, Julie C. Lougheed, Jae Lee, David Chau, Thomas J. Stout, Earl W. May, Cynthia M. Rominger, Michael D. Schaber, Lusong Luo, Ami S. Lakdawala, Jerry L. Adams, Rooja G. Contractor, Keiran S.M. Smalley, Meenhard Herlyn, Michael M. Morrissey, David A. Tuveson, Pearl S. Huang
Journal: Cancer Research
Cancer Res (2006) 66 (23): 11100–11105.
https://doi.org/10.1158/0008-5472.CAN-06-2554
Published: 04 December 2006
View articletitled, Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885
Open the PDF for Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885 in another window
Includes: Supplementary data
Journal Articles

Increased Immunogenicity of Tumor Vaccines Complexed with Anti-Gal: Studies in Knockout Mice for α1,3Galactosyltransferase

Denise C. LaTemple, J. Todd Abrams, Shu Yun Zhang, Uri Galili
Journal: Cancer Research
Cancer Res (1999) 59 (14): 3417–3423.
Published: 15 July 1999
View articletitled, Increased Immunogenicity of Tumor Vaccines Complexed with Anti-Gal: Studies in Knockout Mice for α1,3Galactosyltransferase
Open the PDF for Increased Immunogenicity of Tumor Vaccines Complexed with Anti-Gal: Studies in Knockout Mice for α1,3Galactosyltransferase in another window