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Journal Articles

Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer

Mustafa Emre Gedik, Ozge Saatci, Nathaniel Oberholtzer, Meral Uner, Ozge Akbulut Caliskan, Metin Cetin, Mertkaya Aras, Kubra Ibis, Burcu Caliskan, Erden Banoglu, Stefan Wiemann, Ayşegül Üner, Sercan Aksoy, Shikhar Mehrotra, Ozgur Sahin

Cancer Res (2024) 84 (9): 1475–1490.

https://doi.org/10.1158/0008-5472.CAN-23-2812

Published: 02 May 2024

View article titled, Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer

Includes: Supplementary data

Journal Articles

Abstract LB275: Reactivation of mitotic arrest upon targeting TACC3 restores immunogenic cell death and T-DM1 response in HER2-positive breast cancer

Ozge Saatci, Mustafa Emre Gedik, Nathaniel Oberholtzer, Meral Uner, Ozge Akbulut, Metin Cetin, Mertkaya Aras, Kubra Ibis, Burcu Caliskan, Erden Banoglu, Stefan Wiemann, Aysegul Uner, Sercan Aksoy, Shikhar Mehrotra, Ozgur Sahin

Cancer Res (2024) 84 (7_Supplement): LB275.

https://doi.org/10.1158/1538-7445.AM2024-LB275

Published: 05 April 2024

View article titled, Abstract LB275: Reactivation of mitotic arrest upon targeting TACC3 restores immunogenic cell death and T-DM1 response in HER2-positive breast cancer

Journal Articles

Abstract LB343: Golgi^hi T cells exhibit reduced susceptibility to exhaustion and improved tumor control

Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Zacharia Hedley, Gina Scurti, Monika Gooz, Lauren E. Ball, Elizabeth Hill, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra

Cancer Res (2024) 84 (7_Supplement): LB343.

https://doi.org/10.1158/1538-7445.AM2024-LB343

Published: 05 April 2024

View article titled, Abstract LB343: Golgihi T cells exhibit reduced susceptibility to exhaustion and improved tumor control

Journal Articles

Abstract 1570: Lipid metabolism alterations promote TNBC metastasis and immunotherapy resistance via PD-L1 internalization and signaling

Wyatt O. Wofford, Jisun Kim, Dosung Kim, Alhaji H. Janneh, Han Gyul Lee, F. Cansu Atilgan, Natalia Oleinik, Elizabeth Hill, Ozge Saatci, Salih Gencer, Paramita Chakraborty, Shikhar Mehrotra, Ozgur Sahin, Besim Ogretmen

Cancer Res (2024) 84 (6_Supplement): 1570.

https://doi.org/10.1158/1538-7445.AM2024-1570

Published: 22 March 2024

View article titled, Abstract 1570: Lipid metabolism alterations promote TNBC metastasis and immunotherapy resistance via PD-L1 internalization and signaling

Journal Articles

Abstract 3969: Alzheimer's disease-associated amyloid precursor protein improves anti-tumor immunity by inhibiting ceramide-mediated lethal mitophagy and restoring mitochondrial fumarate metabolism in aging T-cells

Mohamed Faisal Kassir, Han G. Lee, Natalia Oleinik, Wyatt Wofford, Chase Walton, F. Cansu Atilgan, Paramita Chakraborty, Kubra Calisir, Ozgur Sahin, Shikhar Mehrotra, Besim Ogretmen

Cancer Res (2024) 84 (6_Supplement): 3969.

https://doi.org/10.1158/1538-7445.AM2024-3969

Published: 22 March 2024

View article titled, Abstract 3969: Alzheimer's disease-associated amyloid precursor protein improves anti-tumor immunity by inhibiting ceramide-mediated lethal mitophagy and restoring mitochondrial fumarate metabolism in aging T-cells

Journal Articles

Fatty Acids Invigorate Tumor-Resident Memory T Cells

Paramita Chakraborty, Stephanie Mills, Shikhar Mehrotra

Cancer Res (2023) 83 (20): 3321–3323.

https://doi.org/10.1158/0008-5472.CAN-23-2178

Published: 13 October 2023

View article titled, Fatty Acids Invigorate Tumor-Resident Memory T Cells

Journal Articles

Abstract 2867: Ceramide-dependent mitophagy leads to metabolic reprogramming in aging T-cells associated with reduced anti-tumor T-cell functions

Mohamed Faisal Kassir, Han Gyul Lee, Natalia Oleinik, Paramita Chakraborty, John J. Lemasters, Zdzislaw Szulc, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen

Cancer Res (2023) 83 (7_Supplement): 2867.

https://doi.org/10.1158/1538-7445.AM2023-2867

Published: 04 April 2023

View article titled, Abstract 2867: Ceramide-dependent mitophagy leads to metabolic reprogramming in aging T-cells associated with reduced anti-tumor T-cell functions

Journal Articles

Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8⁺ T Cells

Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee

Cancer Res (2022) 82 (14): 2640–2655.

https://doi.org/10.1158/0008-5472.CAN-21-4052

Published: 18 July 2022

View article titled, Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells

Includes: Supplementary data

Journal Articles

Abstract LB014: Carbon monoxide induced PERK regulated autophagy reprograms anti-tumor T cells with robust immunometabolic phenotype

Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Meenal Mehrotra, Eduardo N. Maldonado, Hongjun Wang, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra

Cancer Res (2022) 82 (12_Supplement): LB014.

https://doi.org/10.1158/1538-7445.AM2022-LB014

Published: 15 June 2022

View article titled, Abstract LB014: Carbon monoxide induced PERK regulated autophagy reprograms anti-tumor T cells with robust immunometabolic phenotype

Journal Articles

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Cancer Res (2022) 82 (10): 1969–1990.

https://doi.org/10.1158/0008-5472.CAN-21-3155

Published: 16 May 2022

View article titled, Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Includes: Supplementary data

Journal Articles

Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8⁺ T Cells

C. Bryce Johnson, Bennett R. May, Brian P. Riesenberg, Samantha Suriano, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Mohamed L. Salem, Emily K. Jeng, Hing C. Wong, Chrystal M. Paulos, John M. Wrangle, David J. Cole, Mark P. Rubinstein

Cancer Res (2018) 78 (11): 3067–3074.

https://doi.org/10.1158/0008-5472.CAN-17-2153

Published: 31 May 2018

View article titled, Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8+ T Cells

Includes: Supplementary data

Journal Articles

Abstract 5820: Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset

Sathish Kumar Reddy Padi, Libia Luevano, Neha Singh, Jiin Song, Ritu Pandey, Jon C. Aster, Xue-Zhong Yu, Shikhar Mehrotra, Andrew Kraft

Cancer Res (2017) 77 (13_Supplement): 5820.

https://doi.org/10.1158/1538-7445.AM2017-5820

Published: 01 July 2017

View article titled, Abstract 5820: Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset

Journal Articles

Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma

Jared Klarquist, Kristen Tobin, Peyman Farhangi Oskuei, Steven W. Henning, Manuel F. Fernandez, Emilia R. Dellacecca, Flor C. Navarro, Jonathan M. Eby, Shilpak Chatterjee, Shikhar Mehrotra, Joseph I. Clark, I. Caroline Le Poole

Cancer Res (2016) 76 (21): 6230–6240.

https://doi.org/10.1158/0008-5472.CAN-16-0618

Published: 31 October 2016

View article titled, Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma

Journal Articles

Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death

Matthew J. Scheffel, Gina Scurti, Patricia Simms, Elizabeth Garrett-Mayer, Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson

Cancer Res (2016) 76 (20): 6006–6016.

https://doi.org/10.1158/0008-5472.CAN-16-0587

Published: 13 October 2016

View article titled, Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death

Includes: Supplementary data

Journal Articles

Lack of p53 Augments Antitumor Functions in Cytolytic T Cells

Cancer Res (2016) 76 (18): 5229–5240.

https://doi.org/10.1158/0008-5472.CAN-15-1798

Published: 15 September 2016

View article titled, Lack of p53 Augments Antitumor Functions in Cytolytic T Cells

Includes: Supplementary data

Journal Articles

Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions

Pravin Kesarwani, Amir A. Al-Khami, Gina Scurti, Krishnamurthy Thyagarajan, Navtej Kaur, Shahid Husain, Quan Fang, Osama S. Naga, Patricia Simms, Gyda Beeson, Christina Voelkel-Johnson, Elizabeth Garrett-Mayer, Craig C. Beeson, Michael I. Nishimura, Shikhar Mehrotra

Cancer Res (2014) 74 (21): 6036–6047.

https://doi.org/10.1158/0008-5472.CAN-14-1084

Published: 30 October 2014

View article titled, Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions

Includes: Supplementary data

Journal Articles

Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

Shilpak Chatterjee, Krishnamurthy Thyagarajan, Pravin Kesarwani, Jin H. Song, Myroslawa Soloshchenko, Jianing Fu, Stefanie R. Bailey, Chenthamarkshan Vasu, Andrew S. Kraft, Chrystal M. Paulos, Xue-Zhong Yu, Shikhar Mehrotra

Cancer Res (2014) 74 (21): 6048–6059.

https://doi.org/10.1158/0008-5472.CAN-14-1450

Published: 30 October 2014

View article titled, Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

Includes: Supplementary data

Journal Articles

Inhibition of Superoxide Generation upon T-Cell Receptor Engagement Rescues Mart-1_27-35–Reactive T Cells from Activation-Induced Cell Death

Håkan Norell, Telma Martins da Palma, Aaron Lesher, Navtej Kaur, Meenal Mehrotra, Osama S. Naga, Natalie Spivey, Seye Olafimihan, Nitya G. Chakraborty, Christina Voelkel-Johnson, Michael I. Nishimura, Bijay Mukherji, Shikhar Mehrotra

Cancer Res (2009) 69 (15): 6282–6289.

https://doi.org/10.1158/0008-5472.CAN-09-1176

Published: 29 July 2009

View article titled, Inhibition of Superoxide Generation upon T-Cell Receptor Engagement Rescues Mart-127-35–Reactive T Cells from Activation-Induced Cell Death

Journal Articles

Abstract #3220: Development of a transgenic mouse with high affinity TCR reactive to human tyrosinase epitope

Shikhar Mehrotra, Mingli Li, Gretchen Lyons, Natalie Spivey, Telma Palma, Osama Naga, Haakan Norell, Claudia Diaz, David Cole, Michael Nishimura

Cancer Res (2009) 69 (9_Supplement): 3220.

Published: 01 May 2009

View article titled, Abstract #3220: Development of a transgenic mouse with high affinity TCR reactive to human tyrosinase epitope

Journal Articles

MART-1 specific T lypmhocytes exhibiting effector memory phenotype are preferentially sensitive to activation induced cell death

Shikhar Mehrotra, Haakan Norell, Nitya Chakraborty, Michael Nishimura, Bijay Mukherji

Cancer Res (2007) 67 (9_Supplement): 5115.

Published: 01 May 2007

View article titled, MART-1 specific T lypmhocytes exhibiting effector memory phenotype are preferentially sensitive to activation induced cell death

NARROW

Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer

Abstract LB275: Reactivation of mitotic arrest upon targeting TACC3 restores immunogenic cell death and T-DM1 response in HER2-positive breast cancer

Abstract LB343: Golgi^hi T cells exhibit reduced susceptibility to exhaustion and improved tumor control

Abstract 1570: Lipid metabolism alterations promote TNBC metastasis and immunotherapy resistance via PD-L1 internalization and signaling

Abstract 3969: Alzheimer's disease-associated amyloid precursor protein improves anti-tumor immunity by inhibiting ceramide-mediated lethal mitophagy and restoring mitochondrial fumarate metabolism in aging T-cells

Fatty Acids Invigorate Tumor-Resident Memory T Cells

Abstract 2867: Ceramide-dependent mitophagy leads to metabolic reprogramming in aging T-cells associated with reduced anti-tumor T-cell functions

Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8⁺ T Cells

Abstract LB014: Carbon monoxide induced PERK regulated autophagy reprograms anti-tumor T cells with robust immunometabolic phenotype

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8⁺ T Cells

Abstract 5820: Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset

Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma

Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death

Lack of p53 Augments Antitumor Functions in Cytolytic T Cells

Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions

Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

Inhibition of Superoxide Generation upon T-Cell Receptor Engagement Rescues Mart-1_27-35–Reactive T Cells from Activation-Induced Cell Death

Abstract #3220: Development of a transgenic mouse with high affinity TCR reactive to human tyrosinase epitope

MART-1 specific T lypmhocytes exhibiting effector memory phenotype are preferentially sensitive to activation induced cell death

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