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Scott E. Kern
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Journal Articles

Abstract 3580: Acetaldehyde and drug hypersensitivities of Fanconi anemia defects: Implications for cancer initiation, prevention, and therapy.

Soma Ghosh, Surojit Sur, Sashidhar R. Yerram, Carlo Rago, Anil K. Bhunia, M. Zulfiquer Hossain, Bogdan C. Paun, Yunzhao R. Ren, Christine A. Iacobuzio-Donahue, Nilofer A. Azad, Scott E. Kern
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3580.
https://doi.org/10.1158/1538-7445.AM2013-3580
Published: 15 April 2013
View article titled, Abstract 3580: Acetaldehyde and drug hypersensitivities of Fanconi anemia defects: Implications for cancer initiation, prevention, and therapy.
Journal Articles

Abstract 614: Biological clues to potent DNA-damaging activities in food and flavoring.

Mohammad Zulfiquer Hossain, Samuel F. Gilbert, Kalpesh Patel, Soma Ghosh, Anil K. Bhunia, Scott E. Kern
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 614.
https://doi.org/10.1158/1538-7445.AM2013-614
Published: 15 April 2013
View article titled, Abstract 614: Biological clues to potent DNA-damaging activities in food and flavoring.
Journal Articles

Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures

Scott E. Kern
Journal: Cancer Research
Cancer Res (2012) 72 (23): 6097–6101.
https://doi.org/10.1158/0008-5472.CAN-12-3232
Published: 29 November 2012
View article titled, Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures
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Includes: Supplementary data
Journal Articles

Abstract LB-353: Development of thymidylate synthase ternary complex-specific antibody: A new way to tailor 5-fluorouracil dosing

Kalpesh Patel, Sashidhar R. Yerram, Scott E. Kern
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-353.
https://doi.org/10.1158/1538-7445.AM2012-LB-353
Published: 15 April 2012
View article titled, Abstract LB-353: Development of thymidylate synthase ternary complex-specific antibody: A new way to tailor 5-fluorouracil dosing
Journal Articles

Limits to Thymidylate Synthase and TP53 Genes as Predictive Determinants for Fluoropyrimidine Sensitivity and Further Evidence for RNA-Based Toxicity as a Major Influence

Jonathan R. Brody, Tomas Hucl, Christina L. Costantino, James R. Eshleman, Eike Gallmeier, Heng Zhu, Michiel S. van der Heijden, Jordan M. Winter, Agnieszka K. Wikiewicz, Charles J. Yeo, Scott E. Kern
Journal: Cancer Research
Cancer Res (2009) 69 (3): 984–991.
https://doi.org/10.1158/0008-5472.CAN-08-3610
Published: 29 January 2009
View article titled, Limits to Thymidylate Synthase and <em>TP53</em> Genes as Predictive Determinants for Fluoropyrimidine Sensitivity and Further Evidence for RNA-Based Toxicity as a Major Influence
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Journal Articles

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

Tomas Hucl, Carlo Rago, Eike Gallmeier, Jonathan R. Brody, Myriam Gorospe, Scott E. Kern
Journal: Cancer Research
Cancer Res (2008) 68 (13): 5023–5030.
https://doi.org/10.1158/0008-5472.CAN-07-6189
Published: 01 July 2008
View article titled, A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to <em>BRCA2</em>
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Journal Articles

High Cancer-Specific Expression of Mesothelin (MSLN) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor–Dependent MCAT Motif

Tomas Hucl, Jonathan R. Brody, Eike Gallmeier, Christine A. Iacobuzio-Donahue, Iain K. Farrance, Scott E. Kern
Journal: Cancer Research
Cancer Res (2007) 67 (19): 9055–9065.
https://doi.org/10.1158/0008-5472.CAN-07-0474
Published: 01 October 2007
View article titled, High Cancer-Specific Expression of Mesothelin (<em>MSLN</em>) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor–Dependent MCAT Motif
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Journal Articles

The Fuzzy Math of Solid Tumor Stem Cells: A Perspective

Scott E. Kern, Darryl Shibata
Journal: Cancer Research
Cancer Res (2007) 67 (19): 8985–8988.
https://doi.org/10.1158/0008-5472.CAN-07-1971
Published: 01 October 2007
View article titled, The Fuzzy Math of Solid Tumor Stem Cells: A Perspective
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Journal Articles

High-Throughput Screening Identifies Novel Agents Eliciting Hypersensitivity in Fanconi Pathway–Deficient Cancer Cells

Eike Gallmeier, Tomas Hucl, Jonathan R. Brody, David A. Dezentje, Khola Tahir, Jana Kasparkova, Viktor Brabec, Kurtis E. Bachman, Scott E. Kern
Journal: Cancer Research
Cancer Res (2007) 67 (5): 2169–2177.
https://doi.org/10.1158/0008-5472.CAN-06-2711
Published: 01 March 2007
View article titled, High-Throughput Screening Identifies Novel Agents Eliciting Hypersensitivity in Fanconi Pathway–Deficient Cancer Cells
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Journal Articles

Genomic Copy Number Changes Affecting the Thymidylate Synthase (TYMS) Gene in Cancer: A Model for Patient Classification to Aid Fluoropyrimidine Therapy

Jonathan R. Brody, Tomas Hucl, Eike Gallmeier, Jordan M. Winter, Scott E. Kern, Kathleen M. Murphy
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9369–9373.
https://doi.org/10.1158/0008-5472.CAN-06-2165
Published: 03 October 2006
View article titled, Genomic Copy Number Changes Affecting the Thymidylate Synthase (<em>TYMS</em>) Gene in Cancer: A Model for Patient Classification to Aid Fluoropyrimidine Therapy
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Journal Articles

Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays

Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7920–7928.
https://doi.org/10.1158/0008-5472.CAN-06-0721
Published: 15 August 2006
View article titled, Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays
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Includes: Supplementary data
Journal Articles

Targeted Deletion of MKK4 in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss

Steven C. Cunningham, Eike Gallmeier, Tomas Hucl, David A. Dezentje, Eric S. Calhoun, Geppino Falco, Kotb Abdelmohsen, Myriam Gorospe, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5560–5564.
https://doi.org/10.1158/0008-5472.CAN-06-0555
Published: 01 June 2006
View article titled, Targeted Deletion of <em>MKK4</em> in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss
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Includes: Supplementary data
Journal Articles

Targeted disruption of FANCC and FANCG in human cancer cells provides a preclinical model of specific therapeutic options

Eike Gallmeier, Carlo Rago, Jonathan R. Brody, Tomas Hucl, Eric S. Calhoun, Steven C. Cunninghham, Kurtis E. Bachman, Christoph Lengauer, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 554.
Published: 15 April 2006
View article titled, Targeted disruption of <em>FANCC</em> and <em>FANCG</em> in human cancer cells provides a preclinical model of specific therapeutic options
Journal Articles

A clinical assay for 5-Fluorouracil targeting and metabolism

Jonathan R. Brody, Eike Gallmeier, Tomas Hucl, Kiyoshi Yoshimura, Richard D. Schulick, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 123.
Published: 15 April 2006
View article titled, A clinical assay for 5-Fluorouracil targeting and metabolism
Journal Articles

Large-Scale Allelotype of Pancreaticobiliary Carcinoma Provides Quantitative Estimates of Genome-Wide Allelic Loss

Christine A. Iacobuzio-Donahue, Michiel S. van der Heijden, Mark R. Baumgartner, William J. Troup, Jane M. Romm, Kimberly Doheny, Elizabeth Pugh, Charles J. Yeo, Michael G. Goggins, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2004) 64 (3): 871–875.
https://doi.org/10.1158/0008-5472.CAN-03-2756
Published: 10 February 2004
View article titled, Large-Scale Allelotype of Pancreaticobiliary Carcinoma Provides Quantitative Estimates of Genome-Wide Allelic Loss
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Journal Articles

Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas: A Comprehensive Characterization and Comparison of the Transcription Profiles Obtained from Three Major Technologies

Christine A. Iacobuzio-Donahue, Raheela Ashfaq, Anirban Maitra, N. Volkan Adsay, Grace L. Shen-Ong, Karin Berg, Michael A. Hollingsworth, John L. Cameron, Charles J. Yeo, Scott E. Kern, Michael Goggins, Ralph H. Hruban
Journal: Cancer Research
Cancer Res (2003) 63 (24): 8614–8622.
Published: 24 December 2003
View article titled, Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas: <subtitle>A Comprehensive Characterization and Comparison of the Transcription Profiles Obtained from Three Major Technologies</subtitle>
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Journal Articles

Reply

Michiel S. van der Heijden, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2003) 63 (20): 6999–7001.
Published: 28 October 2003
View article titled, Reply
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Journal Articles

Fanconi Anemia Gene Mutations in Young-onset Pancreatic Cancer

Michiel S. van der Heijden, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2003) 63 (10): 2585–2588.
Published: 15 May 2003
View article titled, Fanconi Anemia Gene Mutations in Young-onset Pancreatic Cancer
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Journal Articles

Evidence of Selection for Clones Having Genetic Inactivation of the Activin A Type II Receptor ( ACVR2 ) Gene in Gastrointestinal Cancers

Paula M. Hempen, Lin Zhang, Ravi K. Bansal, Christine A. Iacobuzio-Donahue, Kathleen M. Murphy, Anirban Maitra, Bert Vogelstein, Robert H. Whitehead, Sanford D. Markowitz, James K. V. Willson, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2003) 63 (5): 994–999.
Published: 01 March 2003
View article titled, Evidence of Selection for Clones Having Genetic Inactivation of the Activin A Type II Receptor ( <em>ACVR2</em> ) Gene in Gastrointestinal Cancers
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Journal Articles

The Desmoplastic Response to Infiltrating Breast Carcinoma: Gene Expression at the Site of Primary Invasion and Implications for Comparisons between Tumor Types

Christine A. Iacobuzio-Donahue, Pedram Argani, Paula M. Hempen, Jessa Jones, Scott E. Kern
Journal: Cancer Research
Cancer Res (2002) 62 (18): 5351–5357.
Published: 15 September 2002
View article titled, The Desmoplastic Response to Infiltrating Breast Carcinoma: <subtitle>Gene Expression at the Site of Primary Invasion and Implications for Comparisons between Tumor Types</subtitle>
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