1-20 of 20
Shiro Akinaga
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract CT251: Immunological and histopathological tumor responses to a novel neoadjuvant peptide vaccine targeting HSP70 and GPC3 antigens in patients with resectable HCC

Masao Nakajima, Shoichi Hazama, Koji Tamada, Keiko Udaka, Shun Doi, Michiie Sakamoto, Akira Saito, Shiro Akinaga, Hiroto Matsui, Yoshitaro Shindo, Satoshi Matsukuma, Yukio Tokumitsu, Shinobu Tomochika, Michihisa Iida, Shin Yoshida, Ryouichi Tsunedomi, Yuki Nakagami, Nobuaki Suzuki, Shigeru Takeda, Hiroaki Nagano
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT251.
https://doi.org/10.1158/1538-7445.AM2020-CT251
Published: 15 August 2020
View article titled, Abstract CT251: Immunological and histopathological tumor responses to a novel neoadjuvant peptide vaccine targeting HSP70 and GPC3 antigens in patients with resectable HCC
Journal Articles

Abstract 3959: PRDM14 silencing by siRNA combined with an innovative nanoparticle reduced breast tumor formation and metastasis in vivo

Hiroaki Taniguchi, Chiharu Moriya, Shiro Akinaga, Kozo Imai, Kazunori Kataoka
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3959.
https://doi.org/10.1158/1538-7445.AM2018-3959
Published: 01 July 2018
View article titled, Abstract 3959: PRDM14 silencing by siRNA combined with an innovative nanoparticle reduced breast tumor formation and metastasis in vivo
Journal Articles

Abstract 920: KW-2450, a novel IGF-1R/IR inhibitor, enhances the antitumor effect of lapatinib, letrozole or 4-hydroxy-tamoxifen in breast cancer cells.

Hiroshi Umehara, Fumito Koizumi, Yoshimi Maekawa, Makiko Shimizu, Hiroaki Nakamura, Toshio Ota, Shinji Nara, Takeshi Takahashi, Yutaka Kanda, Norihiko Shiraishi, Shiro Akinaga, Yukimasa Shiotsu, Shiro Soga
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 920.
https://doi.org/10.1158/1538-7445.AM2013-920
Published: 15 April 2013
View article titled, Abstract 920: KW-2450, a novel IGF-1R/IR inhibitor, enhances the antitumor effect of lapatinib, letrozole or 4-hydroxy-tamoxifen in breast cancer cells.
Journal Articles

Abstract 3605: KW-2450, a novel orally-active dual IGF1R/IR inhibitor: Antitumor effects in vitro and in vivo

Yoshimi Maekawa, Fumito Koizumi, Naomi Kashima, Masayo Suzuki, Hiroshi Umehara, Hiroko Takahashi, Hiroaki Nakamura, Shinji Nara, Tomoyuki Nakazato, Yutaka Kanda, Takeshi Takahashi, Shiro Akinaga, Yukimasa Shiotsu, Shiro Soga
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3605.
https://doi.org/10.1158/1538-7445.AM2011-3605
Published: 15 April 2011
View article titled, Abstract 3605: KW-2450, a novel orally-active dual IGF1R/IR inhibitor: Antitumor effects in vitro and in vivo
Journal Articles

Abstract 1639: The novel c-MET inhibitor, ARQ 197, shows additive growrh-inhibitory effect with erlotinib through enhanced degradation of c-MET protein via ubiquitin/proteasome pathway

Tomoko Kanome, Tsuyoki Kadofuku, Toshimitsu Yamaoka, Takashi Hirose, Shiro Akinaga, Mitsuru Adachi, Nagahiro Saijo, Tohru Ohmori
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1639.
https://doi.org/10.1158/1538-7445.AM10-1639
Published: 15 April 2010
View article titled, Abstract 1639: The novel c-MET inhibitor, ARQ 197, shows additive growrh-inhibitory effect with erlotinib through enhanced degradation of c-MET protein via ubiquitin/proteasome pathway
Journal Articles

Abstract 2636: Preclinical evaluation of the Hsp90 inhibitor KW-2478 in combination with bortezomib as a treatment for multiple myeloma

Toshihiko Ishii, Takayuki Nakashima, Toshihiro Seike, Aiko Shudo, Shiro Akinaga, Shiro Soga, Yukimasa Shiotsu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2636.
https://doi.org/10.1158/1538-7445.AM10-2636
Published: 15 April 2010
View article titled, Abstract 2636: Preclinical evaluation of the Hsp90 inhibitor KW-2478 in combination with bortezomib as a treatment for multiple myeloma
Journal Articles

Abstract #4686: The molecular and biological effects of KW\#8722;2478, a novel non-ansamycin Hsp90 inhibitor, on multiple myeloma cells having various IgH translocations

Takayuki Nakashima, Toshihiko Ishii, Shiro Soga, Hisashi Tagaya, Tadakazu Akiyama, Hiroshi Nakagawa, Shiro Akinaga, Yutaka Kanda, Yukimasa Shiotsu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4686.
Published: 01 May 2009
View article titled, Abstract #4686: The molecular and biological effects of KW\#8722;2478, a novel non-ansamycin Hsp90 inhibitor, on multiple myeloma cells having various IgH translocations
Journal Articles

K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

Ryuichiro Nakai, Shin-ichi Iida, Takeshi Takahashi, Tetsuya Tsujita, Seiho Okamoto, Chie Takada, Kazuhito Akasaka, Shunji Ichikawa, Hiroyuki Ishida, Hideaki Kusaka, Shiro Akinaga, Chikara Murakata, Shinobu Honda, Masayuki Nitta, Hideyuki Saya, Yoshinori Yamashita
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3901–3909.
https://doi.org/10.1158/0008-5472.CAN-08-4373
Published: 30 April 2009
View article titled, K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells
Open the PDF for K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells in another window
Includes: Multimedia, Supplementary data
Journal Articles

Discovery and optimization of novel, orally active and selective Flt3 kinase inhibitors

Hiroshi Ishida, Shoichi Isami, Tsutomu Matsumura, Jiro Kajita, Eiichi Fuse, Koji Umehara, Yoshinori Yamashita, Yukumasa Shiotsu, Shiro Akinaga, Hitoshi Kiyoi, Tomoki Naoe, Hitoshi Arai
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1294.
Published: 01 May 2008
View article titled, Discovery and optimization of novel, orally active and selective Flt3 kinase inhibitors
Journal Articles

New insight of the cell cycle action leading to antitumor activity for Eg5 inhibitor

Shin-Ichi Iida, Shinobu Honda, Masayuki Nitta, Ryuichiro Nakai, Takeshi Takahashi, Tetsuya Tsujita, Seiho Okamoto, Chie Takada, Kazuto Akasaka, Hiroyuki Ishida, Hideaki Kusaka, Shiro Akinaga, Yoshinori Yamashita, Hideyuki Saya
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 397–398.
Published: 01 May 2005
View article titled, New insight of the cell cycle action leading to antitumor activity for Eg5 inhibitor
Journal Articles

Discovery and characterization of new antitumor agents targeting mitotic kinesin Eg5

Ryuichiro Nakai, Takeshi Takahashi, Tetsuya Tsujita, Seiho Okamoto, Chie Takada, Kazuto Akasaka, Hiroyuki Ishida, Shin-Ichi Iida, Shinobu Honda, Masayuki Nitta, Hideyuki Saya, Hideaki Kusaka, Shiro Akinaga, Chikara Murakata, Yoshinori Yamashita
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1391.
Published: 01 May 2005
View article titled, Discovery and characterization of new antitumor agents targeting mitotic kinesin Eg5
Journal Articles

Defucosylated chimeric anti-CCR4 IGG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T cell leukemia and lymphoma.

Kenya Shitara, Rinpei Niwa, Kazuyasu Nakamura, Shiro Akinaga, Nobuo Hanai, Kouji Matsushima, Ryuzo Ueda
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 572.
Published: 01 April 2004
View article titled, Defucosylated chimeric anti-CCR4 IGG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T cell leukemia and lymphoma.
Journal Articles

A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent

Akira Asai, Yuko Oshima, Yoshihiro Yamamoto, Taka-aki Uochi, Hideaki Kusaka, Shiro Akinaga, Yoshinori Yamashita, Krisztina Pongracz, Ronald Pruzan, Ellen Wunder, Mieczyslaw Piatyszek, Shihong Li, Allison C. Chin, Calvin B. Harley, Sergei Gryaznov
Journal: Cancer Research
Cancer Res (2003) 63 (14): 3931–3939.
Published: 21 July 2003
View article titled, A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent
Open the PDF for A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent in another window
Journal Articles

Estrogen Sulfotransferase and Steroid Sulfatase in Human Breast Carcinoma

Takashi Suzuki, Taisuke Nakata, Yasuhiro Miki, Chika Kaneko, Takuya Moriya, Takanori Ishida, Shiro Akinaga, Hisashi Hirakawa, Michio Kimura, Hironobu Sasano
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2762–2770.
Published: 01 June 2003
View article titled, Estrogen Sulfotransferase and Steroid Sulfatase in Human Breast Carcinoma
Open the PDF for Estrogen Sulfotransferase and Steroid Sulfatase in Human Breast Carcinoma in another window
Journal Articles

Decrease in Susceptibility Toward Induction of Apoptosis and Alteration in G1 Checkpoint Function as Determinants of Resistance of Human Lung Cancer Cells against the Antisignaling Drug UCN-01 (7-Hydroxystaurosporine)

Kazuyo Sugiyama, Tadakazu Akiyama, Makiko Shimizu, Tatsuya Tamaoki, Carol Courage, Andreas Gescher, Shiro Akinaga
Journal: Cancer Research
Cancer Res (1999) 59 (17): 4406–4412.
Published: 01 September 1999
View article titled, Decrease in Susceptibility Toward Induction of Apoptosis and Alteration in G<sub>1</sub> Checkpoint Function as Determinants of Resistance of Human Lung Cancer Cells against the Antisignaling Drug UCN-01 (7-Hydroxystaurosporine)
Open the PDF for Decrease in Susceptibility Toward Induction of Apoptosis and Alteration in G<sub>1</sub> Checkpoint Function as Determinants of Resistance of Human Lung Cancer Cells against the Antisignaling Drug UCN-01 (7-Hydroxystaurosporine) in another window
Journal Articles

KF25706, a Novel Oxime Derivative of Radicicol, Exhibits in Vivo Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules

Shiro Soga, Leonard M. Neckers, Theodor W. Schulte, Yukimasa Shiotsu, Kazuhito Akasaka, Hiroaki Narumi, Tsutomu Agatsuma, Yoji Ikuina, Chikara Murakata, Tatsuya Tamaoki, Shiro Akinaga
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2931–2938.
Published: 15 June 1999
View article titled, KF25706, a Novel Oxime Derivative of Radicicol, Exhibits <em>in Vivo</em> Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules
Open the PDF for KF25706, a Novel Oxime Derivative of Radicicol, Exhibits <em>in Vivo</em> Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules in another window
Journal Articles

Unpredicted Clinical Pharmacology of UCN-01 Caused by Specific Binding to Human α1-Acid Glycoprotein

Eiichi Fuse, Hiromi Tanii, Noriaki Kurata, Hiroyuki Kobayashi, Yasuhiro Shimada, Tomohide Tamura, Yasutsuna Sasaki, Yusuke Tanigawara, Richard D. Lush, Donna Headlee, William D. Figg, Susan G. Arbuck, Adrian M. Senderowicz, Edward A. Sausville, Shiro Akinaga, Takashi Kuwabara, Satoshi Kobayashi
Journal: Cancer Research
Cancer Res (1998) 58 (15): 3248–3253.
Published: 01 August 1998
View article titled, Unpredicted Clinical Pharmacology of UCN-01 Caused by Specific Binding to Human α<sub>1</sub>-Acid Glycoprotein
Open the PDF for Unpredicted Clinical Pharmacology of UCN-01 Caused by Specific Binding to Human α<sub>1</sub>-Acid Glycoprotein in another window
Journal Articles

G1 Phase Accumulation Induced by UCN-01 Is Associated with Dephosphorylation of Rb and CDK2 Proteins as well as Induction of CDK Inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated Human Epidermoid Carcinoma A431 Cells

Tadakazu Akiyama, Tetsuo Yoshida, Tetsuya Tsujita, Makiko Shimizu, Tamio Mizukami, Masami Okabe, Shiro Akinaga
Journal: Cancer Research
Cancer Res (1997) 57 (8): 1495–1501.
Published: 01 April 1997
View article titled, G<sub>1</sub> Phase Accumulation Induced by UCN-01 Is Associated with Dephosphorylation of Rb and CDK2 Proteins as well as Induction of CDK Inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated Human Epidermoid Carcinoma A431 Cells
Open the PDF for G<sub>1</sub> Phase Accumulation Induced by UCN-01 Is Associated with Dephosphorylation of Rb and CDK2 Proteins as well as Induction of CDK Inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated Human Epidermoid Carcinoma A431 Cells in another window
Journal Articles

Antitumor Activity of UCN-01, a Selective Inhibitor of Protein Kinase C, in Murine and Human Tumor Models

Shiro Akinaga, Katsushige Gomi, Makoto Morimoto, Tatsuya Tamaoki, Masami Okabe
Journal: Cancer Research
Cancer Res (1991) 51 (18): 4888–4892.
Published: 01 September 1991
View article titled, Antitumor Activity of UCN-01, a Selective Inhibitor of Protein Kinase C, in Murine and Human Tumor Models
Open the PDF for Antitumor Activity of UCN-01, a Selective Inhibitor of Protein Kinase C, in Murine and Human Tumor Models in another window
Journal Articles

Analysis of Receptors, Cell Surface Antigens, and Proteins in Human Melanoma Cell Lines Resistant to Human Recombinant β- or γ-Interferon

Katsushige Gomi, Shiro Akinaga, Tetsuo Oka, Makoto Morimoto
Journal: Cancer Research
Cancer Res (1986) 46 (12_Part_1): 6211–6216.
Published: 01 December 1986
View article titled, Analysis of Receptors, Cell Surface Antigens, and Proteins in Human Melanoma Cell Lines Resistant to Human Recombinant β- or γ-Interferon
Open the PDF for Analysis of Receptors, Cell Surface Antigens, and Proteins in Human Melanoma Cell Lines Resistant to Human Recombinant β- or γ-Interferon in another window