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Seema A. Khan
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Journal Articles

Abstract 6339: Reprogramming SREBP1-dependent metabolism and inflammation in high-risk breast with licochalcone A for the prevention of breast cancer

Free
Atieh Hajirahimkhan, Elizabeth T. Bartom, Xingyu Guo, Kyli Berkley, Ruohui Chen, Wonhwa Cho, Michael Avram, Susan E. Clare, Seema A. Khan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6339.
https://doi.org/10.1158/1538-7445.AM2025-6339
Published: 21 April 2025
View articletitled, Abstract 6339: Reprogramming SREBP1-dependent metabolism and inflammation in high-risk breast with licochalcone A for the prevention of breast cancer
Journal Articles

Abstract 5402: Metabolic shift towards the de novo serine pathway in non-transformed breast cells drives epigenetic plasticity, oxidative DNA damage, and pro-tumorigenic cChanges associated with aging

Free
Mariana Bustamante Eduardo, Gannon Cottone, Curtis McCloskey, Flavio Palma, Shiyu Liu, Maria Paula Zappia, Abul B.M.M.K. Islam, Elizaveta Benevolenskaya, Maxim Frolov, Jason Locasale, Marcelo Bonini, Rama Khokha, Navdeep Chandel, Seema A. Khan, Susan E. Clare
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5402.
https://doi.org/10.1158/1538-7445.AM2025-5402
Published: 21 April 2025
View articletitled, Abstract 5402: Metabolic shift towards the de novo serine pathway in non-transformed breast cells drives epigenetic plasticity, oxidative DNA damage, and pro-tumorigenic cChanges associated with aging
Journal Articles

Abstract 7306: Licochalcone A is an excellent candidate for preventing luminal and non-luminal breast cancers

Free
Atieh Hajirahimkhan, Elizabeth T. Bartom, Sriram Chandrasekaran, Ruohui Chen, Jeremy J. Johnson, Susan E. Clare, Seema A. Khan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7306.
https://doi.org/10.1158/1538-7445.AM2024-7306
Published: 22 March 2024
View articletitled, Abstract 7306: Licochalcone A is an excellent candidate for preventing luminal and non-luminal breast cancers
Journal Articles

Abstract 717: Title: Modulation of local cholesterol biosynthesis and response to oxidative stress in high-risk postmenopausal breast tissue with licochalcone A from licorice

Free
Atieh Hajirahimkhan, Elizabeth Bartom, Susan Clare, Seema A. Khan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 717.
https://doi.org/10.1158/1538-7445.AM2022-717
Published: 15 June 2022
View articletitled, Abstract 717: Title: Modulation of local cholesterol biosynthesis and response to oxidative stress in high-risk postmenopausal breast tissue with licochalcone A from licorice
Journal Articles

Abstract LB165: Preclinical evaluation of carnosic acid (CA) and rosemary extract standardized to 40% carnosic acid (RE40CA) for the prevention of invasive breast cancer

Free
Yan Hong, Aditi Rastogi, Aryamitra Banerjee, Brandon L. Plattner, Matthew Lindeblad, Alexander V. Lyubimov, Timothy Fields, Seema A. Khan, Altaf Mohammed, Jeremy J. Johnson, Fariba Behbod
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB165.
https://doi.org/10.1158/1538-7445.AM2022-LB165
Published: 15 June 2022
View articletitled, Abstract LB165: Preclinical evaluation of carnosic acid (CA) and rosemary extract standardized to 40% carnosic acid (RE40CA) for the prevention of invasive breast cancer
Journal Articles

Abstract P2-09-15: Frequency of germline mutations in breast cancer susceptibility genes among women under age 50 presenting with parity associated breast cancer

Free
Erica Wrubel, Saya Rene Dennis, Takahiro Tsukioki, Theresa Sciaraffa, Yuan Luo, Seema A Khan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-09-15.
https://doi.org/10.1158/1538-7445.SABCS21-P2-09-15
Published: 15 February 2022
View articletitled, Abstract P2-09-15: Frequency of germline mutations in breast cancer susceptibility genes among women under age 50 presenting with parity associated breast cancer
Journal Articles

Abstract P3-09-16: Validating alternative splicing events between bulk and scRNA sequencing data: A bioinformatic approach

Free
Gannon Cottone, Benjamin T Spike, Elnaz Mirzaei Mehrabad, Seema A Khan, Susan Clare
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-16.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-16
Published: 15 February 2022
View articletitled, Abstract P3-09-16: Validating alternative splicing events between bulk and scRNA sequencing data: A bioinformatic approach
Journal Articles

Abstract P2-11-03: Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology

Free
Omid Hosseini, Irene Helenowski, Oukseub Lee, Hui Zhang, Jun Wang, Luis Blanco, Seema A Khan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-11-03.
https://doi.org/10.1158/1538-7445.SABCS21-P2-11-03
Published: 15 February 2022
View articletitled, Abstract P2-11-03: Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology
Journal Articles

Abstract P3-13-03: Heterozygous BRCA1 mutation influences alternative splicing in human benign mammary organoids

Free
Oukseub Lee, Mi-Ran Choi, Gannon Cottone, Priyam Patel, Susan E Clare, Seema A. Khan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-13-03.
https://doi.org/10.1158/1538-7445.SABCS21-P3-13-03
Published: 15 February 2022
View articletitled, Abstract P3-13-03: Heterozygous BRCA1 mutation influences alternative splicing in human benign mammary organoids
Journal Articles

Abstract P1-11-01: Modulation of the high risk postmenopausal breast tissue genomic profiles with licorice and its bioactive compounds

Free
Atieh Hajirahimkhan, Shao-Nong Chen, Guido F Pauli, Elizabeth Bartom, Susan Clare, Seema A Khan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-11-01.
https://doi.org/10.1158/1538-7445.SABCS21-P1-11-01
Published: 15 February 2022
View articletitled, Abstract P1-11-01: Modulation of the high risk postmenopausal breast tissue genomic profiles with licorice and its bioactive compounds
Journal Articles

Abstract 2566: The potential role of licorice and its bioactive compounds in promoting a tumor preventive environment in the postmenopausal breast

Free
Atieh Hajirahimkhan, Caitlin Howell, Shao-Nong Chen, Susan E. Clare, Guido F. Pauli, Judy L. Bolton, Birgit M. Dietz, Seema A. Khan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2566.
https://doi.org/10.1158/1538-7445.AM2021-2566
Published: 01 July 2021
View articletitled, Abstract 2566: The potential role of licorice and its bioactive compounds in promoting a tumor preventive environment in the postmenopausal breast
Journal Articles

Abstract PS8-10: Inhibition of estrogen biosynthesis by hops, licorice species, and their bioactive compounds

Free
Atieh Hajirahimkhan, Caitlin Howell, Tareisha Dunlap, Shao-Nong Chen, Susan E. Clare, Guido F. Pauli, Judy L. Bolton, Birgit M. Dietz, Seema A. Khan
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS8-10.
https://doi.org/10.1158/1538-7445.SABCS20-PS8-10
Published: 15 February 2021
View articletitled, Abstract PS8-10: Inhibition of estrogen biosynthesis by hops, licorice species, and their bioactive compounds
Journal Articles

Abstract PS19-09: Alternative splicing events from progesterone exposure differ based on BRCA1 mutation status

Free
Gannon Cottone, Batzaya Davaadelger, Shivangi Yadav, J Julie Kim, Seema A. Khan, Susan Clare
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS19-09.
https://doi.org/10.1158/1538-7445.SABCS20-PS19-09
Published: 15 February 2021
View articletitled, Abstract PS19-09: Alternative splicing events from progesterone exposure differ based on BRCA1 mutation status
Journal Articles

Abstract PD11-08: Low dose endoxifen represses mouse mammary tumorigenesis: A preclinical study of monotherapy and combination with ulipristal acetate

Free
Oukseub Lee, Minhua Wang, Maarten C. Bosland, Omid Hosseini, Irene Helenowski, Seema A. Khan
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD11-08.
https://doi.org/10.1158/1538-7445.SABCS20-PD11-08
Published: 15 February 2021
View articletitled, Abstract PD11-08: Low dose endoxifen represses mouse mammary tumorigenesis: A preclinical study of monotherapy and combination with ulipristal acetate
Journal Articles

Abstract 1120: Randomized clinical trial of a flaxseed lignan in pre-menopausal women at high risk for development of breast cancer

Free
Carol J. Fabian, Seema A. Khan, Judy E. Garber, William C. Dooley, Lisa D. Yee, Carola M. Zalles, Trina Metheny, Teresa A. Phillips, Jinxiang Hu, Brian K. Petroff, Stephen D. Hursting, Bruce F. Kimler
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1120.
https://doi.org/10.1158/1538-7445.AM2020-1120
Published: 15 August 2020
View articletitled, Abstract 1120: Randomized clinical trial of a flaxseed lignan in pre-menopausal women at high risk for development of breast cancer
Journal Articles

Abstract OT3-09-02: A large-scale multicenter phase II study evaluating the protective effect of a tissue selective estrogen complex (TSEC) in women with newly diagnosed ductal carcinoma in situ (DCIS)

Free
Swati A. Kulkarni, Geoffrey Greene, Thea Tlsty, Luis Blanco, Judy Garber, Al George, Fred Rademaker, Seema A Khan, Nora Hansen, Kevin Bethke, Rebecca Aft, Julia Tchou
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT3-09-02.
https://doi.org/10.1158/1538-7445.SABCS19-OT3-09-02
Published: 15 February 2020
View articletitled, Abstract OT3-09-02: A large-scale multicenter phase II study evaluating the protective effect of a tissue selective estrogen complex (TSEC) in women with newly diagnosed ductal carcinoma in situ (DCIS)
Journal Articles

Abstract P1-12-01: Prevention of BRCA1-associated mammary cancers by selective progesterone receptor modulators (SPRM) in mice

Free
Oukseub Lee, Limin Sun, Maarten C. Bosland, Minhua Wang, Ali Shidfar, Omid Hosseini, Irene Helenowski, Susan E. Clare, Seema A. Khan
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-12-01.
https://doi.org/10.1158/1538-7445.SABCS19-P1-12-01
Published: 15 February 2020
View articletitled, Abstract P1-12-01: Prevention of BRCA1-associated mammary cancers by selective progesterone receptor modulators (SPRM) in mice
Journal Articles

Abstract 4964: Metabolically activated macrophages mediate obesity-driven TNBC progression

Free
Payal Tiwari, Ariane Blank, Chang Cui, Kelly Schoenfelt, Seema A. Khan, Marsha R. Rosner, Lev Becker
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4964.
https://doi.org/10.1158/1538-7445.AM2018-4964
Published: 01 July 2018
View articletitled, Abstract 4964: Metabolically activated macrophages mediate obesity-driven TNBC progression
Journal Articles

Abstract 1812: Mechanism of telapristone acetate (CDB4124) on progesterone receptor action in breast cancer cells

Free
Batzaya Davaadelger, Seema A. Khan, J Julie Kim
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1812.
https://doi.org/10.1158/1538-7445.AM2018-1812
Published: 01 July 2018
View articletitled, Abstract 1812: Mechanism of telapristone acetate (CDB4124) on progesterone receptor action in breast cancer cells
Journal Articles

Abstract A2-03: Hotspot mutation in breast benign biopsy associated with subsequent progression to malignant breast cancer

Free
Jun Wang, Gang Feng, Nadereh Jafari, Ali Shidfar, David Ivanicic, Megan E. Sullivan, Seema A. Khan
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-03.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-03
Published: 15 November 2015
View articletitled, Abstract A2-03: Hotspot mutation in breast benign biopsy associated with subsequent progression to malignant breast cancer