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Journal Articles

Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer

Cynthia Weigel, Melissa A. Maczis, Elisa N.D. Palladino, Christopher D. Green, Michael Maceyka, Chunqing Guo, Xiang-Yang Wang, Mikhail G. Dozmorov, Sheldon Milstien, Sarah Spiegel

Cancer Res (2023) 83 (4): 553–567.

https://doi.org/10.1158/0008-5472.CAN-22-1638

Published: 15 February 2023

View articletitled, Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer

Includes: Supplementary data

Journal Articles

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Masayuki Nagahashi, Akimitsu Yamada, Eriko Katsuta, Tomoyoshi Aoyagi, Wei-Ching Huang, Krista P. Terracina, Nitai C. Hait, Jeremy C. Allegood, Junko Tsuchida, Kizuki Yuza, Masato Nakajima, Manabu Abe, Kenji Sakimura, Sheldon Milstien, Toshifumi Wakai, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2018) 78 (7): 1713–1725.

https://doi.org/10.1158/0008-5472.CAN-17-1423

Published: 01 April 2018

View articletitled, Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Includes: Supplementary data

Journal Articles

Abstract 1694: Conjugated bile acids aggravate metastatic pancreatic cancer via sphingosine-1-phosphate receptor 2

Hiroaki Aoki, Masayo Aoki, Eriko Katsuta, Partha Mukhopadhyay, Jing Yang, Huiping Zhou, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2016) 76 (14_Supplement): 1694.

https://doi.org/10.1158/1538-7445.AM2016-1694

Published: 15 July 2016

View articletitled, Abstract 1694: Conjugated bile acids aggravate metastatic pancreatic cancer via sphingosine-1-phosphate receptor 2

Journal Articles

Abstract 112: FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer

Nitai C. Hait, Dorit Avni, Akimitsu Yamada, Sheldon Milstien, Kazuaki Takabe, Sarah Spiegel

Cancer Res (2015) 75 (15_Supplement): 112.

https://doi.org/10.1158/1538-7445.AM2015-112

Published: 01 August 2015

View articletitled, Abstract 112: FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer

Journal Articles

Abstract 407: FTY720 suppressed CT26 murine colon cancer peritoneal carcinomatosis progression by decreasing tumor associated macrophages and TNF-alpha

Tomoyoshi Aoyagi, Dorit Avini, Masayuki Nagahashi, Akimitsu Yamada, Krista P. Terracina, Wei-Ching Huang, Kazunori Aoki, Yasunori Matsumoto, Sarah Spiegel, Hisahiro Matsubara, Kazuaki Takabe

Cancer Res (2015) 75 (15_Supplement): 407.

https://doi.org/10.1158/1538-7445.AM2015-407

Published: 01 August 2015

View articletitled, Abstract 407: FTY720 suppressed CT26 murine colon cancer peritoneal carcinomatosis progression by decreasing tumor associated macrophages and TNF-alpha

Journal Articles

Abstract 1890: Activated SphK1 and export of S1P via ABCC1 shorten disease free survival in breast cancer

Akimitsu Yamada, Masayuki Nagahashi, Tomoyoshi Aoyagi, Wei C. Huang, Krista P. Terracina, Jeremy C. Allegood, Santiago Lima, Sheldon Milstien, Sarah Spiegel, Kumiko Kida, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe

Cancer Res (2014) 74 (19_Supplement): 1890.

https://doi.org/10.1158/1538-7445.AM2014-1890

Published: 01 October 2014

View articletitled, Abstract 1890: Activated SphK1 and export of S1P via ABCC1 shorten disease free survival in breast cancer

Journal Articles

Abstract 4884: Determination of sphingosine-1-phosphate levels in tissue interstitial fluid and lymphatic fluid utilizing novel collection techniques

Masayuki Nagahashi, Akimitsu Yamada, Hiroshi Miyazaki, Jeremy C. Allegood, Tomoyoshi Aoyagi, Wei-Ching Huang, Krista P. Terracina, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2014) 74 (19_Supplement): 4884.

https://doi.org/10.1158/1538-7445.AM2014-4884

Published: 01 October 2014

View articletitled, Abstract 4884: Determination of sphingosine-1-phosphate levels in tissue interstitial fluid and lymphatic fluid utilizing novel collection techniques

Journal Articles

Abstract 2695: FTY720 as a novel therapeutic approach for colon cancer carcinomatosis

Tomoyoshi Aoyagi, Dorit Avini, Masayuki Nagahashi, Akimitsu Yamada, Krista P. Terracina, Wei-Ching Huang, John Soong, Michael O. Idowu, Kazunori Aoki, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2014) 74 (19_Supplement): 2695.

https://doi.org/10.1158/1538-7445.AM2014-2695

Published: 01 October 2014

View articletitled, Abstract 2695: FTY720 as a novel therapeutic approach for colon cancer carcinomatosis

Journal Articles

Abstract 4887: FTY720 prevent tumorigenesis and suppress the progression of colitis-associated cancer.

Akimitsu Yamada, Jie Liang, Masayuki Nagahashi, Eugene Y. Kim, Kuzhuvelil B. Harikumar, Wei-Ching Huang, Nitai C. Hait, Jeremy C. Allegood, Megan M. Price, Dorit Avni, Tomasz Kordula, Milstien Sheldon, Kazuaki Takabe, Sarah Spiegel

Cancer Res (2013) 73 (8_Supplement): 4887.

https://doi.org/10.1158/1538-7445.AM2013-4887

Published: 15 April 2013

View articletitled, Abstract 4887: FTY720 prevent tumorigenesis and suppress the progression of colitis-associated cancer.

Journal Articles

Abstract 5000: Spinster 2 exports S1P, an important player in lymph node metastasis.

Masayuki Nagahashi, Eugene Y. Kim, Akimitsu Yamada, Subramaniam Ramachandran, Jeremy C. Allegood, Nitai Hait, Michael Maceyka, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2013) 73 (8_Supplement): 5000.

https://doi.org/10.1158/1538-7445.AM2013-5000

Published: 15 April 2013

View articletitled, Abstract 5000: Spinster 2 exports S1P, an important player in lymph node metastasis.

Journal Articles

Abstract 3280: The sphingosine-1-phosphate receptor modulator FTY720 synergistically inhibits colon cancer cell growth with 5-fluorouracil, irinotecan and oxaliplatin.

Tomoyoshi Aoyagi, Akimitsu Yamada, Masayuki Nagahashi, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2013) 73 (8_Supplement): 3280.

https://doi.org/10.1158/1538-7445.AM2013-3280

Published: 15 April 2013

View articletitled, Abstract 3280: The sphingosine-1-phosphate receptor modulator FTY720 synergistically inhibits colon cancer cell growth with 5-fluorouracil, irinotecan and oxaliplatin.

Journal Articles

Abstract LB-325: Sphingosine-1-phosphate links chronic intestinal inflammation to development of colitis-associated cancer.

Masayuki Nagahashi, Jie Liang, Eugene Y. Kim, Kuzhuvelil B. Harikumar, Akimitsu Yamada, Wei-Ching Huang, Nitai C. Hait, Jeremy C. Allegood, Megan M. Price, Dorit Avni, Kazuaki Takabe, Tomasz Kordula, Sheldon Milstien, Sarah Spiegel

Cancer Res (2013) 73 (8_Supplement): LB-325.

https://doi.org/10.1158/1538-7445.AM2013-LB-325

Published: 15 April 2013

View articletitled, Abstract LB-325: Sphingosine-1-phosphate links chronic intestinal inflammation to development of colitis-associated cancer.

Journal Articles

Abstract 5280: Activation of sphingosine kinase 1 is necessary for angiopoietin 2-induced hemangiogenesis and lymphangiogenesis

Akimitsu Yamada, Masayuki Nagahashi, Subramaniam Ramachandran, Eugene Y. Kim, Jeremy C. Allegood, Omar M. Rashid, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2012) 72 (8_Supplement): 5280.

https://doi.org/10.1158/1538-7445.AM2012-5280

Published: 15 April 2012

View articletitled, Abstract 5280: Activation of sphingosine kinase 1 is necessary for angiopoietin 2-induced hemangiogenesis and lymphangiogenesis

Journal Articles

Abstract 4364: S1P generated by SphK1 is important not only for primary tumor growth but also for tumor-induced hemangiogenesis and lymphangiogenesis

Masayuki Nagahashi, Subramaniam Ramachandran, Eugene Y. Kim, Jeremy C. Allegood, Omar M. Rashid, Akimitsu Yamada, Renping Zhao, Sheldon Milstien, Huiping Zhou, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2012) 72 (8_Supplement): 4364.

https://doi.org/10.1158/1538-7445.AM2012-4364

Published: 15 April 2012

View articletitled, Abstract 4364: S1P generated by SphK1 is important not only for primary tumor growth but also for tumor-induced hemangiogenesis and lymphangiogenesis

Journal Articles

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

Masayuki Nagahashi, Subramaniam Ramachandran, Eugene Y. Kim, Jeremy C. Allegood, Omar M. Rashid, Akimitsu Yamada, Renping Zhao, Sheldon Milstien, Huiping Zhou, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2012) 72 (3): 726–735.

https://doi.org/10.1158/0008-5472.CAN-11-2167

Published: 31 January 2012

View articletitled, Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

Includes: Supplementary data

Journal Articles

Abstract 4419: Effect of sphingosine kinase 1 inhibition in validated syngeneic mouse breast cancer metastasis model

Masayuki Nagahashi, Omar M. Rashid, Subramanian Ramachandran, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2011) 71 (8_Supplement): 4419.

https://doi.org/10.1158/1538-7445.AM2011-4419

Published: 15 April 2011

View articletitled, Abstract 4419: Effect of sphingosine kinase 1 inhibition in validated syngeneic mouse breast cancer metastasis model

Journal Articles

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca²⁺-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy Allegood, Dieter Häussinger, Roland Reinehr, Andrew Larner, Sarah Spiegel, Paul B. Fisher, Christina Voelkel-Johnson, Besim Ogretmen, Steven Grant, Paul Dent

Cancer Res (2010) 70 (15): 6313–6324.

https://doi.org/10.1158/0008-5472.CAN-10-0999

Published: 28 July 2010

View articletitled, Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Includes: Supplementary data

Journal Articles

Abstract 475: Resection of primary tumor improves survival in mouse metastatic breast cancer model

Omar M. Rashid, Masayuki Nagahashi, Subramaniam Ramachandran, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2010) 70 (8_Supplement): 475.

https://doi.org/10.1158/1538-7445.AM10-475

Published: 15 April 2010

View articletitled, Abstract 475: Resection of primary tumor improves survival in mouse metastatic breast cancer model

Journal Articles

Abstract 4103: Sphingosine kinase-1 mediates LPA-induced gastric cancer cell proliferation

Subramaniam Ramachandran, Dai Shida, Masayuki Nagahashi, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2010) 70 (8_Supplement): 4103.

https://doi.org/10.1158/1538-7445.AM10-4103

Published: 15 April 2010

View articletitled, Abstract 4103: Sphingosine kinase-1 mediates LPA-induced gastric cancer cell proliferation

Journal Articles

Abstract 4503: Targeting sphingosine kinase 1 is promising novel strategy against breast cancer

Masayuki Nagahashi, Subramaniam Ramachandran, Omar Rashid, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

Cancer Res (2010) 70 (8_Supplement): 4503.

https://doi.org/10.1158/1538-7445.AM10-4503

Published: 15 April 2010

View articletitled, Abstract 4503: Targeting sphingosine kinase 1 is promising novel strategy against breast cancer

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Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Abstract 1694: Conjugated bile acids aggravate metastatic pancreatic cancer via sphingosine-1-phosphate receptor 2

Abstract 112: FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer

Abstract 407: FTY720 suppressed CT26 murine colon cancer peritoneal carcinomatosis progression by decreasing tumor associated macrophages and TNF-alpha

Abstract 1890: Activated SphK1 and export of S1P via ABCC1 shorten disease free survival in breast cancer

Abstract 4884: Determination of sphingosine-1-phosphate levels in tissue interstitial fluid and lymphatic fluid utilizing novel collection techniques

Abstract 2695: FTY720 as a novel therapeutic approach for colon cancer carcinomatosis

Abstract 4887: FTY720 prevent tumorigenesis and suppress the progression of colitis-associated cancer.

Abstract 5000: Spinster 2 exports S1P, an important player in lymph node metastasis.

Abstract 3280: The sphingosine-1-phosphate receptor modulator FTY720 synergistically inhibits colon cancer cell growth with 5-fluorouracil, irinotecan and oxaliplatin.

Abstract LB-325: Sphingosine-1-phosphate links chronic intestinal inflammation to development of colitis-associated cancer.

Abstract 5280: Activation of sphingosine kinase 1 is necessary for angiopoietin 2-induced hemangiogenesis and lymphangiogenesis

Abstract 4364: S1P generated by SphK1 is important not only for primary tumor growth but also for tumor-induced hemangiogenesis and lymphangiogenesis

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

Abstract 4419: Effect of sphingosine kinase 1 inhibition in validated syngeneic mouse breast cancer metastasis model

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca²⁺-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Abstract 475: Resection of primary tumor improves survival in mouse metastatic breast cancer model

Abstract 4103: Sphingosine kinase-1 mediates LPA-induced gastric cancer cell proliferation

Abstract 4503: Targeting sphingosine kinase 1 is promising novel strategy against breast cancer

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