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Sarah J. Freemantle
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Journal Articles

Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors

Free
Ratnakar Singh, Kelly Kries, Aayush Gupta, Amy Li, Zeeshan Fazal, Doha Shokry, Raya Boyd, Brayden Rennels, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6687.
https://doi.org/10.1158/1538-7445.AM2025-6687
Published: 21 April 2025
View articletitled, Abstract 6687: Micromanaging resistance: microRNA expression and chemoresistance in testicular germ cell tumors
Journal Articles

Abstract 4561: Mechanism of histone H3K27me3 demethylase therapy for restoring cisplatin sensitivity in refractory testicular cancer

Free
Doha Naguib Ahmed Mohamed Shokry, Ratnakar Singh, Mehwish Khan, Zeeshan Fazal, Raya Boyd, Christine Powell, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4561.
https://doi.org/10.1158/1538-7445.AM2024-4561
Published: 22 March 2024
View articletitled, Abstract 4561: Mechanism of histone H3K27me3 demethylase therapy for restoring cisplatin sensitivity in refractory testicular cancer
Journal Articles

Abstract 7208: Targeting histone demethylase KDM6B to overcome cisplatin resistance in testicular germ cell tumors

Free
Ratnakar Singh, Doha Shokry, Raya I. Boyd, Brayden C. Rennels, Christine Powell, Mehwish Kahn, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7208.
https://doi.org/10.1158/1538-7445.AM2024-7208
Published: 22 March 2024
View articletitled, Abstract 7208: Targeting histone demethylase KDM6B to overcome cisplatin resistance in testicular germ cell tumors
Journal Articles

Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor

Free
Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Andrea Corbet, Jennifer Rodriguez, Alyssa Steege, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5188.
https://doi.org/10.1158/1538-7445.AM2019-5188
Published: 01 July 2019
View articletitled, Abstract 5188: Epigenetic changes mediated by polycomb repressive complex 2 are associated with cisplatin acquired resistance in testicular germ cell tumor
Journal Articles

Abstract 2999: Low-dose demethylation therapy for the treatment of cisplatin-resistant testicular cancer

Free
Andrea Corbet, Costantine Albany, Emmanuel Bikorimana, Ema Khan, Jennifer Rodriguez, Brock C. Christensen, George Sandusky, Lawrence H. Einhorn, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2999.
https://doi.org/10.1158/1538-7445.AM2018-2999
Published: 01 July 2018
View articletitled, Abstract 2999: Low-dose demethylation therapy for the treatment of cisplatin-resistant testicular cancer
Journal Articles

Abstract 2399: Loss of ubiquitin-specific peptidase 18 (USP18) destabilizes the regulator of thermogenesis uncoupling protein-1 (UCP-1) and represses lung cancer growth

Free
Xi Liu, Yun Lu, Weiguo Hu, Zibo Chen, Lisa M. Mustachio, Jason Roszik, Lin Zheng, Masanori Kawakami, Yulong Chen, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2399.
https://doi.org/10.1158/1538-7445.AM2018-2399
Published: 01 July 2018
View articletitled, Abstract 2399: Loss of ubiquitin-specific peptidase 18 (USP18) destabilizes the regulator of thermogenesis uncoupling protein-1 (UCP-1) and represses lung cancer growth
Journal Articles

Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target

Free
Lisa Maria Mustachio, Yun Lu, Masanori Kawakami, Jason Roszik, Sarah J. Freemantle, Xi Liu, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2018) 78 (3): 587–592.
https://doi.org/10.1158/0008-5472.CAN-17-1752
Published: 31 January 2018
View articletitled, Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target
Open the PDF for Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target in another window
Journal Articles

Abstract 1255: Loss of the ubiquitin protease USP18 represses KRAS mutant lung cancer tumorigenicity in mice by destabilizing KRAS protein

Free
Lisa Maria Mustachio, Yun Lu, Laura J. Tafe, Angeline S. Andrew, Vincent Memoli, Jaime Rodriguez-Canales, Pamela A. Villalobos, Ignacio Wistuba, Jun Yu, Jack J. Lee, Fadzai Chinyengetere, David J. Sekula, Xi Liu, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1255.
https://doi.org/10.1158/1538-7445.AM2016-1255
Published: 15 July 2016
View articletitled, Abstract 1255: Loss of the ubiquitin protease USP18 represses KRAS mutant lung cancer tumorigenicity in mice by destabilizing KRAS protein
Journal Articles

Abstract 2982: Antineoplastic activity of the novel CDK2/9 inhibitor CCT68127 occurs via induced anaphase catastrophe and inhibition of PEA15 phosphorylation in lung cancer

Free
Masanori Kawakami, Xi Liu, Lisa M. Mustachio, David J. Sekula, Shanhu Hu, Lin Zheng, Jaime Rodriguez-Canales, Barbara Mino, Pamela A. Villalobos, Carmen Behrens, Ignacio I. Wistuba, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2982.
https://doi.org/10.1158/1538-7445.AM2016-2982
Published: 15 July 2016
View articletitled, Abstract 2982: Antineoplastic activity of the novel CDK2/9 inhibitor CCT68127 occurs via induced anaphase catastrophe and inhibition of PEA15 phosphorylation in lung cancer
Journal Articles

Abstract 24: Loss of ubiquitin-specific peptidase 18 (USP18) causes cold sensitive mice by destabilizing the critical regulator of thermogenesis: uncoupling protein-1 (UCP-1)

Free
Xi Liu, Yun Lu, Lin Zheng, David J. Sekula, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 24.
https://doi.org/10.1158/1538-7445.AM2016-24
Published: 15 July 2016
View articletitled, Abstract 24: Loss of ubiquitin-specific peptidase 18 (USP18) causes cold sensitive mice by destabilizing the critical regulator of thermogenesis: uncoupling protein-1 (UCP-1)
Journal Articles

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

Free
Christina Y. Yim, David J. Sekula, Mary P. Hever-Jardine, Xi Liu, Joshua M. Warzecha, Janice Tam, Sarah J. Freemantle, Ethan Dmitrovsky, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1204–1213.
https://doi.org/10.1158/0008-5472.CAN-15-2265
Published: 29 February 2016
View articletitled, G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program
Open the PDF for G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program in another window
Includes: Supplementary data
Journal Articles

Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc

Free
Christina Y. Yim, David J. Sekula, Sarah J. Freemantle, Ethan Dmitrovsky, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2026.
https://doi.org/10.1158/1538-7445.AM2015-2026
Published: 01 August 2015
View articletitled, Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc
Journal Articles

Abstract 1782: The ubiquitin protease UBP43 is a target for KRAS mutant lung cancers

Free
Lisa Maria Mustachio, Fadzai Chinyengetere, Yun Lu, Shanhu Hu, Masanori Kawakami, Laura J. Tafe, Alexey Danilov, David J. Sekula, Tian Ma, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1782.
https://doi.org/10.1158/1538-7445.AM2014-1782
Published: 01 October 2014
View articletitled, Abstract 1782: The ubiquitin protease UBP43 is a target for KRAS mutant lung cancers
Journal Articles

Abstract 4549: CDK2 inhibition causes anaphase catastrophe through the centrosomal protein CP110

Free
Shanhu Hu, Alexey V. Danilov, Kristina M. Godek, Bernardo Orr, Laura J. Tafe, Vincent A. Memoli, Fabrizio Galimberti, Saranya Ravi, Andrew J. DeCastro, Yun Lu, Lisa Maria Mustachio, David J. Sekula, Angeline S. Andrew, Sarah J. Freemantle, Duane A. Compton, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4549.
https://doi.org/10.1158/1538-7445.AM2014-4549
Published: 01 October 2014
View articletitled, Abstract 4549: CDK2 inhibition causes anaphase catastrophe through the centrosomal protein CP110
Journal Articles

Abstract 4125: The retinoid-induced G0S2 protein undergoes ISG15ylation and destabilization.

Free
Yun Lu, Lisa Maria Mustachio, Fadzai Chinyengetere, Wei Yang, Tian Ma, Jessica Dong, David J. Sekula, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4125.
https://doi.org/10.1158/1538-7445.AM2013-4125
Published: 15 April 2013
View articletitled, Abstract 4125: The retinoid-induced G0S2 protein undergoes ISG15ylation and destabilization.
Journal Articles

Abstract 4732: Repression of transcriptional activity by the retinoid target gene G0S2

Free
Tian Ma, Jessica P. Dong, Steven Blumen, Dennis L. Fei, Michael Henderson, David J. Sekula, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4732.
https://doi.org/10.1158/1538-7445.AM2012-4732
Published: 15 April 2012
View articletitled, Abstract 4732: Repression of transcriptional activity by the retinoid target gene G0S2
Journal Articles

Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner

Free
Pingping Mao, Mary Jardine, Lynn Niemaszyk, Jessica Haghkerdar, Eric Yang, Esty G. yanco, Damayanti Desai, Maroun Beyrouthy, Joanna S. Kerley-Hamilton, Sarah J. Freemantle, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2958.
https://doi.org/10.1158/1538-7445.AM2012-2958
Published: 15 April 2012
View articletitled, Abstract 2958: The novel protein kinase STK17A is a direct p53 target gene that mediates response to genotoxic and nutritional stress in a cancer cell context-dependent manner
Journal Articles

Abstract 973: Tankyrase inhibition represses Wnt signaling and lung cancer growth

Free
Alexander M. Busch, Kevin C. Johnson, Ofelia Tacchelly, Zhenghan Wang, Yashi F. Ahmed, Ethan Dmitrovsky, Sarah J. Freemantle
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2012-973
Published: 15 April 2012
View articletitled, Abstract 973: Tankyrase inhibition represses Wnt signaling and lung cancer growth
Journal Articles

Abstract LB-412: Combining bexarotene with erlotinib in window of opportunity and phase II trials causes lung cancer responses independent of KRAS mutations

Free
Konstantin H. Dragnev, Tian Ma, Jobin Cyrus, Fabrizio Galimberti, Vincent Memoli, Alexander M. Busch, Gregory J. Tsongalis, Marc A. Seltzer, David Johnstone, Cherie P. Erkmen, William Nugent, James R. Rigas, Xi Liu, Sarah J. Freemantle, Jonathan M. Kurie, Samuel Waxman, Ethan Dmitrovsky
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-412.
https://doi.org/10.1158/1538-7445.AM2011-LB-412
Published: 15 April 2011
View articletitled, Abstract LB-412: Combining bexarotene with erlotinib in window of opportunity and phase II trials causes lung cancer responses independent of KRAS mutations
Journal Articles

Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells

Free
Maroun J. Beyrouthy, Kristen Garner, Mary P. Hever, Sarah J. Freemantle, Alan Eastman, Ethan Dmitrovsky, Michael J. Spinella
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4273.
https://doi.org/10.1158/1538-7445.AM10-4273
Published: 15 April 2010
View articletitled, Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells