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Saïd M. Sebti
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Journal Articles

Abstract 1854: Lysophosphatidic Acid Acyltransferase-Beta contributes to proliferation and anchorage-independent growth in pancreatic adenocarcinoma

Michelle Blaskovich, Harsukh Gevariya, Nicholas J. Lawrence, Saïd M. Sebti, Gregory Springett
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1854.
https://doi.org/10.1158/1538-7445.AM2012-1854
Published: 15 April 2012
View article titled, Abstract 1854: Lysophosphatidic Acid Acyltransferase-Beta contributes to proliferation and anchorage-independent growth in pancreatic adenocarcinoma
Journal Articles

Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases

Roberta Pireddu, Kara Forinash, Nan N. Sun, Mathew P. Martin, Shen-Shu Sung, Brian Alexander, Jin-Yi Zhu, Wayne C. Guida, Ernst Schönbrunn, Saïd M. Sebti, Nicholas J. Lawrence
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3904.
https://doi.org/10.1158/1538-7445.AM2012-3904
Published: 15 April 2012
View article titled, Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases
Journal Articles

Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors

Daniele Pernazza, Xiaolong Li, Harshani R. Lawrence, Wayne C. Guida, Courtney J. DuBoulay, Shawn Watts, Saïd M. Sebti, Jiandong Chen, Nicholas J. Lawrence
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3242.
https://doi.org/10.1158/1538-7445.AM2011-3242
Published: 15 April 2011
View article titled, Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors
Journal Articles

Abstract 732: Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction

Daniele Pernazza, Harshani R. Lawrence, Kenichiro Doi, Shen-Shu Sung, Wayne C. Guida, Saïd M. Sebti, Hong-Gang Wang, Nicholas J. Lawrence
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 732.
https://doi.org/10.1158/1538-7445.AM10-732
Published: 15 April 2010
View article titled, Abstract 732: Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction
Journal Articles

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

Jiazhi Sun, Michelle A. Blaskovich, Rishi K. Jain, Frederic Delarue, Daniel Paris, Steven Brem, Marguerite Wotoczek-Obadia, Qing Lin, Domenico Coppola, Kihang Choi, Michael Mullan, Andrew D. Hamilton, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2004) 64 (10): 3586–3592.
https://doi.org/10.1158/0008-5472.CAN-03-2673
Published: 17 May 2004
View article titled, Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor
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Journal Articles

Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice

Jiazhi Sun, Junko Ohkanda, Domenico Coppola, Hang Yin, Mohit Kothare, Brian Busciglio, Andrew D. Hamilton, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2003) 63 (24): 8922–8929.
Published: 24 December 2003
View article titled, Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice
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Journal Articles

Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor, James Turkson, Richard Jove, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2003) 63 (6): 1270–1279.
Published: 15 March 2003
View article titled, Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice
Open the PDF for Discovery of JSI-124 (Cucurbitacin I), a Selective Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathway Inhibitor with Potent Antitumor Activity against Human and Murine Cancer Cells in Mice in another window
Journal Articles

CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21WAF1 and p27KIP1 Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice

Jiazhi Sun, Sangkil Nam, Chang-Sun Lee, Benyi Li, Domenico Coppola, Andrew D. Hamilton, Q. Ping Dou, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2001) 61 (4): 1280–1284.
Published: 02 February 2001
View article titled, CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21<sup>WAF1</sup> and p27<sup>KIP1</sup> Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice
Open the PDF for CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21<sup>WAF1</sup> and p27<sup>KIP1</sup> Expression and Apoptosis and Inhibits the Growth of the Human Lung Adenocarcinoma A-549 in Nude Mice in another window
Journal Articles

Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine

Jiazhi Sun, Michelle A. Blaskovich, David Knowles, Yimin Qian, Junko Ohkanda, Ratna D. Bailey, Andrew D. Hamilton, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (1999) 59 (19): 4919–4926.
Published: 01 October 1999
View article titled, Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: <subtitle>Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine</subtitle>
Open the PDF for Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: <subtitle>Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine</subtitle> in another window