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Journal Articles

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, Rindert Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Thomas Look, Guoliang Qing, M. Celeste Simon, Hui Feng
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4417–4430.
https://doi.org/10.1158/0008-5472.CAN-20-2153
Published: 01 September 2021
View articletitled, Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma
Open the PDF for Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Zhiwei Dong, Kok Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N. Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M. Levee, Zuag Paj Her, Cassie J. Howe, Xiaonan Hou, Janine H. van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S. Lehman, Alexander Meves, Gina L. Razidlo, Komal S. Rathi, S. John Weroha, A. Thomas Look, Jan M. van Deursen, Hu Li, Jennifer J. Westendorf, John M. Maris, Shizhen Zhu
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2995–3007.
https://doi.org/10.1158/0008-5472.CAN-20-1890
Published: 01 June 2021
View articletitled, GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma
Open the PDF for GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K. Holien, Hassina Massudi, Daniel R. Carter, Olivia C. Ciampa, Mika Herath, Taylor Lim, Janith A. Seneviratne, Giorgio Milazzo, Jayne E. Murray, Joshua A. McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W. Stevenson, Michael A. Gorman, Jessica L. Bell, Larissa Doughty, Stefan Hüttelmaier, Andre Oberthuer, Matthias Fischer, Andrew J. Gifford, Tao Liu, Xiaoling Zhang, Shizhen Zhu, W. Clay Gustafson, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Giovanni Perini, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5652–5667.
https://doi.org/10.1158/0008-5472.CAN-19-1112
Published: 01 November 2019
View articletitled, Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface
Open the PDF for Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface in another window
Includes: Supplementary data
Journal Articles

Abstract IA19: MYC activation through enhancer hijacking or focal enhancer amplification drives a subset of high-risk pediatric neuroblastoma

Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang, Nina Weichert-Leahey, Richard A. Young, Jinghui Zhang, A. Thomas Look
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA19.
https://doi.org/10.1158/1538-7445.PEDCA17-IA19
Published: 01 October 2018
View articletitled, Abstract IA19: MYC activation through enhancer hijacking or focal enhancer amplification drives a subset of high-risk pediatric neuroblastoma
Journal Articles

Abstract 4135: c-MYC drives a subset of high-risk pediatric neuroblastoma and is activated through mechanisms including enhancer hijacking and focal enhancer amplification

Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Xu Beisi, Shizhen Zhu, Xiaoling Zhang, Zhaodong Li, Nina Weichert-Leahey, Richard A. Young, Jinghui Zhang, A. Thomas Look
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4135.
https://doi.org/10.1158/1538-7445.AM2018-4135
Published: 01 July 2018
View articletitled, Abstract 4135: c-MYC drives a subset of high-risk pediatric neuroblastoma and is activated through mechanisms including enhancer hijacking and focal enhancer amplification
Journal Articles

Abstract 1040: LIN28B-mediated let-7 independent activation of AKT promotes neuroblastoma pathogenesis

Ting Tao, John T. Powers, Hui Shi, Pavlos Missios, Antonio R. Perez-Atayde, Shizhen Zhu, George Q. Daley, Thomas A. Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1040.
https://doi.org/10.1158/1538-7445.AM2017-1040
Published: 01 July 2017
View articletitled, Abstract 1040: LIN28B-mediated let-7 independent activation of AKT promotes neuroblastoma pathogenesis
Journal Articles

Abstract 3871: Modeling the chromatin and transcriptional landscape of MYC and MYCN driven neuroblastoma in zebrafish

Mark W. Zimmerman, Shuning He, Shizhen Zhu, Song Yang, Yi Zhou, Leonard I. Zon, A Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3871.
https://doi.org/10.1158/1538-7445.AM2017-3871
Published: 01 July 2017
View articletitled, Abstract 3871: Modeling the chromatin and transcriptional landscape of MYC and MYCN driven neuroblastoma in zebrafish
Journal Articles

Abstract 2456: Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

Shuning He, Marc R. Mansour, Mark W. Zimmerman, Dong Hyuk Ki, Hillary M. Layden, Koshi Akahane, Eric D. de Groh, Antonio R. Perez-Atayde, Shizhen Zhu, Jonathan A. Epstein, A Thomas Look
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2456.
https://doi.org/10.1158/1538-7445.AM2016-2456
Published: 15 July 2016
View articletitled, Abstract 2456: Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain
Journal Articles

Abstract 2433: Loss of chd5-mediated gene repression synergizes with MYCN to accelerate neuroblastoma tumorigenesis in zebrafish

Mark W. Zimmerman, Shuning He, Jimann Shin, Shizhen Zhu, Feng Guo, Marc Mansour, Deepak Reyon, J Keith Joung, Jinhua Quan, Timur Yusufzai, A Thomas Look
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2016-2433
Published: 15 July 2016
View articletitled, Abstract 2433: Loss of chd5-mediated gene repression synergizes with MYCN to accelerate neuroblastoma tumorigenesis in zebrafish
Journal Articles

Abstract 476: Loss of chd5-mediated tumor suppression accelerates MYCN-driven neuroblastoma tumorigenesis in zebrafish

Mark W. Zimmerman, Shuning He, Jimann Shin, Shizhen Zhu, Marc Mansour, Keith Joung, Jinhua Quan, Timur Yusufzai, A. Thomas Look
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 476.
https://doi.org/10.1158/1538-7445.AM2015-476
Published: 01 August 2015
View articletitled, Abstract 476: Loss of chd5-mediated tumor suppression accelerates MYCN-driven neuroblastoma tumorigenesis in zebrafish
Journal Articles

Abstract B43: Role of activated SHP2 in high-risk neuroblastoma pathogenesis

(Jane) shizhen Zhu, Benjamin G. Neel, A. Thomas Look
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B43.
https://doi.org/10.1158/1538-7445.PEDCAN-B43
Published: 09 October 2014
View articletitled, Abstract B43: Role of activated SHP2 in high-risk neuroblastoma pathogenesis
Journal Articles

Abstract 356: Role of the LMO1 oncogene in neuroblastoma pathogenesis.

Shizhen Zhu, Andrew Wood, Shuning He, Rebecca Stanton, Feng Guo, John Maris, A. Thomas Look
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 356.
https://doi.org/10.1158/1538-7445.AM2013-356
Published: 15 April 2013
View articletitled, Abstract 356: Role of the LMO1 oncogene in neuroblastoma pathogenesis.
Journal Articles

Abstract 4252: Activated ALK collaborates with MYCN in neuroblastoma pathogenesis

Shizhen Zhu, Jeong-Soo Lee, Feng Guo, Jimann Shin, Antonio R. Perez-Atayde, Jeffery L. Kutok, Scott J. Rodig, Donna S. Neuberg, Daniel Helman, Hui Feng, Rodney A. Stewart, Wenchao Wang, Rani E. George, John Kanki, A Thomas Look
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4252.
https://doi.org/10.1158/1538-7445.AM2012-4252
Published: 15 April 2012
View articletitled, Abstract 4252: Activated ALK collaborates with MYCN in neuroblastoma pathogenesis
Journal Articles

Abstract 4296: Activated ALK accelerates the onset of neuroblastoma in MYCN-transgenic zebrafish

Shizhen Zhu, Jeong-Soo Lee, Jimann Shin, Antonio R. Perez-Atayde, Jeffery L. Kutok, Scott J. Rodig, Donna S. Neuberg, Feng Guo, Daniel Helman, Hui Feng, Rodney A. Stewart, Wenchao Wang, Rani E. George, John P. Kanki, A. Thomas Look
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4296.
https://doi.org/10.1158/1538-7445.AM2011-4296
Published: 15 April 2011
View articletitled, Abstract 4296: Activated ALK accelerates the onset of neuroblastoma in MYCN-transgenic zebrafish
Journal Articles

Abstract LB-162: The onset of MYCN overexpression-induced neuroblastoma is accelerated by ALK mutation in zebrafish

Jeong-Soo Lee, Shizhen Zhu, Jimann Shin, Antonio R. Perez-Atayde, Hui Feng, Feng Guo, Daniel Helman, Wenchao Wang, Rodney A. Stewart, Rani George, John Kanki, A. Thomas Look
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-162.
https://doi.org/10.1158/1538-7445.AM10-LB-162
Published: 15 April 2010
View articletitled, Abstract LB-162: The onset of MYCN overexpression-induced neuroblastoma is accelerated by ALK mutation in zebrafish