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Journal Articles

Abstract 3998: Metronomic gemcitabine plus neratinib effectively inhibits the growth of human Her-2 positive breast cancer cells intracranially implanted into immunodeficient mice

Serina Batson, Alejandro Sanchez, Hector M. Padilla, Diana L. Prospero, Brenda Lugo, Valeria V. Lopez, Daniella E. Estrada, Nydia De Avila, Saeedeh Darvishi, Arlene Levario, Shan Man, Ping Xu, Robert S. Kerbel, Guido Bocci, Giulio Francia
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3998.
https://doi.org/10.1158/1538-7445.AM2023-3998
Published: 04 April 2023
View article titled, Abstract 3998: Metronomic gemcitabine plus neratinib effectively inhibits the growth of human Her-2 positive breast cancer cells intracranially implanted into immunodeficient mice
Journal Articles

Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers

Florence T.H. Wu, Shan Man, Ping Xu, Annabelle Chow, Marta Paez-Ribes, Christina R. Lee, Steven R. Pirie-Shepherd, Urban Emmenegger, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (23): 6988–7000.
https://doi.org/10.1158/0008-5472.CAN-16-0888
Published: 30 November 2016
View article titled, Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers
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Includes: Supplementary data
Journal Articles

Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy

Yuval Shaked, Elizabeth Pham, Santosh Hariharan, Ksenia Magidey, Ofrat Beyar-Katz, Ping Xu, Shan Man, Florence T.H. Wu, Valeria Miller, David Andrews, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (20): 5983–5993.
https://doi.org/10.1158/0008-5472.CAN-16-0136
Published: 13 October 2016
View article titled, Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy
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Includes: Supplementary data
Journal Articles

Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer

Elizabeth Pham, Melissa Yin, Christian G. Peters, Christina R. Lee, Donna Brown, Ping Xu, Shan Man, Lata Jayaraman, Ellen Rohde, Annabelle Chow, Douglas Lazarus, Scott Eliasof, F. Stuart Foster, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4493–4503.
https://doi.org/10.1158/0008-5472.CAN-15-3435
Published: 31 July 2016
View article titled, Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 4124: Potent anti-tumor and metastatic breast cancer efficacy of bevacizumab with CRLX101, an investigational chemotherapy nanoparticle-drug conjugate that secondarily suppresses HIF-1α

Elizabeth Pham, Christina R. Lee, Ping Xu, Shan Man, Melissa Yin, F. Stuart Foster, Christian G. Peters, Douglas Lazarus, Scott Eliasof, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4124.
https://doi.org/10.1158/1538-7445.AM2015-4124
Published: 01 August 2015
View article titled, Abstract 4124: Potent anti-tumor and metastatic breast cancer efficacy of bevacizumab with CRLX101, an investigational chemotherapy nanoparticle-drug conjugate that secondarily suppresses HIF-1α
Journal Articles

Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma

Elizabeth A. Kuczynski, Christina R. Lee, Shan Man, Eric Chen, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2015) 75 (12): 2510–2519.
https://doi.org/10.1158/0008-5472.CAN-14-3687
Published: 14 June 2015
View article titled, Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 3142: Derivation and analysis of preclinical models of human her-2 positive breast cancer

Paloma A. Valenzuela, Sarah N. Jallad, Karla Parra, Natzidielly Lerma, Irving Miramontes, Alejandra Gallegos, Ping Xu, William Cruz-Munoz, Shan Man, Robert S. Kerbel, Giulio Francia
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3142.
https://doi.org/10.1158/1538-7445.AM2014-3142
Published: 01 October 2014
View article titled, Abstract 3142: Derivation and analysis of preclinical models of human her-2 positive breast cancer
Journal Articles

A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs

Eric Guerin, Shan Man, Ping Xu, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2013) 73 (9): 2743–2748.
https://doi.org/10.1158/0008-5472.CAN-12-4183
Published: 30 April 2013
View article titled, A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs
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Journal Articles

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

William Cruz-Muñoz, Maria L. Jaramillo, Shan Man, Ping Xu, Myriam Banville, Catherine Collins, Andre Nantel, Giulio Francia, Sherif S. Morgan, Lee D. Cranmer, Maureen D. O'Connor-McCourt, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2012) 72 (19): 4909–4919.
https://doi.org/10.1158/0008-5472.CAN-12-2194
Published: 30 September 2012
View article titled, Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma
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Includes: Supplementary data
Journal Articles

Abstract 4377: Metronomic oral prodrug of gemcitabine (LY2334737) causes antitumor effects with concomitant increase in intratumoral blood flow

Giulio Francia, Yuval Shaked, Kae Hashimoto, John Sun, Ping Xu, Shan Man, Christina Hackl, Julie Stewart, Anne H. Dantzig, Mark Uhlik, Stuart Foster, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4377.
https://doi.org/10.1158/1538-7445.AM2012-4377
Published: 15 April 2012
View article titled, Abstract 4377: Metronomic oral prodrug of gemcitabine (LY2334737) causes antitumor effects with concomitant increase in intratumoral blood flow
Journal Articles

Abstract 1452: Examination of mechanisms involved in spontaneous melanoma metastasis to CNS

William Cruz, Shan Man, Maria Jaramillo, Maureen O'Connor-McCourt, Myriam Banville, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM10-1452
Published: 15 April 2010
View article titled, Abstract 1452: Examination of mechanisms involved in spontaneous melanoma metastasis to CNS
Journal Articles

Abstract 382: Platelets are implicated in the rapid host responses induced by cytotoxic chemotherapy which limit its anti-tumor efficacy

Chlöe C. Milsom, Yuval Shaked, Christina R. Lee, Shan Man, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 382.
https://doi.org/10.1158/1538-7445.AM10-382
Published: 15 April 2010
View article titled, Abstract 382: Platelets are implicated in the rapid host responses induced by cytotoxic chemotherapy which limit its anti-tumor efficacy
Journal Articles

Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

Yuval Shaked, Terence Tang, Jill Woloszynek, Laura G. Daenen, Shan Man, Ping Xu, Shi-Rong Cai, Jeffrey M. Arbeit, Emile E. Voest, David J. Chaplin, Jon Smythe, Adrian Harris, Paul Nathan, Ian Judson, Gordon Rustin, Francesco Bertolini, Daniel C. Link, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7524–7528.
https://doi.org/10.1158/0008-5472.CAN-09-0381
Published: 01 October 2009
View article titled, Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
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Includes: Supplementary data
Journal Articles

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

Chris Folkins, Yuval Shaked, Shan Man, Terence Tang, Christina R. Lee, Zhenping Zhu, Robert M. Hoffman, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7243–7251.
https://doi.org/10.1158/0008-5472.CAN-09-0167
Published: 14 September 2009
View article titled, Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1
Open the PDF for Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1 in another window
Includes: Supplementary data
Journal Articles

Development of a Preclinical Model of Spontaneous Human Melanoma Central Nervous System Metastasis

William Cruz-Munoz, Shan Man, Ping Xu, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2008) 68 (12): 4500–4505.
https://doi.org/10.1158/0008-5472.CAN-08-0041
Published: 16 June 2008
View article titled, Development of a Preclinical Model of Spontaneous Human Melanoma Central Nervous System Metastasis
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Journal Articles

Glioma tumor stem-like cells promote tumor angiogenesis via VEGF- and SDF1-mediated promotion of endothelial cell activity and recruitment of bone marrow-derived endothelial progenitor cells

Chris Folkins, Yuval Shaked, Shan Man, Terence Tang, Christina Lee, Robert Kerbel
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1097.
Published: 01 May 2008
View article titled, Glioma tumor stem-like cells promote tumor angiogenesis via VEGF- and SDF1-mediated promotion of endothelial cell activity and recruitment of bone marrow-derived endothelial progenitor cells
Journal Articles

Chemotherapy-induced surge in endothelial precursor cells: Implications for antiangiogenic drugs as chemosensitizing agents

Yuval Shaked, Erik Henke, Jeanine Roodhart, Patrizia Mancuso, Marlies Langenberg, Marco Colleoni, Shan Man, Ping Xu, Laura Daenen, Urban Emmenegger, Terence Tang, Francesco Bertolini, Emile Voest, Robert Benezra, Robert Kerbel
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1120.
Published: 01 May 2008
View article titled, Chemotherapy-induced surge in endothelial precursor cells: Implications for antiangiogenic drugs as chemosensitizing agents
Journal Articles

Molecular mechanisms responsible for vascular disrupting agent-induced acute mobilization and tumor homing of circulating endothelial progenitor cells.

Yuval Shaked, Terence Tang, Jill Mayer, Laura Daenen, Shan Man, Ping Xu, Shi-Rong Cai, John Wong, Jeffrey Arbeit, Judy Varner, Emile Voest, David Chaplin, Adrian Harris, Paul Nathan, Gordon Rustin, Francesco Bertolini, Daniel Link, Robert Kerbel
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5854.
Published: 01 May 2008
View article titled, Molecular mechanisms responsible for vascular disrupting agent-induced acute mobilization and tumor homing of circulating endothelial progenitor cells.
Journal Articles

Anti-cancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors

Chris Folkins, Shan Man, Ping Xu, Yuval Shaked, Daniel Hicklin, Robert Kerbel
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1323.
Published: 01 May 2007
View article titled, Anti-cancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
Journal Articles

Glioma tumor stem-like cells promote tumor angiogenesis and the mobilization of bone marrow-derived circulating endothelial progenitor cells

Chris Folkins, Christina Lee, Shan Man, Yuval Shaked, Robert Kerbel
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1283.
Published: 01 May 2007
View article titled, Glioma tumor stem-like cells promote tumor angiogenesis and the mobilization of bone marrow-derived circulating endothelial progenitor cells