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Said M. Sebti
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Journal Articles

Abstract 4326: KRB-456: A novel KRAS G12D switch-I/II allosteric pocket binder that thwarts pancreatic cancer patient-derived tumors

Aslamuzzaman Kazi, Alok Ranjan, Vasanth M. Kumar, Bogos Agianian, Martin Garcia Chavez, Vignesh Vudatha, Rui Wang, Rajani Kanth Vangipurapu, Liwei Chen, Perry Kennedy, Karthikeyan Subramanian, Quirke Jonathan Charles Kenneth, Francisca Beato, Patrick W. Underwood, Jason B. Fleming, Paul Hergenrother, Jose Trevino, Evripidis Gavathiotis, Said M. Sebti
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4326.
https://doi.org/10.1158/1538-7445.AM2025-4326
Published: 21 April 2025
View articletitled, Abstract 4326: KRB-456: A novel KRAS G12D switch-I/II allosteric pocket binder that thwarts pancreatic cancer patient-derived tumors
Journal Articles

Abstract 4324: Inhibition of ERK reactivation by FGTI-2734: A strategy to overcome sotorasib resistance in KRAS G12C lung cancer

Aslamuzzaman Kazi, Hitesh Kumar Kantilal Vasiyan, Deblina Ghosh, Dipankar Bandyopadhyay, Rachit D. Shah, Vignesh Vudatha, Jose Trevino, Said M. Sebti
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4324.
https://doi.org/10.1158/1538-7445.AM2025-4324
Published: 21 April 2025
View articletitled, Abstract 4324: Inhibition of ERK reactivation by FGTI-2734: A strategy to overcome sotorasib resistance in KRAS G12C lung cancer
Journal Articles

Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Muhammad Ayaz, Steven Fletcher, Christopher Cummings, Harshani Lawrence, Francisca Beato, Ya'an Yang, Michael P. Kim, Andrea Delitto, Patrick Underwood, Jason B. Fleming, Jose Trevino, Andrew D. Hamilton, Said M. Sebti
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3088.
https://doi.org/10.1158/1538-7445.AM2019-3088
Published: 01 July 2019
View articletitled, Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors
Journal Articles

Abstract 1310: Abrogation of KRas-addicted tumors by GSK3 suppression-mediated upregulation of β-catenin and c-myc

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, Jose Trevino, Rays H. Jiang, Muhammad Ayaz, Harshani Lawrence, Perry Kennedy, Said M. Sebti
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1310.
https://doi.org/10.1158/1538-7445.AM2019-1310
Published: 01 July 2019
View articletitled, Abstract 1310: Abrogation of KRas-addicted tumors by GSK3 suppression-mediated upregulation of β-catenin and c-myc
Journal Articles

Abstract 767: Identification of cell surface proteins expressed exclusively on mutant KRas-dependent cancer cells

Vijayendra Agrawal, Bin Fang, Eric A. Welsh, John Koomen, Said M. Sebti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 767.
https://doi.org/10.1158/1538-7445.AM2018-767
Published: 01 July 2018
View articletitled, Abstract 767: Identification of cell surface proteins expressed exclusively on mutant KRas-dependent cancer cells
Journal Articles

Abstract 768: Identification of signal transduction pathways specific for mutant KRas-dependent tumors

Oorvashi Roy Puli, Hua Yang, Bin Fang, Hong Yuan (Rays) Jiang, John Koomen, Said M. Sebti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 768.
https://doi.org/10.1158/1538-7445.AM2018-768
Published: 01 July 2018
View articletitled, Abstract 768: Identification of signal transduction pathways specific for mutant KRas-dependent tumors
Journal Articles

Abstract 1669: Identification of mutant KRas-Raf-1 binding disruptors

Rajanikanth Vangipurapu, Liwei Chen, Perry Kennedy, Karen C. Morrison, Paul J. Hergenrother, Said M. Sebti
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1669.
https://doi.org/10.1158/1538-7445.AM2018-1669
Published: 01 July 2018
View articletitled, Abstract 1669: Identification of mutant KRas-Raf-1 binding disruptors
Journal Articles

Abstract 1098: Delta-tocotrienol chemosensitizes human pancreatic tumor metastasis to gemcitabine targeting cancer stem cells

Kazim Husain, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1098.
https://doi.org/10.1158/1538-7445.AM2017-1098
Published: 01 July 2017
View articletitled, Abstract 1098: Delta-tocotrienol chemosensitizes human pancreatic tumor metastasis to gemcitabine targeting cancer stem cells
Journal Articles

Abstract 3839: Vitamin E delta-tocotrienol targets human colon cancer stem cells and inhibits colon cancer metastasis and induces apoptosis

Kazim Husain, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3839.
https://doi.org/10.1158/1538-7445.AM2016-3839
Published: 15 July 2016
View articletitled, Abstract 3839: Vitamin E delta-tocotrienol targets human colon cancer stem cells and inhibits colon cancer metastasis and induces apoptosis
Journal Articles

Abstract 2605: The geranylgeranyltransferase I inhibitor GGTI-2418 suppresses multiple myeloma malignancy in the 5TMG1 mouse model

Hua Yang, Michael F. Emmons, Christopher Cubitt, Ken Shain, Domenico Coppola, Daniel Sullivan, Conor C. Lynch, Lori Hazlehurst, Said M. Sebti
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2605.
https://doi.org/10.1158/1538-7445.AM2015-2605
Published: 01 August 2015
View articletitled, Abstract 2605: The geranylgeranyltransferase I inhibitor GGTI-2418 suppresses multiple myeloma malignancy in the 5TMG1 mouse model
Journal Articles

Abstract 2153: Kinome inhibitor screen identifies kinase inhibitors that inhibit selectively the survival of mutant K-Ras-dependent human cancer cells

Norbert Berndt, Xiaolei Zhang, Rays H.Y. Jiang, Said M. Sebti
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2153.
https://doi.org/10.1158/1538-7445.AM2015-2153
Published: 01 August 2015
View articletitled, Abstract 2153: Kinome inhibitor screen identifies kinase inhibitors that inhibit selectively the survival of mutant K-Ras-dependent human cancer cells
Journal Articles

Abstract 4383: Vitamin E delta-tocotrienol inhibits metastasis and targets cancer stem cell signaling in human pancreatic cancer

Kazim Husain, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4383.
https://doi.org/10.1158/1538-7445.AM2015-4383
Published: 01 August 2015
View articletitled, Abstract 4383: Vitamin E delta-tocotrienol inhibits metastasis and targets cancer stem cell signaling in human pancreatic cancer
Journal Articles

Abstract 2580: Screening of a mixture-based synthetic combinatorial library identifies small molecules that inhibit the ability of GTP to displace mant-GDP from mutant G12D KRas

Perry C. Kennedy, Marc C. Guilanotti, Travis LsVoi, Said M. Sebti
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2580.
https://doi.org/10.1158/1538-7445.AM2015-2580
Published: 01 August 2015
View articletitled, Abstract 2580: Screening of a mixture-based synthetic combinatorial library identifies small molecules that inhibit the ability of GTP to displace mant-GDP from mutant G12D KRas
Journal Articles

Abstract 1750: Combined blockade of Aurora A and JAK2 kinase is highly effective at inhibiting malignant transformation

Said M. Sebti, Hua Yang, Harshani Lawrence, Aslamuzzaman Kazi, Harsukh Gervaria, Ronil Patel, Yunting Luo, Uwe Rix, Ernst Schonbrunn, Nicholas Lawrence
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1750.
https://doi.org/10.1158/1538-7445.AM2014-1750
Published: 01 October 2014
View articletitled, Abstract 1750: Combined blockade of Aurora A and JAK2 kinase is highly effective at inhibiting malignant transformation
Journal Articles

Abstract 4522: Akt2 and acid ceramidase cooperate to induce malignant transformation

Said M. Sebti, Norbert Berndt, Ronil Patel, Hua Yang, Maria Balasis
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4522.
https://doi.org/10.1158/1538-7445.AM2014-4522
Published: 01 October 2014
View articletitled, Abstract 4522: Akt2 and acid ceramidase cooperate to induce malignant transformation
Journal Articles

Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling

Michelle A. Blaskovich, Yunting Luo, Yiyu Ge, Saïd M. Sebti, Harshani R. Lawrence, Nicholas J. Lawrence, Gregory M. Springett
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1640.
https://doi.org/10.1158/1538-7445.AM2014-1640
Published: 01 October 2014
View articletitled, Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling
Journal Articles

Abstract 1699: Delta-tocotrienol potentiates the antitumor activity of standard chemotherapy with gemcitabine and abraxane in metastatic pancreatic cancer

Kazim Husain, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1699.
https://doi.org/10.1158/1538-7445.AM2014-1699
Published: 01 October 2014
View articletitled, Abstract 1699: Delta-tocotrienol potentiates the antitumor activity of standard chemotherapy with gemcitabine and abraxane in metastatic pancreatic cancer
Journal Articles

Abstract 1810: PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity

Said M. Sebti, Aslamuzzaman Kazi, Sevil Ozcan, Awet G. Tecleab, Ying Sun, Harshani Lawrence
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2014-1810
Published: 01 October 2014
View articletitled, Abstract 1810: PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity
Journal Articles

Abstract 3802: Withacnistin blocks binding of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumors in vivo

Xiaolei Zhang, Michelle A. Blaskovich, Kara D. Forinash, Said M. Sebti
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3802.
https://doi.org/10.1158/1538-7445.AM2014-3802
Published: 01 October 2014
View articletitled, Abstract 3802: Withacnistin blocks binding of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumors in vivo
Journal Articles

Abstract 2070: Natural vitamin E delta-tocotrienol combined with gemcitabine prolongs the survival, induces apoptosis, inhibits tumor growth, angiogenesis and oncogenic signaling in a transgenic mouse model of pancreatic cancer.

Kazim Husain, Barbara Centeno, Marta Perez, Chen Dung-Tsa, Said M. Sebti, Mokenge P. Malafa
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2070.
https://doi.org/10.1158/1538-7445.AM2013-2070
Published: 15 April 2013
View articletitled, Abstract 2070: Natural vitamin E delta-tocotrienol combined with gemcitabine prolongs the survival, induces apoptosis, inhibits tumor growth, angiogenesis and oncogenic signaling in a transgenic mouse model of pancreatic cancer.