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Abstract 2707: Factoring expression data of high-grade serous ovarian cancer tumors for unbiased longitudinal analysis

Antti Häkkinen, Kaiyang Zhang, Susanna Holmström, Sanaz Jamaldazeh, Johanna Hynninen, Sakari Hietanen, Kaisa Huhtinen, Sampsa Hautaniemi

Cancer Res (2022) 82 (12_Supplement): 2707.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2707

Published: 15 June 2022

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Journal Articles

Abstract 192: Ex vivo screening and analysis of novel effective treatments for ovarian cancer

Aikaterini Skorda, Kaisa Huhtinen, Wojciech Senkowski, Krister Wennerberg, Sampsa Hautaniemi, Johanna Hynninen, Tuula Kallunki

Cancer Res (2022) 82 (12_Supplement): 192.

DOI: https://doi.org/10.1158/1538-7445.AM2022-192

Published: 15 June 2022

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Abstract 3069: Efficient establishment and utilization of a high-grade serous ovarian cancer organoid biobank

Cancer Res (2022) 82 (12_Supplement): 3069.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3069

Published: 15 June 2022

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Abstract PR003: Integration of clonal composition and tumor heterogeneity reveals novel evolutionary states and intervention targets in ovarian cancer

Alexandra Lahtinen, Kari Lavikka, Yilin Li, Sanaz Jamalzadeh, Anni Virtanen, Rainer Lehtonen, Olli Carpén, Sakari Hietanen, Kaisa Huhtinen, Antti Häkkinen, Johanna Hynninen, Jaana Oikkonen, Sampsa Hautaniemi

Cancer Res (2022) 82 (10_Supplement): PR003.

DOI: https://doi.org/10.1158/1538-7445.EVODYN22-PR003

Published: 15 May 2022

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Abstract A010: Integration of clonal composition and tumor heterogeneity reveals novel evolutionary states and intervention targets in ovarian cancer

Cancer Res (2022) 82 (10_Supplement): A010.

DOI: https://doi.org/10.1158/1538-7445.EVODYN22-A010

Published: 15 May 2022

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Journal Articles

Abstract 2059: AI - optimized genomic homologous recombination deficiency test (HRDScar) to predict platinum and PARP inhibitor responses in high-grade serous ovarian cancer

Fernando Perez-Villatoro, Jaana Oikkonen, Manuela Tumiati, Julia Casado, Sakari Hietanen, Johanna Hynninen, Elizabeth P. Garcia, Panagiotis Konstantinopoulos, Sampsa Hautaniemi, Liisa Kauppi, Anniina Färkkilä

Cancer Res (2021) 81 (13_Supplement): 2059.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2059

Published: 01 July 2021

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Journal Articles

Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells

Anniina Färkkilä, Alfredo Rodríguez, Jaana Oikkonen, Doga C. Gulhan, Huy Nguyen, Julieta Domínguez, Sandra Ramos, Caitlin E. Mills, Fernando Pérez-Villatoro, Jean-Bernard Lazaro, Jia Zhou, Connor S. Clairmont, Lisa A. Moreau, Peter J. Park, Peter K. Sorger, Sampsa Hautaniemi, Sara Frias, Alan D. D'Andrea

Cancer Res (2021) 81 (10): 2774–2787.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2912

Published: 15 May 2021

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Includes: Supplementary data

Journal Articles

Abstract 4383: Inferring transcription activity changes from copy-number and expression data of longitudinally sampled high-grade serous ovarian cancer tumors

Antti Häkkinen, Kaiyang Zhang, Johanna Hynninen, Sakari Hietanen, Kaisa Huhtinen, Olli Carpén, Rainer Lehtonen, Sampsa Hautaniemi

Cancer Res (2020) 80 (16_Supplement): 4383.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4383

Published: 15 August 2020

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Journal Articles

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer

Emilia Kozłowska, Anniina Färkkilä, Tuulia Vallius, Olli Carpén, Jukka Kemppainen, Seija Grénman, Rainer Lehtonen, Johanna Hynninen, Sakari Hietanen, Sampsa Hautaniemi

Cancer Res (2018) 78 (14): 4036–4044.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-3746

Published: 15 July 2018

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Includes: Supplementary data

Journal Articles

Abstract 5344: Phylogenetic and signature analyses predict treatment response in high-grade serous ovarian cancer

Jaana Oikkonen, Yilin Li, Amjad Alkodsi, Olli Carpen, Kaisa Huhtinen, Sakari Hietanen, Seija E. Grenman, Rainer Lehtonen, Sampsa Hautaniemi

Cancer Res (2018) 78 (13_Supplement): 5344.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5344

Published: 01 July 2018

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Journal Articles

Abstract 325: A functional homologous recombination assay predicts primary chemotherapy response and long-term survival in ovarian cancer patients

Manuela Tumiati, Sakari Hietanen, Johanna Hynninen, Elina Pietilä, Anniina Färkkilä, Katja Kaipio, Amjad Alkodsi, Minna Tuominen, Sampsa Hautaniemi, Olli Carpén, Liisa Kauppi

Cancer Res (2018) 78 (13_Supplement): 325.

DOI: https://doi.org/10.1158/1538-7445.AM2018-325

Published: 01 July 2018

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Journal Articles

Abstract 1428: Single-cell transcriptomics reveals differential DNA repair signatures after chemotherapy in high-grade serous ovarian cancer

Anniina Farkkila, Kaiyang Zhang, Katja Kaipio, Tarja Lamminen, Rainer Lehtonen, Johanna Hynninen, Seija Grénman, Olli Carpén, Sampsa Hautaniemi, Anna Vähärautio

Cancer Res (2017) 77 (13_Supplement): 1428.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1428

Published: 01 July 2017

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Journal Articles

Abstract 3939: Evolution and drug resistance of primary and relapse tumors in diffuse large B-cell lymphoma

Rainer Lehtonen, Amjad Alkodsi, Kaiyang Zhang, Mikko Kivikoski, Emilia Kozlowska, Alejandra Cervera, Annika Pasanen, Harald Holte, Sirpa Leppä, Sampsa Hautaniemi

Cancer Res (2017) 77 (13_Supplement): 3939.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3939

Published: 01 July 2017

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Journal Articles

Abstract 1999: Regulation of the oncogenic, invasion-promoting transcription factor myeloid zinc finger-1 (MZF1) in breast cancer by microRNAs

Tuula Kallunki, Siri A. Tvingsholm, Knut K. Bundgaard Clemmensen, Ditte M. Brix, Bo Rafn, José Moreira, Lisa Frankel, Anders Lund, Riku Louhimo, Sampsa Hautaniemi, Irina Gromova, Marja Jäättelä

Cancer Res (2016) 76 (14_Supplement): 1999.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1999

Published: 15 July 2016

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Journal Articles

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum–Taxane Chemotherapy

Ping Chen, Kaisa Huhtinen, Katja Kaipio, Piia Mikkonen, Viljami Aittomäki, Rony Lindell, Johanna Hynninen, Annika Auranen, Seija Grénman, Rainer Lehtonen, Olli Carpén, Sampsa Hautaniemi

Cancer Res (2015) 75 (15): 2987–2998.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-3242

Published: 02 August 2015

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Includes: Supplementary data

Journal Articles

MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

Olga Tatti, Erika Gucciardo, Pirita Pekkonen, Tanja Holopainen, Riku Louhimo, Pauliina Repo, Pilvi Maliniemi, Jouko Lohi, Ville Rantanen, Sampsa Hautaniemi, Kari Alitalo, Annamari Ranki, Päivi M. Ojala, Jorma Keski-Oja, Kaisa Lehti

Cancer Res (2015) 75 (10): 2083–2094.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-1923

Published: 13 May 2015

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Includes: Supplementary data

Journal Articles

Abstract A57: Nonsense‐mediated decay escaping mutations in microsatellite-unstable colorectal cancer

Alexandra Gylfe, Iina Niittymäki, Leena Ahonen, Heli Lehtonen, Marko Laakso, Johanna Sirkiä, Kari Nousiainen, Jeroen Pouwels, Heikki Järvinen, Kyösti Nuorva, Jukka‐Pekka Mecklin, Ari Ristimäki, Torben Ørntoft, Sampsa Hautaniemi, Auli Karhu, Marko Kallio, Lauri Aaltonen

Cancer Res (2009) 69 (23_Supplement): A57.

DOI: https://doi.org/10.1158/0008-5472.FBCR09-A57

Published: 28 October 2014

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Journal Articles

Abstract 3348: Netrin-4/Integrin beta-4 interaction promotes glioblastoma cell proliferation and protects from temozolomide induced cellular senescence via activating PI3K/AKT pathway

Yizhou Hu, Irene Ylivinkka, Li Li, Ping Chen, Sampsa Hautaniemi, Tuula A. Nyman, Jorma Keski-Oja Keski-Oja, Marko Hyytiäinen

Cancer Res (2014) 74 (19_Supplement): 3348.

DOI: https://doi.org/10.1158/1538-7445.AM2014-3348

Published: 01 October 2014

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Journal Articles

Abstract 4933: Functional properties of PPFIA1, located at the 11q13 amplification region, in epithelial cancer cells.

Henna Pehkonen, Tatiana Lepikhova, Riku Louhimo, Nina Peitsaro, Misa Imai, Rafael Martinez, Juha Kleftsröm, Sampsa Hautaniemi, Outi Monni

Cancer Res (2013) 73 (8_Supplement): 4933.

DOI: https://doi.org/10.1158/1538-7445.AM2013-4933

Published: 15 April 2013

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Journal Articles

FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells

Biswajyoti Sahu, Marko Laakso, Päivi Pihlajamaa, Kristian Ovaska, Ievgenii Sinielnikov, Sampsa Hautaniemi, Olli A. Jänne

Cancer Res (2013) 73 (5): 1570–1580.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-2350

Published: 03 March 2013

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Includes: Supplementary data

NARROW

Abstract 2707: Factoring expression data of high-grade serous ovarian cancer tumors for unbiased longitudinal analysis

Abstract 192: Ex vivo screening and analysis of novel effective treatments for ovarian cancer

Abstract 3069: Efficient establishment and utilization of a high-grade serous ovarian cancer organoid biobank

Abstract PR003: Integration of clonal composition and tumor heterogeneity reveals novel evolutionary states and intervention targets in ovarian cancer

Abstract A010: Integration of clonal composition and tumor heterogeneity reveals novel evolutionary states and intervention targets in ovarian cancer

Abstract 2059: AI - optimized genomic homologous recombination deficiency test (HRDScar) to predict platinum and PARP inhibitor responses in high-grade serous ovarian cancer

Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells

Abstract 4383: Inferring transcription activity changes from copy-number and expression data of longitudinally sampled high-grade serous ovarian cancer tumors

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer

Abstract 5344: Phylogenetic and signature analyses predict treatment response in high-grade serous ovarian cancer

Abstract 325: A functional homologous recombination assay predicts primary chemotherapy response and long-term survival in ovarian cancer patients

Abstract 1428: Single-cell transcriptomics reveals differential DNA repair signatures after chemotherapy in high-grade serous ovarian cancer

Abstract 3939: Evolution and drug resistance of primary and relapse tumors in diffuse large B-cell lymphoma

Abstract 1999: Regulation of the oncogenic, invasion-promoting transcription factor myeloid zinc finger-1 (MZF1) in breast cancer by microRNAs

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum–Taxane Chemotherapy

MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

Abstract A57: Nonsense‐mediated decay escaping mutations in microsatellite-unstable colorectal cancer

Abstract 3348: Netrin-4/Integrin beta-4 interaction promotes glioblastoma cell proliferation and protects from temozolomide induced cellular senescence via activating PI3K/AKT pathway

Abstract 4933: Functional properties of PPFIA1, located at the 11q13 amplification region, in epithelial cancer cells.

FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells

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