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Journal Articles

Abstract CT022: Divarasib plus migoprotafib combination treatment in patients with KRAS G12C-positive non-small cell lung cancer (NSCLC)

Free
Jia Luo, Adrian Sacher, Armando Santoro, Luis Paz-Ares, Sanjeev Deva, Hans Prennen, Maria de Miguel, Rafal Dziadziuszko, Scott A. Laurie, Manish R. Patel, Elena Garralda, Gianluca Del Conte, Loes Latten Jansen, Jayesh Desai, Rita De Cassia Costamilan, Patricia LoRusso, Ben Markman, Salvatore Siena, Pierre Freres, Marloes Van Dongen, Eugenio Fernandez, Andres Cervantes, Josiane Mourão Dias, Sergio Azevedo, Kathryn Arbour, Ruth Perets, Se Hyun Kim, Rasha Cosman, Victor Moreno, Matthew G. Krebs, Yoonha Choi, Sandhya Mandlekar, Mark T. Lin, Zhen Shi, Kenneth K. Yau, Julie Chang, Stephanie Royer-Joo, Tomi Jun, Neekesh V. Dharia, Jennifer L. Schutzman, Myung-Ju Ahn
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT022.
https://doi.org/10.1158/1538-7445.AM2025-CT022
Published: 25 April 2025
View articletitled, Abstract CT022: Divarasib plus migoprotafib combination treatment in patients with KRAS G12C-positive non-small cell lung cancer (NSCLC)
Journal Articles

Abstract CT204: Phase 1a/b study of runimotamab, a HER2 x CD3 T cell-engaging bispecific antibody, administered as a single agent and in combination with trastuzumab in patients with HER2-expressing breast cancer (BC)

Free
Shanu Modi, Timothy A. Yap, Tira J. Tan, Armando Santoro, Valentina Gambardella, Philippe Cassier, Haeseong Park, Erika Hamilton, Chia-Chi Lin, Capucine Baldini, Philippe L. Bedard, Seock-Ah Im, Jean-Luc Canon, Iben Spanggaard, Valentina Boni, Maria de Miguel, Patricia LoRusso, Antoine Italiano, Carlos Gomez-Roca, Simon Lord, Chang-Fang Chiu, Sherene Loi, Victor Moreno, Kohei Shitara, Cristina Saura, Marloes van Dongen, Salvatore Siena, Giuseppe Curigliano, Sharareh Monemi, Sharmeen Hassan, Michelle Wilhite, Emiko Gale, Zao Li, Zhaojun Yin, Chunze Li, Luciana Molinero, Kelly DuPree, Teemu Junttila, Aditi Qamra, Lina Alon, Iris T. Chan, Kyung Hae Jung
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT204.
https://doi.org/10.1158/1538-7445.AM2025-CT204
Published: 25 April 2025
View articletitled, Abstract CT204: Phase 1a/b study of runimotamab, a HER2 x CD3 T cell-engaging bispecific antibody, administered as a single agent and in combination with trastuzumab in patients with HER2-expressing breast cancer (BC)
Journal Articles

Abstract 2370: Microbiome alterations of colorectal cancer according to age of onset, stage, anatomic location, and mismatch repair deficiency

Free
Gianmarco Piccinno, Kelsey N. Thompson, Paolo Manghi, Luca Lazzari, Chiara Pozzi, Andrew R. Ghazi, Andrew M. Thomas, Aitor Blanco-Miguez, Francesco Asnicar, Katarina Mladenovic, Federica Pinto, Federica Armanini, Giulio Ferrero, Sonia Tarallo, Long H. Nguyen, Yan Yan, Mingyang Song, Veronika Vymetalkova, Mario Trompetto, Vaclav Liska, Tomas Hucl, Pavel Vodicka, Beatrix Bencsiková, Martina Čarnogurská, Vlad Popovici, Salvatore Siena, Andrea Sartore-Bianchi, Michela Lizier, Carmen Correale, Alessandra Raimondi, Filippo Pietrantonio, Federica Marmorino, Chiara Cremolini, Barbara Pardini, Francesca Cordero, Lisa Derosa, Silvia Marsoni, Alberto Bardelli, Maria Rescigno, Yin Cao, Andrew T. Chan, Laurence Zitvogel, Curtis Huttenhower, Alessio Naccarati, Eva Budinska, Nicola Segata
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2370.
https://doi.org/10.1158/1538-7445.AM2025-2370
Published: 21 April 2025
View articletitled, Abstract 2370: Microbiome alterations of colorectal cancer according to age of onset, stage, anatomic location, and mismatch repair deficiency
Journal Articles

Abstract 7148: Exploratory biomarker analysis of trastuzumab deruxtecan (T-DXd) treatment for HER2-positive (HER2+) metastatic colorectal cancer (mCRC) in DESTINY-CRC02 (DC-02)

Free
Salvatore Siena, Kanwal Raghav, Atsuo Takashima, Takeshi Kato, Marc Van den Eynde, Filippo Pietrantonio, Yoshito Komatsu, Hisato Kawakami, Marc Peeters, Thierry Andre, Sara Lonardi, Kensei Yamaguchi, Jeanne Tie, Cristina Gravalos Castro, John H. Strickler, Yoshinobu Shiose, Makito Koga, Aislyn Boran, Dipica Haribhai, Hiroki Goto, Daniel Barrios, Kodai Abe, Takayuki Yoshino
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7148.
https://doi.org/10.1158/1538-7445.AM2025-7148
Published: 21 April 2025
View articletitled, Abstract 7148: Exploratory biomarker analysis of trastuzumab deruxtecan (T-DXd) treatment for HER2-positive (HER2+) metastatic colorectal cancer (mCRC) in DESTINY-CRC02 (DC-02)
Journal Articles

Abstract 900: Development and validation of an artificial-intelligence-based pathomics biomarker to predict resistance to first-line treatment in metastatic colorectal cancer

Free
Luca Lazzari, Gianluca Mauri, Valentina Giannini, Debora Cafaro, Giulia Nicoletti, Caterina Marchiò, Andrea Sartore-Bianchi, Federica Marmorino, Maria Nieva Munoz, Nadia Saoudi Gonzalez, Alberto Puccini, Chiara Cremolini, Clara Montagut, Elena Elez, Stefania Sciallero, Enrico Berrino, Martina Carullo, Pietro Paolo Vitiello, Maria Costanza Aquilano, Martina Di Como, Emanuela Bonoldi, Salvatore Siena, Alberto Bardelli, Daniele Regge, Silvia Marsoni
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 900.
https://doi.org/10.1158/1538-7445.AM2024-900
Published: 22 March 2024
View articletitled, Abstract 900: Development and validation of an artificial-intelligence-based pathomics biomarker to predict resistance to first-line treatment in metastatic colorectal cancer
Journal Articles

Immune Checkpoint Inhibitors and the Exposome: Host-Extrinsic Factors Determine Response, Survival, and Toxicity

Open Access
Elio Gregory Pizzutilo, Rebecca Romanò, Laura Roazzi, Alberto G. Agostara, Sara Oresti, Annalisa Zeppellini, Laura Giannetta, Giulio Cerea, Diego Signorelli, Salvatore Siena, Andrea Sartore-Bianchi
Journal: Cancer Research
Cancer Res (2023) 83 (14): 2283–2296.
https://doi.org/10.1158/0008-5472.CAN-23-0161
Published: 14 July 2023
View articletitled, Immune Checkpoint Inhibitors and the Exposome: Host-Extrinsic Factors Determine Response, Survival, and Toxicity
Open the PDF for Immune Checkpoint Inhibitors and the Exposome: Host-Extrinsic Factors Determine Response, Survival, and Toxicity in another window
Includes: Supplementary data
Journal Articles

BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Open Access
Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo, Matteo Benelli, Loris De Cecco, Dario Romagnoli, Enrico Berrino, Claudia Orrù, Salvatore Ribisi, Daniel Moya-Rull, Cristina Migliore, Daniela Conticelli, Irene M. Maina, Elisabetta Puliga, Violeta Serra, Benedetta Pellegrino, Alba Llop-Guevara, Antonino Musolino, Salvatore Siena, Andrea Sartore-Bianchi, Michele Prisciandaro, Federica Morano, Maria Antista, Uberto Fumagalli, Giovanni De Manzoni, Maurizio Degiuli, Gian Luca Baiocchi, Marco F. Amisano, Alessandro Ferrero, Caterina Marchiò, Simona Corso, Silvia Giordano
Journal: Cancer Research
Cancer Res (2023) 83 (10): 1699–1710.
https://doi.org/10.1158/0008-5472.CAN-22-2620
Published: 15 May 2023
View articletitled, BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors
Open the PDF for BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract CT029: Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation

Free
Jayesh Desai, Sae-Won Han, Jong-Seok Lee, Einat Shacham-Shmueli, Erminia Massarelli, Andrés Cervantes, Elena Garralda, Alejandro Falcon, Wilson H. Miller, Eelke Gort, Thomas Karasic, Salvatore Siena, Rafal Stec, Laura Medina, Luis Paz-Arez, Angelo Delmonte, Adrian Sacher, Hans Prenen, Martin Forster, Tae Won Kim, Matthew G. Krebs, Rasha Cosman, Yoonha Choi, Sandhya Mandlekar, Mark T. Lin, Kenneth K. Yau, Julie Chang, Stephanie Royer-Joo, Neekesh V. Dharia, Jennifer L. Schutzman, Manish Patel
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT029.
https://doi.org/10.1158/1538-7445.AM2023-CT029
Published: 14 April 2023
View articletitled, Abstract CT029: Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation
Journal Articles

Abstract 6262: Emergence of tumor mismatch repair deficiency and increased mutational burden in blood and tissue of metastatic colorectal cancer patients treated with temozolomide

Free
Giovanni Crisafulli, Andrea Sartore-Bianchi, Luca Lazzari, Filippo Pietrantonio, Alessio Amatu, Marco Macagno, Ludovic Barault, Andrea Cassingena, Alice Bartolini, Paolo Luraghi, Gianluca Mauri, Paolo Battuello, Nicola Personemi, Valeria Pessei, Pietro Paolo Vitiello, Federica Tosi, Laura Idotta, Emanuele Valtorta, Emanuela Bonoldi, Giovanni Germano, Federica Di Nicolantonio, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6262.
https://doi.org/10.1158/1538-7445.AM2022-6262
Published: 15 June 2022
View articletitled, Abstract 6262: Emergence of tumor mismatch repair deficiency and increased mutational burden in blood and tissue of metastatic colorectal cancer patients treated with temozolomide
Journal Articles

Abstract 5419: A unique pattern of heterogeneous MMR protein expression in colorectal cancer unveils different degrees of tumor mutational burden and distinct tumor microenvironment features

Free
Enrico Berrino, Maria Costanza Aquilano, Emanuele Valtorta, Vito Amodio, Giovanni Germano, Marco Gusmini, Ivana Sarotto, Anna Sapino, Silvia Marsoni, Andrea Sartore-Bianchi, Alberto Bardelli, Salvatore Siena, Emanuela Bonoldi, Caterina Marchio
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5419.
https://doi.org/10.1158/1538-7445.AM2022-5419
Published: 15 June 2022
View articletitled, Abstract 5419: A unique pattern of heterogeneous MMR protein expression in colorectal cancer unveils different degrees of tumor mutational burden and distinct tumor microenvironment features
Journal Articles

Abstract CT167: Pooled analysis of drug-related interstitial lung disease (ILD) in 8 single-arm trastuzumab deruxtecan (T-DXd) studies

Free
Charles A. Powell, Shanu Modi, Hiroji Iwata, Shunji Takahashi, Egbert F. Smit, Salvatore Siena, Dwan-Ying Chang, Charles S. Fuchs, Kun Nie, Amy Qin, Jasmeet Singh, Corina Taitt, Sunil Verma, D. Ross Camidge
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT167.
https://doi.org/10.1158/1538-7445.AM2021-CT167
Published: 01 July 2021
View articletitled, Abstract CT167: Pooled analysis of drug-related interstitial lung disease (ILD) in 8 single-arm trastuzumab deruxtecan (T-DXd) studies
Journal Articles

Abstract CT263: Post-surgical liquid biopsy-guided treatment of stage III and high-risk stage II colon cancer patients: The PEGASUS trial

Free
Elena Elez, Filippo Pietrantonio, Andrea Sartore-Bianchi, Clara Montagut, Andres Cervantes, Stefania Sciallero, Maria Giulia Zampino, Stefania Mosconi, Valter Torri, Noelia Tarazona, Luca Lazzari, Paolo Luraghi, Susana Muñoz, Matteo Fassan, Enzo Medico, Livio Trusolino, Maria Rescigno, Salvatore Siena, Alberto Sobrero, Roberto Labianca, Josep Tabernero, Alberto Bardelli, Sara Lonardi, Silvia Marsoni
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT263.
https://doi.org/10.1158/1538-7445.AM2020-CT263
Published: 15 August 2020
View articletitled, Abstract CT263: Post-surgical liquid biopsy-guided treatment of stage III and high-risk stage II colon cancer patients: The PEGASUS trial
Journal Articles

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Free
Simona Corso, Claudio Isella, Sara E. Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D’Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tânia Capelôa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli, Stefano De Pascale, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Filippo Pietrantonio, Federica Morano, Salvatore Siena, Andrea Sartore-Bianchi, Maria Bencivenga, Valentina Mengardo, Riccardo Rosati, Daniele Marrelli, Paolo Morgagni, Stefano Rausei, Giovanni Pallabazzer, Michele De Simone, Dario Ribero, Silvia Marsoni, Antonino Sottile, Enzo Medico, Paola Cassoni, Anna Sapino, Eirini Pectasides, Aaron R. Thorner, Anwesha Nag, Samantha D. Drinan, Bruce M. Wollison, Adam J. Bass, Silvia Giordano
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5884–5896.
https://doi.org/10.1158/0008-5472.CAN-19-1166
Published: 15 November 2019
View articletitled, A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits
Open the PDF for A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits in another window
Includes: Supplementary data
Journal Articles

Abstract CT192: Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2

Free
Alexander Drilon, Fabrice Barlesi, Filippo De Braud, Byoung Chul Cho, Myung-Ju Ahn, Salvatore Siena, Matthew G. Krebs, Chia-Chi Lin, Tom John, Daniel SW Tan, Takashi Seto, Rafal Dziadziuszko, Hendrick-Tobias Arkenau, Christian Rolfo, Jürgen Wolf, Chenglin Ye, Todd Riehl, Susan Eng, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT192.
https://doi.org/10.1158/1538-7445.AM2019-CT192
Published: 01 July 2019
View articletitled, Abstract CT192: Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2
Journal Articles

Abstract CT215: Pharmacological inactivation of DNA repair to improve response to immunotherapy: The Arethusa trial in metastatic colorectal cancer

Free
Silvia Marsoni, Giovanni Germano, Andrea Sartore Bianchi, Filippo Pietrantonio, Nicola Personeni, Alessio Amatu, Emanuela Bonoldi, Emanuele Valtorta, Ludovic Barault, Federica Di Nicolantonio, Filippo de Braud, Lorenza Rimassa, Armando Santoro, Silvia Ghezzi, Andrea Cassingena, Giovanna Marrapese, Loredana Lupica, Giulia Siravegna, Giuseppe Rospo, Cosimo Martino, Luca Lazzari, Paolo Luraghi, Nabil Amirouchene-Angelozzi, Alberto Bardelli, Salvatore Siena
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT215.
https://doi.org/10.1158/1538-7445.AM2019-CT215
Published: 01 July 2019
View articletitled, Abstract CT215: Pharmacological inactivation of DNA repair to improve response to immunotherapy: The Arethusa trial in metastatic colorectal cancer
Journal Articles

Abstract CT214: AlfaOmega- a master protocol empowering precision research in colorectal cancer

Free
Luca Lazzari, Paolo Luraghi, Nabil Amirouchene-Angelozzi, Andrea Bertotti, Enzo Medico, Federica Di Nicolantonio, Fabrizio d'Adda di Fagagna, Sergio Abrignani, Daniele Regge, Anna Sapino, Emanuela Bonoldi, Angelo Vanzulli, Vittorina Zagonel, Filippo de Braud, Livio Trusolino, Alberto Bardelli, Salvatore Siena, Silvia Marsoni
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT214.
https://doi.org/10.1158/1538-7445.AM2019-CT214
Published: 01 July 2019
View articletitled, Abstract CT214: AlfaOmega- a master protocol empowering precision research in colorectal cancer
Journal Articles

Abstract LB-299: A comprehensive platform of patient-derived xenografts and matched cell lines mirrors the genomic landscape of colorectal cancer

Free
Luca Lazzari, Giorgio Corti, Claudio Isella, Monica Montone, Pamela Arcella, Eugenia Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-299.
https://doi.org/10.1158/1538-7445.AM2019-LB-299
Published: 01 July 2019
View articletitled, Abstract LB-299: A comprehensive platform of patient-derived xenografts and matched cell lines mirrors the genomic landscape of colorectal cancer
Journal Articles

Abstract 5723: Inactivation of DNA repair triggers neoantigen generation and impairs tumor growth

Free
Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magri', Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D'Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Federica DiNicolantonio, Alberto Bardelli
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5723.
https://doi.org/10.1158/1538-7445.AM2018-5723
Published: 01 July 2018
View articletitled, Abstract 5723: Inactivation of DNA repair triggers neoantigen generation and impairs tumor growth
Journal Articles

Abstract 205: Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Free
Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 205.
https://doi.org/10.1158/1538-7445.AM2018-205
Published: 01 July 2018
View articletitled, Abstract 205: Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
Journal Articles

Abstract 2743: Accumulation of predicted neoantigens by MMR deficiency triggered by temozolomide treatment of human colorectal cancer

Free
Ludovic Barault, Giovanni Germano, Simona Lamba, Giuseppe Rospo, Alessandro Magri, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Chiara Falcomatà, Carlotta Cancelliere, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Giovanni Randon, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D'Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Alberto Bardelli, Federica Di Nicolantonio
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2743.
https://doi.org/10.1158/1538-7445.AM2018-2743
Published: 01 July 2018
View articletitled, Abstract 2743: Accumulation of predicted neoantigens by MMR deficiency triggered by temozolomide treatment of human colorectal cancer