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Scott B. Rothbart
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Journal Articles

Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yong Tao, Ray-Whay Chiu Yen, Hariharan Easwaran, Michael J. Topper, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 947.
https://doi.org/10.1158/1538-7445.AM2019-947
Published: 01 July 2019
View article titled, Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity
Journal Articles

Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers

Lindsey I. James, Jake I. Stuckey, Brandi M. Baughman, Michael T. Perfetti, Samantha G. Pattenden, Brad M. Dickson, Jacqueline L. Norris, Gaofeng Cui, Pavel Mader, Aiping Dong, Yunxiang Mu, Scott B. Rothbart, Brian D. Strahl, Jinrong Min, Peter J. Brown, Dmitri B. Kireev, William P. Janzen, Kevin M. McBride, Mark T. Bedford, Georges Mer, Cheryl H. Arrowsmith, Stephen V. Frye
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY08-03.
https://doi.org/10.1158/1538-7445.AM2015-SY08-03
Published: 01 August 2015
View article titled, Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers
Journal Articles

Abstract PR03: Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance

Scott B. Rothbart, Bradley M. Dickson, Michelle S. Ong, Krzysztof Krajewski, Scott Houliston, Dmitri B. Kireev, Cheryl H. Arrowsmith, Brian D. Strahl
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): PR03.
https://doi.org/10.1158/1538-7445.CEC13-PR03
Published: 13 May 2014
View article titled, Abstract PR03: Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance
Journal Articles

Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.”

Scott B. Rothbart, Stephen M. Fuchs, Nataliya Nady, Krzysztof Krajewski, Wolfram Tempel, Sheng Xue, Aimee N. Iberg, Dalia Barsyte-Lovejoy, Jorge Y. Martinez, Mark T. Bedford, Cheryl H. Arrowsmith, Brian D. Strahl
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 993.
https://doi.org/10.1158/1538-7445.AM2012-993
Published: 15 April 2012
View article titled, Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.”
Journal Articles

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

Scott B. Rothbart, Alexandra C. Racanelli, Richard G. Moran
Journal: Cancer Research
Cancer Res (2010) 70 (24): 10299–10309.
https://doi.org/10.1158/0008-5472.CAN-10-1873
Published: 14 December 2010
View article titled, Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas
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Journal Articles

Abstract 5086: Pemetrexed induces a strong activation of AMPK in human carcinoma cells, even in the absence of LKB1

Scott B. Rothbart, Alexandra C. Racanelli, Richard G. Moran
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5086.
https://doi.org/10.1158/1538-7445.AM10-5086
Published: 15 April 2010
View article titled, Abstract 5086: Pemetrexed induces a strong activation of AMPK in human carcinoma cells, even in the absence of LKB1
Journal Articles

Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition

Alexandra C. Racanelli, Scott B. Rothbart, Cortney L. Heyer, Richard G. Moran
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5467–5474.
https://doi.org/10.1158/0008-5472.CAN-08-4979
Published: 01 July 2009
View article titled, Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
Open the PDF for Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition in another window