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Journal Articles

Abstract IA-08: Syndecan 1 is a therapeutic target for KRAS-driven pancreatic cancer

Mitsunobu Takeda, Zecheng Yang, Madeline S Theardy, Alexey Sorokin, Oluwadara Coker, Shuaitong Chen, Long T Vien, Laura Bover, Haoqiang Ying, Scott Kopetz, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): IA-08.
https://doi.org/10.1158/1538-7445.PANCREATIC24-IA-08
Published: 15 September 2024
View article titled, Abstract IA-08: Syndecan 1 is a therapeutic target for KRAS-driven pancreatic cancer
Journal Articles

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype

Vahid Bahrambeigi, Jaewon J. Lee, Vittorio Branchi, Kimal I. Rajapakshe, Zhichao Xu, Naishu Kui, Jason T. Henry, Wang Kun, Bret M. Stephens, Sarah Dhebat, Mark W. Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Scott Kopetz, Anirban Maitra, Paola A. Guerrero
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1719–1732.
https://doi.org/10.1158/0008-5472.CAN-23-4070
Published: 15 May 2024
View article titled, Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype
Open the PDF for Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype in another window
Includes: Supplementary data
Journal Articles

Abstract 7424: iStarTLS: Advanced detection and phenotyping of tertiary lymphoid structures

Kyung Serk Cho, Jiahui Jiang, Daiwei Zhang, Yunhe Liu, Jianfeng Chen, Rossana L. Segura, Xinmiao Yan, Guangsheng Pei, Luisa M. Soto, Yanshuo Chu, Ansam F. Sinjab, Cassian Yee, Scott Kopetz, Anirban Maitra, Andrew Futreal, Alexander Lazar, Amir A. Jazaeri, Humam Kadara, Jianjun Gao, Mingyao Li, Linghua Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7424.
https://doi.org/10.1158/1538-7445.AM2024-7424
Published: 22 March 2024
View article titled, Abstract 7424: iStarTLS: Advanced detection and phenotyping of tertiary lymphoid structures
Journal Articles

Abstract 7417: SpatialCS: A tool to effectively integrate histological annotations and spatial transcriptomics analysis

Yanshuo Chu, Kyung Serk Cho, Isha Khanduri, Tieling Zhou, Jiahui Jiang, Yunhe Liu, Xinmiao Yan, Guangsheng Pei, Yibo Dai, Yang Liu, Ruiping Wang, Akshaya S Jadhav, Sharia Hernandez, Humam Kadara, Luisa Maren Solis Soto, Scott Kopetz, Dipen Maheshbhai Maru, Linghua Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7417.
https://doi.org/10.1158/1538-7445.AM2024-7417
Published: 22 March 2024
View article titled, Abstract 7417: SpatialCS: A tool to effectively integrate histological annotations and spatial transcriptomics analysis
Journal Articles

Abstract 881: Cell-type-specific gene programs suggest immune and stromal drivers of relapse in colorectal cancer

Nicholas J. Hornstein, Mingshuang Wang, Abdelrahman Yousef, Saikat Chowdhury, Fadl Zeineddine, Mohammad Zeineddine, Mahmoud Yousef, Shuangjie You, Betul Gunes, David Menter, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 881.
https://doi.org/10.1158/1538-7445.AM2024-881
Published: 22 March 2024
View article titled, Abstract 881: Cell-type-specific gene programs suggest immune and stromal drivers of relapse in colorectal cancer
Journal Articles

Abstract 3280: ASCL2+ tumor cells modulate the response of colorectal cancer to MAPK targeting therapy

Oscar E. Villarreal, Hey Min Lee, Ha Tran, Annette Machado, Jumanah Alshenaifi, Chi Wut Wong, Olu Coker, Rosalba Minelli, Michael Peoples, Alejandro Hernandez Martinez, Natalie Fowlkes, Preeti Kanikarla, Kangyu Lin, Christopher Bristow, Andrea Viale, Joseph R. Marszalek, John Paul Shen, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3280.
https://doi.org/10.1158/1538-7445.AM2024-3280
Published: 22 March 2024
View article titled, Abstract 3280: ASCL2<sup>+</sup> tumor cells modulate the response of colorectal cancer to MAPK targeting therapy
Journal Articles

Abstract 1290: Racial and ethnic representation and disparities on clinical guideline panels in oncology

Jonathan M. Loree, Arvind Dasari, Mena Shaheed, Himanish Gothwal, Kulwinder Singh, Hewad Shaheed, Riya Mangal, Shivek Gothwal, Jason Willis, Michael J. Overman, Scott Kopetz, Kanwal Pratap Singh Raghav
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1290.
https://doi.org/10.1158/1538-7445.AM2024-1290
Published: 22 March 2024
View article titled, Abstract 1290: Racial and ethnic representation and disparities on clinical guideline panels in oncology
Journal Articles

Abstract 1168: Anti-CSF1R antibody monotherapy inhibits minimal residual disease in a novel immunocompetent murine colorectal cancer metastasis model

Alaa M. Mohamed, Kyung Serk Cho, Melinda Soeung, Amanda Anderson, Jumanah Alshenaifi, Ganiraju Manyam, Oscar Villareal, Jennifer Davis, Will Norton, Sisi Gao, Christopher Bristow, Federica Carbone, Stefania Napolitano, Oluwadara Coker, Isha Khanduri, Justin Huang, Dipen M. Maru, Mauro Di Pilato, Ryan Sun, Linghua Wang, David G. Menter, Giannicola Genovese, Giulio Draetta, Natalie Fowlkes, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1168.
https://doi.org/10.1158/1538-7445.AM2024-1168
Published: 22 March 2024
View article titled, Abstract 1168: Anti-CSF1R antibody monotherapy inhibits minimal residual disease in a novel immunocompetent murine colorectal cancer metastasis model
Journal Articles

Abstract 3815: Clinical efficacy and safety of HER2 targeted therapy in patients with metastatic colorectal cancer: A systematic review and meta-analysis

Oscar E. Villarreal, Lianchun Xiao, Joelle Allam, Alexey Sorokin, Ying Yuan, Scott Kopetz, Kanwal Pratap Raghav
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3815.
https://doi.org/10.1158/1538-7445.AM2024-3815
Published: 22 March 2024
View article titled, Abstract 3815: Clinical efficacy and safety of HER2 targeted therapy in patients with metastatic colorectal cancer: A systematic review and meta-analysis
Journal Articles

Abstract 5056: Molecular characterization of microsatellite stable (MSS) colorectal cancer (CRC) patients with a BRAF V600E mutation

Ymke van der Pol, Binyam Yilma, Van K. Morris, Calvin Chao, Michelle Harris, Justin Guinney, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5056.
https://doi.org/10.1158/1538-7445.AM2024-5056
Published: 22 March 2024
View article titled, Abstract 5056: Molecular characterization of microsatellite stable (MSS) colorectal cancer (CRC) patients with a BRAF V600E mutation
Journal Articles

Abstract 1937: YAP-TAZ-TEAD transcriptional program is a prominent driver of acquired resistance to KRASG12C-based therapies in patients with metastatic colorectal cancer

Oluwadara Coker, Alexey Sorokin, Neal Akhave, Kelsey Pan, Fengqin Gao, Zhensheng Liu, Preeti Kanikarla, HeyMin Lee, Oscar Villarreal, Jumanah Alshenaifi, Giulia Maddalena, Alaa Mohamed, Dionne Prescod, David Menter, Saikat Chowdury, Ryan Corcoran, Kunal Rai, David Hong, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1937.
https://doi.org/10.1158/1538-7445.AM2024-1937
Published: 22 March 2024
View article titled, Abstract 1937: YAP-TAZ-TEAD transcriptional program is a prominent driver of acquired resistance to KRAS<sup>G12C</sup>-based therapies in patients with metastatic colorectal cancer
Journal Articles

Abstract 1934: The PLK1 inhibitor, onvansertib, is active as monotherapy and in combination with cetuximab in RAS wild-type colorectal cancer patient-derived xenografts

Maya Ridinger, Preeti Kanikarla Marie, Fengqin Gao, Zhensheng Liu, Giulia Maddalena, David Menter, Alexey Sorokin, Tod Smeal, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1934.
https://doi.org/10.1158/1538-7445.AM2024-1934
Published: 22 March 2024
View article titled, Abstract 1934: The PLK1 inhibitor, onvansertib, is active as monotherapy and in combination with cetuximab in RAS wild-type colorectal cancer patient-derived xenografts
Journal Articles

Abstract 3241: Elevated H3K27 trimethylation mediates adaptation to DNA demethylation in BRAFV600E-mutated colorectal cancer

Hey Min Lee, Ajay Kumar Saw, Van Karlyle Morris, Anand Kamal Singh, Stefania Napolitano, Alexey Sorokin, Preeti Kanikarla Marie, Oluwadara Coker, Oscar Eduardo Villarreal, Nazanin Esmaeili Anvar, Kunal Rai, Scott Kopetz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3241.
https://doi.org/10.1158/1538-7445.AM2024-3241
Published: 22 March 2024
View article titled, Abstract 3241: Elevated H3K27 trimethylation mediates adaptation to DNA demethylation in BRAF<sup>V600E</sup>-mutated colorectal cancer
Journal Articles

Abstract 6623: Ala59 mutants of KRAS cooperate with Nf1 loss to enhance colon tumorigenesis

Christian William Johnson, Elizabeth M. Terrell, Josh Cook, Bing Shui, Eve O'Donoghue, Shannon Hull, Moon Hee Yang, Shikha Sheth, Rona Yaeger, Scott Kopetz, Deborah K. Morrison, Kevin Haigis
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6623.
https://doi.org/10.1158/1538-7445.AM2024-6623
Published: 22 March 2024
View article titled, Abstract 6623: Ala59 mutants of KRAS cooperate with Nf1 loss to enhance colon tumorigenesis
Journal Articles

Abstract 3321: KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models

David Hwa Peng, Antonio Tedeschi, Lorenz Herdeis, Otmar Schaaf, Fabio Savarese, Francesca Rocchetti, Johannes Popow, Heinrich J. Huber, Birgit Wilding, Matthias Treu, Julian Fuchs, Joachim Bröeker, Tobias Wunberg, Firoella Schischlik, Jesse Lipp, Mariah Williams, Vaness Chandler, Charles E. Deckard, Vandhana Ramamoorthy, Joseph R. Daniele, Scott Kopetz, Michael Kim, Don L. Gibbons, Christopher P. Vellano, Joseph R. Marszalek, TImothy P. Heffernan, Darryl McConnell, Mark Pearson, Norbert Kraut, Dorothea Rudolph
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3321.
https://doi.org/10.1158/1538-7445.AM2024-3321
Published: 22 March 2024
View article titled, Abstract 3321: KRAS<sup>multi</sup> inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS<sup>G12V</sup>-driven preclinical models
Journal Articles

Abstract 3317: KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications

Antonio Tedeschi, David H. Peng, Fiorella Schischlik, Lorenz Herdeis, Otmar Schaaf, Valeria Santoro, Daniel Gerlach, Fabio Savarese, Jesse Lipp, Christian Haslinger, Francesca Rocchetti, Johannes Popow, Heinrich J. Huber, Birgit Wilding, Matthias Treu, Julian Fuchs, Joachim Broeker, Tobias Wunber, Michael Gmachl, Klaus Rumpel, Matthew Rees, Melissa Ron, Jennifer Roth, Mariah Williams, Charles Deckard, Vandhana Ramamoorthy, Joseph R. Daniele, Jaffer A. Ajani, Funda Meric-Bernstam, Scott Kopetz, Michael Kim, Don L. Gibbons, Christopher P. Vellano, Joseph R. Marszalek, Timothy P. Heffernan, Darryl McConnell, Mark Pearson, Norbert Kraut, Dorothea Rudolph
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3317.
https://doi.org/10.1158/1538-7445.AM2024-3317
Published: 22 March 2024
View article titled, Abstract 3317: KRAS<sup>multi</sup> inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRAS<sup>G12V</sup> mutations and KRAS wild-type amplifications
Journal Articles

Abstract 1230: MTX-531, a first-in-class pan-PI3K inhibitor spares hyperinsulinemia yielding durable tumor regressions and resilience to adaptive resistance

Christopher E. Whitehead, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Rachel A. Mumby, June Chung, Jinju Li, Nathaniel Osher, Oluwadara Coker, Michelle Norris, Scott Kopetz, Veera Baladandayuthapani, Melinda Hollingshead, Sharad Verma, Judith S. Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1230.
https://doi.org/10.1158/1538-7445.AM2024-1230
Published: 22 March 2024
View article titled, Abstract 1230: MTX-531, a first-in-class pan-PI3K inhibitor spares hyperinsulinemia yielding durable tumor regressions and resilience to adaptive resistance
Journal Articles

Abstract 1250: Activating PIK3CA mutations and hedgehog signaling may confer resistance to KRAS inhibition in colorectal cancer

Saikat Chowdhury, Jibran Ahmed, Valsala Haridas, David S. Hong, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1250.
https://doi.org/10.1158/1538-7445.AM2024-1250
Published: 22 March 2024
View article titled, Abstract 1250: Activating <em>PIK3CA</em> mutations and hedgehog signaling may confer resistance to KRAS inhibition in colorectal cancer
Journal Articles

Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer

Mitsunobu Takeda, Alexey Sorokin, Madelaine Theardy, Oluwadara Coker, Scott Kopetz, Haoqiang Ying, Giulio Draetta, Ronald A. DePinho, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C096.
https://doi.org/10.1158/1538-7445.PANCA2023-C096
Published: 16 January 2024
View article titled, Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer
Journal Articles

Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer

Benny Johnson, Cara Haymaker, Van K. Morris, Arvind Dasari, Victoria Serpas Higbie, John Paul Shen, Christine Parseghian, Maria Pia Morelli, Ryan Huey, Michael S. Lee, Jason Willis, Kanwal P. Raghav, Ying Yuan, John Zebala, Ronald A. DePinho, Scott Kopetz, Michael Overman
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT118.
https://doi.org/10.1158/1538-7445.AM2023-CT118
Published: 14 April 2023
View article titled, Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive &amp; refractory<em>RAS-</em>mutated microsatellite stable (MSS) colorectal cancer