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Journal Articles

Abstract LB195: AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B

Jia Xu, Xufen Yu, Tiphaine C. Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin, Elias Stratikopoulos, Kaitlyn M. Cahuzac, Li Wang, Ling Xie, Royce Zhou, Yudao Shen, Xuewei Wu, Shen Yao, Ruifang Qiao, Poulikos I. Poulikakos, Xian Chen, Jing Liu, Jian Jin, Ramon Parsons
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB195.
https://doi.org/10.1158/1538-7445.AM2022-LB195
Published: 15 June 2022
View article titled, Abstract LB195: AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild type KRAS and BRAF by destabilizing Aurora kinase B
Journal Articles

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Kimberly McClinch, Rita A. Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B. Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L. Brautigan, Stephen R. Plymate, Cynthia C.T. Sprenger, William K. Oh, Alice C. Levine, Alexander Kirschenbaum, John P. Sfakianos, Rosalie Sears, Analisa DiFeo, Yiannis Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D. Galsky
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2065–2080.
https://doi.org/10.1158/0008-5472.CAN-17-0123
Published: 12 April 2018
View article titled, Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer

Jaya Sangodkar, Rita Tohme, Janna Kiselar, Sudeh Izadmehr, Divya Hoon, Sahar Mazhar, Abbey Perl, Danica Wiredja, Daniela Schlatzer, Shen Yao, David Kastrinsky, Neelesh Sharma, David Brautigan, Mark Chance, Alain Borczuk, Michael Ohlmeyer, Yiannis Ioannou, Goutham Narla
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3865.
https://doi.org/10.1158/1538-7445.AM2016-3865
Published: 15 July 2016
View article titled, Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer
Journal Articles

Abstract PR10: Functional analysis of oncogenic driver mutations in human cancer cells through CRISPR-barcoding

Alexis Guernet, Dorthe Cartier, Sathish Kumar Mungamuri, Sahil Adriouch, Myriam Vezain, Françoise Charbonnier, Sophie Coutant, Shen Yao, Hassan Ainani, David Alexandre, Olivier Boyer, Stuart A. Aaronson, Youssef Anouar, Luca Grumolato
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): PR10.
https://doi.org/10.1158/1538-7445.FBCR15-PR10
Published: 07 April 2016
View article titled, Abstract PR10: Functional analysis of oncogenic driver mutations in human cancer cells through CRISPR-barcoding
Journal Articles

Abstract 5329: Development of small molecule activators of protein phosphatase 2A for the treatment of lung cancer

Jaya Sangodkar, Sudeh Izadmehr, Sahar Mahzar, Divya Hoon, Shen Yao, David Kastrinsky, Daniela Schlatzer, Neelesh Sharma, Alain C. Borczuk, Michael Ohlmeyer, Yiannis Ioannou, Goutham Narla
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5329.
https://doi.org/10.1158/1538-7445.AM2015-5329
Published: 01 August 2015
View article titled, Abstract 5329: Development of small molecule activators of protein phosphatase 2A for the treatment of lung cancer
Journal Articles

Abstract #55: Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells

Xin Hua Liu, SuDao Xiong, Li Hui Yin, Alexander Kirschenbaum, Shen Yao, Goutham Narla, Analisa DiFeo, Kang Yu, Jian Bo Wu, Yong Yuan, Shuk-Mei Ho, Ying Wai Lam, Alice Levine
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 55.
Published: 01 May 2009
View article titled, Abstract #55: Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells
Journal Articles

Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes

Alka M. Mahale, Zahid A.T. Khan, Makoto Igarashi, Gouri J. Nanjangud, Rui Fang Qiao, Shen Yao, Sam W. Lee, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2008) 68 (5): 1417–1426.
https://doi.org/10.1158/0008-5472.CAN-07-3021
Published: 03 March 2008
View article titled, Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes
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Includes: Supplementary data
Journal Articles

Androgen-Induced Wnt Signaling in Preosteoblasts Promotes the Growth of MDA-PCa-2b Human Prostate Cancer Cells

Xin-Hua Liu, Alexander Kirschenbaum, Shen Yao, Guizhong Liu, Stuart A. Aaronson, Alice C. Levine
Journal: Cancer Research
Cancer Res (2007) 67 (12): 5747–5753.
https://doi.org/10.1158/0008-5472.CAN-07-0478
Published: 15 June 2007
View article titled, Androgen-Induced Wnt Signaling in Preosteoblasts Promotes the Growth of MDA-PCa-2b Human Prostate Cancer Cells
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Journal Articles

KLF6 and KLF6-SV1 regulate ovarian cancer progression and dissemination: Identification of a novel KLF6 / E-cadherin pathway

Analisa V. Difeo, Goutham Narla, Jennifer Hirshfeld, Olga Camacho-Vanegas, Jyothsna Narla, Hitomi Nishio, Stephen L. Rose, Shen Yao, Alice Levine, Tamara Kalir, Scott L. Friedman, Martin Walsh, Richard E. Buller, John A. Martignetti
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 977.
Published: 15 April 2006
View article titled, KLF6 and KLF6-SV1 regulate ovarian cancer progression and dissemination: Identification of a novel KLF6 / E-cadherin pathway
Journal Articles

Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread

Goutham Narla, Analisa DiFeo, Shen Yao, Asoka Banno, Eldad Hod, Helen L. Reeves, Rui F. Qiao, Olga Camacho-Vanegas, Alice Levine, Alexander Kirschenbaum, Andrew M. Chan, Scott L. Friedman, John A. Martignetti
Journal: Cancer Research
Cancer Res (2005) 65 (13): 5761–5768.
https://doi.org/10.1158/0008-5472.CAN-05-0217
Published: 01 July 2005
View article titled, Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread
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Journal Articles

Zone specific gene expression and regulation in prostatic basal cells

Xin-Hua Liu, Alexander Kirschenbaum, Shen Yao, Alice C. Levine
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1286.
Published: 01 May 2005
View article titled, Zone specific gene expression and regulation in prostatic basal cells
Journal Articles

Cyclooxygenase-2 suppresses hypoxia-induced p53 activation via promotion of MDM2 phosphorylation and inhibition of p53 nuclear localization in a prostate cancer cell line

Xin-Hua Liu, Alexander Kirschenbaum, Kang Yu, Shen Yao, James F. Holland, Alice C. Levine
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 618.
Published: 01 April 2004
View article titled, Cyclooxygenase-2 suppresses hypoxia-induced p53 activation via promotion of MDM2 phosphorylation and inhibition of p53 nuclear localization in a prostate cancer cell line
Journal Articles

BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma

Jianli Dong, Robert G. Phelps, Rui Qiao, Shen Yao, Outhiriaradjou Benard, Zeev Ronai, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2003) 63 (14): 3883–3885.
Published: 21 July 2003
View article titled, <em>BRAF</em> Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma
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Journal Articles

NS398, a Selective Cyclooxygenase-2 Inhibitor, Induces Apoptosis and Down-Regulates bcl-2 Expression in LNCaP Cells

Xin-Hua Liu, Shen Yao, Alexander Kirschenbaum, Alice C. Levine
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4245–4249.
Published: 01 October 1998
View article titled, NS398, a Selective Cyclooxygenase-2 Inhibitor, Induces Apoptosis and Down-Regulates bcl-2 Expression in LNCaP Cells
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Journal Articles

The Chemopreventive Agent Oltipraz Stimulates Repair of Damaged DNA

Peter J. O'Dwyer, Steven W. Johnson, Christina Khater, Ann Krueger, Yoshihiro Matsumoto, Thomas C. Hamilton, Kang-Shen Yao
Journal: Cancer Research
Cancer Res (1997) 57 (6): 1050–1053.
Published: 01 March 1997
View article titled, The Chemopreventive Agent Oltipraz Stimulates Repair of Damaged DNA
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Journal Articles

Alternative Splicing and Differential Expression of DT-Diaphorase Transcripts in Human Colon Tumors and in Peripheral Mononuclear Cells in Response to Mitomycin C Treatment

Kang-Shen Yao, Andrew K. Godwin, Cheryl Johnson, Peter J. O'Dwyer
Journal: Cancer Research
Cancer Res (1996) 56 (8): 1731–1736.
Published: 01 April 1996
View article titled, Alternative Splicing and Differential Expression of DT-Diaphorase Transcripts in Human Colon Tumors and in Peripheral Mononuclear Cells in Response to Mitomycin C Treatment
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Journal Articles

Evidence for Altered Regulation of γ-Glutamylcysteine Synthetase Gene Expression among Cisplatin-sensitive and Cisplatin-resistant Human Ovarian Cancer Cell Lines

Kang-Shen Yao, Andrew K. Godwin, Steven W. Johnson, Robert F. Ozols, Peter J. O'Dwyer, Thomas C. Hamilton
Journal: Cancer Research
Cancer Res (1995) 55 (19): 4367–4374.
Published: 01 October 1995
View article titled, Evidence for Altered Regulation of γ-Glutamylcysteine Synthetase Gene Expression among Cisplatin-sensitive and Cisplatin-resistant Human Ovarian Cancer Cell Lines
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Journal Articles

Variable Baseline γ-Glutamylcysteine Synthetase Messenger RNA Expression in Peripheral Mononuclear Cells of Cancer Patients, and Its Induction by Buthionine Sulfoximine Treatment

Kang-shen Yao, Andrew K. Godwin, Robert F. Ozols, Thomas C. Hamilton, Peter J. O'Dwyer
Journal: Cancer Research
Cancer Res (1993) 53 (16): 3662–3666.
Published: 01 August 1993
View article titled, Variable Baseline γ-Glutamylcysteine Synthetase Messenger RNA Expression in Peripheral Mononuclear Cells of Cancer Patients, and Its Induction by Buthionine Sulfoximine Treatment
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