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Journal Articles

Abstract 3794: Comprehensive clonal and molecular profiling of primary tumors and distant lung metastases in an amputation model of osteosarcoma

Sylvester Jusu, Sankaranarayanan Kannan, Sahil Seth, Michael D. Peoples, Zhongting Zhang, Wendong Zhang, Zhaohui Xu, Yifei Wang, Xin Zhou, Yizheng Tu, Giuseppe Longo, Michael Roth, Jonathan B. Gill, Richard Gorlick
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3794.
https://doi.org/10.1158/1538-7445.AM2022-3794
Published: 15 June 2022
View article titled, Abstract 3794: Comprehensive clonal and molecular profiling of primary tumors and distant lung metastases in an amputation model of osteosarcoma
Journal Articles

Abstract LB079: Pancreatic clonal replica tumors display functional heterogeneity in response to KRAS pharmacological inhibition and reveal unique epigenetic vulnerabilities to overcome resistance

Hengyu Lyu, Rosalba Minelli, Charles E. Deckard, Sahil Seth, Justin Huang, Hong Jiang, Michael D. Peoples, Meggie Lam, Christopher A. Bristow, Daniel Gerlach, Ulrike Tontsch-Grunt, Chieh-Yuan Li, I-Lin Ho, Christopher P. Vellano, Marco H. Hofmann, Timothy P. Heffernan, Joseph R. Marszalek, Andrea Viale, Alessandro Carugo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB079.
https://doi.org/10.1158/1538-7445.AM2022-LB079
Published: 15 June 2022
View article titled, Abstract LB079: Pancreatic clonal replica tumors display functional heterogeneity in response to KRAS pharmacological inhibition and reveal unique epigenetic vulnerabilities to overcome resistance
Journal Articles

Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics

Sanjana Srinivasan, Johnathon Rose, Wantong Yao, Sahil Seth, Michael Peoples, Annette Machado, Chieh-Yuan Li, I Lin Ho, Jaewon J. Lee, Paola A. Guerrera, Eiru Kim, Mustafa Syed, Joseph Daniele, Angela K. Deem, Michael Kim, Christopher A. Bristow, Eugene Koay, Giannicola Genovese, Andrea Viale, Timothy P. Heffernan, Anirban Maitra, Traver Hart, Alessandro Carugo, Giulio Draetta
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2136.
https://doi.org/10.1158/1538-7445.AM2021-2136
Published: 01 July 2021
View article titled, Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics
Journal Articles

Abstract PD9-05: A tiered algorithm using mid-therapy ultrasound (US) response assessment and a novel gene expression signature (GES) improves the prediction of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in triple-negative breast cancer (TNBC): Results from the ARTEMIS trial (NCT02276443)

Sahil Seth, Gaiane M Rauch, Beatriz Adrada, Helen Piwnica-Worms, Lei Hou, Alastair M Thompson, William F Symmans, Bora Lim, Jason White, Giulio F Draetta, Andrew Futreal, Jeffrey Chang, Stacy Moulder
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD9-05.
https://doi.org/10.1158/1538-7445.SABCS20-PD9-05
Published: 15 February 2021
View article titled, Abstract PD9-05: A tiered algorithm using mid-therapy ultrasound (US) response assessment and a novel gene expression signature (GES) improves the prediction of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in triple-negative breast cancer (TNBC): Results from the ARTEMIS trial (NCT02276443)
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View article titled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 1497: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized trial (ARTEMIS; NCT02276443)

Sahil Seth, Lei Huo, Gaiane M. Rauch, Beatriz Adrada, Helen Piwnica-Worms, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Timothy Heffernan, Jennifer K. Litton, William F. Symmans, Giulio F. Draetta, Andrew P. Futreal, Jeffrey T. Chang, Stacy L. Moulder
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1497.
https://doi.org/10.1158/1538-7445.AM2020-1497
Published: 15 August 2020
View article titled, Abstract 1497: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized trial (ARTEMIS; NCT02276443)
Journal Articles

Abstract 1516: Deep profiling of T-cell repertoire and tumor heterogeneity in chronic lymphocytic leukemia patients following allogeneic T-cell therapy

Celine Kerros, John P. Miller, Xizeng Mao, Haven R. Garber, Hannah C. Beird, Jianhua Zhang, Jason Roszik, Paul Leonard, Li Zhao, Sahil Seth, Pei Lin, Huandong Sun, William G. Wierda, Issa F. Khouri, Karen Clise-Dwyer, Andrew Futreal, Shoudan Liang, Koppikar Priya, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1516.
https://doi.org/10.1158/1538-7445.AM2020-1516
Published: 15 August 2020
View article titled, Abstract 1516: Deep profiling of T-cell repertoire and tumor heterogeneity in chronic lymphocytic leukemia patients following allogeneic T-cell therapy
Journal Articles

Abstract P2-16-08: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443)

Sahil Seth, Lei Huo, Suhas Vasaikar, Gaiane Rauch, Bora Lim, Jason White, Beatriz Adrada, Helen Piwnica-Worms, Naoto T Ueno, Alastair Mark Thompson, Elizabeth Mittendorf, Debashish Tripathy, Jennifer Keating Litton, William Fraser Symmans, Giulio Draetta, Andrew Futreal, Jeffrey Chang, Stacy Moulder
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-16-08.
https://doi.org/10.1158/1538-7445.SABCS19-P2-16-08
Published: 15 February 2020
View article titled, Abstract P2-16-08: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443)
Journal Articles

Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer

Gloria V. Echeverria, Zhongqi Ge, Sahil Seth, Emily Powell, Xiaomei Zhang, Sabrina Jeter-Jones, Xinhui Zhou, Yan Jiang, Aaron McCoy, Shirong Cai, Yizheng Tu, Michael Peoples, Yuting Sun, Huan Qiu, Christopher Bristow, Alessandro Carugo, Jiansu Shao, Stacy L. Moulder, William F. Symmans, Timothy P. Heffernan, Jeffrey T. Chang, Helen M. Piwnica-Worms
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2901.
https://doi.org/10.1158/1538-7445.AM2019-2901
Published: 01 July 2019
View article titled, Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer
Journal Articles

Abstract 2900: Dissection of clonal heterogeneity unmasks pre-existing chemoresistance and new metabolic vulnerabilities in pancreatic cancer

Sahil Seth, Chieh-Yuan Li, Sara Loponte, I-Lin Ho, Denise Corti, Luigi Sapio, Edoardo Del Poggetto, Michael Peoples, Tatiana Karpinets, Frederick S. Robinson, Shan Jiang, Prasanta Dutta, Joseph Marszalek, Maria E. Di Francesco, Timothy P. Heffernan, Virginia Giuliani, Pratip K. Bhattacharya, Giannicola Genovese, Andrew Futreal, Giulio Draetta, Andrea Viale, Alessandro Carugo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2900.
https://doi.org/10.1158/1538-7445.AM2019-2900
Published: 01 July 2019
View article titled, Abstract 2900: Dissection of clonal heterogeneity unmasks pre-existing chemoresistance and new metabolic vulnerabilities in pancreatic cancer
Journal Articles

Abstract 2925: Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors

Curtis Pickering, Manish Kumar, Kathleen Bridges, Tongxin Xie, David Molkentine, Aakash Sheth, Liang Yang, Mitchell Frederick, Tim Heffernan, Sahil Seth, Jeffrey Myers, Heath D. Skinner
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2925.
https://doi.org/10.1158/1538-7445.AM2019-2925
Published: 01 July 2019
View article titled, Abstract 2925: Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors
Journal Articles

Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells

Joseph R. Marszalek, Sahil Seth, Denise Corti, Qi Zhang, Gloria V. Echeverria, Lina Han, Yuting Sun, Jennifer Molina, Sonal Gera, Edward Chang, Tin O. Khor, Mikhila Mahendra, Ningping Feng, Jason P. Gay, Timothy McAfoos, Virginia Giuliani, Xi Shi, Sabrina Jeter-Jones, Sarah Loponte, Chieh-Yuan Li, Christopher A. Bristow, Maria Emilia Di Francesco, Helen Piwnica-Worms, Marina Konopleva, Alessandro Carugo, Andrea Viale, Philip Jones, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2856.
https://doi.org/10.1158/1538-7445.AM2018-2856
Published: 01 July 2018
View article titled, Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Journal Articles

Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms

Gloria Vittone Echeverria, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher Bristow, Prabjhot Mundi, Sabrina Jeter-Jones, Xiaomei Zhang, Xinhui Zhou, Aaron McCoy, Shirong Cai, Yizheng Tu, Yuting Sun, Joseph Marszalek, Andrea Califano, William F. Symmans, Stacy L. Moulder, Jeffery T. Chang, Timothy P. Heffernan, Helen Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 212.
https://doi.org/10.1158/1538-7445.AM2018-212
Published: 01 July 2018
View article titled, Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms
Journal Articles

Abstract 4953: Metabolic targeting of chemoresistance perturbs clonal complexity in pancreatic cancer

Sara Loponte, Denise Corti, Sahil Seth, Edoardo Del Poggetto, I-Lin Ho, Chieh-Yuan Li, Shan Jiang, Joseph R. Marszalek, Maria Emilia Di Francesco, Giannicola Genovese, Giulio Draetta, Alessandro Carugo, Andrea Viale
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4953.
https://doi.org/10.1158/1538-7445.AM2018-4953
Published: 01 July 2018
View article titled, Abstract 4953: Metabolic targeting of chemoresistance perturbs clonal complexity in pancreatic cancer
Journal Articles

Abstract 392: Reverse functional genomics: Identifying differentially regulated functional networks as predictive biomarkers of pivotal vulnerabilities in pancreatic cancer

Johnathon L. Rose, Alessandro Carugo, Wantong Yao, Sahil Seth, Sanjana Srinivasan, Michael Peoples, Traver Hart, Timothy Heffernan, Giulio Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 392.
https://doi.org/10.1158/1538-7445.AM2018-392
Published: 01 July 2018
View article titled, Abstract 392: Reverse functional genomics: Identifying differentially regulated functional networks as predictive biomarkers of pivotal vulnerabilities in pancreatic cancer
Journal Articles

Abstract 1177: Clonal dissection of pancreatic tumors unmasks functional and genomic heterogeneous long-term self-renewing compartments at the origin of treatment resistance

Sahil Seth, Chieh-Yuan Li, I-Lin Ho, Denise Corti, Sara Loponte, Luigi Sapio, Edoardo Del Poggetto, Michael Peoples, Tatiana Karpinets, Giannicola Genovese, Andrew Futreal, Giulio Draetta, Alessandro Carugo, Andrea Viale
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1177.
https://doi.org/10.1158/1538-7445.AM2018-1177
Published: 01 July 2018
View article titled, Abstract 1177: Clonal dissection of pancreatic tumors unmasks functional and genomic heterogeneous long-term self-renewing compartments at the origin of treatment resistance
Journal Articles

Abstract A15: Generation of clonal replica tumors to interrogate complexity of human cancer in vivo

Sahil Seth, Chieh-Yuan Li, Denise Corti, Sara Loponte, I-Lin Ho, Edoardo Del Poggetto, Michael Peoples, Christopher Bristow, Joseph Marszalek, Timothy Heffernan, Giannicola Genovese, Giulio Draetta, Alessandro Carugo, Andrea Viale
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): A15.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-A15
Published: 14 May 2018
View article titled, Abstract A15: Generation of clonal replica tumors to interrogate complexity of human cancer in vivo
Journal Articles

Abstract 414: Identifying selective vulnerabilities in colorectal cancer molecular subtypes using in vivo functional genomic screens

Akira Inoue, Bahar Salimian Rizi, Alessandro Carugo, Sahil Seth, Christopher Bristow, Giannicola Genovese, Andrea Viale, David G. Menter, Scott Kopetz, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 414.
https://doi.org/10.1158/1538-7445.AM2017-414
Published: 01 July 2017
View article titled, Abstract 414: Identifying selective vulnerabilities in colorectal cancer molecular subtypes using <em>in vivo</em> functional genomic screens
Journal Articles

Abstract 415: In vivo shRNA library screening to identify novel targets for head and neck squamous cell carcinoma

Curtis R. Pickering, Tongxin Xie, Manish Kumar, Ramya L. Parimi, Liang P. Yang, Jiping Wang, Sahil Seth, Christopher A. Bristow, Alessandro Carugo, Frederick S. Robinson, Giulio F. Draetta, Heath Skinner, Mitchell J. Frederick, Jeffrey N. Myers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 415.
https://doi.org/10.1158/1538-7445.AM2017-415
Published: 01 July 2017
View article titled, Abstract 415: <em>In vivo</em> shRNA library screening to identify novel targets for head and neck squamous cell carcinoma
Journal Articles

Abstract 2916: The clonal evolution of glioblastoma

Jennifer Brooke Goldstein, Ravesanker Ezhilarasan, Mona Jaffari, Alessandro Carugo, Giulio Draetta, Roeland Verhaak, Sahil Seth, Erik Sulman, Phillip Andrew Futreal
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2916.
https://doi.org/10.1158/1538-7445.AM2017-2916
Published: 01 July 2017
View article titled, Abstract 2916: The clonal evolution of glioblastoma