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Scott E. Martin
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Journal Articles

Abstract PO-101: Transcriptional heterogeneity in lung adenocarcinoma reveals distinct therapeutic vulnerabilities

Anneleen Daemen, Jonathan E. Cooper, Szymon Myrta, Matthew J. Wongchenko, Eva Lin, Jason E. Long, Oded Foreman, Zora Modrusan, Jarrod Tremayne, Cecile C. de la Cruz, Mark Merchant, Scott E. Martin, Yibing Yan, Melissa R. Junttila
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-101.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-101
Published: 03 November 2020
View articletitled, Abstract PO-101: Transcriptional heterogeneity in lung adenocarcinoma reveals distinct therapeutic vulnerabilities
Journal Articles

A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells

Kenneth J. Finn, Scott E. Martin, Jeff Settleman
Journal: Cancer Research
Cancer Res (2020) 80 (1): 79–90.
https://doi.org/10.1158/0008-5472.CAN-19-0729
Published: 03 January 2020
View articletitled, A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells
Open the PDF for A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells in another window
Includes: Supplementary data
Journal Articles

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer

Steffan Vartanian, James Lee, Christiaan Klijn, Florian Gnad, Maria Bagniewska, Gabriele Schaefer, Donglu Zhang, Jenille Tan, Sara A. Watson, Liling Liu, Honglin Chen, Yuxin Liang, Colin Watanabe, Trinna Cuellar, David Kan, Ryan J. Hartmaier, Ted Lau, Michael R. Costa, Scott E. Martin, Mark Merchant, Benjamin Haley, David Stokoe
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4828–4839.
https://doi.org/10.1158/0008-5472.CAN-18-2086
Published: 01 October 2019
View articletitled, ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer
Open the PDF for ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-093: ERK mutations and amplification confer resistance to ERK-inhibitor therapy

Bijay S. Jaiswal, Steffen Durinck, Eric W. Stawiski, Jianping Yin, Weiru Wang, Eva Lin, John Moffat, Scott E. Martin, Zora Modrusan, Somasekar Seshagiri
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-093.
https://doi.org/10.1158/1538-7445.AM2018-LB-093
Published: 01 July 2018
View articletitled, Abstract LB-093: ERK mutations and amplification confer resistance to ERK-inhibitor therapy
Journal Articles

Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors

Ingrid Wertz, Lorna Kategaya, Paola Di Lello, Lionel Rouge, Richard Pastor, Kevin R. Clark, Jason Drummond, Tracy Kleinheinz, Eva Lin, John-Paul Upton, Sumit Prakash, Johanna Heideker, Mark McCleland, Maria Stella Ritorto, Dario R. Alessi, Matthias Trost, Travis W. Bainbridge, Michael C. Kwok, Taylur P. Ma, Zachary Stiffler, Bradley Brasher, Yinyan Tang, Priya Jaishanker, Brian Hearn, Adam R. Renslo, Michelle R. Arkin, Frederick Cohen, Kebing Yu, Frank Peale, Florian Gnad, Matthew T. Chang, Christiaan Klijn, Elizabeth Blackwood, Scott E. Martin, William F. Forrest, James A. Ernst, Chudi Ndubaku, Xiaojing Wang, Maureen H. Beresini, Vickie Tsui, Carsten Schwerdtfeger, Robert A. Blake, Jeremy Murray, Till Maurer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): SY23-03.
https://doi.org/10.1158/1538-7445.AM2018-SY23-03
Published: 01 July 2018
View articletitled, Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors
Journal Articles

Abstract 73: Exploring arrayed synthetic CRISPR for functional genomic screening

Jenille M. Tan, Scott E. Martin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 73.
https://doi.org/10.1158/1538-7445.AM2016-73
Published: 15 July 2016
View articletitled, Abstract 73: Exploring arrayed synthetic CRISPR for functional genomic screening
Journal Articles

Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma

Dominik Bogen, Jun S. Wei, David O. Azorsa, Pinar Ormanoglu, Eugen Buehler, Rajarshi Guha, Jonathan M. Keller, Lesley A. Mathews Griner, Marc Ferrer, Young K. Song, Hongling Liao, Arnulfo Mendoza, Berkley E. Gryder, Sivasish Sindri, Jianbin He, Xinyu Wen, Xinyu Wen, Shile Zhang, John F. Shern, Marielle E. Yohe, Sabine Taschner-Mandl, Jason Shohet, Craig J. Thomas, Scott E. Martin, Peter F. Ambros, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B31.
https://doi.org/10.1158/1538-7445.PEDCA15-B31
Published: 04 April 2016
View articletitled, Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma
Journal Articles

Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma

Patrick J. Grohar, Suntae Kim, Sara Haddock, Guillermo Rangel Rivera, Matt Harlow, Nichole K. Maloney, Konrad Huppi, Kristen Gehlhaus, Magdalena Grandin, Carleen Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 479.
https://doi.org/10.1158/1538-7445.AM2015-479
Published: 01 August 2015
View articletitled, Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma
Journal Articles

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D. Pfister, Philip M. Reaper, Christopher S. Barnes, Julie Jones, Peter Charlton, John R. Pollard, Joel Morris, James H. Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2014) 74 (23): 6968–6979.
https://doi.org/10.1158/0008-5472.CAN-13-3369
Published: 30 November 2014
View articletitled, ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Open the PDF for ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses in another window
Includes: Supplementary data
Journal Articles

Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1

Suntae Kim, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 520.
https://doi.org/10.1158/1538-7445.AM2014-520
Published: 01 October 2014
View articletitled, Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1
Journal Articles

Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation

Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas Pfister, Joel Morris, James H. Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 794.
https://doi.org/10.1158/1538-7445.AM2014-794
Published: 01 October 2014
View articletitled, Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation
Journal Articles

Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

Stéphanie Solier, Michael C. Ryan, Scott E. Martin, Sudhir Varma, Kurt W. Kohn, Hongfang Liu, Barry R. Zeeberg, Yves Pommier
Journal: Cancer Research
Cancer Res (2013) 73 (15): 4830–4839.
https://doi.org/10.1158/0008-5472.CAN-12-3504
Published: 31 July 2013
View articletitled, Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p
Open the PDF for Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p in another window
Includes: Supplementary data
Journal Articles

Abstract 4398: Synthetic lethal siRNA screening to identify novel combinational therapies with Topotecan in neuroblastoma.

Dominik Bogen, Eugen C. Buehler, Pinar Tuzmen, Rajesh Patidar, David Azorsa, Young K. Song, Hongling Liao, Catherine A. Tolman, Xinyu Wen, Jianbin N. He, Scott E. Martin, Jun S. Wei, Javed Khan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4398.
https://doi.org/10.1158/1538-7445.AM2013-4398
Published: 15 April 2013
View articletitled, Abstract 4398: Synthetic lethal siRNA screening to identify novel combinational therapies with Topotecan in neuroblastoma.
Journal Articles

Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells

Lynn M. Pouliot, Jennifer Bai, Matthew D. Hall, Scott E. Martin, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): B12.
https://doi.org/10.1158/1538-7445.NONRNA12-B12
Published: 03 April 2013
View articletitled, Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells
Journal Articles

Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family

Lynn M. Pouliot, Yu-Chi Chen, Jennifer Bai, Rajarshi Guha, Scott E. Martin, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2012) 72 (22): 5945–5955.
https://doi.org/10.1158/0008-5472.CAN-12-1400
Published: 14 November 2012
View articletitled, Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
Open the PDF for Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family in another window
Includes: Supplementary data
Journal Articles

A study of the organization of the mouse miRome with an analysis of the expression and functional roles of a cluster of miRNAs on mouse chromosome 15

Konrad Huppi, Brady Wahlberg, Natalia Volfovsky, Leigh-Ann Cruz, Ravi Patel, Scott E. Martin, Tamara L. Jones, Kristen Gehlhaus, Mark Mackiewicz, Robert Stephens, J. Frederic Mushinski, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5013.
Published: 01 May 2008
View articletitled, A study of the organization of the mouse miRome with an analysis of the expression and functional roles of a cluster of miRNAs on mouse chromosome 15
Journal Articles

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

Joseph A. Ludwig, Gergely Szakács, Scott E. Martin, Benjamin F. Chu, Carol Cardarelli, Zuben E. Sauna, Natasha J. Caplen, Henry M. Fales, Suresh V. Ambudkar, John N. Weinstein, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4808–4815.
https://doi.org/10.1158/0008-5472.CAN-05-3322
Published: 01 May 2006
View articletitled, Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer
Open the PDF for Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer in another window
Journal Articles

The study and application of RNAi against cancer-related genes.

Scott E. Martin, Tamara L. Jones, Cheryl L. Thomas, Dac Nguyen, Timothy Runfola, Gergely Szakacs, Michael M. Gottesman, Joseph A. Ludwig, John N. Weinstein, Michele Gunsior, Paul Goldsmith, Eric Lader, Konrad Huppi, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1319.
Published: 15 April 2006
View articletitled, The study and application of RNAi against cancer-related genes.
Journal Articles

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

Joseph A. Ludwig IV, Gergely Szakacs, Scott E. Martin, Natasha J. Caplen, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1274–1275.
Published: 15 April 2006
View articletitled, Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
Journal Articles

Asparagine synthetase as a biomarker for L-asparaginase activity in ovarian cancer

Philip L. Lorenzi, Cheryl L. Thomas, Michele Gunsior, Paul K. Goldsmith, Kimberly J. Bussey, Mark Raffeld, Uwe Scherf, William C. Reinhold, Scott E. Martin, Martina Rudelius, Daniel D. Von Hoff, Natasha J. Caplen, John N. Weinstein
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 735–736.
Published: 15 April 2006
View articletitled, Asparagine synthetase as a biomarker for L-asparaginase activity in ovarian cancer