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Shigeo Yagi
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Journal Articles

Abstract 1516: HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers

Takuya Murata, Takayuki Enomoto, Yutaka Ueda, Kiyoshi Yoshino, Shigeo Yagi, Robert M. Hoffman, Hiroto Mizushima, Tadashi Kimura, Eisuke Mekada
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1516.
https://doi.org/10.1158/1538-7445.AM2012-1516
Published: 15 April 2012
View articletitled, Abstract 1516: HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers
Journal Articles

HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers

Takuya Murata, Hiroto Mizushima, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M. Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
Journal: Cancer Research
Cancer Res (2011) 71 (21): 6633–6642.
https://doi.org/10.1158/0008-5472.CAN-11-0034
Published: 30 October 2011
View articletitled, HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers
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Includes: Supplementary data
Journal Articles

Efficacy of dietary antioxidants combined with a chemotherapeutic agents on human colon cancer in a fluorescent orthotopic mouse model

Huaiyu Ma, Tapas Das, Suzette Pereira, Xiao-Ming Li, Zhijian Yang, Shigeo Yagi, Pradip Mukerji, Robert Hoffman
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 623.
Published: 01 May 2007
View articletitled, Efficacy of dietary antioxidants combined with a chemotherapeutic agents on human colon cancer in a fluorescent orthotopic mouse model
Journal Articles

Quantitation of PEGylated methioninase protein in blood

Shukuan Li, Zhijian Yang, Huaiyu Ma, Ming Zhao, Xiao-ming Li, Yuying Tan, Shigeo Yagi, Robert Hoffman
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5569.
Published: 01 May 2007
View articletitled, Quantitation of PEGylated methioninase protein in blood
Journal Articles

The effect of PEGylation on the enzyme kinetics of recombinant methioninase

Shukuan Li, Zhijian Yang, Xinghua Sun, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 513.
Published: 15 April 2006
View articletitled, The effect of PEGylation on the enzyme kinetics of recombinant methioninase
Journal Articles

Marked efficacy of the novel camptothecin MEN4901/T-0128 in orthotopic and metastatic human tumor xenograft models

Takayuki Kawaguchi, Xiaoming Li, Mario Bigioni, Kohji Oda, Satoshi Okuno, Masatoshi Kakushima, Monica Binaschi, Fabio Animati, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 264.
Published: 15 April 2006
View articletitled, Marked efficacy of the novel camptothecin MEN4901/T-0128 in orthotopic and metastatic human tumor xenograft models
Journal Articles

An effective method to remove endotoxin from PEGylated recombinant methioninase

Shukuan Li, Xinghua Sun, Zhijian Yang, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 513.
Published: 15 April 2006
View articletitled, An effective method to remove endotoxin from PEGylated recombinant methioninase
Journal Articles

Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant l-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent

Tomoaki Takakura, Akio Takimoto, Yoshihide Notsu, Hiroshi Yoshida, Takaomi Ito, Hirofumi Nagatome, Masahiro Ohno, Yoshinao Kobayashi, Takayuki Yoshioka, Kenji Inagaki, Shigeo Yagi, Robert M. Hoffman, Nobuyoshi Esaki
Journal: Cancer Research
Cancer Res (2006) 66 (5): 2807–2814.
https://doi.org/10.1158/0008-5472.CAN-05-3910
Published: 01 March 2006
View articletitled, Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant l-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent
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Journal Articles

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuki Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 329.
Published: 01 May 2005
View articletitled, PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
Journal Articles

Sensitive assay of tumor S-adenosyl-methionine and S-adenosyl-homocysteine

Shukuan Li, Zhijian Yang, Xinghua Sun, Xiao-Ming Li, Mingxu Xu, Huaiyu Ma, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 556.
Published: 01 May 2005
View articletitled, Sensitive assay of tumor S-adenosyl-methionine and S-adenosyl-homocysteine
Journal Articles

PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuji Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6673–6678.
https://doi.org/10.1158/0008-5472.CAN-04-1822
Published: 16 September 2004
View articletitled, PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates
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Journal Articles

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5775–5778.
https://doi.org/10.1158/0008-5472.CAN-04-1406
Published: 16 August 2004
View articletitled, Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate
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Journal Articles

Oral 5-FU is more effective antimetastatic agent than UFT

Jin-Wei Wang, Meng Yang, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1069.
Published: 01 April 2004
View articletitled, Oral 5-FU is more effective antimetastatic agent than UFT
Journal Articles

Addition of primary amines to proteins increases the extent of polyethylene glycol (PEG) conjugation

Shukuan Li, Zhijian Yang, Xinghua Sun, Yuying Tan, Shigeo Yagi, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 234.
Published: 01 April 2004
View articletitled, Addition of primary amines to proteins increases the extent of polyethylene glycol (PEG) conjugation
Journal Articles

In vivo stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akinori Suginaka, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 234.
Published: 01 April 2004
View articletitled, In vivo stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate
Journal Articles

In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akio Takimoto, Kenji Mitsushima, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8377–8383.
Published: 16 December 2003
View articletitled, In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation
Open the PDF for In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation in another window
Journal Articles

Efficacy of Camptothecin Analog DX-8951f (Exatecan Mesylate) on Human Pancreatic Cancer in an Orthotopic Metastatic Model

Fang-Xian Sun, Akiko Tohgo, Michael Bouvet, Shigeo Yagi, Rounak Nassirpour, Abdoul R. Moossa, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2003) 63 (1): 80–85.
Published: 01 January 2003
View articletitled, Efficacy of Camptothecin Analog DX-8951f (Exatecan Mesylate) on Human Pancreatic Cancer in an Orthotopic Metastatic Model
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Journal Articles

Anticancer Efficacy in Vivo and in Vitro, Synergy with 5-Fluorouracil, and Safety of Recombinant Methioninase

Takayuki Yoshioka, Tohru Wada, Naomi Uchida, Hideo Maki, Hiroshi Yoshida, Nobuyuki Ide, Hisanori Kasai, Kanji Hojo, Kimiyo Shono, Ryuji Maekawa, Shigeo Yagi, Robert M. Hoffman, Kenji Sugita
Journal: Cancer Research
Cancer Res (1998) 58 (12): 2583–2587.
Published: 01 June 1998
View articletitled, Anticancer Efficacy in Vivo and in Vitro, Synergy with 5-Fluorouracil, and Safety of Recombinant Methioninase
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