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Shiv Ram Krishn
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Journal Articles

BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth

Srinivas Reddy Boreddy, Reshmi Nair, Prashant Kumar Pandey, Anshu Kuriakose, Shivakumar Bhadravathi Marigowda, Chaitali Dey, Arindam Banerjee, Hanumant Kulkarni, Milind Sagar, Shiv Ram Krishn, Shruthi Rao, Madhukara AR, Vinita Tiwari, Bhavna Alke, Prashantha Kumar MV, Meena Shri, Chaitrali Dhamne, Sonal Patel, Pinky Sharma, Sankar Periyasamy, Jaya Bhatnagar, Moni Abraham Kuriakose, Ram Bhupal Reddy, Amritha Suresh, Suma Sreenivas, Nagaraja Govindappa, Praveen Reddy Moole, Usha Bughani, Seng-Lai Tan, Pradip Nair
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1883–1904.
https://doi.org/10.1158/0008-5472.CAN-21-4425
Published: 02 June 2023
View article titled, BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth
Open the PDF for BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Abstract 6677: Preliminary immune correlatives from BCA101 trial show favorable modulation of tumor immune microenvironment

Patrick H. Lizotte, Paul Paik, Liviu Niculescu, Seng-Lai H. Tan, David Bohr, Elham Gharakhani, Ralf Reiners, Rachel Salazar, Avanish Varshney, Shiv Ram Krishn, Pradip Nair, Cloud Paweletz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6677.
https://doi.org/10.1158/1538-7445.AM2023-6677
Published: 04 April 2023
View article titled, Abstract 6677: Preliminary immune correlatives from BCA101 trial show favorable modulation of tumor immune microenvironment
Journal Articles

Abstract 6339: BCA101, a novel tumor-targeted bifunctional fusion antibody simultaneously inhibiting EGFR and TGF-β signaling with potential for durable tumor growth inhibition

Srinivas Reddy Boreddy, Reshmi Nair, Prashant Kumar Pandey, Anshu Kuriakose, Arindam Banerjee, Chaitali Dey, Madhukara A R, Bhadravathi Marigowda Shivakumar, Hanumant Kulkarni, Milind Sagar, Prashantha Kumar M. V, Shiv Ram Krishn, Jaya Bhatnagar, Moni Abhram Kuriakose, Ram Bhupal Reddy, Amritha Suresh, Praveen Reddy Moole, Usha Bughani, Seng-Lai Tan, Pradip Nair, Rachel Salazar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6339.
https://doi.org/10.1158/1538-7445.AM2023-6339
Published: 04 April 2023
View article titled, Abstract 6339: BCA101, a novel tumor-targeted bifunctional fusion antibody simultaneously inhibiting EGFR and TGF-β signaling with potential for durable tumor growth inhibition
Journal Articles

Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

Koelina Ganguly, Shiv Ram Krishn, Satyanarayana Rachagani, Rahat Jahan, Ashu Shah, Palanisamy Nallasamy, Sanchita Rauth, Pranita Atri, Jesse L. Cox, Ramesh Pothuraju, Lynette M. Smith, Sudhua Ayala, Christopher Evans, Moorthy P. Ponnusamy, Sushil Kumar, Sukhwinder Kaur, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2021) 81 (1): 91–102.
https://doi.org/10.1158/0008-5472.CAN-20-1293
Published: 04 January 2021
View article titled, Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness
Open the PDF for Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 65: Gel-forming mucin MUC5AC as the nexus for cell-adhesion molecules governing pancreatic cancer aggressiveness and chemoresistance

Koelina Ganguly, Shiv Ram Krishn, Rahat Jahan, Pranita Atri, Satyanarayana Rachagani, Sanchita Rauth, Huang Xi, Yongfeng Lu, Surinder Batra, Sukhwinder Kaur
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 65.
https://doi.org/10.1158/1538-7445.AM2019-65
Published: 01 July 2019
View article titled, Abstract 65: Gel-forming mucin MUC5AC as the nexus for cell-adhesion molecules governing pancreatic cancer aggressiveness and chemoresistance