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Journal Articles

Abstract LB165: A novel PDX-based 2-stage screening platform can identify active drug combinations against KRAS-mutated colorectal cancer

Alexey Sorokin, Preeti Kanikarla Marie, Fengqin Gao, Zhensheng Liu, David Menter, Scott Kopetz
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB165.
https://doi.org/10.1158/1538-7445.AM2023-LB165
Published: 14 April 2023
View article titled, Abstract LB165: A novel PDX-based 2-stage screening platform can identify active drug combinations against KRAS-mutated colorectal cancer
Journal Articles

Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer

Benny Johnson, Cara Haymaker, Van K. Morris, Arvind Dasari, Victoria Serpas Higbie, John Paul Shen, Christine Parseghian, Maria Pia Morelli, Ryan Huey, Michael S. Lee, Jason Willis, Kanwal P. Raghav, Ying Yuan, John Zebala, Ronald A. DePinho, Scott Kopetz, Michael Overman
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT118.
https://doi.org/10.1158/1538-7445.AM2023-CT118
Published: 14 April 2023
View article titled, Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive &amp; refractory<em>RAS-</em>mutated microsatellite stable (MSS) colorectal cancer
Journal Articles

Abstract 183: Evaluating targeted therapy combination for refractory colorectal cancer using MicroOrganoSpheres (MOS)

Shengli Ding, Preeti Kanikarla Marie, Ray Zhang, Alan Bohn, Robert Moseley Moseley, Nicholas Baro, Dan Brown, Kelly Pittman, Marcin Paduch, David Hsu, Scott Kopetz, Xiling Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 183.
https://doi.org/10.1158/1538-7445.AM2023-183
Published: 04 April 2023
View article titled, Abstract 183: Evaluating targeted therapy combination for refractory colorectal cancer using MicroOrganoSpheres (MOS)
Journal Articles

Abstract 5486: Combining bromodomain and extraterminal (BET) protein inhibitor treatment with standard MAPK inhibitors improved MAPK signaling inhibition in colorectal cancer

Hey Min Lee, Alexey Sorokin, Preeti Kanikarla Marie, Saikat Chowdhury, Anand Singh, Amanda Anderson, Jumanah Yousef Alshenaifi, Funda Meric-Bernstam, Kunal Rai, Scott Kopetz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5486.
https://doi.org/10.1158/1538-7445.AM2023-5486
Published: 04 April 2023
View article titled, Abstract 5486: Combining bromodomain and extraterminal (BET) protein inhibitor treatment with standard MAPK inhibitors improved MAPK signaling inhibition in colorectal cancer
Journal Articles

Abstract 2454: Identification of colorectal cancer stem cells from single cell RNA sequencing

Kangyu Lin, Mohammad Zeineddine, Saikat Chowdhury, Nicholas Hornstein, Sendurai Mani, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2454.
https://doi.org/10.1158/1538-7445.AM2023-2454
Published: 04 April 2023
View article titled, Abstract 2454: Identification of colorectal cancer stem cells from single cell RNA sequencing
Journal Articles

Abstract 77: Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease

Alaa M. Mohamed, Melinda Soeung, Jumanah Alshenaifi, Natalie Fowlkes, Ganiraju Manyam, Jennifer Davis, Amanda Anderson, Will Norton, Angela K. Deem, Sisi Gao, Isha Khanduri, Christopher Bistow, Federica Carbone, Stefania Napolitano, Justin Huang, Dipen M. Maru, David G. Menter, Giulio F. Draetta, Giannicola Genovese, Scott Kopetz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 77.
https://doi.org/10.1158/1538-7445.AM2023-77
Published: 04 April 2023
View article titled, Abstract 77: Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease
Journal Articles

Abstract 4273: Integration with benchmark data of paired bulk and single-cell RNA sequencing data substantially improves the accuracy of bulk tissue deconvolution

Shuai Guo, Xuesen Cheng, Andrew Koval, Shuangxi Ji, Qingnan Liang, Yumei Li, Leah A. Owen, Ivana K. Kim, John Weinstein, Scott Kopetz, John Paul Shen, Margaret M. DeAngelis, Rui Chen, Wenyi Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4273.
https://doi.org/10.1158/1538-7445.AM2023-4273
Published: 04 April 2023
View article titled, Abstract 4273: Integration with benchmark data of paired bulk and single-cell RNA sequencing data substantially improves the accuracy of bulk tissue deconvolution
Journal Articles

Abstract 4272: Pan-cancer analysis of intra-tumor heterogeneity in 9,116 cancers using a novel regularized likelihood model

Yujie Jiang, Kaixian Yu, Matthew D. Montierth, Shuangxi Ji, Seung Jun Shin, Shuai Guo, Shaolong Cao, Yuxin Tang, Scott Kopetz, Pavlos Msaouel, Jennifer R. Wang, Marek Kimmel, Peter Van Loo, Hongtu Zhu, Wenyi Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4272.
https://doi.org/10.1158/1538-7445.AM2023-4272
Published: 04 April 2023
View article titled, Abstract 4272: Pan-cancer analysis of intra-tumor heterogeneity in 9,116 cancers using a novel regularized likelihood model
Journal Articles

Abstract B028: Changes in exosomal RNA expression associate with treatment response to BRAF + EGFR + PD-1 blockade in MSS, BRAFV600E colorectal cancer: A liquid biopsy approach

Van Karlyle Morris, Kimal I. Rajapakshe, Vahid Bahrambeigi, Christine M. Parsehgian, Benny Johnson, Kanwal P. Raghav, Arvind Dasari, Ryan W. Huey, Michael J. Overman, Jason Willis, Michael S. Lee, Robert A. Wolff, Bryan K. Kee, Phat Le, Paola A. Guerrero, Scott Kopetz, Anirban Maitra
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): B028.
https://doi.org/10.1158/1538-7445.CRC22-B028
Published: 01 December 2022
View article titled, Abstract B028: Changes in exosomal RNA expression associate with treatment response to BRAF + EGFR + PD-1 blockade in MSS, BRAF<sup>V600E</sup> colorectal cancer: A liquid biopsy approach
Journal Articles

Abstract PR005: Outcomes in colitis-associated metastatic colorectal cancer and intersection with early-onset and signet ring cell carcinoma

Oscar E. Villarreal, Fadl Zeineddine, Ray Chacko, Christine Parseghian, Benny Johnson, Jason Willis, Michael Lee, Van Karlyle Morris, Arvind Dasari, Kanwal Raghav, Michael Overman, Y. Nancy You, Yinghong Wang, Dipen Maru, John Paul Shen, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): PR005.
https://doi.org/10.1158/1538-7445.CRC22-PR005
Published: 01 December 2022
View article titled, Abstract PR005: Outcomes in colitis-associated metastatic colorectal cancer and intersection with early-onset and signet ring cell carcinoma
Journal Articles

Abstract PR013: Transcriptomic profiling of liquid biopsy in colorectal cancer

Vahid Bahrambeigi, Jaewon J. Lee, Kimal I. Rajapakshe, Bret M. Stephens, Jason T. Henry, Sarah Dhebat, Mark W. Hurd, Ryan Sun, Scott Kopetz, Anirban Maitra, Paola A. Guerrero
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): PR013.
https://doi.org/10.1158/1538-7445.CRC22-PR013
Published: 01 December 2022
View article titled, Abstract PR013: Transcriptomic profiling of liquid biopsy in colorectal cancer
Journal Articles

Abstract A023: Influence of pre-diagnosis obesity and post-diagnosis aspirin use on survival from stage IV colorectal cancer

Jennifer S. Davis, Janelle C. Chavez, Melissa Kok, Yazmin San Miguel, Hwa Young Lee, Henry Henderson, Michael J. Overman, Van Karlyle Morris, Bryan Kee, David Fogelman, Shailesh M. Advani, Benny Johnson, Christine Parseghian, John Paul Shen, Arvind Dasari, Kenna R. Shaw, Eduardo Vilar, Kanwal P. Raghav, Imad Shureiqi, Robert A. Wolff, Funda Meric-Bernstam, Dipen Maru, David G. Menter, Scott Kopetz, Shine Chang
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): A023.
https://doi.org/10.1158/1538-7445.CRC22-A023
Published: 01 December 2022
View article titled, Abstract A023: Influence of pre-diagnosis obesity and post-diagnosis aspirin use on survival from stage IV colorectal cancer
Journal Articles

Abstract B027: Circulating tumor DNA in colorectal carcinomatosis: Detection and prognostic value

Abhineet Uppal, Michael G. White, George J. Chang, Scott Kopetz, John Paul Y. C. Shen
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): B027.
https://doi.org/10.1158/1538-7445.CRC22-B027
Published: 01 December 2022
View article titled, Abstract B027: Circulating tumor DNA in colorectal carcinomatosis: Detection and prognostic value
Journal Articles

Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6

Alexey V. Sorokin, Preeti Kanikarla Marie, Lea Bitner, Muddassir Syed, Melanie Woods, Ganiraju Manyam, Lawrence N. Kwong, Benny Johnson, Van K. Morris, Philip Jones, David G. Menter, Michael S. Lee, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (18): 3335–3344.
https://doi.org/10.1158/0008-5472.CAN-22-0198
Published: 16 September 2022
View article titled, Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6
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Includes: Supplementary data
Journal Articles

Abstract CT570: KISIMA-01: A first-in-human trial of the heterologous prime-boost vaccine ATP128/VSV-GP128 with ezabenlimab (BI 754091) in patients with stage IV colorectal cancer

Heinz-Josef Lenz, Thibaud Koessler, Paul Oberstein, Eric Van Cutsem, Sunnie Kim, Ralph Fritsch, Hans Prenen, Michael Morse, Delphine Gani, Madiha Derouazi, Thomas Bogenrieder, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT570.
https://doi.org/10.1158/1538-7445.AM2022-CT570
Published: 15 June 2022
View article titled, Abstract CT570: KISIMA-01: A first-in-human trial of the heterologous prime-boost vaccine ATP128/VSV-GP128 with ezabenlimab (BI 754091) in patients with stage IV colorectal cancer
Journal Articles

Abstract 2285: Co-expressed gene networks in CRC CMS1 subtype

Sha'Kayla K. Nunez, Corey D. Young, Ti'ara L. Griffen, Scott Kopetz, James W. Lillard
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2285.
https://doi.org/10.1158/1538-7445.AM2022-2285
Published: 15 June 2022
View article titled, Abstract 2285: Co-expressed gene networks in CRC CMS1 subtype
Journal Articles

Abstract 3275: Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies

Hey Min Lee, Stefania Napolitano, Alexy Sorokin, Melanie N. Woods, Saikat Chowdhury, Jumanah Y. Alshenaifi, Anand K. Singh, John Paul Shen, Funda Meric-Bernstam, Kunal Rai, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3275.
https://doi.org/10.1158/1538-7445.AM2022-3275
Published: 15 June 2022
View article titled, Abstract 3275: Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies
Journal Articles

Abstract 5152: Mutation-agnostic detection of colorectal cancer-specific cell-free DNA using targeted methylation sequencing

Mohamed A. Gouda, Dzifa Y. Duose, Morten Lapin, Stephanie Zalles, Helen J. Huang, Yuanxin Xi, Xiaofeng Zheng, Amira I. Aldesoky, Alshimaa M. Alhanafy, Mohamed A. Shehata, Jing Wang, Scott Kopetz, Funda Meric-Bernstam, Ignacio I. Wistuba, Rajyalakshmi Luthra, Filip Janku
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5152.
https://doi.org/10.1158/1538-7445.AM2022-5152
Published: 15 June 2022
View article titled, Abstract 5152: Mutation-agnostic detection of colorectal cancer-specific cell-free DNA using targeted methylation sequencing
Journal Articles

Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation

Irene C. Waizenegger, Hengyu Lu, Claus Thamer, Fabio Savarese, Daniel Gerlach, Dorothea Rudolph, Christopher P. Vellano, Marcelo Marotti, John Heymach, Scott Kopetz, Timothy P. Heffernan, Joseph R. Marszalek, Mark P. Petronczki, Marco H. Hofmann, Norbert Kraut
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2667.
https://doi.org/10.1158/1538-7445.AM2022-2667
Published: 15 June 2022
View article titled, Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRAS<sup>G12C</sup> inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRAS<sup>G12C</sup> mutation
Journal Articles

Abstract 1246: Consensus molecular subtypes (CMS) of colorectal cancer predict anti-EGFR response irrespective of tumor sidedness

Saikat Chowdhury, Ria Gupta, Valsala Haridas, Mohammad A. Zeineddine, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1246.
https://doi.org/10.1158/1538-7445.AM2022-1246
Published: 15 June 2022
View article titled, Abstract 1246: Consensus molecular subtypes (CMS) of colorectal cancer predict anti-EGFR response irrespective of tumor sidedness