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Journal Articles

Abstract 1031: PRMT5 inhibition alters mitochondrial dynamics in mantle cell lymphoma, creating vulnerability to BH3 mimetic compounds

Claire Hinterschied, Fiona Brown, Janani Ravikrishnan, JoBeth Helmig-Mason, Kris Vaddi, Peggy Scherle, Jennifer Woyach, Selina Chen-Kiang, Oliver Elemento, Jihye Paik, Robert Baiocchi

Cancer Res (2022) 82 (12_Supplement): 1031.

https://doi.org/10.1158/1538-7445.AM2022-1031

Published: 15 June 2022

View articletitled, Abstract 1031: PRMT5 inhibition alters mitochondrial dynamics in mantle cell lymphoma, creating vulnerability to BH3 mimetic compounds

Journal Articles

Abstract 4840: Radiation therapy as a tool to sensitize HR⁺ breast cancer and mantle cell lymphoma to CDK4/6 inhibitors

Giulia Petroni, Maurizio Di Liberto, Aitziber Buqué Martinez, Selina Chen-Kiang, Lorenzo Galluzzi, Silvia C. Formenti

Cancer Res (2020) 80 (16_Supplement): 4840.

https://doi.org/10.1158/1538-7445.AM2020-4840

Published: 15 August 2020

View articletitled, Abstract 4840: Radiation therapy as a tool to sensitize HR+ breast cancer and mantle cell lymphoma to CDK4/6 inhibitors

Journal Articles

Abstract 2300: CDK4/6 inhibition triggers dissociation of MEIS2 from CRL4^CRBN E3 ligase to induce interferon response and reprogram myeloma for IMiD vulnerability

Xiangao Huang, David Jayabalan, Maurizio Di Liberto, Zhengming Chen, Anna Schinzel, Scott A. Ely, Adriana Rossi, Morton Coleman, Joseph M. Lane, William C. Hahn, Tomer M. Mark, Ruben Niesvizky, Selina Chen-Kiang

Cancer Res (2018) 78 (13_Supplement): 2300.

https://doi.org/10.1158/1538-7445.AM2018-2300

Published: 01 July 2018

View articletitled, Abstract 2300: CDK4/6 inhibition triggers dissociation of MEIS2 from CRL4CRBN E3 ligase to induce interferon response and reprogram myeloma for IMiD vulnerability

Journal Articles

Abstract 1523: Repression of IRF4 and CYTIP unleashes anti-tumor interferon response in CDK4 inhibitor therapy in mantle cell lymphoma

Maurizio Di Liberto, Peter Martin, Xiangao Huang, Priyanka Vijay, David Chiron, Scott Ely, Christopher Mason, Olivier Elemento, John Leonard, Selina Chen-Kiang

Cancer Res (2018) 78 (13_Supplement): 1523.

https://doi.org/10.1158/1538-7445.AM2018-1523

Published: 01 July 2018

View articletitled, Abstract 1523: Repression of IRF4 and CYTIP unleashes anti-tumor interferon response in CDK4 inhibitor therapy in mantle cell lymphoma

Journal Articles

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Cancer Res (2018) 78 (10): 2747–2759.

https://doi.org/10.1158/0008-5472.CAN-17-1900

Published: 14 May 2018

View articletitled, Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Includes: Supplementary data

Journal Articles

Abstract 4031: CDK4/6 inhibition amplifies IMiD killing of myeloma cells by accelerating CRL4CRBN-dependent degradation of IKZF1 and IKZF3 in opposition to MEIS2

Xiangao Huang, David Jayabalan, Maurizio Di Liberto, Tomer M. Mark, Zhengming Chen, Adriana Rossi, Anna C. Schinzel, William C. Hahn, Mohamad A. Hussein, Rubin Niesvizky, Selina Chen-Kiang

Cancer Res (2015) 75 (15_Supplement): 4031.

https://doi.org/10.1158/1538-7445.AM2015-4031

Published: 01 August 2015

View articletitled, Abstract 4031: CDK4/6 inhibition amplifies IMiD killing of myeloma cells by accelerating CRL4CRBN-dependent degradation of IKZF1 and IKZF3 in opposition to MEIS2

Journal Articles

Abstract 3099: Longitudinal genomic and transcriptomic analysis of mantle cell lymphoma in a targeted combination trial of a selective CDK4/6 inhibitor

Priyanka Vijay, Pedro Blecua, Maurizio Di Liberto, David Chiron, Xiangao Huang, Olivier Elemento, Peter Martin, John P. Leonard, Christopher E. Mason, Selina Chen-Kiang

Cancer Res (2015) 75 (15_Supplement): 3099.

https://doi.org/10.1158/1538-7445.AM2015-3099

Published: 01 August 2015

View articletitled, Abstract 3099: Longitudinal genomic and transcriptomic analysis of mantle cell lymphoma in a targeted combination trial of a selective CDK4/6 inhibitor

Journal Articles

Abstract 3095: Longitudinal integrative whole transcriptome and exome sequencing identifies genes that reprogram lymphoma cells for clinical response to CDK4/6 inhibition in combination therapy

Maurizio Di Liberto, Peter Martin, David Chiron, Priyanka Vijay, Xiangao Huang, Pedro Blecua, Scott Ely, Olivier Elemento, John P. Leonard, Christopher E. Mason, Selina Chen-Kiang

Cancer Res (2015) 75 (15_Supplement): 3095.

https://doi.org/10.1158/1538-7445.AM2015-3095

Published: 01 August 2015

View articletitled, Abstract 3095: Longitudinal integrative whole transcriptome and exome sequencing identifies genes that reprogram lymphoma cells for clinical response to CDK4/6 inhibition in combination therapy

Journal Articles

CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity

Chenyi Yang, Cynthia A. Boyson, Maurizio Di Liberto, Xiangao Huang, Jeffrey Hannah, David C. Dorn, Malcolm A.S. Moore, Selina Chen-Kiang, Pengbo Zhou

Cancer Res (2015) 75 (9): 1838–1845.

https://doi.org/10.1158/0008-5472.CAN-14-2486

Published: 30 April 2015

View articletitled, CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity

Includes: Supplementary data

Journal Articles

Abstract 3424: Induction of prolonged early G1-arrest by CDK4/CDK6 inhibition reprograms cycling lymphoma cells for enhanced and sustained inhibition of PI3Kδ/AKT.

David Chiron, Peter Martin, Maurizio Di Liberto, Xiangao Huang, Scott A. Ely, Brian J. Lannutti, John P. Leonard, Christopher E. Mason, Selina Chen-Kiang

Cancer Res (2013) 73 (8_Supplement): 3424.

https://doi.org/10.1158/1538-7445.AM2013-3424

Published: 15 April 2013

View articletitled, Abstract 3424: Induction of prolonged early G1-arrest by CDK4/CDK6 inhibition reprograms cycling lymphoma cells for enhanced and sustained inhibition of PI3Kδ/AKT.

Journal Articles

Abstract 3887: Reversible inhibition of CDK4/CDK6 sensitizes hematological tumor cells for cytotoxic killing by inducing sequential G1 arrest and synchronous S phase entry that enhances the intrinsic apoptosis pathway

Phoebe Joy Ho, Xiangao Huang, Scott Ely, Amy Chadburn, Peter Martin, Malcolm A.S Moore, John Leonard, Ruben Niesvizky, Maurizio Di Liberto, Selina Chen-Kiang

Cancer Res (2010) 70 (8_Supplement): 3887.

https://doi.org/10.1158/1538-7445.AM10-3887

Published: 15 April 2010

View articletitled, Abstract 3887: Reversible inhibition of CDK4/CDK6 sensitizes hematological tumor cells for cytotoxic killing by inducing sequential G1 arrest and synchronous S phase entry that enhances the intrinsic apoptosis pathway

Journal Articles

A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model

Eline Menu, Josefina Garcia, Xiangao Huang, Maurizio Di Liberto, Peter L. Toogood, Isan Chen, Karin Vanderkerken, Selina Chen-Kiang

Cancer Res (2008) 68 (14): 5519–5523.

https://doi.org/10.1158/0008-5472.CAN-07-6404

Published: 15 July 2008

View articletitled, A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model

Journal Articles

A Novel Orally Active Small Molecule Potently Induces G₁ Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Linda B. Baughn, Maurizio Di Liberto, Kaida Wu, Peter L. Toogood, Tracey Louie, Rachel Gottschalk, Ruben Niesvizky, Hearn Cho, Scott Ely, Malcolm A.S. Moore, Selina Chen-Kiang

Cancer Res (2006) 66 (15): 7661–7667.

https://doi.org/10.1158/0008-5472.CAN-06-1098

Published: 02 August 2006

View articletitled, A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Includes: Supplementary data

Journal Articles

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

Scott Ely, Maurizio Di Liberto, Ruben Niesvizky, Linda B. Baughn, Hearn J. Cho, Eunice N. Hatada, Daniel M. Knowles, Joseph Lane, Selina Chen-Kiang

Cancer Res (2005) 65 (24): 11345–11353.

https://doi.org/10.1158/0008-5472.CAN-05-2159

Published: 15 December 2005

View articletitled, Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

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Abstract 1031: PRMT5 inhibition alters mitochondrial dynamics in mantle cell lymphoma, creating vulnerability to BH3 mimetic compounds

Abstract 4840: Radiation therapy as a tool to sensitize HR⁺ breast cancer and mantle cell lymphoma to CDK4/6 inhibitors

Abstract 2300: CDK4/6 inhibition triggers dissociation of MEIS2 from CRL4^CRBN E3 ligase to induce interferon response and reprogram myeloma for IMiD vulnerability

Abstract 1523: Repression of IRF4 and CYTIP unleashes anti-tumor interferon response in CDK4 inhibitor therapy in mantle cell lymphoma

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Abstract 4031: CDK4/6 inhibition amplifies IMiD killing of myeloma cells by accelerating CRL4CRBN-dependent degradation of IKZF1 and IKZF3 in opposition to MEIS2

Abstract 3099: Longitudinal genomic and transcriptomic analysis of mantle cell lymphoma in a targeted combination trial of a selective CDK4/6 inhibitor

Abstract 3095: Longitudinal integrative whole transcriptome and exome sequencing identifies genes that reprogram lymphoma cells for clinical response to CDK4/6 inhibition in combination therapy

CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity

Abstract 3424: Induction of prolonged early G1-arrest by CDK4/CDK6 inhibition reprograms cycling lymphoma cells for enhanced and sustained inhibition of PI3Kδ/AKT.

Abstract 3887: Reversible inhibition of CDK4/CDK6 sensitizes hematological tumor cells for cytotoxic killing by inducing sequential G1 arrest and synchronous S phase entry that enhances the intrinsic apoptosis pathway

A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model

A Novel Orally Active Small Molecule Potently Induces G₁ Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma

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