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Journal Articles

Abstract 3515: Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP

Free
Alex Nisthal, Sung-Hyung Lee, Christine Bonzon, Ruschelle Love, Kendra N. Avery, Rumana Rashid, Panida Lertkiatmongkol, Nicole Rodriguez, Hanh Nguyen, Araz Eivazi, Sher Karki, Norm Barlow, Seung Y. Chu, Greg L. Moore, John R. Desjarlais
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3515.
https://doi.org/10.1158/1538-7445.AM2022-3515
Published: 15 June 2022
View articletitled, Abstract 3515: Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP
Journal Articles

Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody–Drug Conjugates

Available to Purchase
Hui Zhao, John Atkinson, Sara Gulesserian, Zhilan Zeng, Jenny Nater, Jimmy Ou, Peng Yang, Karen Morrison, Jeffrey Coleman, Faisal Malik, Pia Challita-Eid, Sher Karki, Hector Aviña, René Hubert, Linnette Capo, Josh Snyder, Sung-Ju Moon, Roland Luethy, Brian A. Mendelsohn, David R. Stover, Fernando Doñate
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2115–2126.
https://doi.org/10.1158/0008-5472.CAN-17-3202
Published: 12 April 2018
View articletitled, Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody–Drug Conjugates
Open the PDF for Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody–Drug Conjugates in another window
Includes: Supplementary data
Journal Articles

Abstract 2709: Evaluation of CD37 expression and binding of AGS67E, an antibody-drug conjugate (ADC) against CD37, on white blood cells (WBCs) collected from phase I non-Hodgkin lymphoma (NHL) patients

Free
Sher Karki, Hector Avina, Jacqueline Lackey, Ahmed Sawas, Kerry J. Savage, Raymond Perez, Ranjana Advani, Jasmine Zain, Owen A. O'Connor, Sara Gulesserian, Hui Zhao, Peng Yang, Karen Morrison, Leonard Reyno, Fernando Donate
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2709.
https://doi.org/10.1158/1538-7445.AM2017-2709
Published: 01 July 2017
View articletitled, Abstract 2709: Evaluation of CD37 expression and binding of AGS67E, an antibody-drug conjugate (ADC) against CD37, on white blood cells (WBCs) collected from phase I non-Hodgkin lymphoma (NHL) patients
Journal Articles

Abstract 574: AGS62P1, a novel site-specific antibody drug conjugate targeting FLT3 exhibits potent anti-tumor activity regardless of FLT3 kinase activation status

Free
Nandini Rudra-Ganguly, Pia M. Challita-Eid, Christine Lowe, Mike Mattie, Sung-Ju Moon, Brian A. Mendelsohn, Monica Leavitt, Cyrus Virata, Alla Verlinsky, Linnette Capo, Mi Sook Chang, Deanna L. Russell, Baljinder Randhawa, Gao Liu, René Hubert, Mary Brodey, Hector Aviña, Chunying Zhang, Joseph D. Abad, Banmeet Anand, Sher Karki, Zili An, Roland Luethy, Fernando Doñate, Daniel S. Pereira, Kendall Morrison, Ingrid B.J. Joseph, David R. Stover
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 574.
https://doi.org/10.1158/1538-7445.AM2016-574
Published: 15 July 2016
View articletitled, Abstract 574: AGS62P1, a novel site-specific antibody drug conjugate targeting FLT3 exhibits potent anti-tumor activity regardless of FLT3 kinase activation status
Journal Articles

Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models

Free
Pia M. Challita-Eid, Daulet Satpayev, Peng Yang, Zili An, Karen Morrison, Yuriy Shostak, Arthur Raitano, Rossana Nadell, Wendy Liu, Dawn Ratay Lortie, Linnette Capo, Alla Verlinsky, Monica Leavitt, Faisal Malik, Hector Aviña, Claudia I. Guevara, Nick Dinh, Sher Karki, Banmeet S. Anand, Daniel S. Pereira, Ingrid B.J. Joseph, Fernando Doñate, Kendall Morrison, David R. Stover
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (10): 3003–3013.
https://doi.org/10.1158/0008-5472.CAN-15-1313
Published: 12 May 2016
View articletitled, Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models
Open the PDF for Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models in another window
Includes: Supplementary data
Journal Articles

Abstract 2650: Ags67e, an anti-cd37 monomethyl auristatin e antibody (mmae) drug conjugate as a potential therapeutic for non-hodgkin's lymphoma, chronic lymphocytic leukemia and acute myeloid leukemia

Free
Daniel S. Pereira, Claudia Guevara, Alla Verlinsky, Cyrus Virata, J Hsu Ssucheng, Zili An, Chungying Zhang, Nick Dinh, Hector Avina, Lisa Do, Sher Karki, Joseph Abad, Peng Yang, Jimmy Ou, Karen Morrison, Sing-Ju Moon, Faisal Malik, Liqing Jin, Michael Choi, Christina Wu, Banmeet Anand, Scott Cooper, Ingrid Joseph, Xiao-Chi Jia, Kendall Morrison, Pia Challita-Eid, Fernando Donate, Thomas Kipps, John Dick, David Stover
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2650.
https://doi.org/10.1158/1538-7445.AM2014-2650
Published: 01 October 2014
View articletitled, Abstract 2650: Ags67e, an anti-cd37 monomethyl auristatin e antibody (mmae) drug conjugate as a potential therapeutic for non-hodgkin's lymphoma, chronic lymphocytic leukemia and acute myeloid leukemia
Journal Articles

Abstract #1249: Antitumor efficacy of Fc-engineered antibodies in established xenograft tumor models

Free
Holly Horton, Eugene Zhukovsky, Umesh Muchhal, John Richards, Sher Karki, David Carmichael, John Desjarlais
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1249.
Published: 01 May 2009
View articletitled, Abstract #1249: Antitumor efficacy of Fc-engineered antibodies in established xenograft tumor models
Journal Articles

Abstract #5487: XmAb®5592: Fc-engineered anti-HM1.24 monoclonal antibody with potent in vitro and in vivo efficacy against multiple myeloma

Free
Umesh Muchhal, Holly Horton, Hanh Nguyen, Matthew Bernett, Sher Karki, John Richards, John Desjarlais
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5487.
Published: 01 May 2009
View articletitled, Abstract #5487: XmAb®5592: Fc-engineered anti-HM1.24 monoclonal antibody with potent in vitro and in vivo efficacy against multiple myeloma
Journal Articles

Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

Available to Purchase
Holly M. Horton, Matthew J. Bernett, Erik Pong, Matthias Peipp, Sher Karki, Seung Y. Chu, John O. Richards, Igor Vostiar, Patrick F. Joyce, Roland Repp, John R. Desjarlais, Eugene A. Zhukovsky
Journal: Cancer Research
Cancer Res (2008) 68 (19): 8049–8057.
https://doi.org/10.1158/0008-5472.CAN-08-2268
Published: 30 September 2008
View articletitled, Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia
Open the PDF for Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia in another window
Includes: Supplementary data
Journal Articles

Fc-engineered antibodies with increased FcγRIIA (CD32A) affinity enhance macrophage-mediated phagocytosis

Free
Sher Karki, John Richards, Wei Dang, Hsing Chen, Patrick Joyce, Greg Lazar, John Desjarlais
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4902.
Published: 01 May 2008
View articletitled, Fc-engineered antibodies with increased FcγRIIA (CD32A) affinity enhance macrophage-mediated phagocytosis
Journal Articles

Xmab™ Fc-engineered anti-cd19 monoclonal antibodies with in vitro and in vivo efficacy against lymphoma and leukemia

Free
Eugene Zhukovsky, Matthew Bernett, Seung Chu, Sher Karki, Holly Horton, John Richards, Erik Pong, Patrick Joyce, Matthias Peipp, Roland Repp, John Desjarlais
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4903.
Published: 01 May 2008
View articletitled, Xmab™ Fc-engineered anti-cd19 monoclonal antibodies with in vitro and in vivo efficacy against lymphoma and leukemia
Journal Articles

XmAb™ Fc engineered anti-CD19 monoclonal antibodies with enhanced in vitro efficacy against multiple lymphoma cell lines

Free
Eugene Zhukovsky, Seung Chu, Matthew Bernett, Philip Hammond, Sher Karki, Wei Dang, Collin Edler, Nephi Polder, Cheryl Chan, Jonathan Jacinto, John Desjarlais
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3331.
Published: 01 May 2007
View articletitled, XmAb™ Fc engineered anti-CD19 monoclonal antibodies with enhanced in vitro efficacy against multiple lymphoma cell lines