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Shaun O'Brien
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Journal Articles

Abstract C029: Multiple non-redundant immune checkpoints direct therapeutic resistance to chemotherapy and anti-CSF1R in pancreatic ductal adenocarcinoma

Free
Meredith L. Stone, Veronica M. Herrera, Yan Li, Heather Coho, Yuqing Yue, Kathleen Graham, Devora Delman, Shaun O'Brien, Gregory L. Beatty
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C029.
https://doi.org/10.1158/1538-7445.PANCA2023-C029
Published: 16 January 2024
View article titled, Abstract C029: Multiple non-redundant immune checkpoints direct therapeutic resistance to chemotherapy and anti-CSF1R in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 539: A bispecific Fc-silenced IgG1 antibody (MCLA-145) requires PD-L1 binding to activate CD137

Free
Patrick Mayes, Paul Tacken, Steve Wang, Pieter-Fokko van Loo, Thomas Condamine, Hans van der Maaden, Eric Rovers, Steef Engels, Floris Fransen, Ashwini Kulkarni, Yao-bin Liu, Arpita Mondal, Leslie Hall, Soyeon Kim, Marina Martinez, Shaun O'Brien, Edmund Moon, Steven Albelda, Peggy Scherle, Gregory Hollis, Reid Huber, Mark Throsby, Cecile A. Geuijen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 539.
https://doi.org/10.1158/1538-7445.AM2019-539
Published: 01 July 2019
View article titled, Abstract 539: A bispecific Fc-silenced IgG1 antibody (MCLA-145) requires PD-L1 binding to activate CD137
Journal Articles

Abstract 1641: Dual antibody blockade of TIM3 and PD1 on NYESO1 redirected human T cells leads to augmented control of lung cancer tumors

Free
Edmund Moon, Soyeon Kim, Shaun O'Brien, Naomi Saint Jean, Raluca Verona, Linda Snyder, Yangbing Zhao, Steven Albelda
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1641.
https://doi.org/10.1158/1538-7445.AM2017-1641
Published: 01 July 2017
View article titled, Abstract 1641: Dual antibody blockade of TIM3 and PD1 on NYESO1 redirected human T cells leads to augmented control of lung cancer tumors
Journal Articles

Abstract 3707: Tumor-associated neutrophils with antigen-presenting features in early-stage human lung cancer

Free
Jason Stadanlick, Abhishek Rao, Michael Annunziata, Edmund Moon, Shaun O'brien, Pratik Bhojnagarwala, Michael Feldman, Wayne Hancock, Jose Conejo-Garcia, Sunil Singhal, Stephen Albelda, Evgeniy Eruslanov
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3707.
https://doi.org/10.1158/1538-7445.AM2017-3707
Published: 01 July 2017
View article titled, Abstract 3707: Tumor-associated neutrophils with antigen-presenting features in early-stage human lung cancer
Journal Articles

Abstract 3749: Genetic blockade of the protein tyrosine phosphatase SHP1 augments CAR T cell activity against PDL1 expressing solid tumors

Free
Edmund Moon, Soyeon Kim, Naomi Saint Jean, Shaun O'Brien, Steven Maceyko, Jing Sun, Carl June, Steven Albelda
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3749.
https://doi.org/10.1158/1538-7445.AM2017-3749
Published: 01 July 2017
View article titled, Abstract 3749: Genetic blockade of the protein tyrosine phosphatase SHP1 augments CAR T cell activity against PDL1 expressing solid tumors
Journal Articles

Abstract A02: The origin and role of APC-like hybrid tumor-associated neutrophils in early-stage human lung cancer

Free
Evgeniy Eruslanov, Pratik Bhojnagarwala, Jon Quatromoni, Shaun O'Brien, Edmund Moon, Tom Stephen, Abhishek Rao, Alfred Garfall, Wayne Hancock, Jose Conejo-Garcia, Charuhas Deshpande, Michael Feldman, Sunil Singhal, Steven Albelda
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): A02.
https://doi.org/10.1158/1538-7445.TME16-A02
Published: 28 July 2016
View article titled, Abstract A02: The origin and role of APC-like hybrid tumor-associated neutrophils in early-stage human lung cancer
Journal Articles

Abstract B27: Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor efficacy of adoptively transferred chimeric antigen receptor-expressing T cells

Free
Kheng Newick, Shaun O'Brien, Jing Sun, Veena Kapoor, Steve Maceyko, Albert Lo, Ellen Pure, Ed K. Moon, Steven M. Albelda
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): B27.
https://doi.org/10.1158/1538-7445.TME16-B27
Published: 28 July 2016
View article titled, Abstract B27: Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor efficacy of adoptively transferred chimeric antigen receptor-expressing T cells
Journal Articles

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

Free
Tatiana A. Karakasheva, Todd J. Waldron, Evgeniy Eruslanov, Sang-Bae Kim, Ju-Seog Lee, Shaun O'Brien, Philip D. Hicks, Devraj Basu, Sunil Singhal, Fabio Malavasi, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2015) 75 (19): 4074–4085.
https://doi.org/10.1158/0008-5472.CAN-14-3639
Published: 30 September 2015
View article titled, CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer
Open the PDF for CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3175: CD38-expressing myeloid-derived suppressor cells promote tumor growth in a murine model of esophageal cancer

Free
Tatiana A. Karakasheva, Todd J. Waldron, Evgeniy Eruslanov, Ju-Seog Lee, Shaun O'Brien, Devraj Basu, Sunil Singhal, Fabio Malavasi, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3175.
https://doi.org/10.1158/1538-7445.AM2015-3175
Published: 01 August 2015
View article titled, Abstract 3175: CD38-expressing myeloid-derived suppressor cells promote tumor growth in a murine model of esophageal cancer
Journal Articles

Abstract 3142: Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors

Free
Shaun O'Brien, Liang-Chuan Wang, Kheng Newick, Rajan M. Thomas, Andrew Wells, Steven M. Albelda
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3142.
https://doi.org/10.1158/1538-7445.AM2015-3142
Published: 01 August 2015
View article titled, Abstract 3142: Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors
Journal Articles

Abstract 4293: Histamine dihydrochloride as an immune modulator for solid tumors

Free
Kheng Newick, Shaun O'Brien, Veena Kapoor, Liang-chuan Wang, Edmund Moon, Daniel Sterman, Steven Albelda
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4293.
https://doi.org/10.1158/1538-7445.AM2015-4293
Published: 01 August 2015
View article titled, Abstract 4293: Histamine dihydrochloride as an immune modulator for solid tumors
Journal Articles

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

Free
Albert Lo, Liang-Chuan S. Wang, John Scholler, James Monslow, Diana Avery, Kheng Newick, Shaun O'Brien, Rebecca A. Evans, David J. Bajor, Cynthia Clendenin, Amy C. Durham, Elizabeth L. Buza, Robert H. Vonderheide, Carl H. June, Steven M. Albelda, Ellen Puré
Journal: Cancer Research
Cancer Res (2015) 75 (14): 2800–2810.
https://doi.org/10.1158/0008-5472.CAN-14-3041
Published: 14 July 2015
View article titled, Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Open the PDF for Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells in another window
Includes: Supplementary data
Journal Articles

Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF

Free
Lawrence Fong, Serena S. Kwek, Shaun O'Brien, Brian Kavanagh, Douglas G. McNeel, Vivian Weinberg, Amy M. Lin, Jonathan Rosenberg, Charles J. Ryan, Brian I. Rini, Eric J. Small
Journal: Cancer Research
Cancer Res (2009) 69 (2): 609–615.
https://doi.org/10.1158/0008-5472.CAN-08-3529
Published: 15 January 2009
View article titled, Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF
Open the PDF for Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF in another window
Journal Articles

Abstract 2539: CTLA-4 blockade for hormone refractory prostate cancer: Dose-dependent induction of CD8+ T cell activation and clinical responses

Free
Lawrence Fong, Serena Kwek, Brian Kavanagh, Shaun O'Brien, Douglas McNeel, Vivian Weinberg, Brian Rini, Eric J. Small
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2539.
https://doi.org/10.1158/1538-7445.AM2008-2539
Published: 15 May 2008
View article titled, Abstract 2539: CTLA-4 blockade for hormone refractory prostate cancer: Dose-dependent induction of CD8+ T cell activation and clinical responses
Journal Articles

CTLA-4 blockade for hormone refractory prostate cancer: Dose-dependent induction of CD8+ T cell activation and clinical responses

Free
Lawrence Fong, Serena Kwek, Brian Kavanagh, Shaun O'Brien, Douglas McNeel, Vivian Weinberg, Brian Rini, Eric Small
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2539.
Published: 01 May 2008
View article titled, CTLA-4 blockade for hormone refractory prostate cancer: Dose-dependent induction of CD8+ T cell activation and clinical responses