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Journal Articles

Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate

Daniel W. Derwin, David Passmore, Qian Zhang, Bilal Sufi, Chin Pan, Chetana Rao, Mary Huber, Sanjeev Gangwar, Pina Cardarelli, Shrikant Deshpande, Vangipuram Rangan

Cancer Res (2012) 72 (8_Supplement): LB-252.

https://doi.org/10.1158/1538-7445.AM2012-LB-252

Published: 15 April 2012

View article titled, Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate

Journal Articles

Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS

Mohan Srinivasan, Lourdes Thevanayagam, Indrani Chakraborty, Alasdair Bell, Shrikant Deshpande, Chin Pan, Pina M. Cardarelli, Sanjeev Gangwar, Colin Chong, Orville Cortez, David Klitzing, Jerry Jiang, Meghan Greenbaum, James Phillips

Cancer Res (2010) 70 (8_Supplement): 2446.

https://doi.org/10.1158/1538-7445.AM10-2446

Published: 15 April 2010

View article titled, Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS

Journal Articles

Abstract 2575: Activation of antibody drug conjugate MDX-1203 by human carboxylesterase

Dan Derwin, David Passmore, Janette Sung, Daniel Tengco, Brian Lee, Barbara Aguilar, Tim Chen, Allen Zhang, Bilal Sufi, Charlie Cong, Adam Salles, Mary Huber, Alice Stevens, Chetana Rao, Sanjeev Gangwar, Shrikant Deshpande, Vangipuram S. Rangan

Cancer Res (2010) 70 (8_Supplement): 2575.

https://doi.org/10.1158/1538-7445.AM10-2575

Published: 15 April 2010

View article titled, Abstract 2575: Activation of antibody drug conjugate MDX-1203 by human carboxylesterase

Journal Articles

Abstract 2587: In vitro plasma stability of human anti-CD70 antibody drug conjugate, MDX-1203

Janette Sung, Kavitha Vemuri, David Passmore, Andrea Tatum, Tom Kempe, Peter Brams, Dan Derwin, Lourdes Thevanayagam, Mohan Srinivasan, Mary Huber, Chetana Rao, Allen Zhang, Charlie Cong, Bilal Sufi, Sanjeev Gangwar, Shrikant Deshpande, Vangipuram S. Rangan

Cancer Res (2010) 70 (8_Supplement): 2587.

https://doi.org/10.1158/1538-7445.AM10-2587

Published: 15 April 2010

View article titled, Abstract 2587: <em>In vitro</em> plasma stability of human anti-CD70 antibody drug conjugate, MDX-1203

Journal Articles

Abstract 2578: Efficacy of anti-CD22 antibody drug-conjugates in Ramos and Raji tumor xenograft models

Chin Pan, Colin Chong, Orville Cortez, Alison Witte, Ayesha Nazeer, Chetana Rao-Naik, Mary Huber, Alice Stevens, Qian Zhang, Asna Masood, Sanjeev Gangwar, David King, Brigitte Devaux, Pina Cardarelli

Cancer Res (2010) 70 (8_Supplement): 2578.

https://doi.org/10.1158/1538-7445.AM10-2578

Published: 15 April 2010

View article titled, Abstract 2578: Efficacy of anti-CD22 antibody drug-conjugates in Ramos and Raji tumor xenograft models

Journal Articles

Abstract 2452: Efficacy and toxicity of an anti-CD19 antibody drug conjugate

Chetana Rao, Chin Pan, Rangan Vangipuram, Mary Huber, Kavitha Vemuri, Alice Stevens, Colin Chong, Orville Cortez, Janette Sung, Dan Derwin, David Passmore, Qian Zhang, Sanjeev Gangwar, Pina Cardarelli, Shrikant Deshpande

Cancer Res (2010) 70 (8_Supplement): 2452.

https://doi.org/10.1158/1538-7445.AM10-2452

Published: 15 April 2010

View article titled, Abstract 2452: Efficacy and toxicity of an anti-CD19 antibody drug conjugate

Journal Articles

Abstract #1722: The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates

Sanjeev Gangwar, Chin Pan, Qian Zhang, Chetana Rao, Bilal Sufi, Lynae Green, David Passmore, Mary Huber, Collin Chong, Eilene Kwok, Orville Cortez, Peter Sattari, Liang Chen, Vincent Guerlavais, Vangipuram Rangan, Shrikant Deshpande, Pina Cardarelli, David King, Jon Terrett

Cancer Res (2009) 69 (9_Supplement): 1722.

Published: 01 May 2009

View article titled, Abstract #1722: The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates

Journal Articles

Abstract #3235: Efficacy and toxicity of an anti-mesothelin antibody drug conjugate

Chetana Rao, Mary Huber, Kavitha Vemuri, Qian Zhang, Bing Chen, James Phillips, Meghan Greenbaum, Janette Sung, Dan Derwin, David Passmore, Rangan Vangipuram, Jon Terrett, Shrikant Deshpande, Pina Cardarelli, Diann Blanset, Sanjeev Gangwar

Cancer Res (2009) 69 (9_Supplement): 3235.

Published: 01 May 2009

View article titled, Abstract #3235: Efficacy and toxicity of an anti-mesothelin antibody drug conjugate

Journal Articles

Ptk7 as a direct and tumor stroma target in multiple solid malignancies

Cancer Res (2008) 68 (9_Supplement): 1526.

Published: 01 May 2008

View article titled, Ptk7 as a direct and tumor stroma target in multiple solid malignancies

Journal Articles

Preclinical development of anti B7-H4 therapeutic antibodies

Jonathan Terrett, Lisheng Lu, Vidusha Devasthali, David King, Mary Huber, Chetana Rao-Naik, Sanjeev Gangwar, Vincent Guerlavais, Allen Zhang, Bilal Sufi, Liang Chen, Pina Cardarelli, James Phillips, Bing Chen, Haichun Huang, Dapeng Yao, Marco Coccia

Cancer Res (2008) 68 (9_Supplement): 4986.

Published: 01 May 2008

View article titled, Preclinical development of anti B7-H4 therapeutic antibodies

Journal Articles

Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

Chin Pan, Jonathan Terrett, Chetana Rao, Colin Chong, Rory Dai, Eilene Kwok, Mary Huber, Liang Chen, Alan Zhang, Sufi Bilal, Charlie Cong, Rangan Vangipuram, David Passmore, Shrikant Deshpande, Sanjeev Gangwar, Pina Cardarelli, David King

Cancer Res (2008) 68 (9_Supplement): 4062.

Published: 01 May 2008

View article titled, Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

Journal Articles

Mechanism of activation of a human anti-cd70 antibody-mgba conjugate and efficacy in a nude rat model of renal carcinoma

David King, Jon Terrett, Pina Cardarelli, Chin Pan, Chetana Rao, Sanjeev Gangwar, Shrikant Deshpande, Rangan Vangipuram, David Passmore, Jean Francois Mirjolet, Francis Bichat

Cancer Res (2008) 68 (9_Supplement): 4057.

Published: 01 May 2008

View article titled, Mechanism of activation of a human anti-cd70 antibody-mgba conjugate and efficacy in a nude rat model of renal carcinoma

Journal Articles

Efficacy and safety of a human anti-CD70 antibody-MGBA conjugate

Pina Cardarelli, David King, Jon Terrett, Sanjeev Gangwar, Lewis Cohen, Chin Pan, Chetana Rao, Shrikant Deshpande, Rangan Vangipuram, David Passmore, Diann Blanset

Cancer Res (2008) 68 (9_Supplement): 4061.

Published: 01 May 2008

View article titled, Efficacy and safety of a human anti-CD70 antibody-MGBA conjugate

Journal Articles

Efficacy study of anti-CD19 antibody drug-conjugates in Raji tumor xenograft and systemic model

Chetana Rao, Chin Pan, Mary Huber, Peter Sattari, Colin Chong, Rory Dai, Carol Soderberg, Liang Chen, Vincent Guerlavais, Kilian Horgan, Allen Zhang, Bilal Sufi, Haichun Huang, Haibin Chen, Sanjeev Gangwar, Pina Cardarelli, David King

Cancer Res (2007) 67 (9_Supplement): 4104.

Published: 01 May 2007

View article titled, Efficacy study of anti-CD19 antibody drug-conjugates in Raji tumor xenograft and systemic model

Journal Articles

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

Cancer Res (2007) 67 (9_Supplement): 4112.

Published: 01 May 2007

View article titled, Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

Journal Articles

CD70 antibody based drugs: two different mechanisms of action for the treatment of multiple cancer types

Cancer Res (2006) 66 (8_Supplement): 470.

Published: 15 April 2006

View article titled, CD70 antibody based drugs: two different mechanisms of action for the treatment of multiple cancer types

Journal Articles

Human antibody conjugates of DNA minor groove-binding alkylating agents with single dose efficacy in xenograft models which retain activity in drug resistant cells

Cancer Res (2006) 66 (8_Supplement): 277.

Published: 15 April 2006

View article titled, Human antibody conjugates of DNA minor groove-binding alkylating agents with single dose efficacy in xenograft models which retain activity in drug resistant cells

Journal Articles

CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10⁺ Tumors

Chin Pan, Pina M. Cardarelli, Matthew H. Nieder, Lesley B. Pickford, Sanjeev Gangwar, David J. King, Geoffrey T. Yarranton, Dana Buckman, William Roscoe, Fengmin Zhou, Adam Salles, Tseng-Hui Chen, Killian Horgan, Yi-Hong Wang, Thi Nguyen, Christopher R. Bebbington

Cancer Res (2003) 63 (17): 5526–5531.

Published: 18 September 2003

View article titled, CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10<sup>+</sup> Tumors

NARROW

Abstract LB-252: Enzymology of the mechanism of action for MDX-1203 antibody drug conjugate

Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS

Abstract 2575: Activation of antibody drug conjugate MDX-1203 by human carboxylesterase

Abstract 2587: In vitro plasma stability of human anti-CD70 antibody drug conjugate, MDX-1203

Abstract 2578: Efficacy of anti-CD22 antibody drug-conjugates in Ramos and Raji tumor xenograft models

Abstract 2452: Efficacy and toxicity of an anti-CD19 antibody drug conjugate

Abstract #1722: The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates

Abstract #3235: Efficacy and toxicity of an anti-mesothelin antibody drug conjugate

Ptk7 as a direct and tumor stroma target in multiple solid malignancies

Preclinical development of anti B7-H4 therapeutic antibodies

Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

Mechanism of activation of a human anti-cd70 antibody-mgba conjugate and efficacy in a nude rat model of renal carcinoma

Efficacy and safety of a human anti-CD70 antibody-MGBA conjugate

Efficacy study of anti-CD19 antibody drug-conjugates in Raji tumor xenograft and systemic model

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

CD70 antibody based drugs: two different mechanisms of action for the treatment of multiple cancer types

Human antibody conjugates of DNA minor groove-binding alkylating agents with single dose efficacy in xenograft models which retain activity in drug resistant cells

CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10⁺ Tumors

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