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Saravanan Thiyagarajan
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Journal Articles

Abstract 3303: Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignancies

Saravanan Thiyagarajan, Chandrasekhar Abbineni, Krishna Chaitanya T, Achala Apte, Iram Khan Iqbal, Naveen Kumar R, Aravind A B, Avinash Kumar, Dabbeeru Madhu Babu, Shwetha Shwetha, Ankita Manna, Monalisha Mandal, Rituparna Panigrahi, Sivapriya Marappan, Suraj T Gore, Mohamad Fairus, Lim Yang Jin, Subhendu Mukherjee, Girish Daginakatte, Shekar Chelur, Kavitha Nellore, Murali Ramachandra, Susanta Samajdar
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3303.
https://doi.org/10.1158/1538-7445.AM2024-3303
Published: 22 March 2024
View article titled, Abstract 3303: Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignancies
Journal Articles

Abstract 6065: Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapy

Saravanan Thiyagarajan, Chandrasekhar Abbineni, Krishna Chaitanya T, Achala Apte, Iram Khan Iqbal, Naveen Kumar R, Aravind A B, Avinash Kumar, Girish A R, Aishwarya B Kamath, Deepak Dattatray Mane, Gouri Raj A, Reshma Reghu, Subhasmita Mohapatra, Sivapriya Marappan, Suraj T Gore, Subhendu Mukherjee, Girish Daginakatte, Kavitha Nellore, Shekar Chelur, Murali Ramachandra, Susanta Samajdar
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6065.
https://doi.org/10.1158/1538-7445.AM2024-6065
Published: 22 March 2024
View article titled, Abstract 6065: Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapy
Journal Articles

Abstract 4030: Generation of profound anti-tumor immunity by AUR-109, a spectrum-selective tyrosine kinase inhibitor, either as a single agent or in combination with immune checkpoint inhibitors

Girish Daginakatte, Saravanan Thiyagarajan, Kiran Aithal, Mamon Dey, Reshma Reghu, Monalisha Mandal, Kavitha Nellore, Susanta Samajdar, Murali Ramachandra
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4030.
https://doi.org/10.1158/1538-7445.AM2023-4030
Published: 04 April 2023
View article titled, Abstract 4030: Generation of profound anti-tumor immunity by AUR-109, a spectrum-selective tyrosine kinase inhibitor, either as a single agent or in combination with immune checkpoint inhibitors
Journal Articles

Abstract 4114: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers

Chandrasekhar Abbineni, Saravanan Thiyagarajan, Aravind A B, Amit A Dhudashiya, Sivapriya Marappan, Naveen Kumar R, Raghavendra N R, Mamon Dey, Avinash Kumar, Uma Bharathi B V, Girish Aggunda Renukappa, N Venkata Siva Reddy, Asha Babu, Aakanksha J Shetty, Amith A, Narasimha Rao K, Suraj T Gore, Mahaboobi Jaleel, Ramesh S Senaiar, Vijaya Shankar Nataraj, Subhendu Mukherjee, Samiulla D S, Thomas Antony, Girish Daginakatte, Rajesh Eswarappa, Kavitha Nellore, Shekar Chelur, Murali Ramachandra, Susanta Samajdar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4114.
https://doi.org/10.1158/1538-7445.AM2022-4114
Published: 15 June 2022
View article titled, Abstract 4114: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers
Journal Articles

Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers

Chandrasekhar Abbineni, Saravanan Thiyagarajan, Ramesh S Senaiar, Subhendu Mukherjee, Mahaboobi Jaleel, Sivapriya Marappan, Raghavendra N R, Girish Aggunda Renukappa, Aravind A B, Naveen Kumar R, Venkata Siva Reddy, Asha Babu, Akhila Srinivas, Prasad Yadlapalli, Suraj T Gore, Pathange Hemasankar, Mamon Dey, Samiulla D S, Chandranath D Naik, Thomas Antony, Kavitha Nellore, Shekar Chelur, Girish Daginakatte, Mikko Myllymäki, Gerd Wohlfahrt, Murali Ramachandra, Susanta Samajdar
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1143.
https://doi.org/10.1158/1538-7445.AM2021-1143
Published: 01 July 2021
View article titled, Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers
Journal Articles

Abstract 4064: Spatial re-distribution of natural killer cells targets drug resistance and anti-tumor response, ex-vivo

Munisha Smalley, Basava U. Shanthappa, Hans Gertje, Mark Lawson, Manjusha Biswas, Saravanan Thiyagarajan, Biswanath Majumder, D. C. Doval, Anurag Mehta, Neyaz Alam, Nabendu Murmu, S. P. Somashekhar, Aaron Goldman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4064.
https://doi.org/10.1158/1538-7445.AM2018-4064
Published: 01 July 2018
View article titled, Abstract 4064: Spatial re-distribution of natural killer cells targets drug resistance and anti-tumor response, <em>ex-vivo</em>
Journal Articles

Abstract 2835: Temporal sequencing of anticancer drugs, ex vivo, optimizes therapeutic effect by targeting drug-induced glucose-6-phosphate dehydrogenase

Baraneedharan Ulaganathan, Andrew Dhawan, Biswanath Majumder, Munisha Smalley, Saravanan Thiyagarajan, Gopinath S. Kodaganur, S Krishnamurthy, Mohammed Mamunur Rahman, Elizaveta Freinkman, Pradip Majumder, Mohammad Kohandel, Aaron Goldman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2835.
https://doi.org/10.1158/1538-7445.AM2018-2835
Published: 01 July 2018
View article titled, Abstract 2835: Temporal sequencing of anticancer drugs, <em>ex vivo</em>, optimizes therapeutic effect by targeting drug-induced glucose-6-phosphate dehydrogenase
Journal Articles

Abstract 3681: A patient derived ex vivo platform CANScript™ predicts distinct therapeutic outcomes to multiple PD-1 checkpoint inhibitors in single tumor biopsies

Padhma Radhakrishnan, Vasanthakumar Sekar, Nilesh Brijwani, Priyanka Chevour, Babu Balakrishnan, Dency D Pinto, Muthusami Oliyarasi, Debapriya G. Mehrotra, Manjusha Biswas, Sabitha K S, Kodaganur S. Gopinath, Arkasubhra Ghosh, M s Ganesh, Ashok M. Shenoy, Saravanan Thiyagarajan, Biswanath Majumder, Aaron Goldman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3681.
https://doi.org/10.1158/1538-7445.AM2017-3681
Published: 01 July 2017
View article titled, Abstract 3681: A patient derived <em>ex vivo</em> platform CANScript™ predicts distinct therapeutic outcomes to multiple PD-1 checkpoint inhibitors in single tumor biopsies
Journal Articles

Abstract 3397: Intrinsic factors from patient's tumor help neovascularization in an ex vivo platform

Baraneedharan Ulaganathan, Allen Thayakumar B, Manoj Rajappa, Ayyappan Velu, Arun Prasath, Kamal Ameer, Nilesh Brijwani, Padhma Radhakrishnan, Biswanath Majumder, Pradip K. Majumder, Saravanan Thiyagarajan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3397.
https://doi.org/10.1158/1538-7445.AM2016-3397
Published: 15 July 2016
View article titled, Abstract 3397: Intrinsic factors from patient's tumor help neovascularization in an ex vivo platform
Journal Articles

Abstract 5121: Immunomodulating cytokine profiling of docetaxel-treated human prostate cancer specimens

Debapriya G. Mehrotra, Nilesh Brijwani, Biplab Tewary, Vasathkumar Sekar, Abhishek Krishnan, Dency D. Pinto, Muthusamy Oliyarasi, Biswanath Majumder, Saravanan Thiyagarajan, Padhma Radhakrishnan, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5121.
https://doi.org/10.1158/1538-7445.AM2016-5121
Published: 15 July 2016
View article titled, Abstract 5121: Immunomodulating cytokine profiling of docetaxel-treated human prostate cancer specimens
Journal Articles

Abstract 1478: Development of novel Mi-HTX in vivo platform by reconstituting autologous immune components in patient tumor-derived xenografts

Saravanan Thiyagarajan, Padhma Radhakrishnan, Vinod D Radhakrishna, Dency D Pinto, Biswanath Majumder
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1478.
https://doi.org/10.1158/1538-7445.AM2015-1478
Published: 01 August 2015
View article titled, Abstract 1478: Development of novel Mi-HTX in vivo platform by reconstituting autologous immune components in patient tumor-derived xenografts
Journal Articles

Abstract 1304: Identification of responders for Anti-CTLA4 in refractory colorectal cancers using CANScript™ platform

Biswanath Majumder, Baraneedharan Ulaganathan, Allen Thayakumar, Saravanan Thiyagarajan, Nilesh Brijwani, Biplab Tewari, Basavaraja U. Santhappa, Padhma Radhakrishnan, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1304.
https://doi.org/10.1158/1538-7445.AM2015-1304
Published: 01 August 2015
View article titled, Abstract 1304: Identification of responders for Anti-CTLA4 in refractory colorectal cancers using CANScript™ platform
Journal Articles

Abstract 3736: Application of patient tumors-derived tumor ecosystem platform for the development of novel HDAC inhibitor in solid cancers

Mallikarjun Sundaram, Baraneedharan Ulaganathan, Muthu Dhandapani, Allen Thayakumar, Pragnashree Mukhopadhyay, Saravanan Thiyagarajan, Biswanath Majumder, Prasad Shivarudriah, H Jagadheshan, Ganesh Sambasivam, Steve Birnbuam, Padhma Radhakrishnan, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3736.
https://doi.org/10.1158/1538-7445.AM2014-3736
Published: 01 October 2014
View article titled, Abstract 3736: Application of patient tumors-derived tumor ecosystem platform for the development of novel HDAC inhibitor in solid cancers
Journal Articles

Abstract B45: The Twist box domain is required for Twist1-induced metastasis of prostate cancer cells

Rajendra Gajula, Sivarajan Chettiar, Russell Williams, Saravanan Thiyagarajan, Khaled Aziz, Nishant Gandhi, Aaron Wild, Tarek Salih, Yoshinori Kato, Jessica Cades, Elana Fertig, Christine Chung, Joseph Herman, Russell Hales, Charles Rudin, Steven An, Phuoc T. Tran
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): B45.
https://doi.org/10.1158/1538-7445.TIM2013-B45
Published: 01 May 2014
View article titled, Abstract B45: The Twist box domain is required for Twist1-induced metastasis of prostate cancer cells
Journal Articles

Abstract 2051: PAT-1102, a novel HDAC inhibitor exhibits potent anti-tumor efficacy in patient-derived refractory solid tumors.

Padhma Radhakrishnan, Muthu Dhandapani, Baraneedharan Ulaganathan, Allen Thayakumar, Saravanan Thiyagarajan, Dency Pinto, D R. Vinod, Biswanath Majumder, Prasad Shivarudriaah, H Jagadheshan, Ganesh Sambasivam, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2051.
https://doi.org/10.1158/1538-7445.AM2013-2051
Published: 15 April 2013
View article titled, Abstract 2051: PAT-1102, a novel HDAC inhibitor exhibits potent anti-tumor efficacy in patient-derived refractory solid tumors.
Journal Articles

Abstract 1493: The Twist box is required for Twist1-induced prostate cancer metastasis.

Rajendra P. Gajula, Sivarajan T. Chettiar, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Venu Raman, Joseph M. Herman, Russell K. Hales, Steven An, Phuoc T. Tran
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1493.
https://doi.org/10.1158/1538-7445.AM2013-1493
Published: 15 April 2013
View article titled, Abstract 1493: The Twist box is required for Twist1-induced prostate cancer metastasis.
Journal Articles

Abstract 4947: Inhibition of Rapamycin induced AKT activation elicits differential anti-tumor response in head and neck cancers.

Padhma Radhakrishnan, Ulaganathan Baraneedharan, Muthu Dhandapani, Allen Thyakumar, Dency Pinto, Arun Prasath, Ayyappan Velu, A Kamal, Nilesh Brijwani, Rohini Nair, R Basavaraja, Misti Jain, Saravanan Thiyagarajan, Biswanath Majumder, Mallik Sundaram, Prasad Narayanan, Vikram D. Kekatpure, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4947.
https://doi.org/10.1158/1538-7445.AM2013-4947
Published: 15 April 2013
View article titled, Abstract 4947: Inhibition of Rapamycin induced AKT activation elicits differential anti-tumor response in head and neck cancers.
Journal Articles

Abstract 5072: Human tumor derived Oncoprint® platform predicts molecular mechanism of sensitivity and resistance to Fragmin in pancreatic cancer.

Mallikarjun Sundaram, Saravanan Thiyagarajan, Muthu Dhandapani, Nilesh Brijwani, Arun Prasath, Allen Thayakumar, Ameer Kamal, Padhma Radhakrishnan, Biswanath Majumder, Baraneedharan Ulaganathan, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5072.
https://doi.org/10.1158/1538-7445.AM2013-5072
Published: 15 April 2013
View article titled, Abstract 5072: Human tumor derived Oncoprint<sup>®</sup> platform predicts molecular mechanism of sensitivity and resistance to Fragmin in pancreatic cancer.
Journal Articles

Inhibition of Rapamycin-Induced AKT Activation Elicits Differential Antitumor Response in Head and Neck Cancers

Padhma Radhakrishnan, Ulaganathan Baraneedharan, Subhadra Veluchamy, Muthu Dhandapani, Dency D. Pinto, Saravanan Thiyagarajan, Allen Thayakumar, Arun Prasath, Kamal A, Ayyappan Velu, Misti Jain, Nilesh Brijwani, Prasad Narayanan, Vikram D. Kekatpure, Biswanath Majumder, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1118–1127.
https://doi.org/10.1158/0008-5472.CAN-12-2545
Published: 31 January 2013
View article titled, Inhibition of Rapamycin-Induced AKT Activation Elicits Differential Antitumor Response in Head and Neck Cancers
Open the PDF for Inhibition of Rapamycin-Induced AKT Activation Elicits Differential Antitumor Response in Head and Neck Cancers in another window
Journal Articles

Abstract 3191: Primary human tumor-derived Oncoprint platform predicts molecular mechanism of sensitivity and resistance to anti-EGFR in colorectal cancer: A step towards personalized cancer medicine

Misti Jain, Farrah Zahed, Arun Prasath, Muthu Dhandapani, Subhadra Veluchamy, A Kamal, Padhma Radhakrishnan, Saravanan Thiyagarajan, Rajagopalan Surendran, Biswanath Mazumder, Mallik Sundaram, Pradip K. Majumder
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3191.
https://doi.org/10.1158/1538-7445.AM2012-3191
Published: 15 April 2012
View article titled, Abstract 3191: Primary human tumor-derived Oncoprint platform predicts molecular mechanism of sensitivity and resistance to anti-EGFR in colorectal cancer: A step towards personalized cancer medicine