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Samuel Singer
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Journal Articles

Abstract 6168: Beta-catenin and PDGFRB modulate HIF1a in desmoid cells to promote sorafenib-sensitive paracrine signaling pathways

Jia Hu, Anthony Villano, Rachael Connor, Yuliy Rozenberg, Alankrta Venkatesh, Nicholas Socci, Samuel Singer, Aimee Crago
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6168.
https://doi.org/10.1158/1538-7445.AM2022-6168
Published: 15 June 2022
View article titled, Abstract 6168: Beta-catenin and PDGFRB modulate HIF1a in desmoid cells to promote sorafenib-sensitive paracrine signaling pathways
Journal Articles

Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival

George Z. Li, Tomoyo Okada, Young-Mi Kim, Narasimhan P. Agaram, Francisco Sanchez-Vega, Yawei Shen, Norifumi Tsubokawa, Jordan Rios, Axel S. Martin, Mark A. Dickson, Li-Xuan Qin, Nicholas D. Socci, Samuel Singer
Journal: Cancer Research
Cancer Res (2020) 80 (12): 2461–2471.
https://doi.org/10.1158/0008-5472.CAN-19-1269
Published: 15 June 2020
View article titled, Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival
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Includes: Supplementary data
Journal Articles

Abstract 516: Long noncoding RNA NEAT1 promotes lung metastasis of soft tissue sarcoma

Jianguo Huang, Eric Xu, Mohit Sachdeva, Timothy Robinson, Xiaodi Qin, Dadong Zhang, Kouros Owzar, Nalan Gokgoz, Andrew Seto, Irene Andrulis, Jay Wunder, Tomoyo Okada, Samuel Singer, Alexander Lazar, Brian Rubin, David G. Kirsch
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 516.
https://doi.org/10.1158/1538-7445.AM2018-516
Published: 01 July 2018
View article titled, Abstract 516: Long noncoding RNA NEAT1 promotes lung metastasis of soft tissue sarcoma
Journal Articles

SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells

Xiaoliang L. Xu, Zhengke Li, Aihong Liu, Xianqun Fan, Dan-ning Hu, Dong-Lai Qi, David W. Chitty, Renbing Jia, Jianping Qui, Justin Q. Wang, Jake Sharaf, Jun Zou, Rebecca Weiss, Hongyan Huang, Walter J. Joseph, Lily Ng, Richard Rosen, Binghui Shen, Mark W. Reid, Douglas Forrest, David H. Abramson, Samuel Singer, David Cobrinik, Suresh C. Jhanwar
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6838–6850.
https://doi.org/10.1158/0008-5472.CAN-16-3299
Published: 14 December 2017
View article titled, SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells
Open the PDF for SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells in another window
Includes: Supplementary data
Journal Articles

miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

Ying Z. Mazzu, Yulan Hu, Rajesh K. Soni, Kelly M. Mojica, Li-Xuan Qin, Phaedra Agius, Zachary M. Waxman, Aleksandra Mihailovic, Nicholas D. Socci, Ronald C. Hendrickson, Thomas Tuschl, Samuel Singer
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5728–5740.
https://doi.org/10.1158/0008-5472.CAN-16-2253
Published: 31 October 2017
View article titled, miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
Open the PDF for miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells in another window
Includes: Supplementary data
Journal Articles

Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma

Francesca Bersani, Marcello Francesco Lingua, Deborah Morena, Valentina Foglizzo, Silvia Miretti, Letizia Lanzetti, Giovanna Carrà, Alessandro Morotti, Ugo Ala, Paolo Provero, Roberto Chiarle, Samuel Singer, Marc Ladanyi, Thomas Tuschl, Carola Ponzetto, Riccardo Taulli
Journal: Cancer Research
Cancer Res (2016) 76 (20): 6095–6106.
https://doi.org/10.1158/0008-5472.CAN-16-0709
Published: 13 October 2016
View article titled, Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma
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Includes: Supplementary data
Journal Articles

Abstract CT314: Interim results from a phase I/II trial of TPI 287, a novel brain penetrable antimicrotubule agent, in combination with bevacizumab for the treatment of recurrent glioblastoma

Sandra L. Silberman, Samuel Goldlust, L. Burt Nabors, J Paul Duic, Tara Benkers, Nimish Mohile, Donald Picker, Samuel Singer, George Farmer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT314.
https://doi.org/10.1158/1538-7445.AM2015-CT314
Published: 01 August 2015
View article titled, Abstract CT314: Interim results from a phase I/II trial of TPI 287, a novel brain penetrable antimicrotubule agent, in combination with bevacizumab for the treatment of recurrent glioblastoma
Journal Articles

Abstract 5061: Genomic and functional analysis of Myxofibrosarcoma identifies novel prognostic markers and promising therapeutic targets

Ann Y. Lee, Aimee M. Crago, Narasimhan P. Agaram, Tomoyo Okada, Penelope DeCarolis, Rachael B. O'Connor, Li-Xuan Qin, Raya Khanin, Yevgeniy Antipin, Boris A. Reva, Nicholas D. Socci, Samuel Singer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5061.
https://doi.org/10.1158/1538-7445.AM2012-5061
Published: 15 April 2012
View article titled, Abstract 5061: Genomic and functional analysis of Myxofibrosarcoma identifies novel prognostic markers and promising therapeutic targets
Journal Articles

Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma

Stacy Ugras, Elliott Brill, Anders Jacobsen, Markus Hafner, Nicholas D. Socci, Penelope L. DeCarolis, Raya Khanin, Rachael O'Connor, Aleksandra Mihailovic, Barry S. Taylor, Robert Sheridan, Jeffrey M. Gimble, Agnes Viale, Aimee Crago, Cristina R. Antonescu, Chris Sander, Thomas Tuschl, Samuel Singer
Journal: Cancer Research
Cancer Res (2011) 71 (17): 5659–5669.
https://doi.org/10.1158/0008-5472.CAN-11-0890
Published: 30 August 2011
View article titled, Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma
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Includes: Supplementary data
Journal Articles

Expression Profiling of Liposarcoma Yields a Multigene Predictor of Patient Outcome and Identifies Genes That Contribute to Liposarcomagenesis

Ryan M. Gobble, Li-Xuan Qin, Elliott R. Brill, Christina V. Angeles, Stacy Ugras, Rachael B. O'Connor, Nicole H. Moraco, Penelope L. DeCarolis, Cristina Antonescu, Samuel Singer
Journal: Cancer Research
Cancer Res (2011) 71 (7): 2697–2705.
https://doi.org/10.1158/0008-5472.CAN-10-3588
Published: 31 March 2011
View article titled, Expression Profiling of Liposarcoma Yields a Multigene Predictor of Patient Outcome and Identifies Genes That Contribute to Liposarcomagenesis
Open the PDF for Expression Profiling of Liposarcoma Yields a Multigene Predictor of Patient Outcome and Identifies Genes That Contribute to Liposarcomagenesis in another window
Includes: Supplementary data
Journal Articles

ZIC1 Overexpression Is Oncogenic in Liposarcoma

Elliott Brill, Ryan Gobble, Christina Angeles, Mariana Lagos-Quintana, Aimee Crago, Bernadette Laxa, Penelope DeCarolis, Lei Zhang, Cristina Antonescu, Nicholas D. Socci, Barry S. Taylor, Chris Sander, Andrew Koff, Samuel Singer
Journal: Cancer Research
Cancer Res (2010) 70 (17): 6891–6901.
https://doi.org/10.1158/0008-5472.CAN-10-0745
Published: 31 August 2010
View article titled, <em>ZIC1</em> Overexpression Is Oncogenic in Liposarcoma
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Includes: Supplementary data
Journal Articles

Abstract 3100: The RNA-binding protein insulin-like growth factor 2 mRNA-binding protein 3 is oncogenic in liposarcoma

Christina V. Angeles, Markus Hafner, Nicholas D. Socci, Penelope DeCarolis, Thomas Tuschl, Samuel Singer
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3100.
https://doi.org/10.1158/1538-7445.AM10-3100
Published: 15 April 2010
View article titled, Abstract 3100: The RNA-binding protein insulin-like growth factor 2 mRNA-binding protein 3 is oncogenic in liposarcoma
Journal Articles

KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors

Cristina R. Antonescu, Akihiko Yoshida, Tianhuo Guo, Ning-En Chang, Lei Zhang, Narasimhan P. Agaram, Li-Xuan Qin, Murray F. Brennan, Samuel Singer, Robert G. Maki
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7175–7179.
https://doi.org/10.1158/0008-5472.CAN-09-2068
Published: 14 September 2009
View article titled, <em>KDR</em> Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors
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Journal Articles

Abstract #185: Mesenchymal stem cell features of sarcoma cell lines and primary cultures

Alex Morozov, Robert Downey, Emil Lou, Roland Leung, Samuel Singer, Andre Moreira, Mark Edgar, Michael LaQuaglia, John Healey, Robert Maki, Malcolm Moore
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 185.
Published: 01 May 2009
View article titled, Abstract #185: Mesenchymal stem cell features of sarcoma cell lines and primary cultures
Journal Articles

Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma

Samuel Singer, Nicholas D. Socci, Grazia Ambrosini, Elliot Sambol, Penelope Decarolis, Yuhsin Wu, Rachael O'Connor, Robert Maki, Agnes Viale, Chris Sander, Gary K. Schwartz, Cristina R. Antonescu
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6626–6636.
https://doi.org/10.1158/0008-5472.CAN-07-0584
Published: 17 July 2007
View article titled, Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma
Open the PDF for Gene Expression Profiling of Liposarcoma Identifies Distinct Biological Types/Subtypes and Potential Therapeutic Targets in Well-Differentiated and Dedifferentiated Liposarcoma in another window
Includes: Supplementary data
Journal Articles

Flavopiridol Targets c-KIT Transcription and Induces Apoptosis in Gastrointestinal Stromal Tumor Cells

Elliot B. Sambol, Grazia Ambrosini, Rula C. Geha, Peter T. Kennealey, Penelope DeCarolis, Rachael O'Connor, Yuhsin V. Wu, Monica Motwani, Jin-Hong Chen, Gary K. Schwartz, Samuel Singer
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5858–5866.
https://doi.org/10.1158/0008-5472.CAN-05-2933
Published: 01 June 2006
View article titled, Flavopiridol Targets c-KIT Transcription and Induces Apoptosis in Gastrointestinal Stromal Tumor Cells
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Journal Articles

Flavopiridol is an active agent in the treatment of gastrointestinal stromal tumor (GIST) cells with relative resistance to imatinib mesylate via both transcriptional suppression and inhibition of autophosphorylation of KIT

Elliot B. Sambol, Monica Motwani, Grazia Ambrosini, Rula C. Geha, Penelope Decarolis, Rachael O’Connor, Jin-Hong Chen, Gary K. Schwartz, Samuel Singer
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 352–353.
Published: 01 May 2005
View article titled, Flavopiridol is an active agent in the treatment of gastrointestinal stromal tumor (GIST) cells with relative resistance to imatinib mesylate via both transcriptional suppression and inhibition of autophosphorylation of KIT
Journal Articles

Inhibition of MDM2 by nutlin induces apoptosis in response to DNA damage in cells with mutant p53 in an E2F1-dependent manner

Grazia Ambrosini, Elliot Sambol, Robert Maki, Lyubomir Vassilev, Samuel Singer, Gary K. Schwartz
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 403.
Published: 01 May 2005
View article titled, Inhibition of MDM2 by nutlin induces apoptosis in response to DNA damage in cells with mutant p53 in an E2F1-dependent manner
Journal Articles

KIT Activation Is a Ubiquitous Feature of Gastrointestinal Stromal Tumors

Brian P. Rubin, Samuel Singer, Connie Tsao, Anette Duensing, Marcia L. Lux, Robert Ruiz, Michele K. Hibbard, Chang-Jie Chen, Sheng Xiao, David A. Tuveson, George D. Demetri, Christopher D. M. Fletcher, Jonathan A. Fletcher
Journal: Cancer Research
Cancer Res (2001) 61 (22): 8118–8121.
Published: 01 November 2001
View article titled, KIT Activation Is a Ubiquitous Feature of Gastrointestinal Stromal Tumors
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Journal Articles

Pyruvate Utilization, Phosphocholine and Adenosine Triphosphate (ATP) Are Markers of Human Breast Tumor Progression: A 31P- and 13C-Nuclear Magnetic Resonance (NMR) Spectroscopy Study

Samuel Singer, Kerry Souza, William G. Thilly
Journal: Cancer Research
Cancer Res (1995) 55 (22): 5140–5145.
Published: 01 November 1995
View article titled, Pyruvate Utilization, Phosphocholine and Adenosine Triphosphate (ATP) Are Markers of Human Breast Tumor Progression: A <sup>31</sup>P- and <sup>13</sup>C-Nuclear Magnetic Resonance (NMR) Spectroscopy Study
Open the PDF for Pyruvate Utilization, Phosphocholine and Adenosine Triphosphate (ATP) Are Markers of Human Breast Tumor Progression: A <sup>31</sup>P- and <sup>13</sup>C-Nuclear Magnetic Resonance (NMR) Spectroscopy Study in another window