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Sarat Chandarlapaty
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Journal Articles

Abstract 724: Target identification for antibody-drug-conjugate (ADC) therapy in biliary tract cancers (BTC)

Aruj Dhyani, Zeynep Tarcan, Joanne Chou, Rohit Thummalapalli, Walid Chatila, Sharanya Nag, Ezra Rosen, Sydney Bowker, Wungki Park, Elisa De Stanchina, Sarat Chandarlapaty, David Solit, William Jarnagin, Marinela Capanu, Eileen M O'Reilly, Ghassan K Abou-Alfa, Olca Basturk, James Harding
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 724.
https://doi.org/10.1158/1538-7445.AM2025-724
Published: 21 April 2025
View articletitled, Abstract 724: Target identification for antibody-drug-conjugate (ADC) therapy in biliary tract cancers (BTC)
Journal Articles

Abstract 432: Evolution of drug tolerance and resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancer

Justin Rendleman, Matthew Pressler, Joanna Yeung, Lauren Anderson, Arnold Ou, Junyue Cao, Andrew Koff, Sarat Chandarlapaty, Viviana Risca
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 432.
https://doi.org/10.1158/1538-7445.AM2025-432
Published: 21 April 2025
View articletitled, Abstract 432: Evolution of drug tolerance and resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancer
Journal Articles

A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms

Fresia Pareja, Higinio Dopeso, Yi Kan Wang, Andrea M. Gazzo, David N. Brown, Monami Banerjee, Pier Selenica, Jan H. Bernhard, Fatemeh Derakhshan, Edaise M. da Silva, Lorraine Colon-Cartagena, Thais Basili, Antonio Marra, Jillian Sue, Qiqi Ye, Arnaud Da Cruz Paula, Selma Yeni Yildirim, Xin Pei, Anton Safonov, Hunter Green, Kaitlyn Y. Gill, Yingjie Zhu, Matthew C.H. Lee, Ran A. Godrich, Adam Casson, Britta Weigelt, Nadeem Riaz, Hannah Y. Wen, Edi Brogi, Diana L. Mandelker, Matthew G. Hanna, Jeremy D. Kunz, Brandon Rothrock, Sarat Chandarlapaty, Christopher Kanan, Joe Oakley, David S. Klimstra, Thomas J. Fuchs, Jorge S. Reis-Filho
Journal: Cancer Research
Cancer Res (2024) 84 (20): 3478–3489.
https://doi.org/10.1158/0008-5472.CAN-24-1322
Published: 15 October 2024
View articletitled, A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms
Open the PDF for A Genomics-Driven Artificial Intelligence – Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms in another window
Includes: Supplementary data
Journal Articles

Abstract PO3-29-01: Defining the molecular-genetic mechanism of CDK4/6 inhibition therapy induced senescence to identify biomarkers and determine how senescence contributes to patient outcomes

Marimar Benitez, Rei Kudo, Caroline Gleason, Sarat Chandarlapaty, Andrew Koff
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-29-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-29-01
Published: 02 May 2024
View articletitled, Abstract PO3-29-01: Defining the molecular-genetic mechanism of CDK4/6 inhibition therapy induced senescence to identify biomarkers and determine how senescence contributes to patient outcomes
Journal Articles

Abstract GS03-06: Genomic and transcriptomic profiling of primary tumors from patients with HR+, HER2-, node-positive, high-risk early breast cancer in the monarchE trial

Nicholas Turner, Jorge Reis-Filho, Matthew Goetz, Christine Desmedt, Sarat Chandarlapaty, Hironobu Sasano, Carlos Arteaga, Sherene Loi, Stephanie Graff, Deli Liu, Vanessa Rodrik-Outmezguine, Anthony Sireci, Cynthia Sandoval Rubenstein, Helen Won, Lacey M. Litchfield, Maria Munoz, Stephen Johnston
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): GS03-06.
https://doi.org/10.1158/1538-7445.SABCS23-GS03-06
Published: 02 May 2024
View articletitled, Abstract GS03-06: Genomic and transcriptomic profiling of primary tumors from patients with HR+, HER2-, node-positive, high-risk early breast cancer in the monarchE trial
Journal Articles

Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics

Fresia Pareja, Higinio Dopeso, Yikan Wang, Andrea Gazzo, David Brown, Pier Selenica, Jan Bernhard, Fatemeh Derakhshan, Edaise M. da Silva, Lorraine Colon-Cartagena, Thais Basili, Antonio Marra, Jillian Sue, Qiqi Ye, Arnaud Da Cruz Paula, Selma Yeni, Xin Pei, Hunter Green, Kaitlyn Gill, Yingjie Zhu, Matthew Lee, Ran Godrich, Adam Casson, Britta Weigelt, Nadeem Riaz, Hanna Y Wen, Edi Brogi, Matthew Hanna, Diana Mandelker, Jeremy Kunz, Brandon Rothrock, Sarat Chandarlapaty, Christopher Kanan, Gerard Oakley III, David Klimstra, Thomas Fuchs, Jorge Reis-Filho
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): GS03-04.
https://doi.org/10.1158/1538-7445.SABCS23-GS03-04
Published: 02 May 2024
View articletitled, Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics
Journal Articles

Abstract PO5-16-01: Clinicogenomic analysis reveals genomic associations of brain metastatic tropism in breast cancer

Anton Safonov, Deborah Smith, Emanuela Ferraro, Junchao Shen, Ishaani Khatri, Rahul Kumar, Julia An, Mark Robson, Sarat Chandarlapaty, Adrienne Boire, Nikolaus Schultz, Nelson Moss, Luke Pike, Pedram Razavi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO5-16-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO5-16-01
Published: 02 May 2024
View articletitled, Abstract PO5-16-01: Clinicogenomic analysis reveals genomic associations of brain metastatic tropism in breast cancer
Journal Articles

Abstract PO3-29-03: An Emerging Class of ER mutations Enhances ER Dimerization and Promotes ER Activity

Seema Irani, Wuwei Tan, Qing Li, Weiyi Toy, Catherine Jones, Mayur Gadiya, Antonio Marra, John Katzenellenbogen, Kathryn Carlson, Benita S. Katzenellenbogen, Yang Shen, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-29-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-29-03
Published: 02 May 2024
View articletitled, Abstract PO3-29-03: An Emerging Class of ER mutations Enhances ER Dimerization and Promotes ER Activity
Journal Articles

Abstract PO3-04-07: Characterization of response to first-line chemotherapy, trastuzumab, and pertuzumab among patients with de novo metastatic HER2-positive breast cancer

Emanuela Ferraro, Atif Khan, George Plitas, Yuan Chen, Mehnaj Ahmed, Julia An, Chau Dang, Mark Robson, Sarat Chandarlapaty, Shanu Modi, Pedram Razavi, Sherry Shen
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-04-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-04-07
Published: 02 May 2024
View articletitled, Abstract PO3-04-07: Characterization of response to first-line chemotherapy, trastuzumab, and pertuzumab among patients with de novo metastatic HER2-positive breast cancer
Journal Articles

Abstract PS06-01: Results from a pilot study exploring ctDNA detection using a tumor-informed assay in the monarchE trial of adjuvant abemaciclib with endocrine therapy in HR+, HER2-, node-positive, high-risk early breast cancer

Sherene Loi, Stephen Johnston, Carlos Arteaga, Stephanie Graff, Sarat Chandarlapaty, Matthew Goetz, Christine Desmedt, Jorge Reis-Filho, Hironobu Sasano, Vanessa Rodrik-Outmezguine, Anthony Sireci, Cynthia Sandoval Rubenstein, Helen Won, Deli Liu, Lacey M. Litchfield, Nicholas Turner
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS06-01.
https://doi.org/10.1158/1538-7445.SABCS23-PS06-01
Published: 02 May 2024
View articletitled, Abstract PS06-01: Results from a pilot study exploring ctDNA detection using a tumor-informed assay in the monarchE trial of adjuvant abemaciclib with endocrine therapy in HR+, HER2-, node-positive, high-risk early breast cancer
Journal Articles

Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2

Rei Kudo, Anton Safonov, Edaise M. da Silva, Qing Li, Hong Shao, Marie Will, Harikrishna Nakshatri, Jorge Reis-Filho, Shom Goel, Andrew Koff, Britta Weigelt, Qamar Khan, Pedram Razavi, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS12-03.
https://doi.org/10.1158/1538-7445.SABCS23-PS12-03
Published: 02 May 2024
View articletitled, Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2
Journal Articles

Abstract PO5-15-05: Clinical and genomic landscape of ERBB2 and ERBB3 mutated breast cancer

Nadeem Bilani, Jacqueline Tao, Anton Safonov, Dana Casey, Joshua Drago, Mehnaj Ahmed, Barbara Acevedo, Komal Jhaveri, Jorge Reis-Filho, Mark Robson, Eneda Toska, Ariella Hanker, Carlos Arteaga, Sarat Chandarlapaty, Hanna Y Wen, Pedram Razavi
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO5-15-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO5-15-05
Published: 02 May 2024
View articletitled, Abstract PO5-15-05: Clinical and genomic landscape of ERBB2 and ERBB3 mutated breast cancer
Journal Articles

Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets

Fresia Pareja, Andrea Gazzo, Higinio Dopeso, David Brown, Pier Selenica, Yingjie Zhu, Juan Blanco-Heredia, Laxmi Gusain, Xin Pei, Giacomo Montagna, Nour Abuhadra, Hanna Y Wen, Edi Brogi, Nadeem Riaz, Sarat Chandarlapaty, Maurizio Scaltriti, Larry Norton, Simon Powell, Jorge Reis-Filho, Britta Weigelt
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-14-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-14-08
Published: 02 May 2024
View articletitled, Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets
Journal Articles

Abstract 1202: Signatures of selection for biallelic inactivation in tumor suppressor genes across cancer types

Mark R. Zucker, Maria A. Perry, Arielle Elkrief, Anton Safonov, Rohit Thummalapalli, Samuel I. Gould, Debyani Chakravarty, Rose Brannon, Marc Ladanyi, Pedram Razavi, Mark T. Donoghue, Yonina R. Murciano-Goroff, Francisco J. Sánchez-Rivera, Yuan Chen, Ronglai Shen, Sarat Chandarlapaty, David B. Solit, Nikolaus Schultz, Michael F. Berger, Adam J. Schoenfeld, Jason Chang, Ed Reznik, Chaitanya Bandlamudi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2024-1202
Published: 22 March 2024
View articletitled, Abstract 1202: Signatures of selection for biallelic inactivation in tumor suppressor genes across cancer types
Journal Articles

Abstract 2111: Impact of HER2 Expression on trastuzumab deruxtecan(T-DXd) efficacy

Wanyi Chen, Joshua Drago, Avantika Gupta, Bo Liu, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2111.
https://doi.org/10.1158/1538-7445.AM2024-2111
Published: 22 March 2024
View articletitled, Abstract 2111: Impact of HER2 Expression on trastuzumab deruxtecan(T-DXd) efficacy
Journal Articles

Abstract 3412: Benralizumab for treatment of eosinophil-related cutaneous adverse events associated with checkpoint inhibitors and anticancer targeted therapies: Phase 2 study

Mario E. Lacouture, Tara Maier, Alexander Pan, Anna Chen, George Dranitsaris, Neil J. Shah, Sarat Chandarlapaty, Chau Dang, Devika Gajria, Allison Gordon, Neil Iyengar, Pedram Razavi, Mark Robson, Ezra Rosen, Serena Wong, Ucalene Harris, Kwami Ketosugbo, Cindy Bravo, Manu Jain, Alina Markova
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3412.
https://doi.org/10.1158/1538-7445.AM2024-3412
Published: 22 March 2024
View articletitled, Abstract 3412: Benralizumab for treatment of eosinophil-related cutaneous adverse events associated with checkpoint inhibitors and anticancer targeted therapies: Phase 2 study
Journal Articles

Abstract 890: Multimodal modeling of digitized histopathology slides improves risk stratification in hormone receptor-positive breast cancer patients

Kevin M. Boehm, Antonio Marra, Jorge S. Reis-Filho, Sarat Chandarlapaty, Fresia Pareja, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 890.
https://doi.org/10.1158/1538-7445.AM2024-890
Published: 22 March 2024
View articletitled, Abstract 890: Multimodal modeling of digitized histopathology slides improves risk stratification in hormone receptor-positive breast cancer patients
Journal Articles

Abstract 5388: A unified computational pathology method to quantify HER2 expression from raw IHC and IF images in breast cancer

Nicolas Brieu, Joshua Z. Drago, Ansh Kapil, Zonera Hassan, Anatoliy Shumilov, Claire Myers, Fatemeh Derakhshan, Fresia Pareja, Fanni Ratzon, Dana Ross, Jorge Reis-Filho, Thomas Padel, Andreas Spitzmuller, Christian C. Sachs, Felix Fegerer, Sihem Khelifa, J. Carl Barrett, Günter Schmidt, Hadassah Sade, Mark Gustavson, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5388.
https://doi.org/10.1158/1538-7445.AM2023-5388
Published: 04 April 2023
View articletitled, Abstract 5388: A unified computational pathology method to quantify HER2 expression from raw IHC and IF images in breast cancer
Journal Articles

Abstract 3882: tumor adaptations to PI3K inhibition increases and its reversibility decreases as a function of time in drug

Radha Mukherjee, Kiran Gireesan Vanaja, Malvika Sharma, Yangjingyi Ruan Ruan, Hilla Solomon, Elisa deStanchina, Sarat Chandarlapaty, Neal Rosen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3882.
https://doi.org/10.1158/1538-7445.AM2023-3882
Published: 04 April 2023
View articletitled, Abstract 3882: tumor adaptations to PI3K inhibition increases and its reversibility decreases as a function of time in drug
Journal Articles

Abstract P4-02-01: Efficacy of HER2 ADCs against HER2 inhibitor resistance alterations in the PI3K and MAPK pathways in HER2-positive breast cancer

Emanuela Ferraro, Anton Safonov, Yuan Chen, Charlie White, Antonio Marra, Mehnaj Ahmed, Barbara Acevedo, Chau T Dang, Shanu Modi, David B. Solit, Larry Norton, Mark E. Robson, Jorge Reis-Filho, Sarat Chandarlapaty, Pedram Razavi
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-02-01.
https://doi.org/10.1158/1538-7445.SABCS22-P4-02-01
Published: 01 March 2023
View articletitled, Abstract P4-02-01: Efficacy of HER2 ADCs against HER2 inhibitor resistance alterations in the PI3K and MAPK pathways in HER2-positive breast cancer