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Journal Articles

Abstract 1562: Drug repurposing for hepatocellular carcinoma enabled via transcriptomics data from experimental models of sorafenib resistance

Kelly Regan, Ryan Reyes, Samson Jacob, Philip Payne, Tasneem Motiwala
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1562.
https://doi.org/10.1158/1538-7445.AM2017-1562
Published: 01 July 2017
View article titled, Abstract 1562: Drug repurposing for hepatocellular carcinoma enabled via transcriptomics data from experimental models of sorafenib resistance
Journal Articles

Abstract 141: CD44 positive and sorafenib resistant hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128

Mohamed Badawi, Jihye Kim, Dhruvitkumar Sutaria, Tasneem Motiwala, Ryan Reyes, Nissar Wani, Samson Jacob, Mitch Phelps, Thomas Schmittgen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 141.
https://doi.org/10.1158/1538-7445.AM2017-141
Published: 01 July 2017
View article titled, Abstract 141: CD44 positive and sorafenib resistant hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128
Journal Articles

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Fengting Yan, Lapo Alinari, Mark E. Lustberg, Ludmila Katherine Martin, Hector M. Cordero-Nieves, Yeshavanth Banasavadi-Siddegowda, Selene Virk, Jill Barnholtz-Sloan, Erica Hlavin Bell, Jeffrey Wojton, Naduparambil K. Jacob, Arnab Chakravarti, Michal O. Nowicki, Xin Wu, Rosa Lapalombella, Jharna Datta, Bo Yu, Kate Gordon, Amy Haseley, John T. Patton, Porsha L. Smith, John Ryu, Xiaoli Zhang, Xiaokui Mo, Guido Marcucci, Gerard Nuovo, Chang-Hyuk Kwon, John C. Byrd, E. Antonio Chiocca, Chenglong Li, Said Sif, Samson Jacob, Sean Lawler, Balveen Kaur, Robert A. Baiocchi
Journal: Cancer Research
Cancer Res (2014) 74 (6): 1752–1765.
https://doi.org/10.1158/0008-5472.CAN-13-0884
Published: 13 March 2014
View article titled, Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
Open the PDF for Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT-06: The combination of bortezomib (BOR) and decitabine (DEC): A phase I trial in patients (pts) with acute myeloid leukemia (AML) targeting FLT3 expression

Sebastian Schwind, William Blum, Shujun Liu, Somayeh Samadzadeh Tarighat, Susan Geyer, Rebecca Klisovic, Ann-Kathrin Eisfeld, Alison Walker, Susan Whitman, Santhanam Ramasamy, Yue-Zhong Wu, Samson Jacob, Michael Caligiuri, Michael Grever, Danilo Perrotti, John Byrd, Clara Bloomfield, Ramiro Garzon, Guido Marcucci
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): CT-06.
https://doi.org/10.1158/1538-7445.AM2012-CT-06
Published: 15 April 2012
View article titled, Abstract CT-06: The combination of bortezomib (BOR) and decitabine (DEC): A phase I trial in patients (pts) with acute myeloid leukemia (AML) targeting FLT3 expression
Journal Articles

Abstract 2810: Loss of microRNA-122 in mice causes hepatic inflammation and hepatocarcinogenesis

Shu-hao Hsu, Bo Wang, Stefan Costinean, Shoumei Bai, Huban Kutay, Lianbo Yu, Gerard Nuovo, Samson Jacob, Kalpana Ghoshal
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2810.
https://doi.org/10.1158/1538-7445.AM2011-2810
Published: 15 April 2011
View article titled, Abstract 2810: Loss of microRNA-122 in mice causes hepatic inflammation and hepatocarcinogenesis
Journal Articles

Abstract 909: Activation of NF-κB and its downstream targets play a key role in the dramatic induction of hepatocarcinogenesis in metallothionein null mice

Thomas Kaffenberger, Satavisha Roy, Bo Wang, Stefan Costinean, Wendy Frankel, Anna Bratasz, Periannan Kuppusamy, Tsonwin Hai, Kalpana Ghoshal, Samson Jacob, Sarmila Majumder
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 909.
https://doi.org/10.1158/1538-7445.AM2011-909
Published: 15 April 2011
View article titled, Abstract 909: Activation of NF-κB and its downstream targets play a key role in the dramatic induction of hepatocarcinogenesis in metallothionein <em>null</em> mice
Journal Articles

Abstract #1543: Transcriptional and epigenetic regulation of the tumor suppressor protein tyrosine phosphatase receptor-type O in Tcl1 Tg mouse model of chronic lymphocytic leukemia

Tasneem Motiwala, Huban Kutay, Jharna Datta, Allyn Checovich, Nicola Zanesi, Mohamed Kaou, John Hagan, Carlo Croce, Samson Jacob
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1543.
Published: 01 May 2009
View article titled, Abstract #1543: Transcriptional and epigenetic regulation of the tumor suppressor protein tyrosine phosphatase receptor-type O in Tcl1 Tg mouse model of chronic lymphocytic leukemia
Journal Articles

Abstract #2632: Epigenetic regulation of microRNA-1 (miR-1) gene expression in liver and lung cancer: Its role in suppression of tumorigenesis

Jharna Datta, Mohd Nasser, Gerard Nuovo, Huban Kutay, Tasneem Motiwala, Sarmila Majumder, Bo Wang, Stefano Volinia, Thomas Schmittgen, Carlo Croce, Samson Jacob, Kalpana Ghoshal
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2632.
Published: 01 May 2009
View article titled, Abstract #2632: Epigenetic regulation of microRNA-1 (miR-1) gene expression in liver and lung cancer: Its role in suppression of tumorigenesis
Journal Articles

Up-regulation of oncogenic microRNAs and down-regulation of their tumor suppressor targets play a causal role in the initiation of hepatocarcinogenesis in mice fed choline-deficient and amino acid defined diet

KALPANA GHOSHAL, Sarmila Majumder, Bo Wang, Huban Kutay, Jharna Datta, Chang-Gong Lu, Stefano Volinia, Carlo Croce, Gerrard Nuovo, Thomas Schmittgen, Samson Jacob
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5033.
Published: 01 May 2008
View article titled, Up-regulation of oncogenic microRNAs and down-regulation of their tumor suppressor targets play a causal role in the initiation of hepatocarcinogenesis in mice fed choline-deficient and amino acid defined diet
Journal Articles

Estrogen-mediated epigenetic silencing of receptor type protein phosphatase (PTPRO) in breast cancer and its potential role in tamoxifen resistance

Sarmila Majumder, Bhuvaneswari Ramaswamy, Tasneem Motiwala, Huban Kutay, Charles Shapiro, Samson Jacob
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3684.
Published: 01 May 2007
View article titled, Estrogen-mediated epigenetic silencing of receptor type protein phosphatase (PTPRO) in breast cancer and its potential role in tamoxifen resistance
Journal Articles

Novel DNA hypomethylating agents: non-nucleoside compounds that do not incorporate into DNA selectively induce degradation of DNA methyltransferase I (DNMT1) in human cancer cells by the proteasomal pathway and re-express silenced tumor suppressor genes

Jharna Datta, Kalpana Ghoshal, Huban Kutay, Pasit Phiasivongsa, Sanjeev Redkar, Samson Jacob
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4142.
Published: 01 May 2007
View article titled, Novel DNA hypomethylating agents: non-nucleoside compounds that do not incorporate into DNA selectively induce degradation of DNA methyltransferase I (DNMT1) in human cancer cells by the proteasomal pathway and re-express silenced tumor suppressor genes