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Journal Articles

Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate

Nidhi Gupta, Willy A. Solis, Reina N. Fuji, Amy Oldendorp, Glenn Pacheco, Elizabeth Luis, Josefa Chuh, Dorothy M. French, Elizabeth Drake, Mark S. Dennis, Katherine R. Kozak, Sarajane Ross, Jay Tibbitts, Susan D. Spencer, Suzie J. Scales

Cancer Res (2014) 74 (19_Supplement): 4502.

https://doi.org/10.1158/1538-7445.AM2014-4502

Published: 01 October 2014

View articletitled, Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate

Journal Articles

Abstract 4494: A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers

Suzie J. Scales, Nidhi Gupta, Glenn Pacheco, Ron Firestein, Dorothy M. French, Josefa Chuh, Yin Zhang, Leanne Berry, Jenny Bostrom, Elizabeth Luis, Aimee Fourie O'Donohue, Katherine R. Kozak, Sarajane Ross, Mark S. Dennis, Jay Tibbitts, Susan D. Spencer

Cancer Res (2014) 74 (19_Supplement): 4494.

https://doi.org/10.1158/1538-7445.AM2014-4494

Published: 01 October 2014

View articletitled, Abstract 4494: A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers

Journal Articles

Abstract 1363: Inhibition of Neuropilin-1 by anti-Nrp1 results in reduced angiogenesis and inhibition of tumor growth

Judy Mak, Qi Pan, Leanne Berry, Sarajane Ross, Hartmut Koeppen, Plowman Greg, Ryan Watts, Anil Bagri

Cancer Res (2010) 70 (8_Supplement): 1363.

https://doi.org/10.1158/1538-7445.AM10-1363

Published: 15 April 2010

View articletitled, Abstract 1363: Inhibition of Neuropilin-1 by anti-Nrp1 results in reduced angiogenesis and inhibition of tumor growth

Journal Articles

Abstract 1362: Mechanistic evaluation of combination anti-angiogenic effects of anti-neuropilin-1 and anti-VEGF by in vivo imaging

Sharon Ungersma, Glenn Pacheco, Judy Mak, Shang-Fan Yu, Sarajane Ross, Anil Bagri, Richard Carano

Cancer Res (2010) 70 (8_Supplement): 1362.

https://doi.org/10.1158/1538-7445.AM10-1362

Published: 15 April 2010

View articletitled, Abstract 1362: Mechanistic evaluation of combination anti-angiogenic effects of anti-neuropilin-1 and anti-VEGF by in vivo imaging

Journal Articles

Abstract 4289: Early study on LGR5/GPR49 molecule as a potential colon cancer stem cell target for the antibody conjugated drug treatment

Weiguang Mao, Janet Tien, David Goldenberg, Scott Stawicki, Rajesh Vij, Xiaoling Xia, Jo-Anne Hongo, Sarajane Ross, Kathy Kozak, Ron Firestein, Yan Wu, Susan Spencer, Paul Polakis

Cancer Res (2010) 70 (8_Supplement): 4289.

https://doi.org/10.1158/1538-7445.AM10-4289

Published: 15 April 2010

View articletitled, Abstract 4289: Early study on LGR5/GPR49 molecule as a potential colon cancer stem cell target for the antibody conjugated drug treatment

Journal Articles

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Cancer Res (2009) 69 (6): 2358–2364.

https://doi.org/10.1158/0008-5472.CAN-08-2250

Published: 17 March 2009

View articletitled, Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Includes: Supplementary data

Journal Articles

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

Hongkui Jin, Renhui Yang, Zhong Zheng, Mally Romero, Jed Ross, Hani Bou-Reslan, Richard A.D. Carano, Ian Kasman, Elaine Mai, Judy Young, Jiping Zha, Zemin Zhang, Sarajane Ross, Ralph Schwall, Gail Colbern, Mark Merchant

Cancer Res (2008) 68 (11): 4360–4368.

https://doi.org/10.1158/0008-5472.CAN-07-5960

Published: 02 June 2008

View articletitled, MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

Includes: Supplementary data

Journal Articles

Characterization of a humanized anti-IGF-IR monoclonal antibody for its anti-tumor activity in xenograft models

Jiping Zha, Yonglei Shang, Yifan Mao, Jennifer Batson, Suzie Scales, Gail Phillips, Mark Lackner, Simon Williams, Jihong Yang, Zhijun Tang, Christine Tan, Wei-Ching Liang, Siao Ping Tsai, Klara Totpal, Klaus Hoeflich, Janet Tien, Sarajane Ross, Yan Wu, Jean-Philippe Stephan

Cancer Res (2008) 68 (9_Supplement): 3985.

Published: 01 May 2008

View articletitled, Characterization of a humanized anti-IGF-IR monoclonal antibody for its anti-tumor activity in xenograft models

Journal Articles

Site-specific conjugation of cytotoxic drugs to antibodies substantially improves the therapeutic window

Jagath Reddy Junutula, Helga Raab, Sunil Bhakta, Kathryn Parsons, Suzanna Clark, Shang-Fan Yu, Sarajane Ross, Amy Kim, Kevin McDorman, Kelly Flagella, Susan Spencer, Richard Vandlen, Henry Lowman, William Mallet, Paul Polakis, Mark Sliwkowski, Richard Scheller

Cancer Res (2008) 68 (9_Supplement): 2132.

Published: 01 May 2008

View articletitled, Site-specific conjugation of cytotoxic drugs to antibodies substantially improves the therapeutic window

Journal Articles

Understanding pharmacokinetics and pharmacodynamics relationship of anti-IGF1R antibody in vivo

Sang Hoon Lee, Congfen Li, Jiping Zha, Jennifer Batson, Janet Tien, Sarajane Ross, Arthur Reyes, Rong Deng, Anne Wang, Jean-Philippe Stephan, Lisa Damico, Paul Fielder, William Manning, Hong Xiang

Cancer Res (2008) 68 (9_Supplement): 3017.

Published: 01 May 2008

View articletitled, Understanding pharmacokinetics and pharmacodynamics relationship of anti-IGF1R antibody in vivo

Journal Articles

Mechanistic evaluation of the combination effect of anti-VEGF and chemotherapy

Ian Kasman, Anil Bagri, Judy Mak, Franklin Peale, Rick Carano, Jed Ross, Leanne Berry, Young Shin, Patrick Rudewicz, Cary Austin, Ronald Ferrando, Sarajane Ross, Lisa Crocker, Nicolas Van Bruggen, Harriet Pais, Kurt Scudder, Beth Hollister, Greg Plowman

Cancer Res (2008) 68 (9_Supplement): 2494.

Published: 01 May 2008

View articletitled, Mechanistic evaluation of the combination effect of anti-VEGF and chemotherapy

Journal Articles

Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models

Youjun Chen, Suzanna Clark, Terence Wong, Yongmei Chen, Yvonne Chen, Mark S. Dennis, Elizabeth Luis, Fiona Zhong, Sheila Bheddah, Hartmut Koeppen, Alvin Gogineni, Sarajane Ross, Paul Polakis, William Mallet

Cancer Res (2007) 67 (10): 4924–4932.

https://doi.org/10.1158/0008-5472.CAN-06-4512

Published: 17 May 2007

View articletitled, Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models

Includes: Supplementary data

Journal Articles

Anti-tumor activity of Apomab: a fully human agonistic monoclonal antibody that targets the pro-apoptotic receptor DR5

Avi Ashkenazi, Cam Adams, Klara Totpal, Laura Deforge, David Lawrence, Sharon Yee, Sarajane Ross, Roger Pai, Authur Reyes, Christina deZafra, Hong Xiang, Christopher Stebbins

Cancer Res (2007) 67 (9_Supplement): LB-317.

Published: 01 May 2007

View articletitled, Anti-tumor activity of Apomab: a fully human agonistic monoclonal antibody that targets the pro-apoptotic receptor DR5

Journal Articles

ThioMabs: improving safety abd retaining efficacy of antibody drug conjugates

Jagath Reddy Junutula, Helga Raab, Sunil Bhakta, Karen Ervin, Kathryn Parsons, Suzanna Clark, Debra Dugger, Edward Ha, Sarajane Ross, Charles Eigenbrot, William Leach, William Mallet, Richard Vandlen, Paul Polakis, Mark Sliwkowski, Henry Lowman, Richard Scheller

Cancer Res (2007) 67 (9_Supplement): 918.

Published: 01 May 2007

View articletitled, ThioMabs: improving safety abd retaining efficacy of antibody drug conjugates

Journal Articles

Armed antibodies targeted to STEAP1 inhibit growth of human prostate xenografts in vivo

Tracey McKenna, Jennifer Batson, Sarajane Ross, Paul Polakis, Bonnee Rubinfeld

Cancer Res (2007) 67 (9_Supplement): 4468.

Published: 01 May 2007

View articletitled, Armed antibodies targeted to STEAP1 inhibit growth of human prostate xenografts in vivo

Journal Articles

Trastuzumab directed cytotoxic therapy: Efficacy against HER2-positive trastuzumab-insensitive breast cancer models and enhanced response in trastuzumab-sensitive models

Kathryn Parsons, Lisa Crocker, Douglas Leipold, Ginny Li, Janet Tien, Debra Dugger, Gail Lewis Phillips, Sarajane Ross, Jay Tibbitts, Mark Sliwkowski

Cancer Res (2007) 67 (9_Supplement): 649.

Published: 01 May 2007

View articletitled, Trastuzumab directed cytotoxic therapy: Efficacy against HER2-positive trastuzumab-insensitive breast cancer models and enhanced response in trastuzumab-sensitive models

Journal Articles

One-armed 5D5 (OA5D5) is a potent humanized HGF-blocking anti-c-Met monovalent antibody that inhibits HGF-dependent activity in vitro and demonstrates anti-tumor efficacy in vivo

Cancer Res (2007) 67 (9_Supplement): LB-372.

Published: 01 May 2007

View articletitled, One-armed 5D5 (OA5D5) is a potent humanized HGF-blocking anti-c-Met monovalent antibody that inhibits HGF-dependent activity in vitro and demonstrates anti-tumor efficacy in vivo

Journal Articles

Imaging Tumors with an Albumin-Binding Fab, a Novel Tumor-Targeting Agent

Mark S. Dennis, Hongkui Jin, Debra Dugger, Renhui Yang, Leanne McFarland, Annie Ogasawara, Simon Williams, Mary J. Cole, Sarajane Ross, Ralph Schwall

Cancer Res (2007) 67 (1): 254–261.

https://doi.org/10.1158/0008-5472.CAN-06-2531

Published: 08 January 2007

View articletitled, Imaging Tumors with an Albumin-Binding Fab, a Novel Tumor-Targeting Agent

Journal Articles

Kinetic Analysis of Epidermal Growth Factor Receptor Somatic Mutant Proteins Shows Increased Sensitivity to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Erlotinib

Kendall D. Carey, Andrew J. Garton, Maria S. Romero, Jennifer Kahler, Stuart Thomson, Sarajane Ross, Frances Park, John D. Haley, Neil Gibson, Mark X. Sliwkowski

Cancer Res (2006) 66 (16): 8163–8171.

https://doi.org/10.1158/0008-5472.CAN-06-0453

Published: 15 August 2006

View articletitled, Kinetic Analysis of Epidermal Growth Factor Receptor Somatic Mutant Proteins Shows Increased Sensitivity to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Erlotinib

Journal Articles

Albumin-binding Fab derived from Herceptin improves penetration into HER2 breast cancer cells

Hongkui Jin, Renhui Yang, Sarajane Ross, Mark Dennis, Debra Dugger, Mary Cole, Ralph Schwall

Cancer Res (2006) 66 (8_Supplement): 565–566.

Published: 15 April 2006

View articletitled, Albumin-binding Fab derived from Herceptin improves penetration into HER2 breast cancer cells

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Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate

Abstract 4494: A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers

Abstract 1363: Inhibition of Neuropilin-1 by anti-Nrp1 results in reduced angiogenesis and inhibition of tumor growth

Abstract 1362: Mechanistic evaluation of combination anti-angiogenic effects of anti-neuropilin-1 and anti-VEGF by in vivo imaging

Abstract 4289: Early study on LGR5/GPR49 molecule as a potential colon cancer stem cell target for the antibody conjugated drug treatment

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

Characterization of a humanized anti-IGF-IR monoclonal antibody for its anti-tumor activity in xenograft models

Site-specific conjugation of cytotoxic drugs to antibodies substantially improves the therapeutic window

Understanding pharmacokinetics and pharmacodynamics relationship of anti-IGF1R antibody in vivo

Mechanistic evaluation of the combination effect of anti-VEGF and chemotherapy

Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models

Anti-tumor activity of Apomab: a fully human agonistic monoclonal antibody that targets the pro-apoptotic receptor DR5

ThioMabs: improving safety abd retaining efficacy of antibody drug conjugates

Armed antibodies targeted to STEAP1 inhibit growth of human prostate xenografts in vivo

Trastuzumab directed cytotoxic therapy: Efficacy against HER2-positive trastuzumab-insensitive breast cancer models and enhanced response in trastuzumab-sensitive models

One-armed 5D5 (OA5D5) is a potent humanized HGF-blocking anti-c-Met monovalent antibody that inhibits HGF-dependent activity in vitro and demonstrates anti-tumor efficacy in vivo

Imaging Tumors with an Albumin-Binding Fab, a Novel Tumor-Targeting Agent

Kinetic Analysis of Epidermal Growth Factor Receptor Somatic Mutant Proteins Shows Increased Sensitivity to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Erlotinib

Albumin-binding Fab derived from Herceptin improves penetration into HER2 breast cancer cells

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