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Journal Articles

Abstract 663: A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response

Andrei V. Bakin, Ashley Guo, Priyanka Rajan, Mohammed Alruwaili, Joseph Barbi, Scott I. Abrams, Thomas Melendy, Christos Fountzilas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 663.
https://doi.org/10.1158/1538-7445.AM2025-663
Published: 21 April 2025
View articletitled, Abstract 663: A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response
Journal Articles

Abstract 2283: Ancestral and genetic determinants of pathologic tumor infiltrating lymphocytes in a large multi-ethnic population of women with breast cancer

Peter N. Fiorica, Lucas Mendicino, Li Yan, Angela R. Omilian, Elisa V. Bandera, Scott I. Abrams, Lawrence H. Kushi, Thaer Khoury, Christine B. Ambrosone, Song Yao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2283.
https://doi.org/10.1158/1538-7445.AM2025-2283
Published: 21 April 2025
View articletitled, Abstract 2283: Ancestral and genetic determinants of pathologic tumor infiltrating lymphocytes in a large multi-ethnic population of women with breast cancer
Journal Articles

Abstract PR006: Arginine dependent immuno-metabolic reprogramming by metabolic enzyme PFKFB4 underpins breast tumor immune tolerance

Tao Dai, Alphonse N. Dimeck, Hai Wang, Song Liu, Scott I. Abrams, Subhamoy Dasgupta
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): PR006.
https://doi.org/10.1158/1538-7445.TUMBODY-PR006
Published: 17 November 2024
View articletitled, Abstract PR006: Arginine dependent immuno-metabolic reprogramming by metabolic enzyme PFKFB4 underpins breast tumor immune tolerance
Journal Articles

Abstract 2119: KRAS and fungi cooperate to drive IL33 secretion and type 2 immunity in the pancreatic cancer tumor microenvironment

Aftab Alam, Eric Levanduski, Maulasri Bhatta, Sharon Senchanthisai, Sheila Jani Sait, Jianmin Wang, Scott I. Abrams I. Abrams, Prasenjit Dey
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2119.
https://doi.org/10.1158/1538-7445.AM2022-2119
Published: 15 June 2022
View articletitled, Abstract 2119: KRAS and fungi cooperate to drive IL33 secretion and type 2 immunity in the pancreatic cancer tumor microenvironment
Journal Articles

Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity

Craig M Brackett, Alyssa R Aldrich, Kellee F Greene, Bojidar Kandar, Jean Veith, Lyudmila G Burdelya, Scott I. Abrams, Andrei V Gudkov
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-04-02.
https://doi.org/10.1158/1538-7445.SABCS21-P4-04-02
Published: 15 February 2022
View articletitled, Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity
Journal Articles

Abstract LB182: Vaccination by liposomes and synthetic short peptide eradicated HPV-associated tumor

Xuedan He, Shiqi Zhou, Breandan Quinn, Dushyant Jahagirdar, Joaquin Ortega, Scott I. Abrams, Jonathan F. Lovell
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB182.
https://doi.org/10.1158/1538-7445.AM2021-LB182
Published: 01 July 2021
View articletitled, Abstract LB182: Vaccination by liposomes and synthetic short peptide eradicated HPV-associated tumor
Journal Articles

Abstract PO022: Metabolic and transcriptional adaptations under hypoxic stress promote breast cancer progression

Tao Dai, Aaron Novickis, Eriko Katsuta, Kazuaki Takabe, Scott I. Abrams, Subhamoy Dasgupta
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO022.
https://doi.org/10.1158/1538-7445.TME21-PO022
Published: 01 March 2021
View articletitled, Abstract PO022: Metabolic and transcriptional adaptations under hypoxic stress promote breast cancer progression
Journal Articles

Abstract 4968: Blockade of p38 kinase impedes the mobilization of myeloid populations that promote breast cancer metastasis

Justin Zonneville, Sean Colligan, Paul Wallace, Scott I. Abrams, Andrei V. Bakin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4968.
https://doi.org/10.1158/1538-7445.AM2020-4968
Published: 15 August 2020
View articletitled, Abstract 4968: Blockade of p38 kinase impedes the mobilization of myeloid populations that promote breast cancer metastasis
Journal Articles

Abstract P3-01-02: B2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Hemn Mohammadpour, Cameron R. MacDonald, Guanxi Qiao, Minhui Chen, Bowen Dong, Bonnie L. Hylander, Philip L. McCarthy, Scott I. Abrams, Elizabeth A. Repasky
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-01-02.
https://doi.org/10.1158/1538-7445.SABCS19-P3-01-02
Published: 15 February 2020
View articletitled, Abstract P3-01-02: B2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells
Journal Articles

Abstract 3226: The IRF8-osteopontin-CD44 axis functions as an immune checkpoint to control CD8+ T cell activation and tumor immune evasion

John D. Klement, Amy V. Paschall, Priscilla S. Redd, Mohammed L. Ibrahim, Chunwan Lu, Dafeng Yang, Esteban Celis, Scott I. Abrams, Keiko Ozato, Kebin Liu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3226.
https://doi.org/10.1158/1538-7445.AM2019-3226
Published: 01 July 2019
View articletitled, Abstract 3226: The IRF8-osteopontin-CD44 axis functions as an immune checkpoint to control CD8+ T cell activation and tumor immune evasion
Journal Articles

Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity

Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1233.
https://doi.org/10.1158/1538-7445.AM2019-1233
Published: 01 July 2019
View articletitled, Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity
Journal Articles

Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice

Ayumi Hashimoto, Chan Gao, Jerome Mastio, Andrew Kossenkov, Scott I. Abrams, Ashok V. Purandare, Heshani Desilva, Susan Wee, John Hunt, Maria Jure-Kunkel, Dmitry I. Gabrilovich
Journal: Cancer Research
Cancer Res (2018) 78 (19): 5644–5655.
https://doi.org/10.1158/0008-5472.CAN-18-1229
Published: 01 October 2018
View articletitled, Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice
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Includes: Supplementary data
Journal Articles

β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

Mark J. Bucsek, Guanxi Qiao, Cameron R. MacDonald, Thejaswini Giridharan, Lauren Evans, Brian Niedzwecki, Haichao Liu, Kathleen M. Kokolus, Jason W.-L. Eng, Michelle N. Messmer, Kristopher Attwood, Scott I. Abrams, Bonnie L. Hylander, Elizabeth A. Repasky
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (20): 5639–5651.
https://doi.org/10.1158/0008-5472.CAN-17-0546
Published: 15 October 2017
View articletitled, β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy
Open the PDF for β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 3249: Regulation of interferon regulatory factor-8 (IRF8) during myelopoiesis is a critical checkpoint for the formation of defective myeloid cells in cancer

Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3249.
https://doi.org/10.1158/1538-7445.AM2016-3249
Published: 15 July 2016
View articletitled, Abstract 3249: Regulation of interferon regulatory factor-8 (IRF8) during myelopoiesis is a critical checkpoint for the formation of defective myeloid cells in cancer
Journal Articles

Host Immunosurveillance Controls Tumor Growth via IFN Regulatory Factor-8–Dependent Mechanisms

Kristy M. Greeneltch, Monika Schneider, Seth M. Steinberg, David J. Liewehr, Trina J. Stewart, Kebin Liu, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2007) 67 (21): 10406–10416.
https://doi.org/10.1158/0008-5472.CAN-07-1228
Published: 01 November 2007
View articletitled, Host Immunosurveillance Controls Tumor Growth via IFN Regulatory Factor-8–Dependent Mechanisms
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Journal Articles

Repression of IFN Regulatory Factor 8 by DNA Methylation Is a Molecular Determinant of Apoptotic Resistance and Metastatic Phenotype in Metastatic Tumor Cells

Dafeng Yang, Muthusamy Thangaraju, Kristy Greeneltch, Darren D. Browning, Patricia V. Schoenlein, Tomohiko Tamura, Keiko Ozato, Vadivel Ganapathy, Scott I. Abrams, Kebin Liu
Journal: Cancer Research
Cancer Res (2007) 67 (7): 3301–3309.
https://doi.org/10.1158/0008-5472.CAN-06-4068
Published: 04 April 2007
View articletitled, Repression of IFN Regulatory Factor 8 by DNA Methylation Is a Molecular Determinant of Apoptotic Resistance and Metastatic Phenotype in Metastatic Tumor Cells
Open the PDF for Repression of IFN Regulatory Factor 8 by DNA Methylation Is a Molecular Determinant of Apoptotic Resistance and Metastatic Phenotype in Metastatic Tumor Cells in another window
Journal Articles

Bortezomib and Depsipeptide Sensitize Tumors to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand: A Novel Method to Potentiate Natural Killer Cell Tumor Cytotoxicity

Andreas Lundqvist, Scott I. Abrams, David S. Schrump, Gauri Alvarez, Dante Suffredini, Maria Berg, Richard Childs
Journal: Cancer Research
Cancer Res (2006) 66 (14): 7317–7325.
https://doi.org/10.1158/0008-5472.CAN-06-0680
Published: 18 July 2006
View articletitled, Bortezomib and Depsipeptide Sensitize Tumors to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand: A Novel Method to Potentiate Natural Killer Cell Tumor Cytotoxicity
Open the PDF for Bortezomib and Depsipeptide Sensitize Tumors to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand: A Novel Method to Potentiate Natural Killer Cell Tumor Cytotoxicity in another window
Journal Articles

Tumor-specific T cell function diminishes as a consequence of disease progression, but can be enhanced to mediate therapeutic activity

Trina J. Stewart, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1117.
Published: 15 April 2006
View articletitled, Tumor-specific T cell function diminishes as a consequence of disease progression, but can be enhanced to mediate therapeutic activity
Journal Articles

Tumor-induced downregulation of interferon consensus sequence binding protein (ICSBP) in CD11b+Gr-1+ myeloid suppressor cells may underlie a mechanism for their aberrant expansion and function

Kristy M. Greeneltch, Trina J. Stewart, Monika Schneider, Kebin Liu, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 816.
Published: 15 April 2006
View articletitled, Tumor-induced downregulation of interferon consensus sequence binding protein (ICSBP) in CD11b+Gr-1+ myeloid suppressor cells may underlie a mechanism for their aberrant expansion and function
Journal Articles

Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-γ-Regulated Gene Expression

Kebin Liu, Sheila A. Caldwell, Scott I. Abrams
Journal: Cancer Research
Cancer Res (2005) 65 (10): 4376–4388.
https://doi.org/10.1158/0008-5472.CAN-04-4269
Published: 16 May 2005
View articletitled, Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-γ-Regulated Gene Expression
Open the PDF for Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-γ-Regulated Gene Expression in another window