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Shinichi Kitada
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Journal Articles

Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

Jun Wei, William J. Placzek, John L. Stebbins, John C. Reed, Maurizio Pellecchia, Paul B. Fisher, Rupesh Dash, Catriona Jamieson, Shinichi Kitada
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5.
https://doi.org/10.1158/1538-7445.AM2011-5
Published: 15 April 2011
View articletitled, Abstract 5: Synthesis and biological evaluation of 5, 5’ substituted apogossypol and apogossypolone derivatives as pan-active inhibitors of anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
Journal Articles

Abstract #5364: Chemical biology strategy reveals pathway-selective inhibitor of NF-\#954;B activation induced by protein kinase C and antigen receptors

Ranxin Shi, Daniel Re, Eric Dudl, Michael Cuddy, Karl Okolotowicz, Russell Dahl, Ying Su, Andrew Hurder, Shinichi Kitada, Mahesh Peddibhotla, Greg Roth, Layton Smith, Thomas Kipps, Nicholas Cosford, John Cashman, John Reed
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5364.
Published: 01 May 2009
View articletitled, Abstract #5364: Chemical biology strategy reveals pathway-selective inhibitor of NF-\#954;B activation induced by protein kinase C and antigen receptors
Journal Articles

Structure- and NMR-based design of novel Bcl-xL antagonists.

Michele Rega, Jun Wei, Hongbin Yuan, Shinichi Kitada, John Reed, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1278.
Published: 01 May 2008
View articletitled, Structure- and NMR-based design of novel Bcl-xL antagonists.
Journal Articles

Gambogic acid is an antagonist of anti-apoptotic Bcl-2-family proteins.

Dayong Zhai, Chaofang Jin, Chungwai Shiau, Shinichi Kitada, Arnold Satterthwait, John Reed
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4394.
Published: 01 May 2008
View articletitled, Gambogic acid is an antagonist of anti-apoptotic Bcl-2-family proteins.
Journal Articles

In vitro and in vivo efficacy and toxicity comparison between ApoGossypol and Gossypol, Bcl-2 antagonists

Shinichi Kitada, Jun Wei, Christina Kress, Dayong Zhai, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, John Reed
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4387.
Published: 01 May 2008
View articletitled, In vitro and in vivo efficacy and toxicity comparison between ApoGossypol and Gossypol, Bcl-2 antagonists
Journal Articles

Design, synthesis and evaluation of novel Apogossypol derivatives targeting anti-apoptotic Bcl-2 family proteins

Jun Wei, Michele Rega, Shinichi kitada, Hongbin Yuan, John Reed, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2772.
Published: 01 May 2008
View articletitled, Design, synthesis and evaluation of novel Apogossypol derivatives targeting anti-apoptotic Bcl-2 family proteins
Journal Articles

Small-molecule antagonists of apoptosis-suppressor XIAP exhibit broad anti-tumor activity

Aaron D. Schimmer, Kate Welsh, Clemencia Pinilla, Zhiliang Wang, Marie-Josee Bonneau, Irene M. Pedersen, Shinichi Kitada, Fiona L. Scott, Gennadi Glinsky, Dominick Scudiero, Edward Sausville, Guy Salvesen, Adel Nefzi, John M. Ostresh, Richard A. Houghten, John C. Reed
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1286.
Published: 01 April 2004
View articletitled, Small-molecule antagonists of apoptosis-suppressor XIAP exhibit broad anti-tumor activity
Journal Articles

Radiation reverses resistance to mda-7/IL-24 in prostate cancer cells over-expressing the anti-apoptotic proteins Bcl-2 or Bcl-xL

Zhao-Zhong Su, Irina V. Lebedeva, Devanand Sarkar, Shinichi Kitada, Paul Dent, John C. Reed, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1287.
Published: 01 April 2004
View articletitled, Radiation reverses resistance to mda-7/IL-24 in prostate cancer cells over-expressing the anti-apoptotic proteins Bcl-2 or Bcl-xL
Journal Articles

Melanoma Differentiation Associated Gene-7, mda- 7/Interleukin-24, Induces Apoptosis in Prostate Cancer Cells by Promoting Mitochondrial Dysfunction and Inducing Reactive Oxygen Species

Irina V. Lebedeva, Zao-Zhong Su, Devanand Sarkar, Shinichi Kitada, Paul Dent, Samuel Waxman, John C. Reed, Paul B. Fisher
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8138–8144.
Published: 16 December 2003
View articletitled, Melanoma Differentiation Associated Gene-7, mda- 7/Interleukin-24, Induces Apoptosis in Prostate Cancer Cells by Promoting Mitochondrial Dysfunction and Inducing Reactive Oxygen Species
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Journal Articles

Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins

Marilisa Leone, Dayong Zhai, Sina Sareth, Shinichi Kitada, John C. Reed, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8118–8121.
Published: 16 December 2003
View articletitled, Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins
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Journal Articles

Functional Blocks in Caspase Activation Pathways Are Common in Leukemia and Predict Patient Response to Induction Chemotherapy

Aaron D. Schimmer, Irene Munk Pedersen, Shinichi Kitada, Emel Eksioglu-Demiralp, Mark D. Minden, Ryan Pinto, Ken Mah, Michael Andreeff, Youngsoo Kim, Won Suk Suh, John C. Reed
Journal: Cancer Research
Cancer Res (2003) 63 (6): 1242–1248.
Published: 15 March 2003
View articletitled, Functional Blocks in Caspase Activation Pathways Are Common in Leukemia and Predict Patient Response to Induction Chemotherapy
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Journal Articles

An Informatics Approach Identifying Markers of Chemosensitivity in Human Cancer Cell Lines

Sally A. Amundson, Timothy G. Myers, Dominic Scudiero, Shinichi Kitada, John C. Reed, Albert J. Fornace, Jr.
Journal: Cancer Research
Cancer Res (2000) 60 (21): 6101–6110.
Published: 01 November 2000
View articletitled, An Informatics Approach Identifying Markers of Chemosensitivity in Human Cancer Cell Lines
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Journal Articles

ATM Mutations in B-Cell Chronic Lymphocytic Leukemia

Florencia Bullrich, Debora Rasio, Shinichi Kitada, Petr Starostik, Thomas Kipps, Michael Keating, Maher Albitar, John C. Reed, Carlo M. Croce
Journal: Cancer Research
Cancer Res (1999) 59 (1): 24–27.
Published: 01 January 1999
View articletitled, ATM Mutations in B-Cell Chronic Lymphocytic Leukemia
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Journal Articles

Expression and Location of Hsp70/Hsc-Binding Anti-Apoptotic Protein BAG-1 and Its Variants in Normal Tissues and Tumor Cell Lines

Shinichi Takayama, Stanislaw Krajewski, Maryla Krajewska, Shinichi Kitada, Juan M. Zapata, Kristine Kochel, Deborah Knee, Dominic Scudiero, Gabriella Tudor, Gary J. Miller, Toshiyuki Miyashita, Masao Yamada, John C. Reed
Journal: Cancer Research
Cancer Res (1998) 58 (14): 3116–3131.
Published: 01 July 1998
View articletitled, Expression and Location of Hsp70/Hsc-Binding Anti-Apoptotic Protein BAG-1 and Its Variants in Normal Tissues and Tumor Cell Lines
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Journal Articles

Transferrin-like Activity Produced by Murine Malignant T-Lymphoma Cell Lines

Shinichi Kitada, Esther F. Hays
Journal: Cancer Research
Cancer Res (1985) 45 (8): 3537–3540.
Published: 01 August 1985
View articletitled, Transferrin-like Activity Produced by Murine Malignant T-Lymphoma Cell Lines
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