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Sergio Roman-Roman
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Journal Articles

Abstract A050 DNMT3B DNA methyltransferase acts as a major player and therapeutic target in rhabdoid tumors

Céline Chauvin, Mamy Andrianteranagna, Sandrina Turczynski, Joanna Cyrta, Arnault Tauziede-Espariat, Rachida Bouarich, Zhi-Yan Han, Julien Masliah-Planchon, Gaelle Pierron, Mylène Bohec, Sylvain Baulande, Sergio Roman-Roman, Olivier Delattre, Franck Bourdeaut
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A050.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A050
Published: 05 September 2024
View article titled, Abstract A050 DNMT3B DNA methyltransferase acts as a major player and therapeutic target in rhabdoid tumors
Journal Articles

Abstract A051 Genome-wide CRISPR/Cas9 library screening identified TP53 as a critical driver for resistance to EZH2 inhibitor in rhabdoid tumors

Céline Chauvin, Tiphaine Hery, Rachida Bouarich, Fariba Nemati, Diego Teyssonneau, Camille Fouassier, Chiara Giudiceandrea, Zhi-Yan Han, Sakina Zaidi, Didier Surdez, Sergio Roman-Roman, Didier Decaudin, Raphaël Margueron, Franck Bourdeaut
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A051.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A051
Published: 05 September 2024
View article titled, Abstract A051 Genome-wide CRISPR/Cas9 library screening identified TP53 as a critical driver for resistance to EZH2 inhibitor in rhabdoid tumors
Journal Articles

Abstract 2774: Reference free transcriptomic characterization of chemoresistant triple negative breast cancers provides a promising reservoir of predictive biomarkers of early chemoresistance

Nouritza Torossian, Dominika Foretek, Marc Gabriel, Linda Larbi Cherif, Charlotte Lecerf, Maud Kamal, Christophe Le Tourneau, Daniel Gautheret, Sergio Roman-Roman, Antonin Morillon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2774.
https://doi.org/10.1158/1538-7445.AM2022-2774
Published: 15 June 2022
View article titled, Abstract 2774: Reference free transcriptomic characterization of chemoresistant triple negative breast cancers provides a promising reservoir of predictive biomarkers of early chemoresistance
Journal Articles

Abstract LB567: Dramatic in vivo efficacy of the EZH2-inhibitor tazemetostat in PBRM1-mutated human chordoma xenograft

Thibault Passeri, Ahmed Dahmani, Julien Masliah-Planchon, Adnan Naguez, Marine Michou, Rania El-Botty, Sophie Vacher, Rachida Bouarich, André Nicolas, Marc Polivka, Coralie Franck, Anne Schnitzler, Fariba Némati, Sergio Roman-Roman, Franck Bourdeaut, Homa Adle-Biassette, Hamid Mammar, Sébastien Froelich, Ivan Bièche, Didier Decaudin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB567.
https://doi.org/10.1158/1538-7445.AM2022-LB567
Published: 15 June 2022
View article titled, Abstract LB567: Dramatic in vivo efficacy of the EZH2-inhibitor tazemetostat in PBRM1-mutated human chordoma xenograft
Journal Articles

Abstract 4031: PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

Samyuktha Suresh, Solène Huard, Fariba Némati, Rayan Dakroub, André Nicolas, Didier Meseure, Didier Decaudin, Sergio Roman-Roman, Thierry Dubois
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4031.
https://doi.org/10.1158/1538-7445.AM2022-4031
Published: 15 June 2022
View article titled, Abstract 4031: PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer
Journal Articles

Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts

Emilie Vinolo, Joaquin Arribas, Andrea Bertotti, Alejandra Bruna, Annette T. Byrne, Robert B. Clarke, Nathalie Conte, Steven de Jong, Didier Decaudin, Zdenka Dudova, Jos Jonkers, Daniela Krasser, Ales Krenek, Luisa Lanfrancone, Eleonora Leucci, Elisabetta Marangoni, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Jens Henrik Norum, Hector G. Palmer, Alejandro Piris Gimenez, Leo Price, Sergio Roman-Roman, Francesca Sarno, Violeta Serra, Laura Soucek, Livio Trusolino, Marieke van de Ven, Luca Vezzadini, Alberto Villanueva, Andrea Wutte, Enzo Medico, on behalf of the EurOPDX Research Infrastructure
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2020-1685
Published: 15 August 2020
View article titled, Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
Journal Articles

Abstract 2895: MBD4 inactivation results in an alternative evolutionary route in uveal melanoma

Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sophie Gardrat, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Sergio Roman-Roman, Pascale Mariani, Marc-Henri Stern
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2895.
https://doi.org/10.1158/1538-7445.AM2019-2895
Published: 01 July 2019
View article titled, Abstract 2895: MBD4 inactivation results in an alternative evolutionary route in uveal melanoma
Journal Articles

Abstract 3387: Comprehensive detection and analysis of mutant-SF3B1 splice pattern

Samar Alsafadi, Dorine Bellanger, Michele Cornella, Erik Lehnert, Sergio Roman-Roman, Marc-Henri Stern, Tatiana Popova
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3387.
https://doi.org/10.1158/1538-7445.AM2019-3387
Published: 01 July 2019
View article titled, Abstract 3387: Comprehensive detection and analysis of mutant-<em>SF3B1</em> splice pattern
Journal Articles

Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Enzo Medico, Mohamed Bentires-Alj, Andrew V. Biankin, Alejandra Bruna, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Georges Coukos, Olivier Elemento, Manuel Hidalgo, Giorgio Inghirami, Steven de Jong, Jos Jonkers, Ales Krenek, Eleonora Leucci, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Simone P. Niclou, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Leo Price, Sergio Roman-Roman, Livio Trusolino, Luca Vezzadini, Alberto Villanueva, Emilie Vinolo, on behalf of the EurOPDX Consortium
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 985.
https://doi.org/10.1158/1538-7445.AM2018-985
Published: 01 July 2018
View article titled, Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models
Journal Articles

Abstract 5238: Characterization of the enzyme generating the cholesterol metabolite and tumor suppressor dendrogenin A in the breast and its deregulations in breast cancer

Marc Poirot, Emmanuel Noguer, Florence Dalenc, Regis Soules, Lisa Barrett, Arnaud Rives, Hye-Young Kim, Brigitta Sjödin, Camille Franchet, Pilippe Rochaix, Raphaelle Duprez-Paumier, Magali Lacroix-Triki, Thomas Filleron, Leonor Chaltiel, Louise Jones, Emanuala Gadaleta, Claude Chalala, Sergio Roman-Roman, Thierry Dubois, Ned A. Porter, Bengt Mannervik, Michel Record, Sandrine Silvente-Poirot
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5238.
https://doi.org/10.1158/1538-7445.AM2018-5238
Published: 01 July 2018
View article titled, Abstract 5238: Characterization of the enzyme generating the cholesterol metabolite and tumor suppressor dendrogenin A in the breast and its deregulations in breast cancer
Journal Articles

Abstract 5782: Selumetinib-based therapy in uveal melanoma patient-derived xenografts

Didier Decaudin, Rania EL Botty, Béré Diallo, Gerald Massonnet, Justine Fleury, Adnan Naguez, Marine Dubois, Emma J. Davies, Aaron Smith, Joanne Wilson, Colin Howes, Paul Smith, Nathalie Cassoux, Pascale Mariani, Sophie Piperno-Neumann, Sergio Roman Roman, Fariba Nemati
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5782.
https://doi.org/10.1158/1538-7445.AM2018-5782
Published: 01 July 2018
View article titled, Abstract 5782: Selumetinib-based therapy in uveal melanoma patient-derived xenografts
Journal Articles

Abstract 3809: Protein arginine methyltransferase 1 (PRMT1) is a candidate therapeutic target for breast cancers

David Silvestre, Amélie Brisson, Bérengère Marty-Prouvost, Mengliang Ye, Hélène Bonsang, Virginie Maire, Damarys Loew, David Gentien, Didier Meseure, Fabien Reyal, Gordon C. Tucker, Sergio Roman-Roman, Thierry Dubois
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3809.
https://doi.org/10.1158/1538-7445.AM2016-3809
Published: 15 July 2016
View article titled, Abstract 3809: Protein arginine methyltransferase 1 (PRMT1) is a candidate therapeutic target for breast cancers
Journal Articles

Abstract 3027: Dual inhibition of PKC and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

Guillaume Carita, Estelle Frisch Dit Leitz, Ahmed Dahmani, Chloe Raymondie, Nathalie Cassoux, Sophie Piperno-Neumann, Fariba Némati, Ensar Halilovic, Sebastien Jeay, Andrew Wylie, Caroline Emery, Sergio Roman-Roman, Marie Schoumacher, Didier Decaudin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3027.
https://doi.org/10.1158/1538-7445.AM2016-3027
Published: 15 July 2016
View article titled, Abstract 3027: Dual inhibition of PKC and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma
Journal Articles

Abstract 2087: The MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) appears as an efficient targeted therapy when used in an adjuvant setting in patient-derived xenografts of uveal melanoma

Béré Diallo, Gerald Massonnet, Rania El-Botty, Chloé Raymondie, Guillaume Carita, Sergio Roman-Roman, Paul Smith, Emma Davies, Didier Decaudin, Fariba Némati
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2087.
https://doi.org/10.1158/1538-7445.AM2016-2087
Published: 15 July 2016
View article titled, Abstract 2087: The MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) appears as an efficient targeted therapy when used in an adjuvant setting in patient-derived xenografts of uveal melanoma
Journal Articles

Abstract 1452: In vivo TK-NOG liver-humanized model to predict patient pharmacological profile of anti-cancer agents

Caroline Mignard, Olivier Duchamp, Fariba Nemati, Nathalie Cassoux, Sergio Roman-Roman, Yasuyuki Ohnishi, Hiroshi Suemizu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2015-1452
Published: 01 August 2015
View article titled, Abstract 1452: In vivo TK-NOG liver-humanized model to predict patient pharmacological profile of anti-cancer agents
Journal Articles

Abstract LB-155: Epigenetic profiling of chemotherapy sensitivity

Zachary A. Gurard-Levin, Vera Pancaldi, Laurence OW Wilson, Elisabetta Marangoni, Sergio Roman-Roman, Alfonso Valencia, Paul Cottu, Genevieve Almouzni
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-155.
https://doi.org/10.1158/1538-7445.AM2015-LB-155
Published: 01 August 2015
View article titled, Abstract LB-155: Epigenetic profiling of chemotherapy sensitivity
Journal Articles

Abstract 41: The Wnt3a targetome in triple-negative breast cancer cell lines

Sylvie Maubant, Bruno Tesson, Virginie Maire, Mengliang Ye, Guillem Rigaill, David Gentien, Francisco Cruzalegui, Gordon C. Tucker, Sergio Roman-Roman, Thierry Dubois
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 41.
https://doi.org/10.1158/1538-7445.AM2015-41
Published: 01 August 2015
View article titled, Abstract 41: The Wnt3a targetome in triple-negative breast cancer cell lines
Journal Articles

Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data

Manoel Nunes, Patricia Vrignaud, Sophie Vacher, Sophie Richon, Astrid Lièvre, Wulfran Cacheux, Louis-Bastien Weiswald, Gerald Massonnet, Sophie Chateau-Joubert, André Nicolas, Colette Dib, Weidong Zhang, James Watters, Donald Bergstrom, Sergio Roman-Roman, Ivan Bièche, Virginie Dangles-Marie
Journal: Cancer Research
Cancer Res (2015) 75 (8): 1560–1566.
https://doi.org/10.1158/0008-5472.CAN-14-1590
Published: 14 April 2015
View article titled, Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data
Open the PDF for Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data in another window
Includes: Supplementary data
Journal Articles

Abstract 3915: Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target

Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, May-Linda Lepage, André Nicolas, Jordan Madic, Amaury Dumont, Guillaume Carita, Jaques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Xavier Sastre, Didier Decaudin, Sergio Roman-Roman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3915.
https://doi.org/10.1158/1538-7445.AM2014-3915
Published: 01 October 2014
View article titled, Abstract 3915: Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target
Journal Articles

Abstract 2764: The depletion of LRP5, unlike that of LRP6, promotes apoptosis in triple-negative breast cancer cells, making it an interesting therapeutic target

Sylvie Maubant, Virginie Maire, Bruno Tesson, Fariba Némati, David Gentien, Bérengère Marty-Prouvost, Stéphane Depil, Francisco Cruzalegui, Gordon Tucker, Sergio Roman-Roman, Thierry Dubois
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2764.
https://doi.org/10.1158/1538-7445.AM2014-2764
Published: 01 October 2014
View article titled, Abstract 2764: The depletion of LRP5, unlike that of LRP6, promotes apoptosis in triple-negative breast cancer cells, making it an interesting therapeutic target