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Journal Articles

Targeting RAS mutant colorectal cancer with dual inhibition of MEK and CDK4/6

Alexey V. Sorokin, Preeti Kanikarla Marie, Lea Bitner, Muddassir Syed, Melanie Woods, Ganiraju Manyam, Lawrence N. Kwong, Benny Johnson, Van K. Morris, Philip Jones, David G. Menter, Michael S. Lee, Scott Kopetz
Journal: Cancer Research
Cancer Res CAN-22-0198.
DOI: https://doi.org/10.1158/0008-5472.CAN-22-0198
Published: 01 August 2022
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Includes: Supplementary data
Journal Articles

Abstract 694: E-slice: A novel 3D culture platform for precision medicine

Archana Gopalan, Thomas D. Gallup, Stephanie Wood, Jose Maldonado, Corina Margain, Nestor F. Esnaola, Min P. Kim, E. Scott Kopetz, Kyuson Yun
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 694.
DOI: https://doi.org/10.1158/1538-7445.AM2022-694
Published: 15 June 2022
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Journal Articles

Abstract LB119: Precision combination therapies based on recurrent oncogenic co-alterations

Anil Korkut, Xubin Li, Elizabeth Kong, Gonghong Yan, Zeynep Dereli, Behnaz Bozorgui, Parisa Imanirad, Jacob Elnaggar, Augustin Luna, David Menter, Patrick Pilié, Timothy Yap, Scott Kopetz, Chris Sander
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB119.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB119
Published: 15 June 2022
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Journal Articles

Abstract CT570: KISIMA-01: A first-in-human trial of the heterologous prime-boost vaccine ATP128/VSV-GP128 with ezabenlimab (BI 754091) in patients with stage IV colorectal cancer

Heinz-Josef Lenz, Thibaud Koessler, Paul Oberstein, Eric Van Cutsem, Sunnie Kim, Ralph Fritsch, Hans Prenen, Michael Morse, Delphine Gani, Madiha Derouazi, Thomas Bogenrieder, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT570.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT570
Published: 15 June 2022
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Journal Articles

Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation

Irene C. Waizenegger, Hengyu Lu, Claus Thamer, Fabio Savarese, Daniel Gerlach, Dorothea Rudolph, Christopher P. Vellano, Marcelo Marotti, John Heymach, Scott Kopetz, Timothy P. Heffernan, Joseph R. Marszalek, Mark P. Petronczki, Marco H. Hofmann, Norbert Kraut
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2667.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2667
Published: 15 June 2022
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Journal Articles

Abstract 1246: Consensus molecular subtypes (CMS) of colorectal cancer predict anti-EGFR response irrespective of tumor sidedness

Saikat Chowdhury, Ria Gupta, Valsala Haridas, Mohammad A. Zeineddine, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1246.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1246
Published: 15 June 2022
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Journal Articles

Abstract 5152: Mutation-agnostic detection of colorectal cancer-specific cell-free DNA using targeted methylation sequencing

Mohamed A. Gouda, Dzifa Y. Duose, Morten Lapin, Stephanie Zalles, Helen J. Huang, Yuanxin Xi, Xiaofeng Zheng, Amira I. Aldesoky, Alshimaa M. Alhanafy, Mohamed A. Shehata, Jing Wang, Scott Kopetz, Funda Meric-Bernstam, Ignacio I. Wistuba, Rajyalakshmi Luthra, Filip Janku
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5152.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5152
Published: 15 June 2022
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Journal Articles

Abstract CT507: ATP128 vaccine with ezabenlimab promotes antigen-specific immune responses in stage IV colorectal cancer in the KISIMA-01 phase 1b trial

Heinz-Josef Lenz, Hanz Prenen, Eric Van Cutsem, Thibaud Kössler, Jean-François Mayol, Francesca Trapani, Matthieu Tihy, Laura Rubbia-Brandt, Christian Toso, Thomas Bogenrieder, Elodie Belnoue, Madiha Derouazi, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT507.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT507
Published: 15 June 2022
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Journal Articles

Abstract 3275: Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies

Hey Min Lee, Stefania Napolitano, Alexy Sorokin, Melanie N. Woods, Saikat Chowdhury, Jumanah Y. Alshenaifi, Anand K. Singh, John Paul Shen, Funda Meric-Bernstam, Kunal Rai, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3275.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3275
Published: 15 June 2022
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Journal Articles

Abstract 2285: Co-expressed gene networks in CRC CMS1 subtype

Sha'Kayla K. Nunez, Corey D. Young, Ti'ara L. Griffen, Scott Kopetz, James W. Lillard
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2285.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2285
Published: 15 June 2022
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Journal Articles

Abstract 1210: Resolving clonal substructure from single cell genomic data in primary and metastatic tumors using CopyKit

Darlan Conterno Minussi, Junke Wang, Aislyn Schalck, Yun Yan, Hua-Jun Wu, Cheng Peng, Min Hu, Emi Sei, Mary Edgerton, Hui Chen, Alejandro Contreras, David Hui, Senthil Damodaran, Scott Kopetz, Bora Lim, Nicholas Navin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1210.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1210
Published: 15 June 2022
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Journal Articles

Abstract 2909: Tumor microbiota profiles are associated with molecular subtype and survival in colorectal cancer patients

Fangyu Li, Michael G. White, Jennifer Davis, Kristi L. Hoffman, David Menter, Nadim Ajami, Xiaotao Zhang, Jeffrey S. Morris, Robert R. Jenq, Joseph Petrosino, Jennifer A. Wargo, Scott Kopetz, Carrie R. Daniel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2909.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2909
Published: 01 July 2021
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Journal Articles

Abstract LB264: Oncogenic KRASG12C dependency in colorectal cancer

Oluwadara Coker, Alexey Sorokin, Kelly Gale, Fengqin Gao, John Paul Shen, Lawrence Kwong, Ji Wu, Hey Min Lee, Melanie Woods, Oscar Villareal, Scott Kopetz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB264.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB264
Published: 01 July 2021
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Journal Articles

Abstract LB223: Beans to Enrich the Gut microbiome vs. Obesity's Negative Effects: First results from the BE GONE Trial in high-risk colorectal patients

Xiaotao Zhang, Kristi L. Hoffman, Fangyu Li, Ehsan Irajizad, Gladys Browman, Karen Basen-Engquist, Samir Hanash, Paul Scheet, Pablo C. Okhuysen, Scott Kopetz, Joseph Petrosino, Carrie R. Daniel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB223.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB223
Published: 01 July 2021
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Journal Articles

Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone

Jennifer Sarah Davis, Preeti Kanikarla, Patrick L. Yu, Mihai Gagea, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M. Lichtenberger, David Menter, Scott Kopetz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1.
DOI: https://doi.org/10.1158/1538-7445.AM2020-1
Published: 15 August 2020
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Journal Articles

Abstract 3172: Evaluation of cytotoxic T cell infiltration and clinical benefit from PD-L1 checkpoint inhibition among PIK3CA mutant microsatellite stable (MSS) metastatic adenocarcinoma patients

Maliha Nusrat, Coya Tapia, S. Greg Call, David S. Hong, Sarina A. Piha-Paul, Vivek Subbiah, Jordi Rodon, Apostolia M. Tsimberidou, Abha Adat, Yan Wang, Funda Meric-Bernstam, Michael J. Overman, Scott Kopetz, Filip Janku
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3172.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3172
Published: 15 August 2020
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Journal Articles

Abstract NG14: Proteome instability is an immunogenic therapeutic vulnerability in mismatch repair deficient cancer

Nidhi Sahni, Daniel J. McGrail, Jeannine Garnett, Jun Yin, Hui Dai, David J. H. Shih, Guang Peng, David Menter, Melinda S. Yates, Scott Kopetz, Karen Lu, Russell Broaddus, Gordon B. Mills, Shiaw Y. Lin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG14.
DOI: https://doi.org/10.1158/1538-7445.AM2020-NG14
Published: 15 August 2020
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Journal Articles

Abstract 808: Analysis of 1151 prospective research biopsies: Factors influencing tumor yield across patients and biopsy cores

Deepak Bhamidipati, Anuj Verma, Dipen M. Maru, Dawen Sui, Grace Mathew, Wenhua Lang, Juan F. Posadas, Joshua P. Hein, Scott Kopetz, Andrew Futreal, Ignacio I. Wistuba, J. Jack Lee, Michael J. Overman, Alda L. Tam
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 808.
DOI: https://doi.org/10.1158/1538-7445.AM2020-808
Published: 15 August 2020
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Journal Articles

Abstract CT061: Binimetinib in patients with tumors with NRAS mutations: NCI-MATCH ECOG-ACRIN Cancer Research Group subprotocol EAY131-Z1A

James M. Cleary, Victoria Wang, Rebecca Heist, Scott Kopetz, Edith P. Mitchell, James Zwiebel, Helen X. Chen, Shuli Li, Robert Gray, Lisa McShane, Larry Rubinstein, David Patton, Funda Meric-Bernstam, Melissa Dillmon, Mickey Williams, Stanley Hamilton, Barbara Conley, Peter O'Dwyer, Lyndsay Harris, Carlos Arteaga, Alice Chen, Keith Flaherty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT061.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT061
Published: 15 August 2020
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Journal Articles

Abstract B06: A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries

Omkara Veeranki, Zhimin Tong, Alicia Mejia, Anuj Verma, Riham Katkhuda, Roland Bassett, Tae Kim, Jing Wang, Wenhua Lang, Barbara Mino, Luisa Solis, Charles Kingsley, William Norton, Ramesh Tailor, Ji Wu, Sunil Krishnan, Steven Lin, Mariela Blum, Wayne Hofstetter, Jaffer Ajani, Scott Kopetz, Dipen Maru
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B06.
DOI: https://doi.org/10.1158/1538-7445.CAMODELS2020-B06
Published: 02 June 2020
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